利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

13 条记录 (耗时 0.028 秒)

    Conjugates for tumor localization and/or tumor therapy
    2.
    发明授权
    Conjugates for tumor localization and/or tumor therapy 失效
    用于肿瘤定位和/或肿瘤治疗的结合物

    公开(公告)号：US5308604A

    公开(公告)日：1994-05-03

    申请号：US859273

    申请日：1992-03-26

    申请人： Hansjorg Sinn ,  Hans-Hermann Schrenk ,  Wolfgang Maier-Borst ,  Eckhard Friedrich ,  Georgi Graschew ,  Dieter Worhle

    发明人： Hansjorg Sinn ,  Hans-Hermann Schrenk ,  Wolfgang Maier-Borst ,  Eckhard Friedrich ,  Georgi Graschew ,  Dieter Worhle

    IPC分类号： A61K47/48 ,  A61K49/00 ,  A61K51/08 ,  A61K49/02 ,  A61K43/00

    CPC分类号： A61K49/0002 ,  A61K47/48338 ,  A61K47/48715 ,  A61K51/0491 ,  A61K51/08 ,  A61K51/081 ,  A61K51/088 ,  A61K2123/00

    摘要： The invention relates to conjugates composed ofa) at least one polyalcohol or a derivatized polyalcohol,b) at least one active agent,c) at least one linker andd) a protein,wherein the polyalcohol(s) or the derivatized polyalcohol(s) are polyalcohols or derivatized polyalcohols which are not recognized by the defense system of an organism as exogenous, and the protein is a protein which can be taken up by the tumor specifically or non-specifically, and is not recognized by the defense system of an organism as exogenous. These conjugates are suitable for, on the one hand, making possible a very sensitive method in nuclear medicine for the diagnosis of tumors and, on the other hand, for example also offering new methods for diagnosing tumors in X-ray diagnosis, computerized tomography, nuclear spin tomography, electron spin resonance spectroscopy or electron microscopy.

    摘要翻译： 本发明涉及由a）至少一种多元醇或衍生化多元醇组成的缀合物，b）至少一种活性剂，c）至少一种连接体和d）蛋白质，其中所述多元醇或衍生化多元醇 ）是不被生物体的防御系统识别为外源的多元醇或衍生化多元醇，并且该蛋白质是可被肿瘤特异性或非特异性摄取的蛋白质，并且不被抗体系统识别 有机体为外源性。 这些缀合物一方面适合用于核医学中用于诊断肿瘤的非常敏感的方法，另一方面，例如还提供用于诊断X线诊断，计算机断层扫描， 核自旋断层扫描，电子自旋共振光谱或电子显微镜。

    Radiation detection device
    5.
    发明授权
    Radiation detection device 失效
    辐射检测装置

    公开(公告)号：US06310352B1

    公开(公告)日：2001-10-30

    申请号：US09142950

    申请日：1999-03-26

    申请人： Karlheinz Gross ,  Wolfgang Maier-Borst ,  Michael Klaus ,  Hans-Hermann Schrenk ,  Gerd Stehle ,  Hannsjörg Sinn

    发明人： Karlheinz Gross ,  Wolfgang Maier-Borst ,  Michael Klaus ,  Hans-Hermann Schrenk ,  Gerd Stehle ,  Hannsjörg Sinn

    IPC分类号： G01J158

    CPC分类号： G01J1/58 ,  G01J1/48 ,  G01R33/28 ,  G01T1/20

    摘要： The invention relates to a device for detecting input radiation such as X-rays, &ggr;-rays, ionizing radiation or fluorescent and low-level light. The device has at least one detection element comprising a sensor component (scintillator) for converting the input radiation into photons (scintillation light) in the UV, visible or IR part of the electromagnetic spectrum and an optical amplifier component which receives the light converted by the sensor component, forwards it for further processing and amplifies it at the same time. According to the invention, the amplifier component comprises at least one optical waveguide (1, 2, 2a, 2b, 20) whose material is optically pumped to amplify the scintillation light (3, 24, 25).

    摘要翻译： 本发明涉及一种用于检测诸如X射线，γ射线，电离辐射或荧光和低等级光的输入辐射的装置。 该装置具有至少一个检测元件，其包括用于将输入辐射转换成电磁光谱的UV，可见或IR部分中的光子（闪烁光）的传感器部件（闪烁体）和接收由 传感器组件，将其转发进行进一步处理并同时进行放大。 根据本发明，放大器部件包括至少一个光学波导（1,2,2a，2b，20），其光学泵浦材料以放大闪烁光（3,4,24）。