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1.发明授权公开(公告)号：US08710187B2
公开(公告)日：2014-04-29
申请号：US13643618
申请日：2011-04-29
CPC分类号： A61K38/1709 , A61K38/00 , A61K38/16 , A61K47/60 , C07K14/00 , C07K14/47 , C07K17/08 , C07K19/00 , C07K2319/74
摘要： The present invention relates to binding proteins specific for Vascular Endothelial Growth Factor A (VEGF-A), in particular to recombinant binding proteins comprising a polyethylene glycol moiety and a binding domain, which inhibits VEGF-Axxx (wherein xxx denotes the amino acid length of the VEGF-A mature protein) binding to Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2). Examples of such recombinant binding proteins are proteins which comprise an ankyrin repeat domain with the desired binding specificity, and a polyethylene glycol moiety. The binding proteins are useful in the treatment of cancer and other pathological conditions, e.g. eye diseases such as age-related macular degeneration.
摘要翻译： 本发明涉及对血管内皮生长因子A（VEGF-A）特异性的结合蛋白质，特别是涉及抑制VEGF-Axxx（其中xxx表示氨基酸长度）的重组结合蛋白，其包含聚乙二醇部分和结合结构域 VEGF-A成熟蛋白）结合血管内皮生长因子受体2（VEGFR-2）。 这种重组结合蛋白的实例是包含具有所需结合特异性的锚蛋白重复结构域的蛋白质和聚乙二醇部分。 结合蛋白可用于治疗癌症和其它病理状态，例如， 眼睛疾病如年龄相关性黄斑变性。
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2.发明申请公开(公告)号：US20120142611A1
公开(公告)日：2012-06-07
申请号：US13330336
申请日：2011-12-19
CPC分类号： C12N15/1055 , A61K38/00 , A61K38/16 , C07K14/00 , C07K14/47 , C07K14/4703 , C12N15/10 , C12N15/1037 , C12N15/1044 , C12N15/1093
摘要： A repeat protein from a collection of repeat proteins, wherein each repeat protein of said collection comprises a repeat domain, which comprises a set of consecutive repeat modules, wherein the repeat modules have the same fold and stack tightly to create a superhelical structure having a joint hydrophobic core, wherein each of the repeat modules is derived from one or more repeat units and wherein the repeat units comprise framework residues, which contribute to the folding topology of the repeat unit or contribute to an interaction with a neighboring repeat unit, and target interaction residues, which contribute to an interaction with a target substance, wherein the repeat proteins of the collection differ from other repeat proteins in the collection in at least one amino acid position of the repeat modules is described as are related pharmaceuticals and nucleic acid molecules.
摘要翻译： 来自重复蛋白质的重复蛋白质，其中所述收集物的每个重复蛋白质包含重复结构域，其包含一组连续重复模块，其中所述重复模块具有相同的折叠并且紧密堆叠以产生具有关节的超螺旋结构 疏水核心，其中每个重复模块衍生自一个或多个重复单元，并且其中重复单元包括框架残基，其有助于重复单元的折叠拓扑或有助于与相邻重复单元的相互作用，以及靶相互作用 有助于与靶物质相互作用的残基，其中所述集合的重复蛋白质与所述重复模块的至少一个氨基酸位置中的所述集合中的其它重复蛋白质不同描述为相关药物和核酸分子。
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公开(公告)号：US20110207668A1
公开(公告)日：2011-08-25
申请号：US13126821
申请日：2009-11-03
CPC分类号： C07K14/47 , A61K38/00 , A61K47/60 , C07K14/4703
摘要： The present invention relates to binding proteins specific for VEGF-A, in particular to recombinant binding proteins comprising a binding domain, which inhibits VEGF-Axxx binding to VEGFR-2. Examples of such binding proteins are proteins which comprise an ankyrin repeat domain with the desired binding specificity. The binding proteins are useful in the treatment of cancer and other pathological conditions, e.g. eye diseases such as age-related macular degeneration.
摘要翻译： 本发明涉及对VEGF-A特异性的结合蛋白，特别是涉及抑制VEGF-Axxx与VEGFR-2结合的结合结构域的重组结合蛋白。 这种结合蛋白的实例是包含具有所需结合特异性的锚蛋白重复结构域的蛋白质。 结合蛋白可用于治疗癌症和其它病理状态，例如， 眼睛疾病如年龄相关性黄斑变性。
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4.发明授权公开(公告)号：US09006389B2
公开(公告)日：2015-04-14
申请号：US13330336
申请日：2011-12-19
CPC分类号： C12N15/1055 , A61K38/00 , A61K38/16 , C07K14/00 , C07K14/47 , C07K14/4703 , C12N15/10 , C12N15/1037 , C12N15/1044 , C12N15/1093
摘要： A repeat protein from a collection of repeat proteins, wherein each repeat protein of said collection comprises a repeat domain, which comprises a set of consecutive repeat modules, wherein the repeat modules have the same fold and stack tightly to create a superhelical structure having a joint hydrophobic core, wherein each of the repeat modules is derived from one or more repeat units and wherein the repeat units comprise framework residues, which contribute to the folding topology of the repeat unit or contribute to an interaction with a neighboring repeat unit, and target interaction residues, which contribute to an interaction with a target substance, wherein the repeat proteins of the collection differ from other repeat proteins in the collection in at least one amino acid position of the repeat modules is described as are related pharmaceuticals and nucleic acid molecules.
摘要翻译： 来自重复蛋白质的重复蛋白质，其中所述收集物的每个重复蛋白质包含重复结构域，其包含一组连续重复模块，其中所述重复模块具有相同的折叠并且紧密堆叠以产生具有关节的超螺旋结构 疏水核心，其中每个重复模块衍生自一个或多个重复单元，并且其中重复单元包括框架残基，其有助于重复单元的折叠拓扑或有助于与相邻重复单元的相互作用，以及靶相互作用 有助于与靶物质相互作用的残基，其中所述集合的重复蛋白质与所述重复模块的至少一个氨基酸位置中的所述集合中的其它重复蛋白质不同描述为相关药物和核酸分子。
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5.发明申请公开(公告)号：US20130116197A1
公开(公告)日：2013-05-09
申请号：US13643618
申请日：2011-04-29
IPC分类号： C07K17/08
CPC分类号： A61K38/1709 , A61K38/00 , A61K38/16 , A61K47/60 , C07K14/00 , C07K14/47 , C07K17/08 , C07K19/00 , C07K2319/74
摘要： The present invention relates to binding proteins specific for VEGF-A, in particular to recombinant binding proteins comprising a polyethylene glycol moiety and a binding domain, which inhibits VEGF-Axxx binding to VEGFR-2. Examples of such recombinant binding proteins are proteins which comprise an ankyrin repeat domain with the desired binding specificity, and a polyethylene glycol moiety. The binding proteins are useful in the treatment of cancer and other pathological conditions, e.g. eye diseases such as age-related macular degeneration.
摘要翻译： 本发明涉及对VEGF-A特异性的结合蛋白，特别是涉及抑制VEGF-Axxx与VEGFR-2结合的包含聚乙二醇部分和结合结构域的重组结合蛋白。 这种重组结合蛋白的实例是包含具有所需结合特异性的锚蛋白重复结构域的蛋白质和聚乙二醇部分。 结合蛋白可用于治疗癌症和其它病理状态，例如， 眼睛疾病如年龄相关性黄斑变性。
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公开(公告)号：US08110653B2
公开(公告)日：2012-02-07
申请号：US12222525
申请日：2008-08-11
CPC分类号： C12N15/1055 , A61K38/00 , A61K38/16 , C07K14/00 , C07K14/47 , C07K14/4703 , C12N15/10 , C12N15/1037 , C12N15/1044 , C12N15/1093
摘要： A collection of repeat proteins, each repeat protein comprising a repeat domain, which comprises a set of consecutive repeat modules, wherein each of the repeat modules is derived from one or more repeat units and wherein the repeat units comprise framework residues, which contribute to the folding topology of the repeat unit or contribute to an interaction with a neighboring repeat unit, and target interaction residues, which contribute to an interaction with a target substance, wherein the repeat proteins differ from other repeat proteins in the collection in at least one amino acid position of the repeat modules is described.
摘要翻译： 重复蛋白质的集合，每个重复蛋白质包含重复结构域，其包含一组连续重复模块，其中每个重复模块衍生自一个或多个重复单元，并且其中重复单元包含框架残基，其有助于 重复单元的折叠拓扑或有助于与相邻重复单元的相互作用，以及有助于与靶物质相互作用的靶相互作用残基，其中所述重复蛋白与所述集合中的至少一个氨基酸中的其它重复蛋白不同 描述重复模块的位置。
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公开(公告)号：US08901076B2
公开(公告)日：2014-12-02
申请号：US13126821
申请日：2009-11-03
CPC分类号： C07K14/47 , A61K38/00 , A61K47/60 , C07K14/4703
摘要： The present invention relates to binding proteins specific for VEGF-A, in particular to recombinant binding proteins comprising a binding domain, which inhibits VEGF-Axxx binding to VEGFR-2. Examples of such binding proteins are proteins which comprise an ankyrin repeat domain with the desired binding specificity. The binding proteins are useful in the treatment of cancer and other pathological conditions, e.g. eye diseases such as age-related macular degeneration.
摘要翻译： 本发明涉及对VEGF-A特异性的结合蛋白，特别是涉及抑制VEGF-Axxx与VEGFR-2结合的结合结构域的重组结合蛋白。 这种结合蛋白的实例是包含具有所需结合特异性的锚蛋白重复结构域的蛋白质。 结合蛋白可用于治疗癌症和其它病理状态，例如， 眼睛疾病如年龄相关性黄斑变性。
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公开(公告)号：US20090082274A1
公开(公告)日：2009-03-26
申请号：US12222525
申请日：2008-08-11
CPC分类号： C12N15/1055 , A61K38/00 , A61K38/16 , C07K14/00 , C07K14/47 , C07K14/4703 , C12N15/10 , C12N15/1037 , C12N15/1044 , C12N15/1093
摘要： The present invention relates to collections of repeat proteins comprising repeat modules which are derived from one or more repeat units of a family of naturally occurring repeat proteins, to collections of nucleic acid molecules encoding said repeat proteins, to methods for the construction and application of such collections and to individual members of such collections.
摘要翻译： 本发明涉及包含衍生自天然存在的重复蛋白家族的一个或多个重复单元的重复模块的重复蛋白质的集合，编码所述重复蛋白质的核酸分子的集合，其构建和应用的方法 收藏品和收藏品的个别成员。
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9.发明申请公开(公告)号：US20110118146A1
公开(公告)日：2011-05-19
申请号：US11988389
申请日：2006-06-30
CPC分类号： C07K1/047 , C07K2319/034 , C07K2319/43 , C07K2319/50 , C07K2319/735 , C12N15/1037 , C12N15/625 , C12N15/63 , C40B40/02
摘要： The present invention relates to a filamentous phage display method wherein the polypeptides of interest displayed on the phage particle are cotranslationally translocated across the cytoplasmic membrane of Gram-negative bacteria based on the signal recognition particle pathway. This method is particularly suitable for polypeptides, which are known to be difficult to display on phages, and for proteins of cDNA libraries and other combinatorial libraries, in particular when derived from very fast folding, stable protein scaffolds. The invention further relates to phage or phagemid vectors useful in the method comprising a gene construct coding for a fusion polypeptide comprising the polypeptide to be displayed on the phage particle and an N-terminal signal sequence promoting cotranslational translocation.
摘要翻译： 本发明涉及一种丝状噬菌体展示法，其中显示在噬菌体颗粒上的感兴趣多肽基于信号识别颗粒途径共转移穿过革兰氏阴性细菌的细胞质膜。 该方法特别适用于已知难以在噬菌体上显示的多肽，以及cDNA文库和其他组合文库的蛋白质，特别是当从非常快的折叠的稳定的蛋白质支架衍生时。 本发明还涉及可用于包含编码融合多肽的基因构建体的噬菌体或噬菌粒载体，所述融合多肽包含要显示在噬菌体颗粒上的多肽和促进共翻译易位的N末端信号序列。
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10.发明授权公开(公告)号：US08846577B2
公开(公告)日：2014-09-30
申请号：US11988389
申请日：2006-06-30
CPC分类号： C07K1/047 , C07K2319/034 , C07K2319/43 , C07K2319/50 , C07K2319/735 , C12N15/1037 , C12N15/625 , C12N15/63 , C40B40/02
摘要： The present invention relates to a filamentous phage display method wherein the polypeptides of interest displayed on the phage particle are cotranslationally translocated across the cytoplasmic membrane of Gram-negative bacteria based on the signal recognition particle pathway. This method is particularly suitable for polypeptides, which are known to be difficult to display on phages, and for proteins of cDNA libraries and other combinatorial libraries, in particular when derived from very fast folding, stable protein scaffolds. The invention further relates to phage or phagemid vectors useful in the method comprising a gene construct coding for a fusion polypeptide comprising the polypeptide to be displayed on the phage particle and an N-terminal signal sequence promoting cotranslational translocation.
摘要翻译： 本发明涉及一种丝状噬菌体展示法，其中显示在噬菌体颗粒上的感兴趣多肽基于信号识别颗粒途径共转移穿过革兰氏阴性细菌的细胞质膜。 该方法特别适用于已知难以在噬菌体上显示的多肽，以及cDNA文库和其他组合文库的蛋白质，特别是当从非常快的折叠的稳定的蛋白质支架衍生时。 本发明还涉及可用于包含编码融合多肽的基因构建体的噬菌体或噬菌粒载体，所述融合多肽包含要显示在噬菌体颗粒上的多肽和促进共翻译易位的N末端信号序列。
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