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1.发明授权公开(公告)号：US09006389B2
公开(公告)日：2015-04-14
申请号：US13330336
申请日：2011-12-19
CPC分类号： C12N15/1055 , A61K38/00 , A61K38/16 , C07K14/00 , C07K14/47 , C07K14/4703 , C12N15/10 , C12N15/1037 , C12N15/1044 , C12N15/1093
摘要： A repeat protein from a collection of repeat proteins, wherein each repeat protein of said collection comprises a repeat domain, which comprises a set of consecutive repeat modules, wherein the repeat modules have the same fold and stack tightly to create a superhelical structure having a joint hydrophobic core, wherein each of the repeat modules is derived from one or more repeat units and wherein the repeat units comprise framework residues, which contribute to the folding topology of the repeat unit or contribute to an interaction with a neighboring repeat unit, and target interaction residues, which contribute to an interaction with a target substance, wherein the repeat proteins of the collection differ from other repeat proteins in the collection in at least one amino acid position of the repeat modules is described as are related pharmaceuticals and nucleic acid molecules.
摘要翻译： 来自重复蛋白质的重复蛋白质，其中所述收集物的每个重复蛋白质包含重复结构域，其包含一组连续重复模块，其中所述重复模块具有相同的折叠并且紧密堆叠以产生具有关节的超螺旋结构 疏水核心，其中每个重复模块衍生自一个或多个重复单元，并且其中重复单元包括框架残基，其有助于重复单元的折叠拓扑或有助于与相邻重复单元的相互作用，以及靶相互作用 有助于与靶物质相互作用的残基，其中所述集合的重复蛋白质与所述重复模块的至少一个氨基酸位置中的所述集合中的其它重复蛋白质不同描述为相关药物和核酸分子。
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2.发明申请公开(公告)号：US20120142611A1
公开(公告)日：2012-06-07
申请号：US13330336
申请日：2011-12-19
CPC分类号： C12N15/1055 , A61K38/00 , A61K38/16 , C07K14/00 , C07K14/47 , C07K14/4703 , C12N15/10 , C12N15/1037 , C12N15/1044 , C12N15/1093
摘要： A repeat protein from a collection of repeat proteins, wherein each repeat protein of said collection comprises a repeat domain, which comprises a set of consecutive repeat modules, wherein the repeat modules have the same fold and stack tightly to create a superhelical structure having a joint hydrophobic core, wherein each of the repeat modules is derived from one or more repeat units and wherein the repeat units comprise framework residues, which contribute to the folding topology of the repeat unit or contribute to an interaction with a neighboring repeat unit, and target interaction residues, which contribute to an interaction with a target substance, wherein the repeat proteins of the collection differ from other repeat proteins in the collection in at least one amino acid position of the repeat modules is described as are related pharmaceuticals and nucleic acid molecules.
摘要翻译： 来自重复蛋白质的重复蛋白质，其中所述收集物的每个重复蛋白质包含重复结构域，其包含一组连续重复模块，其中所述重复模块具有相同的折叠并且紧密堆叠以产生具有关节的超螺旋结构 疏水核心，其中每个重复模块衍生自一个或多个重复单元，并且其中重复单元包括框架残基，其有助于重复单元的折叠拓扑或有助于与相邻重复单元的相互作用，以及靶相互作用 有助于与靶物质相互作用的残基，其中所述集合的重复蛋白质与所述重复模块的至少一个氨基酸位置中的所述集合中的其它重复蛋白质不同描述为相关药物和核酸分子。
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3.发明授权公开(公告)号：US08710187B2
公开(公告)日：2014-04-29
申请号：US13643618
申请日：2011-04-29
CPC分类号： A61K38/1709 , A61K38/00 , A61K38/16 , A61K47/60 , C07K14/00 , C07K14/47 , C07K17/08 , C07K19/00 , C07K2319/74
摘要： The present invention relates to binding proteins specific for Vascular Endothelial Growth Factor A (VEGF-A), in particular to recombinant binding proteins comprising a polyethylene glycol moiety and a binding domain, which inhibits VEGF-Axxx (wherein xxx denotes the amino acid length of the VEGF-A mature protein) binding to Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2). Examples of such recombinant binding proteins are proteins which comprise an ankyrin repeat domain with the desired binding specificity, and a polyethylene glycol moiety. The binding proteins are useful in the treatment of cancer and other pathological conditions, e.g. eye diseases such as age-related macular degeneration.
摘要翻译： 本发明涉及对血管内皮生长因子A（VEGF-A）特异性的结合蛋白质，特别是涉及抑制VEGF-Axxx（其中xxx表示氨基酸长度）的重组结合蛋白，其包含聚乙二醇部分和结合结构域 VEGF-A成熟蛋白）结合血管内皮生长因子受体2（VEGFR-2）。 这种重组结合蛋白的实例是包含具有所需结合特异性的锚蛋白重复结构域的蛋白质和聚乙二醇部分。 结合蛋白可用于治疗癌症和其它病理状态，例如， 眼睛疾病如年龄相关性黄斑变性。
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4.发明申请公开(公告)号：US20130116197A1
公开(公告)日：2013-05-09
申请号：US13643618
申请日：2011-04-29
IPC分类号： C07K17/08
CPC分类号： A61K38/1709 , A61K38/00 , A61K38/16 , A61K47/60 , C07K14/00 , C07K14/47 , C07K17/08 , C07K19/00 , C07K2319/74
摘要： The present invention relates to binding proteins specific for VEGF-A, in particular to recombinant binding proteins comprising a polyethylene glycol moiety and a binding domain, which inhibits VEGF-Axxx binding to VEGFR-2. Examples of such recombinant binding proteins are proteins which comprise an ankyrin repeat domain with the desired binding specificity, and a polyethylene glycol moiety. The binding proteins are useful in the treatment of cancer and other pathological conditions, e.g. eye diseases such as age-related macular degeneration.
摘要翻译： 本发明涉及对VEGF-A特异性的结合蛋白，特别是涉及抑制VEGF-Axxx与VEGFR-2结合的包含聚乙二醇部分和结合结构域的重组结合蛋白。 这种重组结合蛋白的实例是包含具有所需结合特异性的锚蛋白重复结构域的蛋白质和聚乙二醇部分。 结合蛋白可用于治疗癌症和其它病理状态，例如， 眼睛疾病如年龄相关性黄斑变性。
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公开(公告)号：US20110207668A1
公开(公告)日：2011-08-25
申请号：US13126821
申请日：2009-11-03
CPC分类号： C07K14/47 , A61K38/00 , A61K47/60 , C07K14/4703
摘要： The present invention relates to binding proteins specific for VEGF-A, in particular to recombinant binding proteins comprising a binding domain, which inhibits VEGF-Axxx binding to VEGFR-2. Examples of such binding proteins are proteins which comprise an ankyrin repeat domain with the desired binding specificity. The binding proteins are useful in the treatment of cancer and other pathological conditions, e.g. eye diseases such as age-related macular degeneration.
摘要翻译： 本发明涉及对VEGF-A特异性的结合蛋白，特别是涉及抑制VEGF-Axxx与VEGFR-2结合的结合结构域的重组结合蛋白。 这种结合蛋白的实例是包含具有所需结合特异性的锚蛋白重复结构域的蛋白质。 结合蛋白可用于治疗癌症和其它病理状态，例如， 眼睛疾病如年龄相关性黄斑变性。
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公开(公告)号：US07417130B2
公开(公告)日：2008-08-26
申请号：US10363552
申请日：2001-09-10
CPC分类号： C12N15/1055 , A61K38/00 , A61K38/16 , C07K14/00 , C07K14/47 , C07K14/4703 , C12N15/10 , C12N15/1037 , C12N15/1044 , C12N15/1093
摘要： The present invention relates to collections of repeat proteins comprising repeat modules which are derived from one or more repeat units of a family of naturally occurring repeat proteins, to collections of nucleic acid molecules encoding said repeat proteins, to methods for the constructions and application of such collections and to individual members of such collections.
摘要翻译： 本发明涉及包含衍生自天然存在的重复蛋白家族的一个或多个重复单元的重复模块的重复蛋白质的集合，编码所述重复蛋白的核酸分子的集合，其构建和应用的方法 收藏品和收藏品的个别成员。
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公开(公告)号：US09284361B2
公开(公告)日：2016-03-15
申请号：US13989174
申请日：2011-11-25
申请人： Daniel Steiner , Hans Kaspar Binz , Maya Gulotti-Georgieva , Frieder W. Merz , Douglas Phillips , Ivo Sonderegger
发明人： Daniel Steiner , Hans Kaspar Binz , Maya Gulotti-Georgieva , Frieder W. Merz , Douglas Phillips , Ivo Sonderegger
CPC分类号： A61K47/64 , A61K38/00 , C07K14/001 , C07K14/47 , C07K14/4702 , C07K16/00 , C07K2318/20 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/30 , C07K2319/31 , C07K2319/55 , C07K2319/60
摘要： New designed repeat proteins with binding specificity for serum albumin are described, as well as nucleic acids encoding such serum albumin binding proteins, pharmaceutical compositions comprising such proteins, the use of such proteins to modify the pharmacokinetics of therapeutic relevant polypeptides and the use of such proteins in the treatment of diseases. The repeat proteins of the invention have a substantially increased half-life in plasma compared to proteins not binding serum albumin.
摘要翻译： 描述了对血清白蛋白具有结合特异性的新设计的重复蛋白质，以及编码这种血清白蛋白结合蛋白的核酸，包含这种蛋白质的药物组合物，使用这些蛋白质来改变治疗性相关多肽的药代动力学和使用这种蛋白质 在治疗疾病。 与不结合血清白蛋白的蛋白质相比，本发明的重复蛋白质具有显着增加的血浆半衰期。
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公开(公告)号：US20130244940A1
公开(公告)日：2013-09-19
申请号：US13989174
申请日：2011-11-25
申请人： Daniel Steiner , Hans Kaspar Binz , Maya Gulotti-Georgieva , Frieder W. Merz , Douglas Phillips , Ivo Sonderegger
发明人： Daniel Steiner , Hans Kaspar Binz , Maya Gulotti-Georgieva , Frieder W. Merz , Douglas Phillips , Ivo Sonderegger
IPC分类号： C07K14/00
CPC分类号： A61K47/64 , A61K38/00 , C07K14/001 , C07K14/47 , C07K14/4702 , C07K16/00 , C07K2318/20 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/30 , C07K2319/31 , C07K2319/55 , C07K2319/60
摘要： New designed repeat proteins with binding specificity for serum albumin are described, as well as nucleic acids encoding such serum albumin binding proteins, pharmaceutical compositions comprising such proteins, the use of such proteins to modify the pharmacokinetics of therapeutic relevant polypeptides and the use of such proteins in the treatment of diseases. The repeat proteins of the invention have a substantially increased half-life in plasma compared to proteins not binding serum albumin.
摘要翻译： 描述了对血清白蛋白具有结合特异性的新设计的重复蛋白质，以及编码这种血清白蛋白结合蛋白的核酸，包含这种蛋白质的药物组合物，使用这些蛋白质来改变治疗性相关多肽的药代动力学和使用这种蛋白质 在治疗疾病。 与不结合血清白蛋白的蛋白质相比，本发明的重复蛋白质具有显着增加的血浆半衰期。
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公开(公告)号：US09221892B2
公开(公告)日：2015-12-29
申请号：US13989181
申请日：2011-11-25
申请人： Hans Kaspar Binz
发明人： Hans Kaspar Binz
IPC分类号： C07K14/435 , C07K14/47 , C07K14/00 , A61K38/00
CPC分类号： A61K47/64 , A61K38/00 , C07K14/001 , C07K14/47 , C07K14/4702 , C07K16/00 , C07K2318/20 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/30 , C07K2319/31 , C07K2319/55 , C07K2319/60
摘要： Improved N-terminal capping modules for designed ankyrin repeat proteins (DARPins) conferring improved thermal stability to the DARPins are described, as well as nucleic acids encoding such proteins, pharmaceutical compositions comprising such proteins and the use of such proteins in the treatment of diseases.
摘要翻译： 描述了赋予DARPins的改进的热稳定性的设计的锚蛋白重复蛋白（DARPins）的改进的N-末端封端模块，以及编码这种蛋白质的核酸，包含这种蛋白质的药物组合物和这种蛋白质在疾病治疗中的用途。
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公开(公告)号：US20130296221A1
公开(公告)日：2013-11-07
申请号：US13989181
申请日：2011-11-25
申请人： Hans Kaspar Binz
发明人： Hans Kaspar Binz
IPC分类号： C07K14/47
CPC分类号： A61K47/64 , A61K38/00 , C07K14/001 , C07K14/47 , C07K14/4702 , C07K16/00 , C07K2318/20 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/30 , C07K2319/31 , C07K2319/55 , C07K2319/60
摘要： Improved N-terminal capping modules for designed ankyrin repeat proteins (DARPins) conferring improved thermal stability to the DARPins are described, as well as nucleic acids encoding such proteins, pharmaceutical compositions comprising such proteins and the use of such proteins in the treatment of diseases.
摘要翻译： 描述了赋予DARPins的改进的热稳定性的设计的锚蛋白重复蛋白（DARPins）的改进的N-末端封端模块，以及编码这种蛋白质的核酸，包含这种蛋白质的药物组合物和这种蛋白质在疾病治疗中的用途。
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