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    MODULAR INGESTIBLE DRUG DELIVERY CAPSULE
    2.
    发明申请
    MODULAR INGESTIBLE DRUG DELIVERY CAPSULE 有权
    模块不可食用药物输送胶囊

    公开(公告)号：US20120116358A1

    公开(公告)日：2012-05-10

    申请号：US13262841

    申请日：2010-04-02

    申请人： Johan Frederik Dijksman ,  Anke Pierik ,  Frits Tobi De Jongh ,  Jeff Shimizu ,  Hans Zou ,  Lucian Remus Albu ,  Olaf Weiner

    发明人： Johan Frederik Dijksman ,  Anke Pierik ,  Frits Tobi De Jongh ,  Jeff Shimizu ,  Hans Zou ,  Lucian Remus Albu ,  Olaf Weiner

    IPC分类号： A61M37/00

    CPC分类号： A61K9/4808 ,  A61K9/0009 ,  A61K9/0097 ,  A61M31/002

    摘要： An ingestible capsule (10) is provided for delivery of a drug, the capsule (10) comprises a first module (11) and a second module (12). The first module (11) has at least one drug compartment (13) for comprising an amount of the drug. The drug compartment (13) is sealed by a foil (14) with an embedded conducting heating wire (15). The second (12) module comprises electronics (18) for providing an electrical pulse to the heating wire (15) in order to open the drug compartment (13) by melting the foil (14). The first module (11) and second module (12) comprise interoperable connection means (19) for securing the first module (11) to the second module (12) such that the heating wire (15) is electronically coupled to the electronics (18).

    摘要翻译： 提供用于输送药物的可摄取胶囊（10），所述胶囊（10）包括第一模块（11）和第二模块（12）。 第一模块（11）具有至少一个用于包含一定量药物的药物隔室（13）。 药物隔室（13）由具有嵌入的导电加热丝（15）的箔（14）密封。 第二（12）模块包括用于向加热丝（15）提供电脉冲以便通过熔化箔（14）打开药物隔室（13）的电子器件（18）。 第一模块（11）和第二模块（12）包括用于将第一模块（11）固定到第二模块（12）的可互操作的连接装置（19），使得电热丝（15）电连接到电子装置 ）。

    Medicine reservoir for drug delivery device
    3.
    发明授权
    Medicine reservoir for drug delivery device 有权
    药物输送装置药库

    公开(公告)号：US08852155B2

    公开(公告)日：2014-10-07

    申请号：US13390110

    申请日：2010-08-09

    申请人： Hans Zou ,  Jeff Shimizu ,  Lucian Remus Albu

    发明人： Hans Zou ,  Jeff Shimizu ,  Lucian Remus Albu

    IPC分类号： A61M5/178 ,  A61M31/00

    CPC分类号： A61M31/00 ,  A61M31/002

    摘要： A medicine reservoir (10) is provided for use with a drug delivery device (50). The medicine reservoir (10) is arranged for comprising a drug (13) and comprises a dispensing hole (15) for dispensing the drug (13) into an environment of the drug delivery device (50). The medicine reservoir (10) further comprises a deformable plug (14) which plug (14) is removable by pressure caused by a dispensing action of the drug delivery device (50).

    摘要翻译： 提供药物贮存器（10）以与药物输送装置（50）一起使用。 药液贮存器（10）被布置成包括药物（13），并且包括用于将药物（13）分配到药物输送装置（50）的环境中的分配孔（15）。 药物储存器（10）还包括可变形插塞（14），该插塞（14）可以由药物输送装置（50）的分配动作引起的压力移除。

    MEDICINE RESERVOIR FOR DRUG DELIVERY DEVICE
    4.
    发明申请
    MEDICINE RESERVOIR FOR DRUG DELIVERY DEVICE 有权
    药物储存器用于药物递送装置

    公开(公告)号：US20130197440A1

    公开(公告)日：2013-08-01

    申请号：US13390110

    申请日：2010-08-09

    申请人： Hans Zou ,  Jeff Shimizu ,  Lucian Remus Albu

    发明人： Hans Zou ,  Jeff Shimizu ,  Lucian Remus Albu

    IPC分类号： A61M31/00

    CPC分类号： A61M31/00 ,  A61M31/002

    摘要： A medicine reservoir (10) is provided for use with a drug delivery device (50). The medicine reservoir (10) is arranged for comprising a drug (13) and comprises a dispensing hole (15) for dispensing the drug (13) into an environment of the drug delivery device (50). The medicine reservoir (10) further comprises a deformable plug (14) which plug (14) is removable by pressure caused by a dispensing action of the drug delivery device (50).

    摘要翻译： 提供药物贮存器（10）以与药物输送装置（50）一起使用。 药液贮存器（10）被布置成包括药物（13），并且包括用于将药物（13）分配到药物输送装置（50）的环境中的分配孔（15）。 药物储存器（10）还包括可变形插塞（14），该插塞（14）可以由药物输送装置（50）的分配动作引起的压力移除。

    Drug delivery device with compressible drug reservoir
    5.
    发明授权
    Drug delivery device with compressible drug reservoir 有权

    公开(公告)号：US10046109B2

    公开(公告)日：2018-08-14

    申请号：US13390111

    申请日：2010-08-10

    申请人： Hans Zou ,  Jeff Shimizu ,  Johan Frederik Dijksman

    发明人： Hans Zou ,  Jeff Shimizu ,  Johan Frederik Dijksman

    IPC分类号： A61M5/145 ,  A61M31/00

    摘要： A drug delivery device (50) is provided comprising a drug reservoir (10) and a piston (11). The drug reservoir (10) is provided for comprising a drug and comprises a flexible wall (22) and a dispensing hole (15) for dispensing the drug into an environment of the drug de delivery device (50). The piston (11) is provide for pressing against the flexible wall (22) to compress the drug reservoir (10) for pushing an amount of the drug through the dispensing hole (15). An adhesion interface (51) between a surface of the piston (11) and the flexible wall (22) prevents sliding between the surface of the piston (11) and the flexible wall (22).

    Swallowable medication capsule
    6.
    发明授权
    Swallowable medication capsule 有权

    公开(公告)号：US09687638B2

    公开(公告)日：2017-06-27

    申请号：US14006901

    申请日：2012-03-23

    申请人： Hans Zou ,  Jeff Shimizu

    发明人： Hans Zou ,  Jeff Shimizu

    IPC分类号： A61M31/00 ,  A61K9/48

    CPC分类号： A61M31/00 ,  A61K9/4808 ,  A61M31/002

    摘要： The invention relates to a swallowable medication capsule capable 200 of dispensing fluid medicine stored in a medication compartment 211 through a valveless exit hole 207. A vent hole 206 enables ventilation of an actuator cavity 212 which houses an actuator used for displacing a surface 205 which separates the medication cavity 211 and the actuator cavity 212. By locating the vent and exit holes close to each other so that contact with contracting parts of the gastrointestinal tract and the exterior surface 221 is not able to prohibit a pressure passageway between the vent and exit holes, creation of a pressure difference of pressures in the medication and actuator cavity is prohibited.

    ELECTRONIC PILL COMPRISING A PLURALITY OF MEDICINE RESERVOIRS
    8.
    发明申请
    ELECTRONIC PILL COMPRISING A PLURALITY OF MEDICINE RESERVOIRS 有权
    包含多种药物储存的电子药丸

    公开(公告)号：US20110092959A1

    公开(公告)日：2011-04-21

    申请号：US12992613

    申请日：2009-06-18

    申请人： Hans Zou ,  Jeff Shimizu ,  Lucian R. Albu ,  Johan F. Dijksman

    发明人： Hans Zou ,  Jeff Shimizu ,  Lucian R. Albu ,  Johan F. Dijksman

    IPC分类号： A61M37/00 ,  B65B3/04

    CPC分类号： A61M31/002

    摘要： Electronic pill (1, 11, 21) comprising a plurality of medicine reservoirs (2, 12, 22), each of the reservoirs comprising a discharge opening (3, 13, 23) covered by a removable cover (6, 16, 26). The pill comprises at least one actuator responsive to control circuitry for removing the cover from the discharge opening (3, 13, 23). The actuator can for example be a spring loaded piston (4) breaking a foil cover when dispensing the medicament. 5 Alternatively, the cover can be a rotatable disk (16) or cylinder (26) with an opening (17, 27) which can be brought in line with the discharge opening of a reservoir under the action of the actuator.

    摘要翻译： 包括多个药物储存器（2,12,22）的电子药丸（1,11,21），每个储存器包括由可移除的盖（6,16,26）覆盖的排出口（3,13,33） 。 所述药丸包括响应于控制电路的至少一个致动器，用于从所述排放开口（3,13,33）移除所述盖。 致动器可以例如是在分配药物时破坏箔盖的弹簧加载的活塞（4）。 或者，盖可以是具有开口（17,27）的可旋转盘（16）或圆筒（26），该开口可在致动器的作用下与储存器的排出口一致。

    METHOD AND APPARATUS FOR CHEMICAL ANALYSIS OF FLUIDS
    9.
    发明申请
    METHOD AND APPARATUS FOR CHEMICAL ANALYSIS OF FLUIDS 有权
    流体化学分析方法与装置

    公开(公告)号：US20110089050A1

    公开(公告)日：2011-04-21

    申请号：US12673845

    申请日：2008-08-29

    申请人： Lucian R. Albu ,  Hans Zou ,  Jeff Shimizu

    发明人： Lucian R. Albu ,  Hans Zou ,  Jeff Shimizu

    IPC分类号： G01N27/413 ,  G01N27/416

    CPC分类号： A63B69/0002 ,  A63B69/3641 ,  A63B2069/0008 ,  A63B2209/00 ,  A63B2210/50 ,  A63B2225/09 ,  A63B2225/093

    摘要： An apparatus and method for electrochemical fluid analysis comprises a chamber (1202) having a depth dimension for accommodating a volume of a fluid under test, first and second electrodes (A1) disposed within the chamber and extending along the depth dimension in spaced relation with each other, and a soluble solid, such as an annealed polymer, e.g. EUDRAGIT occupying a lateral gap between the first and second electrodes. The rate of dissolution as monitored by electrochemical impedance spectroscopy (EIS) of the soluble solid within the fluid depends on the chemical concentration of a corresponding analyte present in solution in the fluid. In one embodiment a silicon-based integrated circuit device defining an upper margin includes an array of electrodes disposed along said upper margin to permit direct exposure of the electrode array to the fluid under test. The device is constructed using CMOS technology.

    摘要翻译： 用于电化学流体分析的装置和方法包括具有用于容纳待测流体体积的深度尺寸的腔室（1202），设置在腔室内的第一和第二电极（A1），并且沿与所述腔室间隔开的深度尺寸延伸 另一种和可溶性固体，例如退火的聚合物，例如 EUDRAGIT占据第一和第二电极之间的横向间隙。 通过流体中可溶性固体的电化学阻抗谱（EIS）监测的溶解速率取决于流体中溶液中存在的相应分析物的化学浓度。 在一个实施例中，限定上边缘的硅基集成电路器件包括沿着所述上边缘设置的电极阵列，以允许电极阵列直接暴露于待测流体。 该器件采用CMOS技术构建。