公开(公告)号：US08852155B2

公开(公告)日：2014-10-07

申请号：US13390110

申请日：2010-08-09

申请人： Hans Zou ,  Jeff Shimizu ,  Lucian Remus Albu

发明人： Hans Zou ,  Jeff Shimizu ,  Lucian Remus Albu

IPC分类号： A61M5/178 ,  A61M31/00

CPC分类号： A61M31/00 ,  A61M31/002

摘要： A medicine reservoir (10) is provided for use with a drug delivery device (50). The medicine reservoir (10) is arranged for comprising a drug (13) and comprises a dispensing hole (15) for dispensing the drug (13) into an environment of the drug delivery device (50). The medicine reservoir (10) further comprises a deformable plug (14) which plug (14) is removable by pressure caused by a dispensing action of the drug delivery device (50).

摘要翻译： 提供药物贮存器（10）以与药物输送装置（50）一起使用。 药液贮存器（10）被布置成包括药物（13），并且包括用于将药物（13）分配到药物输送装置（50）的环境中的分配孔（15）。 药物储存器（10）还包括可变形插塞（14），该插塞（14）可以由药物输送装置（50）的分配动作引起的压力移除。

公开(公告)号：US20130197440A1

公开(公告)日：2013-08-01

申请号：US13390110

申请日：2010-08-09

申请人： Hans Zou ,  Jeff Shimizu ,  Lucian Remus Albu

发明人： Hans Zou ,  Jeff Shimizu ,  Lucian Remus Albu

IPC分类号： A61M31/00

CPC分类号： A61M31/00 ,  A61M31/002

摘要： A medicine reservoir (10) is provided for use with a drug delivery device (50). The medicine reservoir (10) is arranged for comprising a drug (13) and comprises a dispensing hole (15) for dispensing the drug (13) into an environment of the drug delivery device (50). The medicine reservoir (10) further comprises a deformable plug (14) which plug (14) is removable by pressure caused by a dispensing action of the drug delivery device (50).

摘要翻译： 提供药物贮存器（10）以与药物输送装置（50）一起使用。 药液贮存器（10）被布置成包括药物（13），并且包括用于将药物（13）分配到药物输送装置（50）的环境中的分配孔（15）。 药物储存器（10）还包括可变形插塞（14），该插塞（14）可以由药物输送装置（50）的分配动作引起的压力移除。

公开(公告)号：US09744139B2

公开(公告)日：2017-08-29

申请号：US13262841

申请日：2010-04-02

申请人： Johan Frederik Dijksman ,  Anke Pierik ,  Frits Tobi De Jongh ,  Jeff Shimizu ,  Hans Zou ,  Lucian Remus Albu ,  Olaf Weiner

发明人： Johan Frederik Dijksman ,  Anke Pierik ,  Frits Tobi De Jongh ,  Jeff Shimizu ,  Hans Zou ,  Lucian Remus Albu ,  Olaf Weiner

IPC分类号： A61K9/48 ,  A61K9/00 ,  A61M31/00

CPC分类号： A61K9/4808 ,  A61K9/0009 ,  A61K9/0097 ,  A61M31/002

摘要： An ingestible capsule (10) is provided for delivery of a drug, the capsule (10) comprises a first module (11) and a second module (12). The first module (11) has at least one drug compartment (13) for comprising an amount of the drug. The drug compartment (13) is sealed by a foil (14) with an embedded conducting heating wire (15). The second (12) module comprises electronics (18) for providing an electrical pulse to the heating wire (15) in order to open the drug compartment (13) by melting the foil (14). The first module (11) and second module (12) comprise interoperable connection means (19) for securing the first module (11) to the second module (12) such that the heating wire (15) is electronically coupled to the electronics (18).

公开(公告)号：US20120116358A1

公开(公告)日：2012-05-10

申请号：US13262841

申请日：2010-04-02

申请人： Johan Frederik Dijksman ,  Anke Pierik ,  Frits Tobi De Jongh ,  Jeff Shimizu ,  Hans Zou ,  Lucian Remus Albu ,  Olaf Weiner

发明人： Johan Frederik Dijksman ,  Anke Pierik ,  Frits Tobi De Jongh ,  Jeff Shimizu ,  Hans Zou ,  Lucian Remus Albu ,  Olaf Weiner

IPC分类号： A61M37/00

CPC分类号： A61K9/4808 ,  A61K9/0009 ,  A61K9/0097 ,  A61M31/002

摘要： An ingestible capsule (10) is provided for delivery of a drug, the capsule (10) comprises a first module (11) and a second module (12). The first module (11) has at least one drug compartment (13) for comprising an amount of the drug. The drug compartment (13) is sealed by a foil (14) with an embedded conducting heating wire (15). The second (12) module comprises electronics (18) for providing an electrical pulse to the heating wire (15) in order to open the drug compartment (13) by melting the foil (14). The first module (11) and second module (12) comprise interoperable connection means (19) for securing the first module (11) to the second module (12) such that the heating wire (15) is electronically coupled to the electronics (18).

摘要翻译： 提供用于输送药物的可摄取胶囊（10），所述胶囊（10）包括第一模块（11）和第二模块（12）。 第一模块（11）具有至少一个用于包含一定量药物的药物隔室（13）。 药物隔室（13）由具有嵌入的导电加热丝（15）的箔（14）密封。 第二（12）模块包括用于向加热丝（15）提供电脉冲以便通过熔化箔（14）打开药物隔室（13）的电子器件（18）。 第一模块（11）和第二模块（12）包括用于将第一模块（11）固定到第二模块（12）的可互操作的连接装置（19），使得电热丝（15）电连接到电子装置 ）。

公开(公告)号：US20100045309A1

公开(公告)日：2010-02-25

申请号：US12521015

申请日：2007-12-26

申请人： Han Zou ,  Lucian Remus Albu ,  Jeff Shimizu ,  Johan Frederik Dijksman ,  Anke Pierik ,  Judith Margreet Rensen ,  Adam Schleicher ,  Frits Tobi De Jongh

发明人： Han Zou ,  Lucian Remus Albu ,  Jeff Shimizu ,  Johan Frederik Dijksman ,  Anke Pierik ,  Judith Margreet Rensen ,  Adam Schleicher ,  Frits Tobi De Jongh

IPC分类号： G01R27/26

CPC分类号： A61B5/053 ,  A61B5/073 ,  A61B5/14539 ,  A61B5/42

摘要： A fluid sensor for use within the gastro-intestinal tract of a human being is disclosed. The sensor includes a sensing coil which is immersible in the sample fluid of the gastro-intestinal tract; a signal generator in electrical with the sensing coil for applying an electrical current pulse to the sensing coil; a signal receiver in communication with the sensing coil for measuring an electrical reflection relative to said electrical current pulse; and a data processor for receiving the electrical reflection and for calculating data representative of at least one property, such as pH of the sample fluid based on the electrical reflection. The fluid sensor can also include a reference coil for calibrating the sensing coil. The sensor coil and reference coil can be encapsulated in a swallowable pill shell. The sensor coil can also function as an antenna for transmitting and receiving signals to/form a remote location.

摘要翻译： 公开了一种在人胃肠道内使用的流体传感器。 该传感器包括一感测线圈，该感测线圈可浸入胃肠道的样品流体中; 与所述感测线圈电连接以将电流脉冲施加到所述感测线圈的信号发生器; 与传感线圈通信的信号接收器，用于测量相对于所述电流脉冲的电反射; 以及数据处理器，用于接收电反射并且用于计算代表至少一个性质的数据，例如基于电反射的样品流体的pH。 流体传感器还可以包括用于校准感测线圈的参考线圈。 传感器线圈和参考线圈可以封装在可吞咽的药丸壳中。 传感器线圈还可以用作用于向/形成远程位置发送和接收信号的天线。

公开(公告)号：US08636980B2

公开(公告)日：2014-01-28

申请号：US13376847

申请日：2010-06-14

申请人： Daniel R. Elgort ,  Lucian Remus Albu

发明人： Daniel R. Elgort ,  Lucian Remus Albu

IPC分类号： A61B5/055

CPC分类号： G01R33/4804 ,  A61B5/01 ,  A61B5/055 ,  G01N24/006 ,  G01R33/282 ,  G01R33/62

摘要： A magnetic resonance examination system comprises an RF-system for inducing resonance in polarized dipoles and receiving magnetic resonance signals from an object to be examined. A thermometry module dervies a temperature distribution of the object to be examined from the magnetic resonance signals. The magnetic resonance examination system further comprises a photonic-based hyperpolarization device with a photonic source for emitting electromagnetic radiation, a moder converter, such as a phase hologram to impart orbital angular momentum to the electromagnetic radiation and via spatial filter to select from the phase hologram a diffracted photonic beam endowed with orbital angular momentum for polarizing the dipoles via transferred orbital angular momentum.

摘要翻译： 磁共振检查系统包括用于在极化偶极子中诱发共振的RF系统，并接收来自被检查物体的磁共振信号。 温度测量模块从磁共振信号中得出待检测对象的温度分布。 磁共振检查系统还包括具有用于发射电磁辐射的光子源的基于光子的超极化装置，诸如相位全息图的慢速转换器，以向电磁辐射赋予轨道角动量，并且经由空间滤波器从相位全息图中选择 衍射光子束具有轨道角动量，用于通过转移的轨道角动量极化偶极子。

公开(公告)号：US08611982B2

公开(公告)日：2013-12-17

申请号：US13131881

申请日：2009-11-05

申请人： Daniel R. Elgort ,  Lucian Remus Albu

发明人： Daniel R. Elgort ,  Lucian Remus Albu

IPC分类号： G01V3/00

CPC分类号： A61B34/20 ,  A61B5/055 ,  A61B5/06 ,  A61B2034/2051 ,  A61B2090/373 ,  A61B2090/374

摘要： One or more light beam endowed with photonic orbital angular momentum generating devices are mounted at preselected locations on an insertable instrument to hyperpolarize nuclear magnetic dipoles in a region of interest. The hyperpolarized nuclear magnetic dipoles are caused to resonate, generating magnetic resonance signals. A controller controls gradient coils to induce a magnetic field gradient across the region of interest, such that the frequency of the resonance signals is indicative of spatial positions. A frequency-to-position decoder converts the resonance signal frequencies into spatial positions. A video processor combines the spatial positions and a portion of a diagnostic image from a diagnostic image memory into a combined image which depicts the location of the region of interest or a portion of the instrument marked on the diagnostic image and displays the combined image on a monitor.

摘要翻译： 具有光子轨道角动量产生装置的一个或多个光束被安装在可插入仪器上的预选位置处，以在感兴趣的区域中超极化核磁偶极子。 引起超极化核磁偶极子共振，产生磁共振信号。 控制器控制梯度线圈以在感兴趣区域上引起磁场梯度，使得谐振信号的频率指示空间位置。 频率到位置解码器将谐振信号频率转换成空间位置。 视频处理器将空间位置和来自诊断图像存储器的诊断图像的一部分组合成组合图像，该组合图像描绘了标记在诊断图像上的感兴趣区域或仪器的一部分的位置，并将组合图像显示在 监控。

公开(公告)号：US06967638B2

公开(公告)日：2005-11-22

申请号：US10165905

申请日：2002-06-10

申请人： Peter J. Janssen ,  Lucian Remus Albu

发明人： Peter J. Janssen ,  Lucian Remus Albu

IPC分类号： G02F1/133 ,  G09G3/20 ,  G09G3/36

CPC分类号： G09G3/3674 ,  G09G3/20 ,  G09G3/3677 ,  G09G2310/0205 ,  G09G2310/0251 ,  G09G2310/0267

摘要： A row addressing circuit and method for addressing multiple rows of a visual display in a single cycle. The circuit comprises: a decoder coupled to a plurality of signal lines, wherein the decoder includes a system for decoding a row select address, a first pre-write address and a second pre-write address and selecting three corresponding signals lines during the single cycle; and wherein each of the plurality of signal lines is further coupled to a dedicated set of latches, wherein each set of latches includes a row select latch, a first pre-write latch, and a second pre-write latch.

摘要翻译： 用于在单个周期中寻址多行视觉显示的行寻址电路和方法。 电路包括：耦合到多个信号线的解码器，其中解码器包括用于解码行选择地址的系统，第一预写地址和第二预写地址，并且在单周期期间选择三个对应的信号线 ; 并且其中所述多个信号线中的每一个还被耦合到专用锁存器组，其中每组锁存器包括行选择锁存器，第一预写锁存器和第二预写锁存器。

公开(公告)号：US06384817B1

公开(公告)日：2002-05-07

申请号：US09469455

申请日：1999-12-21

申请人： Peter J. Janssen ,  Lucian Remus Albu ,  John E. Dean

发明人： Peter J. Janssen ,  Lucian Remus Albu ,  John E. Dean

IPC分类号： G09G500

CPC分类号： G09G3/2011 ,  G02F1/13306 ,  G09G3/3685 ,  G09G2310/0259 ,  G09G2320/02

摘要： In an electro-optic display device, such as a liquid crystal display device which serves as a modulator for projected light, a global ramp generator is used in conjunction with track and hold circuits to convert incoming digital display signals to analog signals, and to address the individual pixels of the display device with such analog signals. A plurality of column drivers, each coupled to the ramp generator and to the pixels in a column of the display device, track and hold the ramp voltage signal when it reaches a value corresponding to the desired brightness level of a particular pixel in the respective column. At least one current source is provided, coupled to the signal source output, for supplying current to the signal source output, as needed, to compensate for switching the capacitive load of the column drivers on and off. As a result, transient voltages in the ramp signal are avoided.

摘要翻译： 在诸如用作投影光的调制器的液晶显示装置的电光显示装置中，全局斜坡发生器与轨道和保持电路结合使用以将输入的数字显示信号转换为模拟信号，并且寻址 具有这种模拟信号的显示装置的各个像素。 每个耦合到斜坡发生器和显示装置的列中的像素的列驱动器当其达到对应于相应列中的特定像素的期望亮度水平的值时跟踪并保持斜坡电压信号 。 提供耦合到信号源输出的至少一个电流源，用于根据需要向信号源输出提供电流，以补偿对列驱动器的容性负载的开关。 结果，避免了斜坡信号中的瞬态电压。

公开(公告)号：US08830549B2

公开(公告)日：2014-09-09

申请号：US12303964

申请日：2007-05-29

申请人： Alok Govil ,  Lucian Remus Albu

发明人： Alok Govil ,  Lucian Remus Albu

IPC分类号： G03H1/08 ,  G03H1/22

CPC分类号： G03H1/2294 ,  G03H2222/31 ,  G03H2225/22 ,  G03H2225/52 ,  G03H2240/15

摘要： An electroholographic display system (800, 900) for displaying a holographic image, includes a coherent light source (830, 930) producing a coherent, collimated, light beam; a spatial light modulator (SLM) (820, 920) adapted to receive and spatially modulate the coherent, collimated, light beam to produce therefrom a spatially modulated light beam including first portions having a first polarization and second portions having a second polarization orthogonal to the first polarization; and a processor and driver unit (810, 910) adapted to generate hologram data representing a holographic image and to apply appropriate voltages to the pixels of the SLM to cause the SLM to modulate the coherent collimated light beam with the hologram data. The spatially modulated light beam is projected to an image plane to produce the holographic image including the first portions having the first polarization and the second portions having a second polarization orthogonal to the first polarization.

摘要翻译： 用于显示全息图像的电子照相显示系统（800,900）包括产生相干，准直光束的相干光源（830,930）; 空间光调制器（SLR），其适于接收和空间调制所述相干平行的光束，从而产生空间调制的光束，所述空间调制光束包括具有第一偏振的第一部分和具有与所述第一极化正交的第二偏振的第二部分 第一极化 以及适于产生表示全息图像的全息图数据并且向SLM的像素施加适当电压以使SLM利用全息图数据调制相干准直光束的处理器和驱动单元（810,910）。 将空间调制的光束投影到图像平面，以产生包括具有第一偏振的第一部分和第二部分具有与第一偏振正交的第二偏振的全息图像。