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    ELECTRONIC PILL COMPRISING A PLURALITY OF MEDICINE RESERVOIRS
    1.
    发明申请
    ELECTRONIC PILL COMPRISING A PLURALITY OF MEDICINE RESERVOIRS 有权
    包含多种药物储存的电子药丸

    公开(公告)号：US20110092959A1

    公开(公告)日：2011-04-21

    申请号：US12992613

    申请日：2009-06-18

    申请人： Hans Zou ,  Jeff Shimizu ,  Lucian R. Albu ,  Johan F. Dijksman

    发明人： Hans Zou ,  Jeff Shimizu ,  Lucian R. Albu ,  Johan F. Dijksman

    IPC分类号： A61M37/00 ,  B65B3/04

    CPC分类号： A61M31/002

    摘要： Electronic pill (1, 11, 21) comprising a plurality of medicine reservoirs (2, 12, 22), each of the reservoirs comprising a discharge opening (3, 13, 23) covered by a removable cover (6, 16, 26). The pill comprises at least one actuator responsive to control circuitry for removing the cover from the discharge opening (3, 13, 23). The actuator can for example be a spring loaded piston (4) breaking a foil cover when dispensing the medicament. 5 Alternatively, the cover can be a rotatable disk (16) or cylinder (26) with an opening (17, 27) which can be brought in line with the discharge opening of a reservoir under the action of the actuator.

    摘要翻译： 包括多个药物储存器（2,12,22）的电子药丸（1,11,21），每个储存器包括由可移除的盖（6,16,26）覆盖的排出口（3,13,33） 。 所述药丸包括响应于控制电路的至少一个致动器，用于从所述排放开口（3,13,33）移除所述盖。 致动器可以例如是在分配药物时破坏箔盖的弹簧加载的活塞（4）。 或者，盖可以是具有开口（17,27）的可旋转盘（16）或圆筒（26），该开口可在致动器的作用下与储存器的排出口一致。

    DEVICE FOR DELIVERY OF POWDER LIKE MEDICATION IN A HUMID ENVIRONMENT
    2.
    发明申请
    DEVICE FOR DELIVERY OF POWDER LIKE MEDICATION IN A HUMID ENVIRONMENT 有权
    用于在湿润环境中输送类似药物的装置

    公开(公告)号：US20110106064A1

    公开(公告)日：2011-05-05

    申请号：US12992305

    申请日：2009-06-17

    申请人： Hans Zou ,  Jeff Shimizu ,  Lucian R. Albu ,  Johan F. Dijksman

    发明人： Hans Zou ,  Jeff Shimizu ,  Lucian R. Albu ,  Johan F. Dijksman

    IPC分类号： A61M37/00

    CPC分类号： A61M5/14276 ,  A61M31/002 ,  A61M2202/064 ,  A61M2205/3365 ,  A61M2210/1053 ,  A61M2210/1064

    摘要： A device for placement in an environment, particularly a humid environment, for delivery of medication to said environment. The device comprises a reservoir (103) having an orifice (104), a conveying unit for conveying a reservoir's content (106) through the orifice (104) and an actuator arrangement for driving the conveying unit. In order to provide a reliable delivery of medication in a humid environment, the conveying unit comprises an auger (110) extending in the reservoir (103).

    摘要翻译： 一种用于放置在环境中，特别是潮湿环境中用于将药物递送到所述环境的装置。 该装置包括具有孔口（104）的储存器（103），用于通过孔口（104）输送储存器内容物（106）的输送单元和用于驱动输送单元的致动器装置。 为了在潮湿环境中提供药物的可靠递送，输送单元包括在贮存器（103）中延伸的螺旋推运器（110）。

    Electronic pill comprising a plurality of medicine reservoirs
    4.
    发明授权
    Electronic pill comprising a plurality of medicine reservoirs 有权
    电子药丸包含多个药物储存器

    公开(公告)号：US08961498B2

    公开(公告)日：2015-02-24

    申请号：US12992613

    申请日：2009-06-18

    申请人： Hans Zou ,  Jeff Shimizu ,  Lucian R. Albu ,  Johan F. Dijksman

    发明人： Hans Zou ,  Jeff Shimizu ,  Lucian R. Albu ,  Johan F. Dijksman

    IPC分类号： A61K9/22 ,  A61K9/20 ,  A61M5/20 ,  A61M31/00

    CPC分类号： A61M31/002

    摘要： Electronic pill (1, 11, 21) comprising a plurality of medicine reservoirs (2, 12, 22), each of the reservoirs comprising a discharge opening (3, 13, 23) covered by a removable cover (6, 16, 26). The pill comprises at least one actuator responsive to control circuitry for removing the cover from the discharge opening (3, 13, 23). The actuator can for example be a spring loaded piston (4) breaking a foil cover when dispensing the medicament. 5 Alternatively, the cover can be a rotatable disk (16) or cylinder (26) with an opening (17, 27) which can be brought in line with the discharge opening of a reservoir under the action of the actuator.

    摘要翻译： 包括多个药物储存器（2,12,22）的电子药丸（1,11,21），每个储存器包括由可移除的盖（6,16,26）覆盖的排出口（3,13,33） 。 所述药丸包括响应于控制电路的至少一个致动器，用于从所述排放开口（3,13,33）移除所述盖。 致动器可以例如是在分配药物时破坏箔盖的弹簧加载的活塞（4）。 或者，盖可以是具有开口（17,27）的可旋转盘（16）或圆筒（26），该开口可在致动器的作用下与储存器的排出口一致。

    METHOD AND APPARATUS FOR CHEMICAL ANALYSIS OF FLUIDS
    5.
    发明申请
    METHOD AND APPARATUS FOR CHEMICAL ANALYSIS OF FLUIDS 有权
    流体化学分析方法与装置

    公开(公告)号：US20110089050A1

    公开(公告)日：2011-04-21

    申请号：US12673845

    申请日：2008-08-29

    申请人： Lucian R. Albu ,  Hans Zou ,  Jeff Shimizu

    发明人： Lucian R. Albu ,  Hans Zou ,  Jeff Shimizu

    IPC分类号： G01N27/413 ,  G01N27/416

    CPC分类号： A63B69/0002 ,  A63B69/3641 ,  A63B2069/0008 ,  A63B2209/00 ,  A63B2210/50 ,  A63B2225/09 ,  A63B2225/093

    摘要： An apparatus and method for electrochemical fluid analysis comprises a chamber (1202) having a depth dimension for accommodating a volume of a fluid under test, first and second electrodes (A1) disposed within the chamber and extending along the depth dimension in spaced relation with each other, and a soluble solid, such as an annealed polymer, e.g. EUDRAGIT occupying a lateral gap between the first and second electrodes. The rate of dissolution as monitored by electrochemical impedance spectroscopy (EIS) of the soluble solid within the fluid depends on the chemical concentration of a corresponding analyte present in solution in the fluid. In one embodiment a silicon-based integrated circuit device defining an upper margin includes an array of electrodes disposed along said upper margin to permit direct exposure of the electrode array to the fluid under test. The device is constructed using CMOS technology.

    摘要翻译： 用于电化学流体分析的装置和方法包括具有用于容纳待测流体体积的深度尺寸的腔室（1202），设置在腔室内的第一和第二电极（A1），并且沿与所述腔室间隔开的深度尺寸延伸 另一种和可溶性固体，例如退火的聚合物，例如 EUDRAGIT占据第一和第二电极之间的横向间隙。 通过流体中可溶性固体的电化学阻抗谱（EIS）监测的溶解速率取决于流体中溶液中存在的相应分析物的化学浓度。 在一个实施例中，限定上边缘的硅基集成电路器件包括沿着所述上边缘设置的电极阵列，以允许电极阵列直接暴露于待测流体。 该器件采用CMOS技术构建。

    Method and apparatus for chemical analysis of fluids
    6.
    发明授权
    Method and apparatus for chemical analysis of fluids 有权
    流体化学分析方法和装置

    公开(公告)号：US08585878B2

    公开(公告)日：2013-11-19

    申请号：US12673845

    申请日：2008-08-29

    申请人： Lucian R. Albu ,  Hans Zou ,  Jeff Shimizu

    发明人： Lucian R. Albu ,  Hans Zou ,  Jeff Shimizu

    IPC分类号： G01N27/26

    CPC分类号： A63B69/0002 ,  A63B69/3641 ,  A63B2069/0008 ,  A63B2209/00 ,  A63B2210/50 ,  A63B2225/09 ,  A63B2225/093

    摘要： An apparatus and method for electrochemical fluid analysis comprises a chamber (1202) having a depth dimension for accommodating a volume of a fluid under test, first and second electrodes (A1) disposed within the chamber and extending along the depth dimension in spaced relation with each other, and a soluble solid, such as an annealed polymer, e.g. EUDRAGIT occupying a lateral gap between the first and second electrodes. The rate of dissolution as monitored by electrochemical impedance spectroscopy (EIS) of the soluble solid within the fluid depends on the chemical concentration of a corresponding analyte present in solution in the fluid. In one embodiment a silicon-based integrated circuit device defining an upper margin includes an array of electrodes disposed along said upper margin to permit direct exposure of the electrode array to the fluid under test. The device is constructed using CMOS technology.

    摘要翻译： 用于电化学流体分析的装置和方法包括具有用于容纳待测流体体积的深度尺寸的腔室（1202），设置在腔室内的第一和第二电极（A1），并且沿与所述腔室间隔开的深度尺寸延伸 另一种和可溶性固体，例如退火的聚合物，例如 EUDRAGIT占据第一和第二电极之间的横向间隙。 通过流体中可溶性固体的电化学阻抗谱（EIS）监测的溶解速率取决于流体中溶液中存在的相应分析物的化学浓度。 在一个实施例中，限定上边缘的硅基集成电路器件包括沿着所述上边缘设置的电极阵列，以允许电极阵列直接暴露于待测流体。 该器件采用CMOS技术构建。

    ELECTRONIC PILL COMPRISING A MEDICINE RESERVOIR
    7.
    发明申请
    ELECTRONIC PILL COMPRISING A MEDICINE RESERVOIR 有权
    包含医药储存器的电子药丸

    公开(公告)号：US20110106063A1

    公开(公告)日：2011-05-05

    申请号：US12995817

    申请日：2009-07-03

    申请人： Johan F. Dijksman ,  Anke Pierik ,  Jeff Shimizu ,  Hans Zou

    发明人： Johan F. Dijksman ,  Anke Pierik ,  Jeff Shimizu ,  Hans Zou

    IPC分类号： A61M37/00 ,  B65B3/04

    CPC分类号： A61K9/4808 ,  A61K9/0009 ,  A61K47/00 ,  A61K47/38 ,  A61M31/002

    摘要： Electronic pill (1, 11) comprising at least one medicine reservoir (2, 12) with a solid powder or granulate medicine, a discharge opening (3, 13) and an actuator responsive to control circuitry for displacing medicine from the reservoir (2, 12) to the discharge opening (3, 13). The medicine comprises a dispersion of one or more active ingredients—e.g., solids in powder or granulate form—in an inert carrier matrix. Optionally, the active ingredients are dispersed using intestinal moisture absorbed into the pill via a semi-permeable wall section (14).

    摘要翻译： 包括具有固体粉末或颗粒药物的至少一个药物储存器（2,12）的电子药丸（1,11），排出口（3,13）和响应于控制电路的致动器，所述控制电路用于将药物从贮存器 12）到排出口（3,13）。 药物包含一种或多种活性成分的分散体，例如粉末或颗粒形式的固体 - 在惰性载体基质中。 任选地，活性成分通过经由半透壁部分（14）吸收到药丸中的肠水分散。

    Drug delivery device with compressible drug reservoir
    8.
    发明授权
    Drug delivery device with compressible drug reservoir 有权

    公开(公告)号：US10046109B2

    公开(公告)日：2018-08-14

    申请号：US13390111

    申请日：2010-08-10

    申请人： Hans Zou ,  Jeff Shimizu ,  Johan Frederik Dijksman

    发明人： Hans Zou ,  Jeff Shimizu ,  Johan Frederik Dijksman

    IPC分类号： A61M5/145 ,  A61M31/00

    摘要： A drug delivery device (50) is provided comprising a drug reservoir (10) and a piston (11). The drug reservoir (10) is provided for comprising a drug and comprises a flexible wall (22) and a dispensing hole (15) for dispensing the drug into an environment of the drug de delivery device (50). The piston (11) is provide for pressing against the flexible wall (22) to compress the drug reservoir (10) for pushing an amount of the drug through the dispensing hole (15). An adhesion interface (51) between a surface of the piston (11) and the flexible wall (22) prevents sliding between the surface of the piston (11) and the flexible wall (22).

    Swallowable medication capsule
    9.
    发明授权
    Swallowable medication capsule 有权

    公开(公告)号：US09687638B2

    公开(公告)日：2017-06-27

    申请号：US14006901

    申请日：2012-03-23

    申请人： Hans Zou ,  Jeff Shimizu

    发明人： Hans Zou ,  Jeff Shimizu

    IPC分类号： A61M31/00 ,  A61K9/48

    CPC分类号： A61M31/00 ,  A61K9/4808 ,  A61M31/002

    摘要： The invention relates to a swallowable medication capsule capable 200 of dispensing fluid medicine stored in a medication compartment 211 through a valveless exit hole 207. A vent hole 206 enables ventilation of an actuator cavity 212 which houses an actuator used for displacing a surface 205 which separates the medication cavity 211 and the actuator cavity 212. By locating the vent and exit holes close to each other so that contact with contracting parts of the gastrointestinal tract and the exterior surface 221 is not able to prohibit a pressure passageway between the vent and exit holes, creation of a pressure difference of pressures in the medication and actuator cavity is prohibited.