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    SUBSTITUTED SODIUM-1H-PYRAZOLE-5-OLATE
    4.
    发明申请
    SUBSTITUTED SODIUM-1H-PYRAZOLE-5-OLATE 有权
    取代的钠-1H-吡唑-5-醇

    公开(公告)号：US20130310381A1

    公开(公告)日：2013-11-21

    申请号：US13988141

    申请日：2011-11-15

    申请人： Hans-Christian Militzer ,  Jörg Gries ,  Stefan Koep

    发明人： Hans-Christian Militzer ,  Jörg Gries ,  Stefan Koep

    IPC分类号： C07D403/14 ,  A61K45/06 ,  A61K31/5377

    CPC分类号： C07D403/14 ,  A61K31/5377 ,  A61K45/06

    摘要： The present application relates to sodium 1-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-5-olate, to processes for its preparation, to its use for the treatment and/or prophylaxis of diseases and to its use for the preparation of medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and haematological diseases and kidney diseases, and for promoting wound healing.

    摘要翻译： 本申请涉及1- [6-（吗啉-4-基）嘧啶-4-基] -4-（1H-1,2,3-三唑-1-基）-1H-吡唑-5-醇酸钠 ，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液病和肾脏疾病的药物的用途，以及用于 促进伤口愈合。

    SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE SALTS
    8.
    发明申请
    SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE SALTS 审中-公开
    取代的2,3-二氢吲哚并[1,2-C]喹唑啉盐

    公开(公告)号：US20140072529A1

    公开(公告)日：2014-03-13

    申请号：US14009599

    申请日：2012-03-29

    申请人： Jan-Georg Peters ,  Hans-Christian Militzer ,  Hartwig Müller

    发明人： Jan-Georg Peters ,  Hans-Christian Militzer ,  Hartwig Müller

    IPC分类号： C07D487/04 ,  A61K45/06 ,  A61K31/5377

    CPC分类号： A61K31/5377 ,  A61K45/06 ,  C07D487/04

    摘要： The present invention relates:—to 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salt of formula (II): or a tautomer, solvate or hydrate thereof;—to methods of preparing said dihydrochloride salt;—to said dihydrochloride salt for the treatment and/or prophylaxis of a disease;—to the use of said dihydrochloride salt for the preparation of a medicament for the treatment and/or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, more particularly for the treatment or prophylaxis of a cancer, particularly lung cancer, in particular non-small cell lung carcinoma, colorectal cancer, melanoma, pancreatic cancer, hepatocyte carcinoma, pancreatic cancer, hepatocyte carcinoma or breast cancer;—to a pharmaceutical composition comprising said dihydrochloride salt; and to a pharmaceutical combination comprising said dihydrochloride salt in combination with one or more further pharmaceutical agents.

    摘要翻译： 本发明涉及2-氨基-N-〔7-甲氧基-8-（3-吗啉-4-基丙氧基）-2,3-二氢咪唑并〔1,2-c〕喹唑啉-5-基〕嘧啶 式（II）的5-甲酰胺二盐酸盐：或其互变异构体，溶剂化物或水合物; - 制备所述二盐酸盐的方法; - 用于治疗和/或预防疾病的所述二盐酸盐; - 使用 的所述二盐酸盐用于制备用于治疗和/或预防疾病，特别是高增殖和/或血管生成障碍的药物，更特别是用于治疗或预防癌症，特别是肺癌， 特定的非小细胞肺癌，结肠直肠癌，黑素瘤，胰腺癌，肝细胞癌，胰腺癌，肝细胞癌或乳腺癌; - 包含所述二盐酸盐的药物组合物; 以及包含所述二盐酸盐与一种或多种其它药剂组合的药物组合。