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    Endosulfan microcapsule dispersion
    1.
    发明授权
    Endosulfan microcapsule dispersion 失效
    硫丹微胶囊分散体

    公开(公告)号：US06294570B1

    公开(公告)日：2001-09-25

    申请号：US09265111

    申请日：1999-03-09

    申请人： Hans-Peter Krause ,  Thomas Maier ,  Jan Nicolaas Bremmer

    发明人： Hans-Peter Krause ,  Thomas Maier ,  Jan Nicolaas Bremmer

    IPC分类号： A01N4302

    CPC分类号： A01N25/28 ,  A01N43/24 ,  Y10S514/974 ,  A01N2300/00

    摘要： Aqueous endosulfan microcapsule dispersions in which the dispersed microcapsules comprise endosulfan, an organic solvent or solvent mixture and a capsule-forming material based on isocyanate prepolymers and the aqueous phase which represents the dispersion medium comprises surfactants, a water-soluble inorganic salt with or without other formulation aids, which include a relatively small amount of capsule-forming material, and a process for their preparation.

    摘要翻译： 其中分散的微胶囊包含硫丹，有机溶剂或溶剂混合物的水性硫丹微胶囊分散体和基于异氰酸酯预聚物的胶囊形成材料和代表分散介质的水相包括表面活性剂，具有或不具有其它的水溶性无机盐 制剂助剂，其包括相对少量的胶囊形成材料及其制备方法。

    MASS SPECTROMETRIC DIAGNOSIS OF SEPSIS WITHOUT BLOOD CULTURE
    3.
    发明申请
    MASS SPECTROMETRIC DIAGNOSIS OF SEPSIS WITHOUT BLOOD CULTURE 有权
    没有血液文化的食物的大量光谱诊断

    公开(公告)号：US20160251694A1

    公开(公告)日：2016-09-01

    申请号：US14113354

    申请日：2011-07-29

    申请人： Jochen Franzen ,  Mark Kostrzewa ,  Thomas Maier ,  Karsten Michelmann ,  Wolfgang Pusch

    发明人： Jochen Franzen ,  Mark Kostrzewa ,  Thomas Maier ,  Karsten Michelmann ,  Wolfgang Pusch

    IPC分类号： C12Q1/04 ,  G01N21/77

    CPC分类号： C12Q1/04 ,  G01N21/77 ,  G01N33/6851 ,  G01N2021/7786 ,  G01N2800/26

    摘要： The invention relates to methods and instruments for the rapid detection and rapid mass spectrometric identification of microbial infective agents in blood or other body fluids. The invention recognizes that blood is not a good environment for the cultivation of microbes and provides a method which (a) largely destroys or dissolves the human particles in body fluids, such as erythrocytes and leukocytes in blood, without impairing the ability of the microbes to reproduce, (b) separates the microbial pathogens from the fluid, (c) cultivates them in a nutrient broth which contains none of the antimicrobial components of the body fluids, (d) separates them from the nutrient broth, and (e) identifies the microbes by a mass spectrum of the microbial proteins. The dissolution of the human particles also releases the microbes nesting in macrophages. The cultivation in an optically clear nutrient broth with optimum composition not only accelerates the propagation of the microbes compared to all other cultivation methods, but also makes it possible to continuously measure their quantitative growth starting from a low microbe density. This firstly allows the mass spectrometric identification to be carried out at the earliest possible time, secondly provides a positive detection of microbes far ahead of their identification, which can be lifesaving for the patient; and thirdly makes it possible to start the determination of resistances early.

    摘要翻译： 本发明涉及快速检测和快速质谱鉴定血液或其他体液中微生物感染因子的方法和仪器。 本发明认识到，血液不是培养微生物的良好环境，并且提供了（a）在体内流体中大量地破坏或溶解血液中的红细胞和白细胞的方法，而不会损害微生物的能力 （b）将微生物病原体与流体分离，（c）将其培养在不含体液抗微生物成分的营养肉汤中，（d）将其与营养液分离，以及（e） 微生物通过微生物蛋白质的质谱。 人类颗粒的溶解也释放出嵌入巨噬细胞的微生物。 在具有最佳组成的光学透明营养肉汤中培养不仅加速微生物与所有其他培养方法相比的繁殖，而且可以从低微生物密度开始连续测量其定量生长。 这首先允许在早期进行质谱鉴定，其次提供远远超过其鉴定的微生物的阳性检测，这可以为患者挽救; 第三，可以提前开始确定电阻。

    Method for the production of sulphonylpyrroles as HDAC inhibitors
    4.
    发明授权
    Method for the production of sulphonylpyrroles as HDAC inhibitors 有权
    制备磺酰吡喃作为HDAC抑制剂的方法

    公开(公告)号：US08785659B2

    公开(公告)日：2014-07-22

    申请号：US12921928

    申请日：2009-03-11

    申请人： Matthias Müller ,  Bernd Müller ,  Thomas Maier

    发明人： Matthias Müller ,  Bernd Müller ,  Thomas Maier

    IPC分类号： C07D207/48

    CPC分类号： C07D207/48 ,  C07D403/12

    摘要： Process for the preparation of a compound of formula (I) wherein R1, R2, R3, R4, R5 and R6 have the meanings as defined in the specification, comprising the step of reacting an acrylic acid chloride compound of formula (II′): wherein R1, R2, R3, R4, R5 and R6 have the meanings as defined in the specification, with aqueous hydroxylamine and optionally converting the resulting compound into an acid addition salt thereof.

    摘要翻译： 制备其中R 1，R 2，R 3，R 4，R 5和R 6具有如本说明书中所定义的含义的式（I）化合物的方法，包括使式（II'）的丙烯酰氯化合物： 其中R 1，R 2，R 3，R 4，R 5和R 6具有本说明书中定义的含义，与羟胺水解反应，并任选地将所得化合物转化为其酸加成盐。

    Control device for a motor and method for controlling said motor
    5.
    发明授权
    Control device for a motor and method for controlling said motor 有权
    一种用于电动机的控制装置和用于控制所述电动机的方法

    公开(公告)号：US08618755B2

    公开(公告)日：2013-12-31

    申请号：US13129434

    申请日：2009-10-23

    申请人： Thomas Maier ,  Christoph Schikora ,  Thomas Wiercioch

    发明人： Thomas Maier ,  Christoph Schikora ,  Thomas Wiercioch

    IPC分类号： H02P6/16

    CPC分类号： H02P6/16 ,  H02P6/15 ,  H02P6/17

    摘要： A control device is for a motor, especially a brushless DC motor. The control device contains a bridge circuit for generating a rotating field for the motor and a sensor system for detecting a position of a rotor of the motor, a control signal for the bridge circuit being derivable from the signal representing the rotor position. The sensor system includes an absolute value transmitter which detects the absolute position of the rotor and which is configured to derive at least one incremental signal from the absolute position and to make it directly available to a control component for controlling the bridge circuit for commuting the motor.

    摘要翻译： 控制装置用于电动机，特别是无刷直流电动机。 控制装置包括用于产生用于电动机的旋转场的桥接电路和用于检测电动机的转子位置的传感器系统，桥接电路的控制信号可从表示转子位置的信号导出。 传感器系统包括绝对值发射器，其检测转子的绝对位置，其被配置为从绝对位置导出至少一个增量信号，并使其直接用于控制部件，用于控制用于使电动机通勤的桥接电路 。

    MASS SPECTROMETRIC DIAGNOSIS OF SEPTICEMIA
    6.
    发明申请
    MASS SPECTROMETRIC DIAGNOSIS OF SEPTICEMIA 有权
    大分子诊断分析

    公开(公告)号：US20120115182A1

    公开(公告)日：2012-05-10

    申请号：US13322363

    申请日：2010-07-14

    申请人： Thomas Maier

    发明人： Thomas Maier

    IPC分类号： C12Q1/04

    CPC分类号： C12Q1/24 ,  C12Q1/04 ,  G01N33/6851 ,  G01N2560/00 ,  G01N2570/00 ,  G01N2800/26

    摘要： The invention mainly relates to the mass spectrometric identification of pathogens in blood cultures from blood-stream infections (septicemia). The invention provides a method with which microbial pathogens can be separated in purified form from blood after a relatively brief cultivation in a blood culture flask, without any interfering human proteins or any residual fractions of blood particles such as erythrocytes and leukocytes, and can be directly identified by mass spectrometric measurement of their protein profiles. The method is based on the use of relatively strong tensides to destroy the blood particles by dissolving the weak cell membranes and most of the internal structures of the blood particles; in spite of the fact that tensides are regarded as strong ionization inhibitors in MALDI and other ionization processes required for mass spectrometric measurements. This method allows unknown pathogens to be obtained in their pure form by centrifuging or filtration and to be identified on the taxonomic level of species or subspecies. Problems with DNA from high levels of leukocytes can be resolved by special measures. After sufficient cultivation, the identification in a mass spectrometric laboratory takes only half an hour.

    摘要翻译： 本发明主要涉及血流感染（败血病）血液培养物中病原体的质谱鉴定。 本发明提供了一种在血培养瓶中比较短暂的培养后，将微生物病原体与血液分离的方法，其中没有任何干扰的人类蛋白质或血液颗粒如红细胞和白细胞的任何残留部分，并且可直接 通过其蛋白质谱的质谱测定来鉴定。 该方法基于使用相对较强的表面活性剂通过溶解弱细胞膜和血液颗粒的大部分内部结构来破坏血液颗粒; 尽管在MALDI和质谱测量所需的其他电离过程中，表面活性剂被认为是强电离抑制剂。 该方法允许通过离心或过滤以其纯形式获得未知的病原体，并根据物种或亚种的分类级别进行鉴定。 通过特殊措施可以解决高水平白细胞DNA的问题。 在充分培养后，质谱实验室的鉴定只需半小时。

    SPECTROPHOTOMETRIC IDENTIFICATION OF MICROBE SUBSPECIES
    9.
    发明申请
    SPECTROPHOTOMETRIC IDENTIFICATION OF MICROBE SUBSPECIES 有权
    微量元素的分光光度鉴定

    公开(公告)号：US20110012016A1

    公开(公告)日：2011-01-20

    申请号：US12834504

    申请日：2010-07-12

    申请人： Thomas Maier ,  Markus Kostrzewa

    发明人： Thomas Maier ,  Markus Kostrzewa

    IPC分类号： B01D59/44

    CPC分类号： G01N33/6848 ,  C12Q1/04 ,  G01N2560/00 ,  G06F19/24

    摘要： A dual-stage method is provided for identifying a microbe by, for example, its species or its subspecies. The method includes measuring a mass spectrum of the microbe using a mass spectrometer, calculating indicators for similarities between reference mass spectra in a library and the measured mass spectrum, selecting a group of reference mass spectra similar to the measured mass spectrum, determining a distinguishing weight for each mass signal of the reference mass spectra in the group, where the distinguishing weights emphasize differences between the reference mass spectra in the group, and calculating indicators for similarities between the reference mass spectra in the group and the measured mass spectrum as a function of the distinguishing weights.

    摘要翻译： 提供了用于通过例如其物种或其亚种鉴定微生物的双阶段方法。 该方法包括使用质谱仪测量微生物的质谱，计算文库中参考质谱与测量质谱之间的相似性的指标，选择与测得的质谱相似的一组参考质谱，确定鉴别重量 对于组中参考质谱的每个质量信号，其中区分权重强调组中参考质谱之间的差异，并且计算组中参考质谱与测量质谱之间的相似性的指标，作为 区别权重。