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1.发明申请SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT 有权取代的环丙基化合物，包含这些化合物的组合物和处理方法公开(公告)号：US20120142706A1
公开(公告)日：2012-06-07
申请号：US13390147
申请日：2010-08-03
申请人： Harold B. Wood , Alan D. Adams , Jason W. Szewczyk , Yong Zhang , Meng Yang
发明人： Harold B. Wood , Alan D. Adams , Jason W. Szewczyk , Yong Zhang , Meng Yang
IPC分类号： A61K31/506 , C07D401/04 , A61P3/10 , C07D401/14
CPC分类号： C07D401/14 , C07D401/04 , C07D413/14
摘要： Substituted cyclopropyl compounds of the formula I: are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.
摘要翻译： 式I的取代的环丙基化合物被公开用于治疗或预防2型糖尿病和类似病症。 也包括药学上可接受的盐。 该化合物可用作g-蛋白偶联受体GPR-119的激动剂。
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2.发明授权Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment 有权取代的环丙基化合物，含有这些化合物的组合物和处理方法公开(公告)号：US08552022B2
公开(公告)日：2013-10-08
申请号：US13390147
申请日：2010-08-03
申请人： Harold B. Wood , Alan D. Adams , Jason W. Szewczyk , Yong Zhang , Meng Yang
发明人： Harold B. Wood , Alan D. Adams , Jason W. Szewczyk , Yong Zhang , Meng Yang
IPC分类号： A61K31/505 , C07D239/02 , C07D403/04
CPC分类号： C07D401/14 , C07D401/04 , C07D413/14
摘要： Substituted cyclopropyl compounds of the formula I: are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.
摘要翻译： 式I的取代的环丙基化合物被公开用于治疗或预防2型糖尿病和类似病症。 也包括药学上可接受的盐。 该化合物可用作g-蛋白偶联受体GPR-119的激动剂。
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3.发明授权Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment 有权取代的环丙基化合物，含有这些化合物的组合物和处理方法公开(公告)号：US08343990B2
公开(公告)日：2013-01-01
申请号：US12936313
申请日：2009-03-26
申请人： Harold B. Wood , Jason W. Szewczyk , Yong Huang , Alan D. Adams
发明人： Harold B. Wood , Jason W. Szewczyk , Yong Huang , Alan D. Adams
IPC分类号： C07D239/02 , C07D413/14 , A61K31/435
CPC分类号： C07D401/04 , C07D401/14 , C07D413/14
摘要： Substituted cyclopropyl compounds of formula (I) are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.
摘要翻译： 公开式（I）的取代的环丙基化合物可用于治疗或预防2型糖尿病和类似病状。 也包括药学上可接受的盐和溶剂化物。 该化合物可用作g-蛋白偶联受体GPR-119的激动剂。
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4.发明申请SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT 有权取代的环丙基化合物，包含这些化合物的组合物和处理方法公开(公告)号：US20110028501A1
公开(公告)日：2011-02-03
申请号：US12936313
申请日：2009-03-26
申请人： Harold B Wood , Jason W. Szewczyk , Yong Huang , Alan D. Adams
发明人： Harold B Wood , Jason W. Szewczyk , Yong Huang , Alan D. Adams
IPC分类号： A61K31/513 , C07D413/14 , C07D401/04 , C07D401/14 , A61K31/506 , A61K31/4545 , A61P3/10 , A61P5/50
CPC分类号： C07D401/04 , C07D401/14 , C07D413/14
摘要： Substituted cyclopropyl compounds of formula (I) are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.
摘要翻译： 公开式（I）的取代的环丙基化合物可用于治疗或预防2型糖尿病和类似病状。 也包括药学上可接受的盐和溶剂化物。 这些化合物可用作g-蛋白偶联受体GPR-119的激动剂。
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5.发明授权Bipiperidinyl compounds, compositions, containing such compounds and methods of treatment 失效双哌啶基化合物，含有这些化合物的组合物和处理方法公开(公告)号：US08445499B2
公开(公告)日：2013-05-21
申请号：US13426418
申请日：2012-03-21
申请人： Harold B. Wood , Alan D. Adams , Stanley Freeman , Jason W. Szewczyk , Conrad Santini , Yong Huang
发明人： Harold B. Wood , Alan D. Adams , Stanley Freeman , Jason W. Szewczyk , Conrad Santini , Yong Huang
IPC分类号： A01N43/54
CPC分类号： C07D417/14 , C07D401/14 , C07D413/14
摘要： Bipiperidinyl compounds of the formula: are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.
摘要翻译： 公开了用于治疗或预防2型糖尿病和类似病症的下式的二哌啶基化合物： 也包括药学上可接受的盐和溶剂化物。 该化合物可用作g-蛋白偶联受体GPR-119的激动剂。
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公开(公告)号：US08399485B2
公开(公告)日：2013-03-19
申请号：US12517142
申请日：2007-12-10
申请人： Harold B. Wood , Alan D. Adams , Stanley Freeman , Jason W. Szewczyk , Conrad Santini , Yong Huang , Ralph T. Mosley
发明人： Harold B. Wood , Alan D. Adams , Stanley Freeman , Jason W. Szewczyk , Conrad Santini , Yong Huang , Ralph T. Mosley
IPC分类号： A61K31/445
CPC分类号： C07D211/26 , C07D401/14 , C07D413/14 , C07D417/14
摘要： Bipiperidyl compounds of the formula: (I) are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.
摘要翻译： 公开了式（I）的双哌啶基化合物用于治疗或预防2型糖尿病和类似病症。 也包括药学上可接受的盐和溶剂化物。 该化合物可用作g-蛋白偶联受体GPR-119的激动剂。
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7.发明申请BIPIPERIDINYL COMPOUNDS, COMPOSITIONS, CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT 失效BIPIPERIDINYL化合物，组合物，含有这些化合物和处理方法公开(公告)号：US20120178681A1
公开(公告)日：2012-07-12
申请号：US13426418
申请日：2012-03-21
申请人： HAROLD B. WOOD , Alan D. Adams , Stanley Freeman , Jason W. Szewczyk , Conrad Santini , Yong Huang
发明人： HAROLD B. WOOD , Alan D. Adams , Stanley Freeman , Jason W. Szewczyk , Conrad Santini , Yong Huang
IPC分类号： A61K38/28 , C07D401/14 , C07D417/14 , A61K31/4545 , A61K31/506 , A61K31/497 , A61K31/501 , A61K31/551 , A61K31/519 , A61K31/675 , A61K31/472 , A61P3/10 , A61P3/04 , A61P3/06 , A61P9/10 , A61P1/18 , A61P25/00 , A61P27/02 , A61P13/12 , A61P9/12 , C07D413/14
CPC分类号： C07D417/14 , C07D401/14 , C07D413/14
摘要： Bipiperidinyl compounds of the formula I, are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.
摘要翻译： 公开了式I的二哌啶基化合物用于治疗或预防2型糖尿病和类似病症。 也包括药学上可接受的盐和溶剂化物。 该化合物可用作g-蛋白偶联受体GPR-119的激动剂。
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8.发明申请ACYL BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT 失效ACYL BIPIPERIDINYL化合物，含有这些化合物的组合物和处理方法公开(公告)号：US20100075987A1
公开(公告)日：2010-03-25
申请号：US12517142
申请日：2007-12-10
申请人： Harold B. Wood , Alan D. Adams , Stanley Freeman , Jason W. Szewczyk , Conrad Santini , Yong Huang , Ralph T. Mosley
发明人： Harold B. Wood , Alan D. Adams , Stanley Freeman , Jason W. Szewczyk , Conrad Santini , Yong Huang , Ralph T. Mosley
IPC分类号： A61K31/497 , A61K31/506 , A61P3/04 , A61K31/445 , A61P3/10 , C07D401/04
CPC分类号： C07D211/26 , C07D401/14 , C07D413/14 , C07D417/14
摘要： Bipiperidyl compounds of the formula: (I) are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.
摘要翻译： 公开了式（I）的双哌啶基化合物用于治疗或预防2型糖尿病和类似病症。 也包括药学上可接受的盐和溶剂化物。 该化合物可用作g-蛋白偶联受体GPR-119的激动剂。
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9.发明授权Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment 有权取代的环丙基化合物，含有这些化合物的组合物和处理方法公开(公告)号：US08957062B2
公开(公告)日：2015-02-17
申请号：US14110332
申请日：2012-04-05
申请人： Scott Edmondson , Zhiqiang Guo , Harold B. Wood , Andrew W. Stamford , Michael W. Miller , Duane E. DeMong , Gregori J. Morriello , Rajan Anand , Vincent J. Colandrea , Megan Macala , Milana Maletic , Cheng Zhu , Yuping Zhu , Wanying Sun , Kake Zhao , Yong Huang , Joel M. Harris , Lehua Chang , Nam Fung Kar , Zhiyong Hu , Liping Wang , Bowei Wang , Ping Liu , Jason W. Szewczyk , William B. Geiss
发明人： Scott Edmondson , Zhiqiang Guo , Harold B. Wood , Andrew W. Stamford , Michael W. Miller , Duane E. DeMong , Gregori J. Morriello , Rajan Anand , Vincent J. Colandrea , Megan Macala , Milana Maletic , Cheng Zhu , Yuping Zhu , Wanying Sun , Kake Zhao , Yong Huang , Joel M. Harris , Lehua Chang , Nam Fung Kar , Zhiyong Hu , Liping Wang , Bowei Wang , Ping Liu , Jason W. Szewczyk , William B. Geiss
IPC分类号： C07D513/04 , C07D401/12 , C07D413/14 , C07D413/04 , C07D211/22 , C07D405/04 , C07D471/04 , C07D487/04 , C07D498/04 , A61K9/48 , C07D417/14 , C07D495/04
CPC分类号： C07D513/04 , A61K9/4858 , C07D211/22 , C07D401/12 , C07D405/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04
摘要： Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译： 公开了取代的式I的环丙基化合物及其药学上可接受的盐可用于治疗或预防2型糖尿病和类似病症。 该化合物可用作G蛋白偶联受体GPR-119的激动剂。 还包括药物组合物和治疗方法。
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10.发明申请SUBSTITUTED CYCLOPROPLY COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT 有权取代的环状化合物，包含这些化合物的组合物和处理方法公开(公告)号：US20140057893A1
公开(公告)日：2014-02-27
申请号：US14110332
申请日：2012-04-05
申请人： Scott Edmondson , Zhiqiang Guo , Harold B. Wood , Andrew W. Stamford , Michael W. Miller , Duane E. DeMong , Gregori J. Morriello , Rajan Anand , Vincent J. Colandrea , Megan Macala , Milana Maletic , Cheng Zhu , Yuping Zhu , Wanying Sun , Kake Zhao , Yong Huang , Joel M. Harris , Lehua Chang , Nam Fung Kar , Zhiyong Hu , Liping Wang , Bowei Wang , Ping Liu , Jason W. Szewczyk , William B. Geiss
发明人： Scott Edmondson , Zhiqiang Guo , Harold B. Wood , Andrew W. Stamford , Michael W. Miller , Duane E. DeMong , Gregori J. Morriello , Rajan Anand , Vincent J. Colandrea , Megan Macala , Milana Maletic , Cheng Zhu , Yuping Zhu , Wanying Sun , Kake Zhao , Yong Huang , Joel M. Harris , Lehua Chang , Nam Fung Kar , Zhiyong Hu , Liping Wang , Bowei Wang , Ping Liu , Jason W. Szewczyk , William B. Geiss
IPC分类号： C07D513/04 , C07D413/14 , C07D413/04 , C07D498/04 , C07D405/04 , C07D471/04 , C07D487/04 , C07D401/12 , C07D211/22
CPC分类号： C07D513/04 , A61K9/4858 , C07D211/22 , C07D401/12 , C07D405/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04
摘要： Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included
摘要翻译： 公开了取代的式I的环丙基化合物及其药学上可接受的盐可用于治疗或预防2型糖尿病和类似病状。 该化合物可用作G蛋白偶联受体GPR-119的激动剂。 还包括药物组合物和治疗方法
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