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    Water soluble tri-substituted 1, 2-dioxetane compounds having increased storage stability, synthetic processes and intermediates
    1.
    发明授权
    Water soluble tri-substituted 1, 2-dioxetane compounds having increased storage stability, synthetic processes and intermediates 失效
    具有增加储存稳定性的水溶性三取代1,2-二氧环乙烷化合物，合成方法和中间体

    公开(公告)号：US06410751B1

    公开(公告)日：2002-06-25

    申请号：US09839472

    申请日：2001-04-20

    申请人： Hashem Akhavan-Tafti ,  Renuka DeSilva ,  Kumar Thakur ,  Zahra Arghavani

    发明人： Hashem Akhavan-Tafti ,  Renuka DeSilva ,  Kumar Thakur ,  Zahra Arghavani

    IPC分类号： C07F909

    CPC分类号： G01N33/582 ,  C07C69/734 ,  C07C2603/74 ,  C07D321/00 ,  C07F9/12 ,  C07F9/65512 ,  G01N33/5308 ,  G01N33/54326

    摘要： Stable, enzymatically triggered chemiluminescent 1,2-dioxetanes with improved water solubility and storage stability are provided as well as synthetic processes and intermediates used in their preparation. Dioxetanes further substituted with two or more water-solubilizing groups disposed on the dioxetane structure and an additional fluorine atom or lower alkyl group provide superior performance by eliminating the problem of reagent carryover when used in assays performed on capsule chemistry analytical systems. These dioxetanes display substantially improved stability on storage. Compositions comprising these dioxetanes, a non-polymeric cationic surfactant enhancer and optionally a fluorescer, for providing enhanced chemiluminescence are also provided.

    摘要翻译： 提供了具有改善的水溶性和储存稳定性的稳定的，酶促触发的化学发光1,2-二氧杂环丁烷，以及用于其制备的合成方法和中间体。 二氧杂环丁烷进一步被设置在二氧杂环丁烷结构上的水溶性基团和另外的氟原子或低级烷基取代，当用于胶囊化学分析系统的测定中时，通过消除试剂残留的问题而提供优异的性能。 这些二氧杂环丁烷在储存时显示出显着提高的稳定性。 还提供了包含这些二氧杂环丁烷的组合物，非聚合阳离子表面活性剂增强剂和任选的荧光剂，用于提供增强的化学发光。

    Water soluble tri-substituted 1,2-dioxetane compounds having increased storage stability, synthetic processes and intermediates
    4.
    发明授权
    Water soluble tri-substituted 1,2-dioxetane compounds having increased storage stability, synthetic processes and intermediates 失效
    具有增加储存稳定性，合成方法和中间体的水溶性三取代1,2-二氧杂环丁烷化合物

    公开(公告)号：US06245928B1

    公开(公告)日：2001-06-12

    申请号：US09506263

    申请日：2000-02-17

    申请人： Zahra Arghavani ,  Hashem Akhavan-Tafti ,  Renuka DeSilva ,  Kumar Thakur

    发明人： Zahra Arghavani ,  Hashem Akhavan-Tafti ,  Renuka DeSilva ,  Kumar Thakur

    IPC分类号： C07F906

    CPC分类号： G01N33/582 ,  C07C69/734 ,  C07C2603/74 ,  C07D321/00 ,  C07F9/12 ,  C07F9/65512 ,  G01N33/5308 ,  G01N33/54326

    摘要： Stable, enzymatically triggered chemiluminescent 1,2-dioxetanes with improved water solubility and storage stability are provided as well as synthetic processes and intermediates used in their preparation. Dioxetanes further substituted with two or more water-solubilizing groups disposed on the dioxetane structure and an additional fluorine atom or lower alkyl group provide superior performance by eliminating the problem of reagent carryover when used in assays performed on capsule chemistry analytical systems. These dioxetanes display substantially improved stability on storage. Compositions comprising these dioxetanes, a non-polymeric cationic surfactant enhancer and optionally a fluorescer, for providing enhanced chemiluminescence are also provided.

    摘要翻译： 提供了具有改善的水溶性和储存稳定性的稳定的，酶促触发的化学发光1,2-二氧杂环丁烷，以及用于其制备的合成方法和中间体。 二氧杂环丁烷进一步被设置在二氧杂环丁烷结构上的水溶性基团和另外的氟原子或低级烷基取代，当用于胶囊化学分析系统的测定中时，通过消除试剂残留的问题而提供优异的性能。 这些二氧杂环丁烷在储存时显示出显着提高的稳定性。 还提供了包含这些二氧杂环丁烷的组合物，非聚合阳离子表面活性剂增强剂和任选的荧光剂，用于提供增强的化学发光。

    Water soluble tri-substituted 1,2-dioxetane compounds having increased storage stability, synthetic processes and intermediates
    5.
    发明授权
    Water soluble tri-substituted 1,2-dioxetane compounds having increased storage stability, synthetic processes and intermediates 失效
    具有增加储存稳定性，合成方法和中间体的水溶性三取代1,2-二氧杂环丁烷化合物

    公开(公告)号：US06353129B1

    公开(公告)日：2002-03-05

    申请号：US09839622

    申请日：2001-04-20

    申请人： Hashem Akhavan-Tafti ,  Renuka DeSilva ,  Kumar Thakur ,  Zahra Arghavani

    发明人： Hashem Akhavan-Tafti ,  Renuka DeSilva ,  Kumar Thakur ,  Zahra Arghavani

    IPC分类号： C07C6973

    CPC分类号： G01N33/582 ,  C07C69/734 ,  C07C2603/74 ,  C07D321/00 ,  C07F9/12 ,  C07F9/65512 ,  G01N33/5308 ,  G01N33/54326

    摘要： Stable, enzymatically triggered chemiluminescent 1,2-dioxetanes with improved water solubility and storage stability are provided as well as synthetic processes and intermediates used in their preparation. Dioxetanes further substituted with two or more water-solubilizing groups disposed on the dioxetane structure and an additional fluorine atom or lower alkyl group provide superior performance by eliminating the problem of reagent carryover when used in assays performed on capsule chemistry analytical systems. These dioxetanes display substantially improved stability on storage. Compositions comprising these dioxetanes, a non-polymeric cationic surfactant enhancer and optionally a fluorescer, for providing enhanced chemiluminescence are also provided.

    摘要翻译： 提供了具有改善的水溶性和储存稳定性的稳定的，酶促触发的化学发光1,2-二氧杂环丁烷，以及用于其制备的合成方法和中间体。 二氧杂环丁烷进一步被设置在二氧杂环丁烷结构上的水溶性基团和另外的氟原子或低级烷基取代，当用于胶囊化学分析系统的测定中时，通过消除试剂残留的问题而提供优异的性能。 这些二氧杂环丁烷在储存时显示出显着提高的稳定性。 还提供了包含这些二氧杂环丁烷的组合物，非聚合阳离子表面活性剂增强剂和任选的荧光剂，用于提供增强的化学发光。