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1.发明授权Methods and devices for correcting spinal deformity with pharmaceutical-eluting pedicle screws 有权用药物洗脱椎弓根螺钉矫正脊柱畸形的方法和装置公开(公告)号：US09327015B2
公开(公告)日：2016-05-03
申请号：US12730469
申请日：2010-03-24
IPC分类号： A61K31/65 , A61B17/58 , A61B17/70 , A61K38/30 , A61K38/18 , A61B17/86 , A61B17/00 , A61B17/56
CPC分类号： A61K38/30 , A61B17/7061 , A61B17/7098 , A61B17/864 , A61B2017/00893 , A61B2017/561 , A61K31/65 , A61K38/1875
摘要： A method of correcting spinal deformity, which includes locating pharmaceutical-loaded implants adjacent to targeted spinal growth plates, and then eluting the pharmaceutical onto the growth plates. Preferably, the method involves correcting spinal deformity by simply inserting a pharmaceutical-eluting pedicle screw onto the concave side of a scoliotic curve. In some embodiments, the screw has a cannulated internal reservoir that contains a growth-inhibiting pharmaceutical (such as a tetracycline) and at least one fenestration that allows the pharmaceutical to elute onto the vertebral body growth plate.
摘要翻译： 一种校正脊柱畸形的方法，其包括将邻近目标脊柱生长板的药物负载植入物定位，然后将该药物洗脱到生长板上。 优选地，该方法包括通过简单地将药物洗脱的椎弓根螺钉插入脊柱侧弯曲线的凹侧来校正脊柱畸形。 在一些实施方案中，螺杆具有包含生长抑制药物（例如四环素）的插管内部储存器和允许药物洗脱到椎体生长板上的至少一个开窗。
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2.发明申请Methods and Devices for Correcting Spinal Deformity With Pharmaceutical-Eluting Pedicle Screws 有权用药物洗脱椎弓根螺钉矫正脊柱畸形的方法和装置公开(公告)号：US20110097377A1
公开(公告)日：2011-04-28
申请号：US12730469
申请日：2010-03-24
CPC分类号： A61K38/30 , A61B17/7061 , A61B17/7098 , A61B17/864 , A61B2017/00893 , A61B2017/561 , A61K31/65 , A61K38/1875
摘要： A method of correcting spinal deformity, which includes locating pharmaceutical-loaded implants adjacent to targeted spinal growth plates, and then eluting the pharmaceutical onto the growth plates. Preferably, the method involves correcting spinal deformity by simply inserting a pharmaceutical-eluting pedicle screw onto the concave side of a scoliotic curve. In some embodiments, the screw has a cannulated internal reservoir that contains a growth-inhibiting pharmaceutical (such as a tetracycline) and at least one fenestration that allows the pharmaceutical to elute onto the vertebral body growth plate.
摘要翻译： 一种校正脊柱畸形的方法，其包括将邻近目标脊柱生长板的药物负载植入物定位，然后将该药物洗脱到生长板上。 优选地，该方法包括通过简单地将药物洗脱的椎弓根螺钉插入脊柱侧弯曲线的凹侧来校正脊柱畸形。 在一些实施方案中，螺杆具有包含生长抑制药物（例如四环素）的插管内部储存器和允许药物洗脱到椎体生长板上的至少一个开窗。
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3.发明授权Methods and devices for correcting spinal deformity with pharmaceutical-eluting pedicle screws 有权用药物洗脱椎弓根螺钉矫正脊柱畸形的方法和装置公开(公告)号：US08916186B2
公开(公告)日：2014-12-23
申请号：US12605122
申请日：2009-10-23
申请人： Hassan Serhan , Michael J. O'Neil
发明人： Hassan Serhan , Michael J. O'Neil
CPC分类号： A61K38/30 , A61K38/1875
摘要： A method of correcting spinal deformity, which includes locating pharmaceutical-loaded implants adjacent to targeted spinal growth plates, and then eluting the pharmaceutical onto the growth plates. Preferably, the method involves correcting spinal deformity by simply inserting a pharmaceutical-eluting pedicle screw onto the concave side of a scoliotic curve. The screw has a cannulated internal reservoir that contains a chondrocyte growth-inducing pharmaceutical (such as a growth factor or small molecule) and at least one fenestration that allows the pharmaceutical to elute onto the vertebral body growth plate.
摘要翻译： 一种校正脊柱畸形的方法，其包括将邻近目标脊柱生长板的药物负载植入物定位，然后将该药物洗脱到生长板上。 优选地，该方法包括通过简单地将药物洗脱的椎弓根螺钉插入脊柱侧弯曲线的凹侧来校正脊柱畸形。 螺杆具有插管的内部储存器，其包含软骨细胞生长诱导药物（例如生长因子或小分子）和至少一个允许药物洗脱到椎体生长板上的开窗。
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公开(公告)号：US20110319999A1
公开(公告)日：2011-12-29
申请号：US13163427
申请日：2011-06-17
IPC分类号： A61F2/44
CPC分类号： A61F2/4455 , A61B5/4893 , A61B17/1659 , A61B17/1671 , A61B17/1757 , A61B2017/0256 , A61B2017/3433 , A61F2/30771 , A61F2/4425 , A61F2/446 , A61F2/4465 , A61F2/447 , A61F2/4611 , A61F2/4637 , A61F2002/30326 , A61F2002/30523 , A61F2002/30593 , A61F2002/443 , A61F2002/4623 , A61F2002/4642 , A61M25/0054 , A61M25/0133 , A61M29/02
摘要： An intervertebral fusion device comprising inferior and superior fusion cage devices that provide an ability to correct spondylolisthesis via in-situ adjustment.
摘要翻译： 一种椎间融合装置，其包括通过原位调整提供矫正脊椎前移的能力的下部和上部融合笼装置。
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5.发明申请Methods and Devices for Correcting Spinal Deformity With Pharmaceutical-Eluting Pedicle Screws 有权用药物洗脱椎弓根螺钉矫正脊柱畸形的方法和装置公开(公告)号：US20110097374A1
公开(公告)日：2011-04-28
申请号：US12605122
申请日：2009-10-23
申请人： Hassan Serhan , Michael J. O'Neil
发明人： Hassan Serhan , Michael J. O'Neil
CPC分类号： A61K38/30 , A61K38/1875
摘要： A method of correcting spinal deformity, which includes locating pharmaceutical-loaded implants adjacent to targeted spinal growth plates, and then eluting the pharmaceutical onto the growth plates. Preferably, the method involves correcting spinal deformity by simply inserting a pharmaceutical-eluting pedicle screw onto the concave side of a scoliotic curve. The screw has a cannulated internal reservoir that contains a chondrocyte growth-inducing pharmaceutical (such as a growth factor or small molecule) and at least one fenestration that allows the pharmaceutical to elute onto the vertebral body growth plate.
摘要翻译： 一种校正脊柱畸形的方法，其包括将邻近目标脊柱生长板的药物负载植入物定位，然后将该药物洗脱到生长板上。 优选地，该方法包括通过简单地将药物洗脱的椎弓根螺钉插入脊柱侧弯曲线的凹侧来校正脊柱畸形。 螺杆具有插管的内部储存器，其包含软骨细胞生长诱导药物（例如生长因子或小分子）和至少一个允许药物洗脱到椎体生长板上的开窗。
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公开(公告)号：US20090005873A1
公开(公告)日：2009-01-01
申请号：US11770802
申请日：2007-06-29
申请人： Michael Andrew Slivka , Michael J. O'Neil , Hassan Serhan , Michael Fisher , John Riley Hawkins
发明人： Michael Andrew Slivka , Michael J. O'Neil , Hassan Serhan , Michael Fisher , John Riley Hawkins
CPC分类号： A61B17/7068 , A61B17/7053 , A61B17/7062 , A61B17/8869 , A61B2017/681
摘要： An interspinous spacer comprising: a) a first brace having an upper throughhole and a lower throughhole, b) a second brace having an upper throughhole and a lower throughhole, c) a ligament having a first end and a second end, wherein the ligament extends from the upper throughhole of the first brace through the upper throughhole of the second brace.
摘要翻译： 棘突间间隔物包括：a）具有上通孔和下通孔的第一支架，b）具有上通孔和下通孔的第二支架，c）具有第一端和第二端的韧带，其中所述韧带延伸 从第一支架的上部通孔穿过第二支架的上部通孔。
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公开(公告)号：US20110077655A1
公开(公告)日：2011-03-31
申请号：US12889385
申请日：2010-09-23
申请人： Michael A. Fisher , Thomas M. DiMauro , John Riley Hawkins , Douglas Hester , Michael J. O'Neil , Jamie Lockwood , Matthew Parsons
发明人： Michael A. Fisher , Thomas M. DiMauro , John Riley Hawkins , Douglas Hester , Michael J. O'Neil , Jamie Lockwood , Matthew Parsons
IPC分类号： A61B17/60
CPC分类号： A61B17/025 , A61B17/0218 , A61B17/06166 , A61B17/8852 , A61B2017/00398 , A61B2017/0256 , A61B2017/2929
摘要： A mandrel is inserted into the tissue to be distracted and a filament is repeatedly wrapped around the mandrel to make a spool. As the mandrel turns, the filament coils around the mandrel to create of spool of increasing diameter. This spool can be used as a distractor, tamp, or implant. A spool implant can be cemented to further stabilize the device in situ, such as a vertebral body. The filament deposition upon the mandrel is controlled by rotation and the volume creation is incremental. This makes the spool ideal for creating highly controlled distraction forces or insertion of bulking material. In some embodiments, fibers having a low glass transition temperature are used.
摘要翻译： 将心轴插入组织以分散，并且将细丝重复地缠绕在心轴周围以制成线轴。 当心轴转动时，围绕心轴的细丝线圈产生直径增加的线轴。 该线轴可用作牵引器，夯实或植入物。 可以将线轴植入物胶合以进一步稳定装置，例如椎体。 心轴上的细丝沉积通过旋转来控制，并且体积的产生是增量的。 这使得阀芯非常适合创建高度受控的牵引力或插入膨胀材料。 在一些实施方案中，使用具有低玻璃化转变温度的纤维。
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公开(公告)号：US20140172105A1
公开(公告)日：2014-06-19
申请号：US13744789
申请日：2013-01-18
CPC分类号： A61F2/4611 , A61F2/442 , A61F2/4465 , A61F2/4684 , A61F2002/30542 , A61F2002/30777 , A61F2002/30779 , A61F2002/30785 , A61F2002/30787 , A61F2002/4475 , A61F2002/4628 , A61F2002/4629
摘要： A polyaxial instrument suitable for preparing the intervertebral disc space of a patient through an anterior, posterior, transforaminal or anterolateral approach. The trial can be partially inserted into a disc space and then its angle adjusted to ease its further insertion into the disc space. The trial work tip can be interchangeable with the working tip of another type of instrument such as a curette, a rasp, a spreader, a shaver, a cobb elevator, a penfield, a woodson, a chisel and an osteotome.
摘要翻译： 一种适用于通过前，后，椎间孔或前外侧方法制备患者椎间盘空间的多轴仪器。 试验可以部分地插入到盘空间中，然后调整其角度以便其进一步插入到盘空间中。 试验工作提示可以与另一种类型的仪器的工作尖端互换，例如刮匙，锉刀，撒布机，剃须刀，鹅卵石升降机，冲锋枪，木砧，凿子和砧骨。
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公开(公告)号：US20080288074A1
公开(公告)日：2008-11-20
申请号：US11748755
申请日：2007-05-15
CPC分类号： A61F2/442 , A61F2/30965 , A61F2002/30069 , A61F2002/30563 , A61F2002/30971 , A61F2002/4495 , A61F2310/00011
摘要： Two techniques to minimize intervertebral disc height loss due to polymer creep following implantation of an elastomeric disc with the use of internal reinforcement are disclosed. The specific devices and methods relate to use of (i) singular or multiple internal reinforcement members to increase construct stiffness, reduce peripheral bulging and corresponding height loss; and (ii) internal elastomer fillers of various shapes which are compounded into the elastomer to share the load and constrain the elastomeric material from excessive deformations.
摘要翻译： 公开了两种使用内部加强件植入弹性体盘后由于聚合物蠕变导致的椎间盘高度损失最小化的技术。 具体的装置和方法涉及使用（i）单个或多个内部加强构件来增加结构刚度，减少外围凸起和相应的高度损失; 和（ii）各种形状的内部弹性体填料，其被复合到弹性体中以共享载荷并且限制弹性材料过度变形。
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公开(公告)号：US20130289356A1
公开(公告)日：2013-10-31
申请号：US13925145
申请日：2013-06-24
申请人： Tony Tannoury , Michael J. O'Neil , Derek Shaw , Hassan Serhan
发明人： Tony Tannoury , Michael J. O'Neil , Derek Shaw , Hassan Serhan
IPC分类号： A61B1/32
CPC分类号： A61B1/32 , A61B17/0218
摘要： A self-retaining neural retraction clip, preferably having controlled retraction level and an off-set retraction means. This device can reduce operative site clutter to enhance disc access while providing consistent and stable dural retraction.
摘要翻译： 一种自我保持神经回缩夹，优选具有受控缩回水平和偏移缩回装置。 该装置可以减少手术部位杂乱，增强椎间盘通路，同时提供一致稳定的硬脑膜回缩。
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