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1.Methods and devices for correcting spinal deformity with pharmaceutical-eluting pedicle screws 有权
标题翻译: 用药物洗脱椎弓根螺钉矫正脊柱畸形的方法和装置公开(公告)号:US09327015B2
公开(公告)日:2016-05-03
申请号:US12730469
申请日:2010-03-24
IPC分类号: A61K31/65 , A61B17/58 , A61B17/70 , A61K38/30 , A61K38/18 , A61B17/86 , A61B17/00 , A61B17/56
CPC分类号: A61K38/30 , A61B17/7061 , A61B17/7098 , A61B17/864 , A61B2017/00893 , A61B2017/561 , A61K31/65 , A61K38/1875
摘要: A method of correcting spinal deformity, which includes locating pharmaceutical-loaded implants adjacent to targeted spinal growth plates, and then eluting the pharmaceutical onto the growth plates. Preferably, the method involves correcting spinal deformity by simply inserting a pharmaceutical-eluting pedicle screw onto the concave side of a scoliotic curve. In some embodiments, the screw has a cannulated internal reservoir that contains a growth-inhibiting pharmaceutical (such as a tetracycline) and at least one fenestration that allows the pharmaceutical to elute onto the vertebral body growth plate.
摘要翻译: 一种校正脊柱畸形的方法,其包括将邻近目标脊柱生长板的药物负载植入物定位,然后将该药物洗脱到生长板上。 优选地,该方法包括通过简单地将药物洗脱的椎弓根螺钉插入脊柱侧弯曲线的凹侧来校正脊柱畸形。 在一些实施方案中,螺杆具有包含生长抑制药物(例如四环素)的插管内部储存器和允许药物洗脱到椎体生长板上的至少一个开窗。
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2.Methods and Devices for Correcting Spinal Deformity With Pharmaceutical-Eluting Pedicle Screws 有权
标题翻译: 用药物洗脱椎弓根螺钉矫正脊柱畸形的方法和装置公开(公告)号:US20110097377A1
公开(公告)日:2011-04-28
申请号:US12730469
申请日:2010-03-24
CPC分类号: A61K38/30 , A61B17/7061 , A61B17/7098 , A61B17/864 , A61B2017/00893 , A61B2017/561 , A61K31/65 , A61K38/1875
摘要: A method of correcting spinal deformity, which includes locating pharmaceutical-loaded implants adjacent to targeted spinal growth plates, and then eluting the pharmaceutical onto the growth plates. Preferably, the method involves correcting spinal deformity by simply inserting a pharmaceutical-eluting pedicle screw onto the concave side of a scoliotic curve. In some embodiments, the screw has a cannulated internal reservoir that contains a growth-inhibiting pharmaceutical (such as a tetracycline) and at least one fenestration that allows the pharmaceutical to elute onto the vertebral body growth plate.
摘要翻译: 一种校正脊柱畸形的方法,其包括将邻近目标脊柱生长板的药物负载植入物定位,然后将该药物洗脱到生长板上。 优选地,该方法包括通过简单地将药物洗脱的椎弓根螺钉插入脊柱侧弯曲线的凹侧来校正脊柱畸形。 在一些实施方案中,螺杆具有包含生长抑制药物(例如四环素)的插管内部储存器和允许药物洗脱到椎体生长板上的至少一个开窗。
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3.Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor 有权
标题翻译: 局部骨内施用骨形成剂和抗吸收剂及其装置公开(公告)号:US08895540B2
公开(公告)日:2014-11-25
申请号:US10723250
申请日:2003-11-26
申请人: Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Melissa Grace , Michael Slivka , Thomas G. Ferro , Vivek N. Shenoy , Alonzo D. Cook , Scott Bruder
发明人: Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Melissa Grace , Michael Slivka , Thomas G. Ferro , Vivek N. Shenoy , Alonzo D. Cook , Scott Bruder
IPC分类号: A01N45/00 , A61K45/06 , A61K33/42 , A61K38/39 , A61K31/565 , A61K39/395 , A61K38/18 , A61K31/566 , A61B17/34 , A61K9/00 , A61M5/145 , A61M5/142 , A61F2/30 , A61F2/28
CPC分类号: A61K33/42 , A61B17/3472 , A61F2002/2817 , A61F2002/30677 , A61K9/0004 , A61K31/565 , A61K31/566 , A61K38/1825 , A61K38/1875 , A61K38/39 , A61K39/395 , A61K45/06 , A61M5/14276 , A61M2005/14513 , A61K2300/00
摘要: This invention relates to local administration of a bone-forming agent and at least one anti-resorptive agent to treat osteoporosis and related disorders.
摘要翻译: 本发明涉及局部施用骨形成剂和至少一种抗再吸收剂来治疗骨质疏松症和相关疾病。
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4.Transdiscal administration of anti-TNFα antibodies and growth differentiation factors 有权
标题翻译: 反式TNFα抗体和生长分化因子的经半径给药公开(公告)号:US08877193B2
公开(公告)日:2014-11-04
申请号:US12290998
申请日:2008-11-05
申请人: Hassan Serhan , Mohamed Attawia , Thomas M. DiMauro , Sudhakar Kadiyala , David Urbahns , Scott Bruder
发明人: Hassan Serhan , Mohamed Attawia , Thomas M. DiMauro , Sudhakar Kadiyala , David Urbahns , Scott Bruder
IPC分类号: A61K39/00 , A61K39/395 , A61K38/17
CPC分类号: A61K35/28 , A61B5/055 , A61B17/7061 , A61K9/0012 , A61K9/0019 , A61K9/0085 , A61K35/32 , A61K38/17 , A61K38/1793 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K38/20 , A61K38/363 , A61K38/4833 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/34 , C12Y304/21005 , G01N33/6869 , G01N2333/54
摘要: The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
摘要翻译: 本发明涉及将高特异性细胞因子拮抗剂注射到患病的椎间盘中。
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公开(公告)号:US08273347B2
公开(公告)日:2012-09-25
申请号:US10714594
申请日:2003-11-14
CPC分类号: A61K35/19 , A61K35/28 , A61K35/32 , A61K35/33 , A61K38/1841 , A61K2300/00
摘要: The present invention relates to administering autologous uncultured cells into a diseased intervertebral disc.
摘要翻译: 本发明涉及将自体未培养的细胞施用于患病的椎间盘。
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6.Transdiscal administration of specific inhibitors of pro-inflammatory cytokines 有权
标题翻译: 跨时间给药促炎细胞因子的特异性抑制剂公开(公告)号:US20090175943A1
公开(公告)日:2009-07-09
申请号:US12291378
申请日:2008-11-07
申请人: Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder
发明人: Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder
IPC分类号: A61K9/10 , A61K39/395
CPC分类号: A61K35/28 , A61B5/055 , A61B17/7061 , A61K9/0012 , A61K9/0019 , A61K9/0085 , A61K35/32 , A61K38/17 , A61K38/1793 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K38/20 , A61K38/363 , A61K38/4833 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/34 , C12Y304/21005 , G01N33/6869 , G01N2333/54
摘要: The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
摘要翻译: 本发明涉及将高特异性细胞因子拮抗剂注射到患病的椎间盘中。
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公开(公告)号:US07429378B2
公开(公告)日:2008-09-30
申请号:US10610355
申请日:2003-06-30
申请人: Hassan Serhan , Thomas M. DiMauro , Mohamed Attawia , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Laura J. Brown , Jeffrey C. Geesin
发明人: Hassan Serhan , Thomas M. DiMauro , Mohamed Attawia , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Laura J. Brown , Jeffrey C. Geesin
IPC分类号: A61K35/00
CPC分类号: A61K38/1841 , A61K35/28 , A61K38/57 , A61K2300/00
摘要: The present invention relates to injecting a high affinity antagonist of MMPs into a diseased intervertebral disc.
摘要翻译: 本发明涉及将MMP的高亲和力拮抗剂注射到患病的椎间盘中。
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公开(公告)号:US20080213261A1
公开(公告)日:2008-09-04
申请号:US11881926
申请日:2007-07-30
申请人: Thomas M. DiMauro , Hassan Serhan , Mohamed Attawia , Sudhakar Kadiyala , David Urbahns , Scott Bruder
发明人: Thomas M. DiMauro , Hassan Serhan , Mohamed Attawia , Sudhakar Kadiyala , David Urbahns , Scott Bruder
IPC分类号: A61K39/395 , A61K35/00 , A61P19/00 , A61K35/12
CPC分类号: A61K35/28 , A61B5/055 , A61B17/7061 , A61K9/0012 , A61K9/0019 , A61K9/0085 , A61K35/32 , A61K38/17 , A61K38/1793 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K38/20 , A61K38/363 , A61K38/4833 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/34 , C12Y304/21005 , G01N33/6869 , G01N2333/54
摘要: The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
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9.Transdiscal administration of specific inhibitors of pro-inflammatory cytokines 有权
标题翻译: 跨时间给药促炎细胞因子的特异性抑制剂公开(公告)号:US08728523B2
公开(公告)日:2014-05-20
申请号:US12291378
申请日:2008-11-07
申请人: Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder
发明人: Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder
IPC分类号: A61K45/00 , A61K39/395
CPC分类号: A61K35/28 , A61B5/055 , A61B17/7061 , A61K9/0012 , A61K9/0019 , A61K9/0085 , A61K35/32 , A61K38/17 , A61K38/1793 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K38/20 , A61K38/363 , A61K38/4833 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/34 , C12Y304/21005 , G01N33/6869 , G01N2333/54
摘要: The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
摘要翻译: 本发明涉及将高特异性细胞因子拮抗剂注射到患病的椎间盘中。
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10.Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints 有权
标题翻译: 将高特异性细胞因子抑制剂的跨荚膜施用于矫形关节公开(公告)号:US08361467B2
公开(公告)日:2013-01-29
申请号:US10630227
申请日:2003-07-30
申请人: Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Martin A. Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura J. Brown , Jeff Geesin , Pamela L. Plouhar , Catherine Smith , John Siekierka
发明人: Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Martin A. Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura J. Brown , Jeff Geesin , Pamela L. Plouhar , Catherine Smith , John Siekierka
IPC分类号: A61K39/395 , A61K39/00 , A61K38/18
CPC分类号: A61K38/30 , A61K31/198 , A61K31/436 , A61K38/1816 , A61K2039/505
摘要: The present invention relates to trans-capsularly administering into a diseased joint a high specificity antagonist selected from the group consisting of: i) an inhibitor of a pro-inflammatory interleukin; ii) an inhibitor of TNF-α synthesis; iii) an inhibitor of membrane-bound TNF-α; iv) an inhibitor of a natural receptor of TNF-α; v) an inhibitor of NO synthase, vi) an inhibitor of PLA2 enzyme; vii) an anti-proliferative agent; viii) an anti-oxidant; ix) an apoptosis inhibitor selected from the group consisting of EPO mimetic peptides, EPO mimetibodies, IGF-I, IGF-II, and caspase inhibitors, and x) an inhibitor of MMPs; and xi) an inhibitor of p38 kinase.
摘要翻译: 本发明涉及向患病关节中透射施用高特异性拮抗剂,所述高特异性拮抗剂选自:i)促炎白细胞介素的抑制剂; ii)TNF-α合成抑制剂; iii)膜结合TNF-α的抑制剂; iv)TNF-α的天然受体的抑制剂; v)NO合酶抑制剂,vi)PLA2酶抑制剂; vii)抗增殖剂; viii)抗氧化剂; ix)选自EPO模拟肽,EPO模拟物,IGF-I,IGF-II和胱天蛋白酶抑制剂的细胞凋亡抑制剂,和x)MMP的抑制剂; 和xi)p38激酶的抑制剂。
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