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    APPARATUS AND METHOD FOR MULTI-MODAL IMAGING USING NANOPARTICLE MULTI-MODAL IMAGING PROBES
    1.
    发明申请
    APPARATUS AND METHOD FOR MULTI-MODAL IMAGING USING NANOPARTICLE MULTI-MODAL IMAGING PROBES 审中-公开
    使用纳米尺度多模式成像探针进行多模式成像的装置和方法

    公开(公告)号：US20090093700A1

    公开(公告)日：2009-04-09

    申请号：US12201204

    申请日：2008-08-29

    申请人： Heidi Hall ,  Mark Edward Bridges ,  Silas J. Leavesley ,  Valeri P. Patsekin ,  J. Paul Robinson ,  David L. Patton ,  Douglas Lincoln Vizard ,  William E. McLaughlin ,  Bartlomeiej P. Rajwa

    发明人： Heidi Hall ,  Mark Edward Bridges ,  Silas J. Leavesley ,  Valeri P. Patsekin ,  J. Paul Robinson ,  David L. Patton ,  Douglas Lincoln Vizard ,  William E. McLaughlin ,  Bartlomeiej P. Rajwa

    IPC分类号： A61B5/05

    CPC分类号： A61B5/0059 ,  A61B5/0035 ,  A61B6/00 ,  A61B6/4417 ,  A61B6/508

    摘要： An apparatus for multimodal imaging of an object includes a support stage for receiving an object to be imaged; an object supported on the stage, a light source for producing a beam to illuminate the object; a filter positioned to receive and pass the beam toward the object; and a lens and camera system for capturing an image of the object. The apparatus may include a tiltable filter for filtering light from the source. The apparatus may include a mechanism for selectively directing light from the light source through a first filter assembly to produce a first beam of light of a first frequency range for illuminating an object on the stage in a first imaging mode or through a second filter assembly to produce a second beam of light of a second frequency range for illuminating an object on the stage in a second imaging mode, so that the lens and camera system captures light from the object illuminated by either the first or second beam of light to produce a first image in response to the first beam and a second image, different from the first image, in response to the second image. An x-ray source and phosphor plate may be included to provide an additional imaging mode.

    摘要翻译： 用于物体的多模式成像的装置包括用于接收待成像对象的支撑台; 支撑在舞台上的物体，用于产生用于照射物体的光束的光源; 定位成接收并将光束传递到物体的过滤器; 以及用于捕获对象的图像的镜头和相机系统。 该装置可以包括用于过滤来自源的光的可倾斜滤光器。 该装置可以包括用于选择性地引导来自光源的光通过第一滤光器组件以产生第一频率范围的第一光束的机构，用于以第一成像模式照射舞台上的物体或通过第二滤光器组件 产生第二频率范围的第二光束，用于在第二成像模式下照射舞台上的物体，使得透镜和照相机系统捕获来自被第一或第二光束照射的物体的光，以产生第一 响应于第一光束的图像和与第一图像不同的第二图像。 可以包括x射线源和磷光体板以提供附加的成像模式。

    APPARATUS AND METHOD FOR MULTI-MODAL IMAGING USING NANOPARTICLE MULTI-MODAL IMAGING PROBES
    2.
    发明申请
    APPARATUS AND METHOD FOR MULTI-MODAL IMAGING USING NANOPARTICLE MULTI-MODAL IMAGING PROBES 审中-公开
    使用纳米尺度多模式成像探针进行多模式成像的装置和方法

    公开(公告)号：US20090086908A1

    公开(公告)日：2009-04-02

    申请号：US12196300

    申请日：2008-08-22

    申请人： John William Harder ,  David L. Patton ,  Shiying Zheng ,  Ruizheng Wang ,  Joseph Francis Bringley ,  Douglas Lincoln Vizard ,  William E. McLaughlin ,  Heidi Hall ,  Mark E. Bridges

    发明人： John William Harder ,  David L. Patton ,  Shiying Zheng ,  Ruizheng Wang ,  Joseph Francis Bringley ,  Douglas Lincoln Vizard ,  William E. McLaughlin ,  Heidi Hall ,  Mark E. Bridges

    IPC分类号： G01N23/04 ,  G03B42/02

    CPC分类号： A61B6/00 ,  A61B5/0035 ,  A61B5/0059 ,  A61B6/4216 ,  A61B6/4417 ,  A61B6/481 ,  A61B6/508 ,  A61B2503/40 ,  A61B2562/0242

    摘要： An apparatus for multimodal imaging of an object includes a support stage for receiving an object to be imaged; an object supported on the stage, the object having been treated with a biocompatible imaging probe comprising nanoparticles carrying one or more targeting moieties and one or more diagnostic components for enabling capture of images of the object; a light source for producing a beam to illuminate the object; a filter positioned to receive and pass the beam toward the object; and a lens and camera system for capturing an image of the object. The apparatus may include a tiltable filter for filtering light from the source. The apparatus may include a mechanism for selectively directing light from the light source through a first filter assembly to produce a first beam of light of a first frequency range for illuminating an object on the stage in a first imaging mode or through a second filter assembly to produce a second beam of light of a second frequency range for illuminating an object on the stage in a second imaging mode, so that the lens and camera system captures light from the object illuminated by either the first or second beam of light to produce a first image in response to the first beam and a second image, different from the first image, in response to the second image. An x-ray source and phosphor plate may be included to provide an additional imaging mode.

    摘要翻译： 用于物体的多模式成像的装置包括用于接收待成像对象的支撑台; 支撑在舞台上的物体，已经用生物相容性成像探针处理了物体，所述生物相容性成像探针包含携带一个或多个靶向部分的纳米颗粒和一个或多个诊断部件，用于能够捕获物体的图像; 用于产生用于照射物体的光束的光源; 定位成接收并将光束传递到物体的过滤器; 以及用于捕获对象的图像的镜头和相机系统。 该装置可以包括用于过滤来自源的光的可倾斜滤光器。 该装置可以包括用于选择性地引导来自光源的光通过第一滤光器组件以产生第一频率范围的第一光束的机构，用于以第一成像模式照射舞台上的物体或通过第二滤光器组件 产生第二频率范围的第二光束，用于在第二成像模式下照射舞台上的物体，使得透镜和照相机系统捕获来自被第一或第二光束照射的物体的光，以产生第一 响应于第一光束的图像和与第一图像不同的第二图像。 可以包括x射线源和磷光体板以提供附加的成像模式。

    APPARATUS AND METHOD FOR MULTI-MODAL IMAGING
    6.
    发明申请
    APPARATUS AND METHOD FOR MULTI-MODAL IMAGING 有权
    多模式成像的装置和方法

    公开(公告)号：US20090159805A1

    公开(公告)日：2009-06-25

    申请号：US12354830

    申请日：2009-01-16

    申请人： Gilbert Feke ,  Douglas Lincoln Vizard ,  William E. McLaughlin

    发明人： Gilbert Feke ,  Douglas Lincoln Vizard ,  William E. McLaughlin

    IPC分类号： G01T1/20

    CPC分类号： A61B5/0059 ,  A61B5/0035 ,  A61B6/00 ,  A61B6/4417 ,  A61B6/508 ,  A61B6/5247

    摘要： An imaging system for imaging an object, including: a support member adapted to receive the object in an immobilized state; a removable phosphor plate assembly adapted to respond to ionizing radiation by emitting visible light; first imaging means for imaging the immobilized object in a first imaging mode to capture a first image; second imaging means for imaging the immobilized object in a second imaging mode, different from the first imaging mode, to capture a second image; and third imaging means for imaging the immobilized object in a third imaging mode, different from the first and second imaging modes, to capture a third image, wherein the first imaging mode uses the phosphor plate assembly and is selected from the group: x-ray mode and low energy radio isotope mode; the second imaging mode uses the phosphor plate assembly and a high energy radio isotope mode, and the third imaging mode is selected from the group: bright-field mode, fluorescence mode and luminescence mode.

    摘要翻译： 一种用于成像对象的成像系统，包括：适于以固定状态接收对象的支撑构件; 适于通过发射可见光来响应电离辐射的可去除的荧光体板组件; 第一成像装置，用于在第一成像模式下成像固定的物体以捕获第一图像; 第二成像装置，用于在与第一成像模式不同的第二成像模式下对固定物体进行成像以捕获第二图像; 以及第三成像装置，用于在与第一和第二成像模式不同的第三成像模式下成像固定的物体，以捕获第三图像，其中第一成像模式使用磷光体板组件，并且选自x射线 模式和低能放射同位素模式; 第二成像模式使用荧光体板组件和高能量放射性同位素模式，并且第三成像模式选自亮场模式，荧光模式和发光模式。

    Apparatus and method for multi-modal imaging
    8.
    发明授权
    Apparatus and method for multi-modal imaging 有权
    多模态成像装置及方法

    公开(公告)号：US08050735B2

    公开(公告)日：2011-11-01

    申请号：US12354830

    申请日：2009-01-16

    申请人： Gilbert Feke ,  Douglas Lincoln Vizard ,  William E. McLaughlin

    发明人： Gilbert Feke ,  Douglas Lincoln Vizard ,  William E. McLaughlin

    IPC分类号： A61B6/00

    CPC分类号： A61B5/0059 ,  A61B5/0035 ,  A61B6/00 ,  A61B6/4417 ,  A61B6/508 ,  A61B6/5247

    摘要： An imaging system for imaging an object, including: a support member adapted to receive the object in an immobilized state; a removable phosphor plate assembly adapted to respond to ionizing radiation by emitting visible light; first imaging means for imaging the immobilized object in a first imaging mode to capture a first image; second imaging means for imaging the immobilized object in a second imaging mode, different from the first imaging mode, to capture a second image; and third imaging means for imaging the immobilized object in a third imaging mode, different from the first and second imaging modes, to capture a third image, wherein the first imaging mode uses the phosphor plate assembly and is selected from the group: x-ray mode and low energy radio isotope mode; the second imaging mode uses the phosphor plate assembly and a high energy radio isotope mode, and the third imaging mode is selected from the group: bright-field mode, fluorescence mode and luminescence mode.

    摘要翻译： 一种用于成像对象的成像系统，包括：适于以固定状态接收对象的支撑构件; 适于通过发射可见光来响应电离辐射的可去除的荧光体板组件; 第一成像装置，用于在第一成像模式下成像固定的物体以捕获第一图像; 第二成像装置，用于在与第一成像模式不同的第二成像模式下对固定物体进行成像以捕获第二图像; 以及第三成像装置，用于在与第一和第二成像模式不同的第三成像模式下成像固定的物体，以捕获第三图像，其中第一成像模式使用磷光体板组件，并且选自x射线 模式和低能放射同位素模式; 第二成像模式使用荧光体板组件和高能量放射性同位素模式，并且第三成像模式选自亮场模式，荧光模式和发光模式。

    FLUORESCENT NIRF ACTIVATABLE PROBES FOR DISEASE DETECTION
    9.
    发明申请
    FLUORESCENT NIRF ACTIVATABLE PROBES FOR DISEASE DETECTION 有权
    用于疾病检测的荧光近红外激活探针

    公开(公告)号：US20110293529A1

    公开(公告)日：2011-12-01

    申请号：US13101370

    申请日：2011-05-05

    申请人： Tao Ji ,  Warren M. Leevy ,  William E. McLaughlin ,  Yawfui Yong

    发明人： Tao Ji ,  Warren M. Leevy ,  William E. McLaughlin ,  Yawfui Yong

    IPC分类号： A61K49/00 ,  C12Q1/68 ,  C12Q1/37 ,  G01N33/53 ,  B82Y15/00

    CPC分类号： G01N33/587 ,  A61K49/0485 ,  B82Y5/00 ,  B82Y15/00 ,  C12Q1/34 ,  G01N33/542

    摘要： Fluorescent activatable probes for imaging biological processes and disease detection in vitro and in vivo. There is also described a method for detecting the presence of an enzyme. A sample is contacted with a nanoparticle including a monomer, at least one cleavable spacer comprising at least one fluorescence activation site, and at least two dyes of at least two types. The cleavable spacer is attached at one end to the nanoparticle. The at least two types comprise an energy donor type and an energy acceptor type. At least one dye of one type is embedded in the nanoparticle and the cleavable spacer has at least one dye of the other type attached. The at least two dyes comprise at least one matched pair capable of fluorescence resonance energy transfer. Fluorescence is detected by exposing the sample to a light source, and detecting emitted light with a detector.

    摘要翻译： 用于成像生物过程和体外和体内疾病检测的荧光可激活探针。 还描述了检测酶的存在的方法。 将样品与包含单体的纳米颗粒，至少一个可切割间隔基包含至少一个荧光活化位点和至少两种至少两种类型的染料接触。 可切割间隔物的一端连接到纳米颗粒。 至少两种类型包括能量供体类型和能量受体类型。 至少一种一种染料被包埋在纳米颗粒中，并且可切割间隔物具有至少一种所连接的另一种类型的染料。 所述至少两种染料包含能够进行荧光共振能量转移的至少一个匹配对。 通过将样品暴露于光源并用检测器检测发射光来检测荧光。

    Method and apparatus for measuring long bone density of small-animals
    10.
    发明授权
    Method and apparatus for measuring long bone density of small-animals 失效
    测量小动物长骨密度的方法和装置

    公开(公告)号：US07706501B2

    公开(公告)日：2010-04-27

    申请号：US12204132

    申请日：2008-09-04

    申请人： Douglas L. Vizard ,  Douglas O. Wood ,  William E. McLaughlin ,  Gilbert Feke ,  Rao Papineni

    发明人： Douglas L. Vizard ,  Douglas O. Wood ,  William E. McLaughlin ,  Gilbert Feke ,  Rao Papineni

    IPC分类号： G01N23/083 ,  G01B15/00

    CPC分类号： G01N23/087 ,  G01N2223/407 ,  G01N2223/6123

    摘要： A method and apparatus are disclosed for measuring long bone density of small animals. A phosphor screen or plate is provided of a type that transduces incident ionizing radiation to emitted light. A small animal is positioned before the phosphor screen or plate and exposed to soft X-radiation having an energy level in the range of 11 to 16 Kev. Light emitted by the phosphor screen or plate is captured using a digital camera and a digital X-ray image is prepared of a long bone of the animal. The X-ray image is transformed into an X-ray density image and a region of interest is defined on the long bone in the X-ray density image. At least one row of pixels is scanned within the region of interest of the X-ray density image. A nonlinear least squares analysis of data obtained from the scanning step is conducted using a cylindrical model for the long bone within the region of interest.

    摘要翻译： 公开了测量小动物长骨密度的方法和装置。 提供了将入射电离辐射转换为发射光的类型的荧光屏或板。 将小动物放置在荧光屏或板之前并暴露于能量水平在11至16Kev范围内的软X-辐射。 使用数字照相机捕获由荧光屏或板发射的光，并且制备动物的长骨的数字X射线图像。 将X射线图像转换为X射线密度图像，并且在X射线密度图像中的长骨上限定感兴趣区域。 在X射线密度图像的感兴趣区域内扫描至少一行像素。 从扫描步骤获得的数据的非线性最小二乘法分析是使用感兴趣区域内的长骨的圆柱模型进行的。