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1.发明授权公开(公告)号：US08680282B2
公开(公告)日：2014-03-25
申请号：US12671154
申请日：2008-08-01
申请人： Heinz W. Pauls , Bryan T. Forrest , Peter Brent Sampson , Yong Liu , Radoslaw Laufer , Yunhui Lang , Miklos Feher , Yi Yao , Guohua Pan
发明人： Heinz W. Pauls , Bryan T. Forrest , Peter Brent Sampson , Yong Liu , Radoslaw Laufer , Yunhui Lang , Miklos Feher , Yi Yao , Guohua Pan
IPC分类号： C07D211/58 , A61K31/4468
CPC分类号： C07D211/58 , C07C275/36 , C07D205/04 , C07D207/09 , C07D211/56 , C07D405/12
摘要： A CPT1 inhibitor compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof: or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating a subject having cancer comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译： CPT1抑制剂化合物由结构式（I）或其药学上可接受的盐表示：或其药学上可接受的盐。 药物组合物包含由结构式（I）表示的化合物或其药学上可接受的盐。 治疗患有癌症的受试者的方法包括向受试者施用治疗有效量的由结构式（I）表示的化合物或其药学上可接受的盐。
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2.发明申请公开(公告)号：US20110015174A1
公开(公告)日：2011-01-20
申请号：US12671154
申请日：2008-08-01
申请人： Heinz W. Pauls , Bryan T. Forrest , Peter Brent Sampson , Yong Liu , Radoslaw Laufer , Yunhui Lang , Miklos Feher , Yi Yao , Guohua Pan
发明人： Heinz W. Pauls , Bryan T. Forrest , Peter Brent Sampson , Yong Liu , Radoslaw Laufer , Yunhui Lang , Miklos Feher , Yi Yao , Guohua Pan
IPC分类号： A61K31/397 , C07D211/58 , C07D405/12 , C07D207/14 , C07D205/04 , A61K31/44 , A61K31/443 , A61K31/40 , A61P35/00 , A61P29/00 , A61P31/00 , A61P3/10 , A61P35/02
CPC分类号： C07D211/58 , C07C275/36 , C07D205/04 , C07D207/09 , C07D211/56 , C07D405/12
摘要： A CPT1 inhibitor compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof: or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating a subject having cancer comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译： CPT1抑制剂化合物由结构式（I）或其药学上可接受的盐表示：或其药学上可接受的盐。 药物组合物包含由结构式（I）表示的化合物或其药学上可接受的盐。 治疗患有癌症的受试者的方法包括给予受试者治疗有效量的由结构式（I）表示的化合物或其药学上可接受的盐。
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3.发明申请INHIBITORS OF CARNITINE PALMITOYLTRANSFERASE AND TREATING CANCER 有权CARNITINE PALMITOYLTRANSFERASE和治疗癌症的抑制剂公开(公告)号：US20100105900A1
公开(公告)日：2010-04-29
申请号：US12530429
申请日：2008-03-09
申请人： Heinz W. Pauls , Peter Brent Sampson , Bryan T. Forrest , Radoslaw Laufer , Yong Liu , Miklos Feher , Yi Yao , Guohua Pan
发明人： Heinz W. Pauls , Peter Brent Sampson , Bryan T. Forrest , Radoslaw Laufer , Yong Liu , Miklos Feher , Yi Yao , Guohua Pan
IPC分类号： C07D295/18 , C07D307/02 , C07D333/22 , C07C229/00 , C07D239/02 , C07D213/78 , C07D417/04
CPC分类号： C07D409/06 , C07C1/26 , C07C17/10 , C07C2529/40 , C07D207/325 , C07D213/71 , C07D213/82 , C07D231/12 , C07D231/14 , C07D263/34 , C07D277/48 , C07D295/215 , C07D307/24 , C07D307/68 , C07D307/82 , C07D333/34 , C07D333/40 , C07D401/04 , C07D405/06 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07C9/00 , C07C19/075
摘要： A CPT inhibitor compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof: or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating a subject having cancer comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译： CPT抑制剂化合物由结构式（I）或其药学上可接受的盐表示：或其药学上可接受的盐。 药物组合物包含由结构式（I）表示的化合物或其药学上可接受的盐。 治疗患有癌症的受试者的方法包括向受试者施用治疗有效量的由结构式（I）表示的化合物或其药学上可接受的盐。
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公开(公告)号：US08410150B2
公开(公告)日：2013-04-02
申请号：US12530429
申请日：2008-03-06
申请人： Heinz W. Pauls , Peter Brent Sampson , Bryan T. Forrest , Radoslaw Laufer , Yong Liu , Miklos Feher , Yi Yao , Guohua Pan
发明人： Heinz W. Pauls , Peter Brent Sampson , Bryan T. Forrest , Radoslaw Laufer , Yong Liu , Miklos Feher , Yi Yao , Guohua Pan
IPC分类号： C07D307/66 , C07D333/32 , C07D213/18 , C07D233/70 , C07D417/04 , C07D263/36 , C07D249/12 , C07D261/10 , C07D207/36 , C07D275/03 , C07D271/06 , C07D285/08 , C07C335/16 , C07C327/40 , C07C327/08 , C07C311/10 , C07C237/14 , A61K31/34 , A61K31/381 , A61K31/4025 , A61K31/40 , A61K31/415 , A61K31/4164 , A61K31/4196 , A61K31/42 , A61K31/4245 , A61K31/425 , A61K31/433 , A61K31/435 , A61K31/64 , A61K31/155
CPC分类号： C07D409/06 , C07C1/26 , C07C17/10 , C07C2529/40 , C07D207/325 , C07D213/71 , C07D213/82 , C07D231/12 , C07D231/14 , C07D263/34 , C07D277/48 , C07D295/215 , C07D307/24 , C07D307/68 , C07D307/82 , C07D333/34 , C07D333/40 , C07D401/04 , C07D405/06 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07C9/00 , C07C19/075
摘要： A CPT inhibitor compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof: or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating a subject having cancer comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译： CPT抑制剂化合物由结构式（I）或其药学上可接受的盐表示：或其药学上可接受的盐。 药物组合物包含由结构式（I）表示的化合物或其药学上可接受的盐。 治疗患有癌症的受试者的方法包括向受试者施用治疗有效量的由结构式（I）表示的化合物或其药学上可接受的盐。
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5.发明授权Indazolyl, benzimidazolyl, benzotriazolyl substituted indolinone derivatives as kinase inhibitors useful in the treatment of cancer 有权吲唑基，苯并咪唑基，苯并三唑基取代的二氢吲哚酮衍生物作为可用于治疗癌症的激酶抑制剂公开(公告)号：US08765748B2
公开(公告)日：2014-07-01
申请号：US12808961
申请日：2008-12-19
申请人： Heinz W. Pauls , Bryan T. Forrest , Radoslaw Laufer , Miklos Feher , Peter Brent Sampson , Guohua Pan , Sze-Wan Li , Yong Liu
发明人： Heinz W. Pauls , Bryan T. Forrest , Radoslaw Laufer , Miklos Feher , Peter Brent Sampson , Guohua Pan , Sze-Wan Li , Yong Liu
IPC分类号： A61P35/00 , A61P35/02 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/10 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , A61K31/416 , A61K31/4192 , A61K31/4184 , A61K31/4439 , A61K31/496 , A61K31/437 , A61K31/5377
CPC分类号： C07D403/06 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present invention is directed to a compound is represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The present invention is also directed to a pharmaceutical composition comprising a compound represented by Structural Formula (A) described above or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a subject having cancer, wherein the method comprises administering a therapeutically effective amount of a compound represented by Structural Formula (A) described above or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及由结构式（A）表示的化合物或其药学上可接受的盐。 本发明还涉及包含由上述结构式（A）表示的化合物或其药学上可接受的盐和药学上可接受的载体或稀释剂的药物组合物。 还公开了治疗患有癌症的受试者的方法，其中所述方法包括施用治疗有效量的由上述结构式（A）表示的化合物或其药学上可接受的盐。
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6.发明申请INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL SUBSTITUTED INDOLINONE DERIVATIVES AS KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER 有权辛唑，苯并咪唑，苯并三唑取代的吲哚啉酮衍生物作为激素治疗癌症中的激素抑制剂公开(公告)号：US20110065702A1
公开(公告)日：2011-03-17
申请号：US12808961
申请日：2008-12-19
申请人： Heinz W. Pauls , Bryan T. Forrest , Radoslaw Laufer , Miklos Feher , Peter Brent Sampson , Guohua Pan , Sze-Wan Li , Yong Liu
发明人： Heinz W. Pauls , Bryan T. Forrest , Radoslaw Laufer , Miklos Feher , Peter Brent Sampson , Guohua Pan , Sze-Wan Li , Yong Liu
IPC分类号： A61K31/416 , C07D403/10 , C07D403/14 , C07D471/04 , C07D413/14 , A61K31/4192 , A61K31/4184 , A61K31/4439 , A61K31/496 , A61K31/437 , A61K31/5377 , A61P35/00 , A61P35/02
CPC分类号： C07D403/06 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present invention is directed to a compound is represented by Structural Formula (A):or a pharmaceutically acceptable salt therof. The present invention is also directed to a pharmaceutical composition comprising a compound represented by Structural Formula (A) described above or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a subject having cancer, wherein the method comprises administering a therapeutically effective amount of a compound represented by Structural Formula (A) described above or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及由结构式（A）表示的化合物或其药学上可接受的盐。 本发明还涉及包含由上述结构式（A）表示的化合物或其药学上可接受的盐和药学上可接受的载体或稀释剂的药物组合物。 还公开了治疗患有癌症的受试者的方法，其中所述方法包括施用治疗有效量的由上述结构式（A）表示的化合物或其药学上可接受的盐。
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公开(公告)号：US08481533B2
公开(公告)日：2013-07-09
申请号：US13529542
申请日：2012-06-21
申请人： Peter B. Sampson , Yong Liu , Sze-Wan Li , Bryan T. Forrest , Heinz W. Pauls , Louise G. Edwards , Miklos Feher , Narendra Kumar B. Patel , Radoslaw Laufer , Guohua Pan
发明人： Peter B. Sampson , Yong Liu , Sze-Wan Li , Bryan T. Forrest , Heinz W. Pauls , Louise G. Edwards , Miklos Feher , Narendra Kumar B. Patel , Radoslaw Laufer , Guohua Pan
IPC分类号： A61K31/5377 , A61K31/416 , C07D273/01 , C07D231/54
CPC分类号： C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
摘要： The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
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公开(公告)号：US20110263598A1
公开(公告)日：2011-10-27
申请号：US13081254
申请日：2011-04-06
申请人： Peter B. Sampson , Yong Liu , Sze-Wan Li , Bryan T. Forrest , Heinz W. Pauls , Louise G. Edwards , Miklos Feher , Narendra Kumar B. Patel , Radoslaw Laufer , Guohua Pan
发明人： Peter B. Sampson , Yong Liu , Sze-Wan Li , Bryan T. Forrest , Heinz W. Pauls , Louise G. Edwards , Miklos Feher , Narendra Kumar B. Patel , Radoslaw Laufer , Guohua Pan
IPC分类号： A61K31/5377 , A61P35/02 , A61K31/416 , A61P35/00 , C07D487/04 , C07D273/01
CPC分类号： C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
摘要： The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
摘要翻译： 本发明涉及由以下结构式表示的化合物及其药学上可接受的盐：由该结构式表示的化合物是激酶抑制剂，因此本文公开了用于治疗癌症的化合物。 本文提供了结构式中变量的定义。
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公开(公告)号：US08481525B2
公开(公告)日：2013-07-09
申请号：US13262888
申请日：2010-04-06
申请人： Peter Brent Sampson , Yong Liu , Sze-Wan Li , Bryan T. Forrest , Heinz W. Pauls , Louise G. Edwards , Miklos Feher , Narendra Kumar B. Patel , Guohua Pan
发明人： Peter Brent Sampson , Yong Liu , Sze-Wan Li , Bryan T. Forrest , Heinz W. Pauls , Louise G. Edwards , Miklos Feher , Narendra Kumar B. Patel , Guohua Pan
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/496 , A61K31/4427 , A61K31/416 , C07D223/14 , C07D273/00 , C07D237/02 , C07D215/00 , C07D231/54
CPC分类号： A61K31/553 , A61K31/416 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/10
摘要： The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
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公开(公告)号：US20120149686A1
公开(公告)日：2012-06-14
申请号：US13262888
申请日：2010-04-06
申请人： Peter B. Sampson , Yong liu , Sze-Wan Le , Brian T. Forrest , Heinz W. Pauls , Louise G. Edwards , Miklos Feher , Narendra Kumar B. Patel , Guohua Pan
发明人： Peter B. Sampson , Yong liu , Sze-Wan Le , Brian T. Forrest , Heinz W. Pauls , Louise G. Edwards , Miklos Feher , Narendra Kumar B. Patel , Guohua Pan
IPC分类号： A61K31/416 , C07D471/10 , A61K31/437 , C07D401/14 , A61P35/02 , C07D413/14 , A61K31/5377 , A61K31/553 , A61P35/00 , C07D403/10 , A61K31/496
CPC分类号： A61K31/553 , A61K31/416 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/10
摘要： The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
摘要翻译： 本发明涉及由以下结构式表示的化合物及其药学上可接受的盐：由该结构式表示的化合物是激酶抑制剂，因此本文公开了用于治疗癌症的化合物。 本文提供了结构式中变量的定义。
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