公开(公告)号：US5284877A

公开(公告)日：1994-02-08

申请号：US897711

申请日：1992-06-12

申请人： Helen M. Organ ,  Mark A. Holmes ,  Judith M. Pisano ,  Matthew J. Wyvratt

发明人： Helen M. Organ ,  Mark A. Holmes ,  Judith M. Pisano ,  Matthew J. Wyvratt

IPC分类号： C07D498/18 ,  C07H19/01 ,  A61K31/395 ,  C07D267/00

CPC分类号： C07D498/18 ,  C07H19/01

摘要： Alkyl and alkenyl macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by oxidation and derivitization at C-17. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants. In addition, these macrolide immunosuppressants are useful in the topical treatment of inflammatory and hyperproliferative skin diseases and cutaneous manifestations of immunologically-mediated illnesses. Also, these macrolides are useful in the treatment of reversible obstructive airways disease, particularly asthma; as hair revitalizing agents, especially in the treatment of male pattern alopecia oralopecia senilis; in the reversal of multidrug resistance of tumor cells; in treatment of inflammation of mucosa and blood vessels, gastric ulcers, vascular damage, ischemic bowel disease, inflammatory bowel disease, necrotizing entercolitis, intestinal lesions associated with thermal burns; in the treatment of cytomegalovirus infection; and in the treatment of idiopathic thrombocytopenic purpura and Basedow's disease.

摘要翻译： 一般结构式I的烷基和链烯基大环内酯：通过在C-17处的氧化和衍生，由合适的前体制备。 这些大环内酯类免疫抑制剂可用于哺乳动物宿主用于治疗自身免疫性疾病，感染性疾病和/或预防外来器官移植排斥反应。 此外，这些大环内酯类免疫抑制剂可用于局部治疗炎性和过度增生性皮肤病以及免疫介导疾病的皮肤表现。 此外，这些大环内酯可用于治疗可逆性阻塞性气道疾病，特别是哮喘; 作为头发活化剂，特别是在治疗男性脱发性秃发症的过程中， 在逆转肿瘤细胞的多药耐药性; 治疗粘膜和血管炎症，胃溃疡，血管损伤，缺血性肠病，炎性肠病，坏死性肠炎，与热灼伤相关的肠道损伤; 在治疗巨细胞病毒感染; 并在治疗特发性血小板减少性紫癜和基诺病。

公开(公告)号：US5880280A

公开(公告)日：1999-03-09

申请号：US259831

申请日：1994-06-15

申请人： Helen M. Organ ,  Mark A. Holmes

发明人： Helen M. Organ ,  Mark A. Holmes

IPC分类号： A61K31/435 ,  A61P31/04 ,  A61P37/06 ,  C07D498/18 ,  C07D267/22 ,  C07D281/18 ,  C07D337/16 ,  C07D513/00

CPC分类号： C07D498/18

摘要： Aryl, alkyl, alkenyl and alkynyl macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by modification at C-30, C-33, and/or C-34 of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.

摘要翻译： 通过在环己基环的C-30，C-33和/或C-34上进行修饰，由合适的前体制备通式结构式Ⅰ的芳基，烷基，烯基和炔基大环内酯：。 这些大环内酯类免疫抑制剂可用于哺乳动物宿主用于治疗自身免疫性疾病，感染性疾病和/或预防外来器官移植排斥和/或相关疾病，疾病和疾病。

公开(公告)号：US4850995A

公开(公告)日：1989-07-25

申请号：US87162

申请日：1987-08-19

申请人： Thomas K. Tie ,  Mark A. Holmes ,  Anne W. Rank

发明人： Thomas K. Tie ,  Mark A. Holmes ,  Anne W. Rank

IPC分类号： A61M1/02 ,  A61M1/36

CPC分类号： A61M1/3693 ,  A61M1/3643 ,  A61M1/3646 ,  A61M1/3696

摘要： Returning red blood cells to a patient after a centrifuge separation procedure by connecting an inflow line of a separation channel to an outflow line to provide a closed loop and recirculating liquid through it to remove blood cells. Also disclosed is pulling more liquid out of a flexible separation channel than permitted into it in order to reduce the volume of liquid to be used in returning cells to the patient.

摘要翻译： 通过将分离通道的流入管线连接到流出管线，将离心分离程序后的红细胞返回给患者，以提供闭环并将液体通过其循环以除血细胞。 还公开了从允许进入其中的柔性分离通道拉出更多的液体，以便减少用于将细胞返回到患者体内的液体的体积。

公开(公告)号：US4685900A

公开(公告)日：1987-08-11

申请号：US809857

申请日：1985-12-18

申请人： Mark R. Honard ,  Mark A. Holmes ,  Robert D. Jarrett

发明人： Mark R. Honard ,  Mark A. Holmes ,  Robert D. Jarrett

IPC分类号： A61M1/36 ,  A61M37/00

CPC分类号： A61M1/3687 ,  A61M2206/12

摘要： A therapeutic device for removing pathological effectors brom body fluids of a patient is disclosed. Said device includes a chamber for receiving the body fluids and positioned within the chamber is a biospecific polymer. Said biospecific polymer interacts with and binds specific pathological effectors carried by the body fluid that is passed through the chamber.

摘要翻译： 公开了一种用于去除患者的病理效应器溴体液的治疗装置。 所述装置包括用于接收体液并且定位在室内的室是生物特异性聚合物。 所述生物特异性聚合物与通过所述室的体液携带的特定病理效应物相互作用并结合。

公开(公告)号：US06959650B2

公开(公告)日：2005-11-01

申请号：US10315328

申请日：2002-12-10

申请人： Cory D. Greene ,  Mark A. Holmes

发明人： Cory D. Greene ,  Mark A. Holmes

IPC分类号： B65D19/00 ,  B65D19/38

CPC分类号： B65D19/0018 ,  B65D2519/00034 ,  B65D2519/00069 ,  B65D2519/00273 ,  B65D2519/00288 ,  B65D2519/00318 ,  B65D2519/00333 ,  B65D2519/00407 ,  B65D2519/00557 ,  B65D2519/00562 ,  B65D2519/00835

摘要： A Conveyorable Plastic Thermoformed Pallet, having a support member and support legs with outer walls, internal walls and inner walls, is utilized to transport product on a conveyor system. The Pallet is made using a twin-sheet thermoforming process that requires two molds for an upper sheet of thermoplastic material and a lower sheet of thermoplastic material. The upper sheet forms a top deck of the support member and the internal walls of the support legs. The lower sheet forms the underside of the support member, the inner walls of the support legs, and leg bottoms. Both sheets are fused to form the twin-sheet outer walls. The upper sheet also forms web strips which stabilize the walls of the support legs and prevent deflection of the walls.

摘要翻译： 具有支撑构件和具有外壁，内壁和内壁的支撑腿的可输送塑料热成型托盘用于在输送系统上运输产品。 托盘使用双板热成型工艺制成，其需要用于上部热塑性材料的模具和下部热塑性材料片。 上板形成支撑构件的顶板和支撑腿的内壁。 下片形成支撑构件的下侧，支撑腿的内壁和腿部底部。 两片被熔合以形成双板外壁。 上片还形成网条，其使支撑腿的壁稳定并防止壁的偏转。

公开(公告)号：US06498165B1

公开(公告)日：2002-12-24

申请号：US09604305

申请日：2000-06-26

申请人： Helen M. Armstrong ,  Richard Beresis ,  Joung L. Goulet ,  Mark A. Holmes ,  Xingfang Hong ,  Sander G. Mills ,  William H. Parsons ,  Peter J. Sinclair ,  Mark G. Steiner ,  Frederick Wong ,  Dennis M. Zaller

发明人： Helen M. Armstrong ,  Richard Beresis ,  Joung L. Goulet ,  Mark A. Holmes ,  Xingfang Hong ,  Sander G. Mills ,  William H. Parsons ,  Peter J. Sinclair ,  Mark G. Steiner ,  Frederick Wong ,  Dennis M. Zaller

IPC分类号： A61K31505

CPC分类号： C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： Pyrimidine compounds (Formula I), or their pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers, and pharmaceutical compositions including the same, which are inhibitors of tyrosine kinase enzymes, and as such are useful in the prophylaxis and treatment of protein tyrosine kinase-associated disorders, such as immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to play a role, such as cancer, angiogensis, atheroscelerosis, graft rejection, rheumatoid arthritis and psoriasis.

摘要翻译： 嘧啶化合物（式I）或其药学上可接受的盐，水合物，溶剂合物，晶体形式和单独的非对映异构体，以及包含其的药物组合物，其是酪氨酸激酶的抑制剂，因此可用于预防和治疗蛋白质 酪氨酸激酶相关疾病，例如免疫疾病，过度增殖性疾病和其中认为不适当的蛋白激酶作用发挥作用的其它疾病，例如癌症，血管生成素，动脉粥样硬化症，移植排斥反应，类风湿性关节炎和牛皮癣。

公开(公告)号：US06329380B1

公开(公告)日：2001-12-11

申请号：US09603688

申请日：2000-06-26

申请人： Joung L. Goulet ,  Mark A. Holmes ,  Julianne A. Hunt ,  Sander G. Mills ,  William H. Parsons ,  Peter J. Sinclair ,  Dennis M. Zaller

发明人： Joung L. Goulet ,  Mark A. Holmes ,  Julianne A. Hunt ,  Sander G. Mills ,  William H. Parsons ,  Peter J. Sinclair ,  Dennis M. Zaller

IPC分类号： C07D40114

CPC分类号： C07D401/14 ,  C07D403/14 ,  C07D409/14 ,  C07D471/04 ,  C07D487/04 ,  C07F9/59 ,  C07F9/65583

摘要： Pyrimidine compounds (Formula I), or their pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers, and pharmaceutical compositions including the same, which are inhibitors of tyrosine kinase enzymes, and as such are useful in the prophylaxis and treatment of proteins tyrosine kinase-associated disorders, such as immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to play a role, such as cancer, angiogensis, atheroscelerosis, graft rejection, rheumatoid arthritis and psoriasis.

摘要翻译： 嘧啶化合物（式I）或其药学上可接受的盐，水合物，溶剂合物，晶体形式和单独的非对映异构体，以及包含其的药物组合物，其是酪氨酸激酶的抑制剂，因此可用于预防和治疗蛋白质 酪氨酸激酶相关疾病，例如免疫疾病，过度增殖性疾病和其中认为不适当的蛋白激酶作用发挥作用的其它疾病，例如癌症，血管生成素，动脉粥样硬化症，移植排斥反应，类风湿性关节炎和牛皮癣。