公开(公告)号：US20080102057A1

公开(公告)日：2008-05-01

申请号：US11969481

申请日：2008-01-04

申请人： Helene Strick-Marchand ,  Mary Weiss ,  Serban Morosan ,  Dina Kremsdorf ,  Pierre Charneau

发明人： Helene Strick-Marchand ,  Mary Weiss ,  Serban Morosan ,  Dina Kremsdorf ,  Pierre Charneau

IPC分类号： A61K48/00 ,  A01N1/02 ,  A61P43/00 ,  C12N5/00 ,  C12N5/02 ,  G01N33/53

CPC分类号： G01N33/5067 ,  A61K35/12 ,  C12N5/067 ,  C12N5/0672 ,  C12N2501/105 ,  C12N2501/11 ,  C12N2501/33 ,  C12N2503/02 ,  C12N2510/00

摘要： The present invention relates to a hepatic cell line derived from wild-type mammalian liver tissue by culture methodology, the cells of the cell line being capable of differentiating into hepatocytes and bile duct cells. The present invention also relates to methods of producing such cells as well as to their applications in therapy and as an investigational tool.

摘要翻译： 本发明涉及通过培养方法从野生型哺乳动物肝组织衍生的肝细胞系，细胞系的细胞能够分化成肝细胞和胆管细胞。 本发明还涉及生产这种细胞的方法及其在治疗中的应用和作为研究工具。

公开(公告)号：US20050074876A1

公开(公告)日：2005-04-07

申请号：US10677303

申请日：2003-10-03

申请人： Helene Strick-Marchand ,  Mary Weiss ,  Serban Morosan ,  Dina Kremsdorf ,  Pierre Charneau

发明人： Helene Strick-Marchand ,  Mary Weiss ,  Serban Morosan ,  Dina Kremsdorf ,  Pierre Charneau

IPC分类号： A61K35/12 ,  C12N5/02 ,  C12N5/071 ,  C12N5/074 ,  C12N5/00 ,  C12N5/08

CPC分类号： G01N33/5067 ,  A61K35/12 ,  C12N5/067 ,  C12N5/0672 ,  C12N2501/105 ,  C12N2501/11 ,  C12N2501/33 ,  C12N2503/02 ,  C12N2510/00

摘要： The present invention relates to a hepatic cell line derived from wild-type mammalian liver tissue by culture methodology, the cells of the cell line being capable of differentiating into hepatocytes and bile duct cells. The present invention also relates to methods of producing such cells as well as to their applications in therapy and as an investigational tool.

摘要翻译： 本发明涉及通过培养方法从野生型哺乳动物肝组织衍生的肝细胞系，细胞系的细胞能够分化成肝细胞和胆管细胞。 本发明还涉及生产这种细胞的方法及其在治疗中的应用和作为研究工具。