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1.发明授权公开(公告)号：US08659651B2
公开(公告)日：2014-02-25
申请号：US12639804
申请日：2009-12-16
申请人： Helge Jess , Dieter Quendt , Werner Nahm , Joachim Steffen
发明人： Helge Jess , Dieter Quendt , Werner Nahm , Joachim Steffen
CPC分类号： G02B21/0012 , G02B21/0064 , G02B21/0076 , G02B21/16 , G02B21/22 , G02B27/1013 , G02B27/144 , G02B27/145 , G02B27/149
摘要： A surgical microscope for observing an infrared fluorescence includes a camera system 25 having three chips, wherein infrared light emanating from an object is supplied to only one of the three camera chips via a dichroic beam splitter.
摘要翻译： 用于观察红外荧光的手术显微镜包括具有三个芯片的相机系统25，其中从物体发出的红外光仅通过二向色分束器提供给三个相机芯片中的一个。
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2.发明申请SURGICAL MICROSCOPE FOR OBSERVING AN INFRARED FLUORESCENCE AND CORRESPONDING METHOD 有权用于观察红外荧光和相关方法的手术显微镜公开(公告)号：US20100182418A1
公开(公告)日：2010-07-22
申请号：US12639804
申请日：2009-12-16
申请人： Helge Jess , Dieter Quendt , Werner Nahm , Joachim Steffen
发明人： Helge Jess , Dieter Quendt , Werner Nahm , Joachim Steffen
CPC分类号： G02B21/0012 , G02B21/0064 , G02B21/0076 , G02B21/16 , G02B21/22 , G02B27/1013 , G02B27/144 , G02B27/145 , G02B27/149
摘要： A surgical microscope for observing an infrared fluorescence includes a camera system 25 having three chips, wherein infrared light emanating from an object is supplied to only one of the three camera chips via a dichroic beam splitter.
摘要翻译： 用于观察红外荧光的手术显微镜包括具有三个芯片的相机系统25，其中从物体发出的红外光仅通过二向色分束器提供给三个相机芯片中的一个。
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公开(公告)号：US07924307B2
公开(公告)日：2011-04-12
申请号：US10918387
申请日：2004-08-16
申请人： Helge Jess , Ulrich Gold , Dieter Quendt , Christoph Hauger
发明人： Helge Jess , Ulrich Gold , Dieter Quendt , Christoph Hauger
CPC分类号： G02B21/0012 , G02B21/22 , G02B21/361 , G02B21/365 , G02B26/008 , G02B26/023 , H04N13/239 , H04N13/332
摘要： An optical viewing system (100) for viewing an object region has a display unit (105) which has a plurality of controllable display segments which make available color pulse sequences in order to generate a display image which is built up of a plurality of image points. The optical viewing system (100) includes a superposition unit (110) which superposes an image, which is made available by the display unit (105), onto the image of an object region (104). The optical viewing system has a camera unit (111, 113) to which the superposed image of display unit (105) and object region (104) is supplied. The camera unit (111, 113) has image sensors (112, 114) whose light sensitivity is adjustable as a function of time. The light sensitivity of the image sensors (112, 114) is matched to the color pulse sequence in such a manner that the image sensor (112, 114) can detect at least two light pulses of different color from the color pulse sequence from a display segment.
摘要翻译： 用于观看物体区域的光学观察系统（100）具有显示单元（105），该显示单元具有多个可控显示区段，该可显示区段提供可用的色彩脉冲序列，以便产生由多个图像点构成的显示图像 。 光学观察系统（100）包括将由显示单元（105）可用的图像叠加在对象区域（104）的图像上的叠加单元（110）。 光学观察系统具有显示单元（105）和对象区域（104）的叠加图像被提供到的相机单元（111,113）。 相机单元（111,113）具有其光敏度作为时间的函数可调的图像传感器（112,114）。 图像传感器（112,114）的光灵敏度与色彩脉冲序列匹配，使得图像传感器（112,114）可以从显示器的颜色脉冲序列中检测不同颜色的至少两个光脉冲 分割。
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公开(公告)号：US20050237384A1
公开(公告)日：2005-10-27
申请号：US10918387
申请日：2004-08-16
申请人： Helge Jess , Ulrich Gold , Dieter Quendt , Christoph Hauger
发明人： Helge Jess , Ulrich Gold , Dieter Quendt , Christoph Hauger
CPC分类号： G02B21/0012 , G02B21/22 , G02B21/361 , G02B21/365 , G02B26/008 , G02B26/023 , H04N13/239 , H04N13/332
摘要： An optical viewing system (100) for viewing an object region has a display unit (105) which has a plurality of controllable display segments which make available color pulse sequences in order to generate a display image which is built up of a plurality of image points. The optical viewing system (100) includes a superposition unit (110) which superposes an image, which is made available by the display unit (105), onto the image of an object region (104). The optical viewing system has a camera unit (111, 113) to which the superposed image of display unit (105) and object region (104) is supplied. The camera unit (111, 113) has image sensors (112, 114) whose light sensitivity is adjustable as a function of time. The light sensitivity of the image sensors (112, 114) is matched to the color pulse sequence in such a manner that the image sensor (112, 114) can detect at least two light pulses of different color from the color pulse sequence from a display segment.
摘要翻译： 用于观看物体区域的光学观察系统（100）具有显示单元（105），该显示单元具有多个可控显示区段，该可显示区段提供可用的色彩脉冲序列，以便产生由多个图像点构成的显示图像 。 光学观察系统（100）包括将由显示单元（105）可用的图像叠加在对象区域（104）的图像上的叠加单元（110）。 光学观察系统具有显示单元（105）和对象区域（104）的叠加图像被提供到的相机单元（111,113）。 相机单元（111,113）具有其光敏度作为时间的函数可调的图像传感器（112,114）。 图像传感器（112,114）的光灵敏度与色彩脉冲序列匹配，使得图像传感器（112,114）可以从显示器的颜色脉冲序列中检测不同颜色的至少两个光脉冲 分割。
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公开(公告)号：US08040599B2
公开(公告)日：2011-10-18
申请号：US12162601
申请日：2007-01-30
申请人： Joachim Steffen , Helge Jess , Christoph Hauger
发明人： Joachim Steffen , Helge Jess , Christoph Hauger
摘要： A microscope system is for sequential observation of different fluorescent dyes that are accumulated in a tissue in an object plane. An illumination system and an observation system have at least two operating states. In one operating state, illumination radiation has a spectrum that includes an excitation band of a first fluorescent dye and is partly free from an excitation band of another fluorescent dye. In one operating state of the observation system, observation radiation guided in the first observation optical path has a spectrum in sections of the first observation optical path, which includes a first fluorescence band of the first fluorescent dye, while in another operating state observation radiation has a spectrum in at least some sections which is partly free from the first fluorescence band. A controller is configured to selectively switch the illumination system and the observation system into the first and second operating states.
摘要翻译： 显微镜系统用于顺序观察积聚在物体平面中的组织中的不同荧光染料。 照明系统和观察系统具有至少两个操作状态。 在一个操作状态下，照射辐射具有包括第一荧光染料的激发带并且部分没有另一荧光染料的激发带的光谱。 在观察系统的一个操作状态下，在第一观察光路中引导的观察辐射具有包括第一荧光染料的第一荧光带的第一观察光路的部分的光谱，而在另一个操作状态下，观察辐射具有 在至少部分无第一荧光带的部分的光谱。 控制器被配置为选择性地将照明系统和观察系统切换到第一和第二操作状态。
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公开(公告)号：US20100110538A1
公开(公告)日：2010-05-06
申请号：US12162601
申请日：2007-01-30
申请人： Joachim Steffen , Helge Jess , Christoph Hauger
发明人： Joachim Steffen , Helge Jess , Christoph Hauger
摘要： Disclosed is a microscope system (1) for sequential observation of different fluorescent dyes that are accumulated in a tissue located in an object plane (22). An illumination system (70) of the microscope system (1) for illuminating the object plane (22) with illumination radiation has at least two operating states. In one of the at least two operating states, the illumination radiation has a spectrum which includes an excitation band (A1) of a first fluorescent dye and, at the same time, is partly free from an excitation band (A2) of another fluorescent dye. An observation system (2) of the microscope system (1) for providing a first observation optical path (33) for optically imaging the object plane (22) has two different operating states as well. In one of the at least two operating states observation radiation guided in the first observation optical path (33) has a spectrum in sections of the first observation optical path which includes a first fluorescence band (F1) of the first fluorescent dye, while in at least one other operating state observation radiation guided in the first observation optical path (33) has a spectrum in at least some sections of the first observation optical path which is partly free from the first fluorescence band (F1) of the first fluorescent dye. The disclosed microscope system (1) further comprises a controller (3) which is configured to selectively switch the illumination system (70) as well as the observation system (2) into the first operating state, or to switch the illumination system (70) as well as the observation system (2) into the second operating state.
摘要翻译： 公开了用于顺序观察累积在位于物平面（22）内的组织中的不同荧光染料的显微镜系统（1）。 用照明辐射照射物平面（22）的显微镜系统（1）的照明系统（70）具有至少两个操作状态。 在所述至少两个操作状态中的一个中，所述照射辐射具有包括第一荧光染料的激发带（A1）的光谱，并且同时部分地不含另一荧光染料的激发带（A2） 。 用于提供用于对物平面（22）进行光学成像的第一观察光路（33）的显微镜系统（1）的观察系统（2）也具有两种不同的工作状态。 在所述至少两个操作状态中的一个中，在所述第一观察光路（33）中引导的观察辐射中的所述第一观察光路的具有所述第一荧光染料的第一荧光带（F1）的部分的光谱， 在第一观察光路（33）中引导的至少一个其他操作状态观察辐射在第一观察光路的至少部分没有第一荧光染料的第一荧光带（F1）的部分具有光谱。 所公开的显微镜系统（1）还包括控制器（3），其被配置为选择性地将照明系统（70）以及观察系统（2）切换到第一操作状态，或者切换照明系统（70） 以及观察系统（2）进入第二操作状态。
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公开(公告)号：US20070090985A1
公开(公告)日：2007-04-26
申请号：US11544269
申请日：2006-10-06
IPC分类号： H03M1/12
CPC分类号： G02B21/0076 , G01N21/6428 , G01N21/6458
摘要： An image sensor and a circuitry associated with the image sensor is used for recording a series of fluorescence images. The image sensor comprises a plurality of pixels for accumulating charges generated by incident radiation, and the circuitry converts the charges accumulated in the pixels into binary numbers. A gain of the circuitry is adjustable. The gain is set to a suitable maximum value at the beginning of a recording procedure. The gain is reduced if it is determined during the recording procedure that one or more brightness values of the recorded image exceed a suitably chosen maximum brightness value.
摘要翻译： 图像传感器和与图像传感器相关联的电路用于记录一系列荧光图像。 图像传感器包括用于累积由入射辐射产生的电荷的多个像素，并且电路将在像素中累积的电荷转换为二进制数。 电路的增益可调。 在记录过程开始时，增益被设置为合适的最大值。 如果在记录过程中确定记录图像的一个或多个亮度值超过适当选择的最大亮度值，则增益减小。
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8.发明申请Illuminating system and an optical viewing apparatus incorporating said illuminating system 有权照明系统和包含所述照明系统的光学观察装置公开(公告)号：US20100321772A1
公开(公告)日：2010-12-23
申请号：US12801526
申请日：2010-06-14
申请人： Peter Reimer , Markus Bausewein , Helge Jess
发明人： Peter Reimer , Markus Bausewein , Helge Jess
CPC分类号： A61B5/0071 , A61B1/043 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B1/0684 , A61B5/0084 , A61B90/20 , G01N21/6458 , G02B21/0012 , G02B21/0032 , G02B21/06 , G02B23/2461
摘要： An illuminating system (21) is provided for an optical viewing apparatus (1) which can be operated in a fluorescence mode. The illuminating system includes at least one broadband light source (31) for illuminating a viewed object (3) and at least one narrowband light source (37) for exciting fluorescence in the viewed object (3) and/or for background illumination in the fluorescence mode. The illuminating system further includes a light conductor (23) having a light source end inlet end (49) and an outlet end (25) facing toward the viewed object. Furthermore, the illuminating system (21, 210) includes a superposer (43) for superposing the light of the narrowband light source (37) with the light of the broadband light source (31). The superposer (43) is mounted at the inlet end (49) or at the light source side ahead of the inlet end (49) of the light conductor (23).
摘要翻译： 为能够以荧光模式操作的光学观察装置（1）提供照明系统（21）。 所述照明系统包括至少一个宽带光源（31），用于照射被观看物体（3）和至少一个窄带光源（37），用于激发被观察物体（3）中的荧光和/或用于荧光背景照明 模式。 照明系统还包括具有光源端入口端（49）和朝向被观察物体的出口端（25）的光导体（23）。 此外，照明系统（21,210）包括用于将窄带光源（37）的光与宽带光源（31）的光重叠的上光装置（43）。 上光装置（43）安装在光导体（23）的入口端（49）的入口端（49）处或光源侧。
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公开(公告)号：US07369073B2
公开(公告)日：2008-05-06
申请号：US11544269
申请日：2006-10-06
IPC分类号： H03M1/00
CPC分类号： G02B21/0076 , G01N21/6428 , G01N21/6458
摘要： An image sensor and a circuitry associated with the image sensor is used for recording a series of fluorescence images. The image sensor comprises a plurality of pixels for accumulating charges generated by incident radiation, and the circuitry converts the charges accumulated in the pixels into binary numbers. A gain of the circuitry is adjustable. The gain is set to a suitable maximum value at the beginning of a recording procedure. The gain is reduced if it is determined during the recording procedure that one or more brightness values of the recorded image exceed a suitably chosen maximum brightness value.
摘要翻译： 图像传感器和与图像传感器相关联的电路用于记录一系列荧光图像。 图像传感器包括用于累积由入射辐射产生的电荷的多个像素，并且电路将在像素中累积的电荷转换为二进制数。 电路的增益可调。 在记录过程开始时，增益被设置为合适的最大值。 如果在记录过程中确定记录图像的一个或多个亮度值超过适当选择的最大亮度值，则增益减小。
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10.发明授权Illuminating system and an optical viewing apparatus incorporating said illuminating system 有权照明系统和包含所述照明系统的光学观察装置公开(公告)号：US09025244B2
公开(公告)日：2015-05-05
申请号：US12801526
申请日：2010-06-14
申请人： Peter Reimer , Markus Bausewein , Helge Jess
发明人： Peter Reimer , Markus Bausewein , Helge Jess
CPC分类号： A61B5/0071 , A61B1/043 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B1/0684 , A61B5/0084 , A61B90/20 , G01N21/6458 , G02B21/0012 , G02B21/0032 , G02B21/06 , G02B23/2461
摘要： An illuminating system (21) is provided for an optical viewing apparatus (1) which can be operated in a fluorescence mode. The illuminating system includes at least one broadband light source (31) for illuminating a viewed object (3) and at least one narrowband light source (37) for exciting fluorescence in the viewed object (3) and/or for background illumination in the fluorescence mode. The illuminating system further includes a light conductor (23) having a light source end inlet end (49) and an outlet end (25) facing toward the viewed object. Furthermore, the illuminating system (21, 210) includes a superposer (43) for superposing the light of the narrowband light source (37) with the light of the broadband light source (31). The superposer (43) is mounted at the inlet end (49) or at the light source side ahead of the inlet end (49) of the light conductor (23).
摘要翻译： 为能够以荧光模式操作的光学观察装置（1）提供照明系统（21）。 所述照明系统包括至少一个宽带光源（31），用于照亮被观看物体（3）和至少一个用于激发被观察物体（3）中的荧光的窄带光源（37）和/或荧光背景照明 模式。 照明系统还包括具有光源端入口端（49）和朝向被观察物体的出口端（25）的光导体（23）。 此外，照明系统（21,210）包括用于将窄带光源（37）的光与宽带光源（31）的光重叠的上光装置（43）。 上光装置（43）安装在光导体（23）的入口端（49）的入口端（49）处或光源侧。
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