公开(公告)号：US07949477B2

公开(公告)日：2011-05-24

申请号：US12342346

申请日：2008-12-23

申请人： Helmut Rinne ,  Gregor Ocvirk

发明人： Helmut Rinne ,  Gregor Ocvirk

IPC分类号： G06F19/00

CPC分类号： A61B5/14865 ,  A61B5/14528 ,  A61B5/14532 ,  Y10S210/929

摘要： The invention relates to a method for monitoring an arrangement for determining a concentration of an analyte in a body fluid. The determination of the concentration of the analyte by means of the arrangement involves a procedure in which the analyte from the body fluid passes through an interface and is transported in a stream of liquid into a flowmeter chamber, in which a measurement is carried out to determine the concentration of the analyte. The evaluation of the measurement takes place in a signal processor. The monitoring of the arrangement comprises the following steps: measurement of measured values of at least two correlated system parameters of the arrangement by means of a sensor system, and comparison of the measured values with limit values stored for each of the system parameters in a storage unit, to obtain a combination of at least two comparison results.

摘要翻译： 本发明涉及一种用于监测用于确定体液中分析物浓度的装置的方法。 通过该装置确定分析物的浓度包括其中来自体液的分析物通过界面并以液体流输送到流量计室中的程序，其中进行测量以确定 分析物的浓度。 测量的评估发生在信号处理器中。 该装置的监视包括以下步骤：通过传感器系统测量装置的至少两个相关系统参数的测量值，以及将测量值与存储在存储器中的每个系统参数的限制值进行比较 单位，以获得至少两个比较结果的组合。

公开(公告)号：US08942778B2

公开(公告)日：2015-01-27

申请号：US13110335

申请日：2011-05-18

申请人： Gregor Ocvirk ,  Helmut Rinne ,  Arnulf Staib

发明人： Gregor Ocvirk ,  Helmut Rinne ,  Arnulf Staib

IPC分类号： A61B5/05 ,  A61B5/1486 ,  A61B5/145

CPC分类号： A61B5/14865 ,  A61B5/14532

摘要： The invention generally relates to a sensor system. In particular to a sensor for glucose monitoring. The invention also also relates to an arrangement and a method for monitoring a constituent and in particular glucose in body tissue using a sensor system.

摘要翻译： 本发明一般涉及传感器系统。 具体涉及用于葡萄糖监测的传感器。 本发明还涉及一种使用传感器系统监测身体组织中的成分，特别是葡萄糖的装置和方法。

公开(公告)号：US20060287591A1

公开(公告)日：2006-12-21

申请号：US11425020

申请日：2006-06-19

申请人： Gregor Ocvirk ,  Helmut Rinne ,  Arnulf Staib

发明人： Gregor Ocvirk ,  Helmut Rinne ,  Arnulf Staib

IPC分类号： A61B5/05 ,  A61B5/00

CPC分类号： A61B5/14865 ,  A61B5/14532

摘要： The invention generally relates to a sensor system. In particular to a sensor for glucose monitoring The invention also also relates to an arrangement and a method for monitoring a constituents and in particular glucose in body tissue using a sensor system.

摘要翻译： 本发明一般涉及传感器系统。 具体涉及用于葡萄糖监测的传感器本发明还涉及一种使用传感器系统来监测组分，特别是体内组织中的葡萄糖的装置和方法。

公开(公告)号：US07967752B2

公开(公告)日：2011-06-28

申请号：US11425020

申请日：2006-06-19

申请人： Gregor Ocvirk ,  Helmut Rinne ,  Arnulf Staib

发明人： Gregor Ocvirk ,  Helmut Rinne ,  Arnulf Staib

IPC分类号： A61B5/00

CPC分类号： A61B5/14865 ,  A61B5/14532

摘要： The invention generally relates to a sensor system. In particular to a sensor for glucose monitoring. The invention also also relates to an arrangement and a method for monitoring a constituent and in particular glucose in body tissue using a sensor system.

摘要翻译： 本发明一般涉及传感器系统。 具体涉及用于葡萄糖监测的传感器。 本发明还涉及一种使用传感器系统监测身体组织中的成分，特别是葡萄糖的装置和方法。

公开(公告)号：US20090157330A1

公开(公告)日：2009-06-18

申请号：US12342346

申请日：2008-12-23

申请人： Helmut Rinne ,  Gregor Ocvirk

发明人： Helmut Rinne ,  Gregor Ocvirk

IPC分类号： G01L7/00 ,  G06F19/00

CPC分类号： A61B5/14865 ,  A61B5/14528 ,  A61B5/14532 ,  Y10S210/929

摘要： The invention relates to a method for monitoring an arrangement for determining a concentration of an analyte in a body fluid. The determination of the concentration of the analyte by means of the arrangement involves a procedure in which the analyte from the body fluid passes through an interface and is transported in a stream of liquid into a flowmeter chamber, in which a measurement is carried out to determine the concentration of the analyte. The evaluation of the measurement takes place in a signal processor. The monitoring of the arrangement comprises the following steps: measurement of measured values of at least two correlated system parameters of the arrangement by means of a sensor system, and comparison of the measured values with limit values stored for each of the system parameters in a storage unit, to obtain a combination of at least two comparison results.

摘要翻译： 本发明涉及一种用于监测用于确定体液中分析物浓度的装置的方法。 通过该装置确定分析物的浓度包括其中来自体液的分析物通过界面并以液体流输送到流量计室中的程序，其中进行测量以确定 分析物的浓度。 测量的评估发生在信号处理器中。 该装置的监视包括以下步骤：通过传感器系统测量装置的至少两个相关系统参数的测量值，以及将测量值与存储在存储器中的每个系统参数的限制值进行比较 单位，以获得至少两个比较结果的组合。

公开(公告)号：US4400258A

公开(公告)日：1983-08-23

申请号：US358529

申请日：1982-03-16

申请人： Busack Hans-Jurgen ,  Klaus Kaross ,  Helmut Rinne

发明人： Busack Hans-Jurgen ,  Klaus Kaross ,  Helmut Rinne

IPC分类号： G01N27/404 ,  G01N27/28 ,  G01N27/40 ,  G01N27/50

CPC分类号： G01N27/28 ,  G01N27/40

摘要： A measuring device for facilitating the electro-chemical measurement of a substance such as a gas comprises a holder ring which has an opening therethrough with an inwardly extending annular resilient sealing lip extending into the opening and an end face with an inner annular projecting portion defining a fitting strip and an outer annular projecting portion spaced radially outwardly from the inner annular portion. A membrane is engaged over the opening and the inner annular projecting portion and its periphery rests in a space between the inner and outer projecting portions. A tightening ring is engaged with the hole of the ring and it includes an end face with an annular groove which is positionable over the inner annular projection of the holder ring. The tightening ring includes an inner annular counter ring part engageable over the membrane and against the sealing lip of the holder ring. It also includes an outer annular part disposed between the inner annular projecting portion and the outer annular projection of the holder ring. The groove of the tightening ring defines an electrolytic receiving space overlying the membrane. The inner annular counterring part of the tightening ring and the sealing lip of the holder ring define with the membrane a releasable seal for the electrolyte in this electrolyte sealing space. The measuring device also includes a body having a central projecting part which contains two electrodes in spaced apart insulated relationship which engage against the membrane. The projecting part deflects the sealing lip of the holding ring to release this electrolyte seal and to permit the electrolyte to flow over the membrane to the electrodes.

摘要翻译： 用于促进诸如气体的物质的电化学测量的测量装置包括保持环，其具有穿过其的开口，其具有延伸到开口中的向内延伸的环形弹性密封唇缘和具有内环形突出部分的端面， 装配条和从内环形部分径向向外间隔开的外环形突出部分。 膜在该开口上接合并且内部环形突出部分及其周边搁置在内部和外部突出部分之间的空间中。 紧固环与环的孔接合，并且其包括具有可定位在保持环的内环形突起上的环形槽的端面。 紧固环包括可在隔膜上接合并抵靠保持环的密封唇的内环形计数器环部分。 它还包括设置在保持环的内环形突出部分和外环形突起之间的外环形部分。 紧固环的槽限定覆盖膜的电解接收空间。 紧固环的内环形反向部分和保持环的密封唇缘在膜中限定了用于该电解质密封空间中的电解质的可释放密封。 测量装置还包括具有中心突出部分的主体，该中心突出部分包含两个彼此隔开的绝缘关系的电极，该电极与膜接合。 突出部分使保持环的密封唇偏转以释放该电解质密封并允许电解质在膜上流过电极。

公开(公告)号：US07806853B2

公开(公告)日：2010-10-05

申请号：US12471150

申请日：2009-05-22

申请人： Uwe Wittmann ,  Helmut Rinne ,  Ralf Gessler ,  Hans-Joerg Pfleiderer

发明人： Uwe Wittmann ,  Helmut Rinne ,  Ralf Gessler ,  Hans-Joerg Pfleiderer

IPC分类号： A61M31/00

CPC分类号： A61M5/1723 ,  A61B5/14532 ,  A61M5/14244 ,  A61M2230/201 ,  A61M2230/62 ,  G06F19/00

摘要： The invention concerns an array and a method for dosing a hormone regulating the blood glucose, especially insulin, of a diabetic patient. In order to improve the administration of the hormone, the invention provides the following characteristic combination: a first sensor for measuring tissue glucose level; a controller having as an input the measured tissue glucose level from the first sensor, the controller having a control algorithm to determine an amount of hormone to be dosed based upon the measured tissue glucose level; a hormone dosing unit connected to the controller and automatically administering a hormone dose based upon a signal received from the controller; a second sensor for measuring an influencing patient variable; a pilot control device connected to the second sensor, the pilot control device connected to and forming a circuit with the controller, the pilot control device acting on the controller in accordance with the influencing patient variable that is measured by the second sensor, whereby the pilot control device reduces dead time of the controller.

摘要翻译： 本发明涉及用于给予调节糖尿病患者的血糖，特别是胰岛素的激素的阵列和方法。 为了改善激素的施用，本发明提供以下特征组合：用于测量组织葡萄糖水平的第一传感器; 控制器具有来自第一传感器的测量的组织葡萄糖水平作为输入，控制器具有控制算法，用于基于所测量的组织葡萄糖水平来确定要给药的激素的量; 激素计量单元，其连接到所述控制器并基于从所述控制器接收的信号自动施用激素剂量; 用于测量影响患者变量的第二传感器; 连接到所述第二传感器的先导控制装置，所述先导控制装置与所述控制器连接并与所述控制器形成电路，所述先导控制装置根据由所述第二传感器测量的影响的患者变量作用在所述控制器上， 控制装置减少控制器的死区时间。

公开(公告)号：US20090254024A1

公开(公告)日：2009-10-08

申请号：US12471150

申请日：2009-05-22

申请人： Uwe Wittmann ,  Helmut Rinne ,  Ralf Gessler ,  Hans-Joerg Pfleiderer

发明人： Uwe Wittmann ,  Helmut Rinne ,  Ralf Gessler ,  Hans-Joerg Pfleiderer

IPC分类号： A61M37/00

CPC分类号： A61M5/1723 ,  A61B5/14532 ,  A61M5/14244 ,  A61M2230/201 ,  A61M2230/62 ,  G06F19/00

摘要： The invention concerns an array and a method for dosing a hormone regulating the blood glucose, especially insulin, of a diabetic patient (10). In order to improve the administration of the hormone, the invention provides the following characteristic combination: a) a measuring device (16) to detect measured values correlatable with blood sugar; b) a controlling means (12) comprising a controller (44) and a hormone dosing device (46) for supplying a hormone dosage; c) a pilot control device (14) acting on the hormone fine dosage controlling means (12) for performing a coarse pre-control in accordance with at least one influence variable that influences blood glucose.

摘要翻译： 本发明涉及用于给予调节糖尿病患者的血糖特别是胰岛素的激素的阵列和方法（10）。 为了改善激素的施用，本发明提供以下特征组合：a）检测与血糖相关的测量值的测量装置（16）; b）包括用于提供激素剂量的控制器（44）和激素计量装置（46）的控制装置（12） c）作用于激素精细剂量控制装置（12）的先导控制装置（14），用于根据影响血糖的至少一个影响变量执行粗略预控制。

公开(公告)号：US4157288A

公开(公告)日：1979-06-05

申请号：US858447

申请日：1977-12-07

申请人： Wolfgang Fleckenstein ,  Helmut Rinne

发明人： Wolfgang Fleckenstein ,  Helmut Rinne

IPC分类号： G01N27/404 ,  G01N27/30 ,  G01N27/333 ,  G01N27/48 ,  G01N27/46

CPC分类号： G01N27/404

摘要： Measuring probe for a polarographic determination of gas partial pressures in aqueous, and more particularly in biologic, medium, comprises at least a part made up of a plurality of thin films including a polarographic surface having a diffusion film membrane which applies directly on at least the polarographing surface, and wherein at least the film material contiguous to the polarographing surface comprises a thin film of an inorganic insulating material.

摘要翻译： 用于极性测定水性气体分压，尤其是生物培养基中的气体分压的测量探针包括至少一部分由多个薄膜构成的部分，该多个薄膜包括具有扩散膜膜的极谱表面，该极化膜表面直接施加在至少 极谱法表面，并且其中至少与极谱法表面相邻的膜材料包括无机绝缘材料的薄膜。

公开(公告)号：US07556613B2

公开(公告)日：2009-07-07

申请号：US10203673

申请日：2001-01-20

申请人： Uwe Wittmann ,  Helmut Rinne ,  Ralf Gessler ,  Hans-Joerg Pfleiderer

发明人： Uwe Wittmann ,  Helmut Rinne ,  Ralf Gessler ,  Hans-Joerg Pfleiderer

IPC分类号： A61M31/00 ,  A61K9/22

CPC分类号： A61M5/1723 ,  A61B5/14532 ,  A61M5/14244 ,  A61M2230/201 ,  A61M2230/62 ,  G06F19/00

摘要： The invention concerns an array and a method for dosing a hormone regulating the blood glucose, especially insulin of a diabetic patient (10). In order to improve the administration of the hormone, the invention provides the following characteristic combination: a) a measuring device (16) to detect measured values correlatable with blood sugar; b) a controlling means (12) comprising a controller (44) and a hormone dosing device (46) for supplying a hormone dosage; c) a pilot control device (14) acting on the hormone fine dosage controlling means (12) for performing a coarse pre-control in accordance with at least one influence variable that influences blood glucose.

摘要翻译： 本发明涉及用于给予调节血糖的激素，特别是糖尿病患者的胰岛素的激素的阵列和方法（10）。 为了改善激素的施用，本发明提供以下特征组合：a）检测与血糖相关的测量值的测量装置（16）; b）包括用于提供激素剂量的控制器（44）和激素计量装置（46）的控制装置（12） c）作用于激素精细剂量控制装置（12）的先导控制装置（14），用于根据影响血糖的至少一个影响变量执行粗略预控制。