公开(公告)号：US07156118B2

公开(公告)日：2007-01-02

申请号：US10525400

申请日：2003-08-21

申请人： Gregor Ocvirk ,  Carlo Effenhauser ,  Karl-Heinz Koelker

发明人： Gregor Ocvirk ,  Carlo Effenhauser ,  Karl-Heinz Koelker

IPC分类号： F16K51/00 ,  F15C1/06

CPC分类号： F16K51/00 ,  B01F7/16 ,  B01F13/0059 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/0086 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/0681 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2400/084 ,  Y10T137/0329 ,  Y10T137/0352 ,  Y10T137/0491 ,  Y10T137/2224

摘要： The invention relates to the technical field of microfluidic channel structures. The invention discloses a microfluidic channel system with a high aspect ratio as well as a process for producing the microfluidic system. The process according to the invention enables the production of channel structures with aspect ratios of any magnitude without the process being limited by the manufacturing conditions to certain materials for the channel system. The channel system can thus be optimally adapted to a desired field of application.

摘要翻译： 本发明涉及微流体通道结构的技术领域。 本发明公开了具有高纵横比的微流体通道系统以及用于生产微流体系统的方法。 根据本发明的方法使得能够生产具有任何幅度的纵横比的通道结构，而不会使制造条件限制于通道系统的某些材料。 因此，信道系统可以最佳地适应于期望的应用领域。

公开(公告)号：US09220451B2

公开(公告)日：2015-12-29

申请号：US13608618

申请日：2012-09-10

申请人： Gregor Ocvirk ,  Karl-Heinz Kölker

发明人： Gregor Ocvirk ,  Karl-Heinz Kölker

IPC分类号： A61B5/1486 ,  A61B5/145 ,  H01M8/16 ,  C12Q1/00

CPC分类号： G01N27/3271 ,  A61B5/14532 ,  A61B5/1486 ,  C12Q1/001 ,  H01M8/16 ,  Y02E60/527

摘要： The invention relates to a method for the electrochemical measurement of an analyte concentration in vivo, comprising a fuel cell with which the analyte to be measured is reacted catalytically with an enzyme contained in an enzyme layer and which supplies an electrical voltage, dependent on the analyte concentration to be measured, beween an anode and a cathode, which voltage is measured. In the catalytic reaction of the analyte to be measured in the enzyme layer, a product is generated which, as fuel of the fuel cell, oxidizes on the anode and is reduced on the cathode. The invention further relates to a fuel cell for such a method.

摘要翻译： 本发明涉及一种用于体内分析物浓度的电化学测量的方法，其包括燃料电池，待测分析物与酶层中包含的酶进行催化反应，并且根据分析物提供电压 在阳极和阴极之间要测量的浓度，测量哪个电压。 在酶层中要测量的分析物的催化反应中，产生作为燃料电池的燃料在阳极上氧化并在阴极上减少的产物。 本发明还涉及一种用于这种方法的燃料电池。

公开(公告)号：US07949477B2

公开(公告)日：2011-05-24

申请号：US12342346

申请日：2008-12-23

申请人： Helmut Rinne ,  Gregor Ocvirk

发明人： Helmut Rinne ,  Gregor Ocvirk

IPC分类号： G06F19/00

CPC分类号： A61B5/14865 ,  A61B5/14528 ,  A61B5/14532 ,  Y10S210/929

摘要： The invention relates to a method for monitoring an arrangement for determining a concentration of an analyte in a body fluid. The determination of the concentration of the analyte by means of the arrangement involves a procedure in which the analyte from the body fluid passes through an interface and is transported in a stream of liquid into a flowmeter chamber, in which a measurement is carried out to determine the concentration of the analyte. The evaluation of the measurement takes place in a signal processor. The monitoring of the arrangement comprises the following steps: measurement of measured values of at least two correlated system parameters of the arrangement by means of a sensor system, and comparison of the measured values with limit values stored for each of the system parameters in a storage unit, to obtain a combination of at least two comparison results.

摘要翻译： 本发明涉及一种用于监测用于确定体液中分析物浓度的装置的方法。 通过该装置确定分析物的浓度包括其中来自体液的分析物通过界面并以液体流输送到流量计室中的程序，其中进行测量以确定 分析物的浓度。 测量的评估发生在信号处理器中。 该装置的监视包括以下步骤：通过传感器系统测量装置的至少两个相关系统参数的测量值，以及将测量值与存储在存储器中的每个系统参数的限制值进行比较 单位，以获得至少两个比较结果的组合。

公开(公告)号：US07527740B2

公开(公告)日：2009-05-05

申请号：US10492256

申请日：2002-09-14

申请人： Carlo Effenhauser ,  Gregor Ocvirk ,  Wolfgang Fiedler

发明人： Carlo Effenhauser ,  Gregor Ocvirk ,  Wolfgang Fiedler

IPC分类号： B01D37/00 ,  B01D11/00

CPC分类号： G01N15/05 ,  A61M1/3693 ,  B01L3/502753 ,  B01L2200/0647 ,  B01L2300/0816 ,  G01N33/491 ,  G01N2015/055 ,  G01N2015/1486 ,  Y10T436/25 ,  Y10T436/25375

摘要： A method for separating particles from a fluid dispersion, particularly for separating corpuscular components from biological samples, above all from blood. A separating module suitable for performing the method has a substrate with flow channels, comprising a feed channel for supplying the dispersion to a junction, a first drain channel for draining fluid having a reduced particle concentration away from the junction, and a second drain channel for draining fluid having an increased particle concentration away from the junction. The fluid flows so much faster in the second drain channel than in the first drain channel that due to the different flow speeds the dispersed particles preferentially flow at the junction further in the second drain channel.

摘要翻译： 一种用于从流体分散体中分离颗粒的方法，特别是用于从生物样品中分离出红细胞成分，尤其是血液。 适于执行该方法的分离模块具有带有流动通道的基底，包括用于将分散体供应到结点的进料通道，用于排出离开结点的具有降低的粒子浓度的流体的第一排出通道和用于 具有离开结点的具有增加的颗粒浓度的排出流体。 在第二排水通道中流体流动比在第一排水通道中要快得多，由于不同的流速，分散的颗粒优先在第二排水通道中的结点处流动。

公开(公告)号：US06605472B1

公开(公告)日：2003-08-12

申请号：US09169146

申请日：1998-10-09

申请人： Cameron Skinner ,  Thompson Tang ,  D. Jed Harrison ,  Nicolas Bings ,  Can Wang ,  Gregor Ocvirk ,  Jianjun Li ,  Pierre Thibault

发明人： Cameron Skinner ,  Thompson Tang ,  D. Jed Harrison ,  Nicolas Bings ,  Can Wang ,  Gregor Ocvirk ,  Jianjun Li ,  Pierre Thibault

IPC分类号： G01N3300

CPC分类号： B01L3/502707 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2400/0421 ,  G01N27/44791 ,  G01N30/6034 ,  G01N30/6095 ,  G01N30/7266 ,  Y10T436/14 ,  Y10T436/142222 ,  Y10T436/143333 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/255 ,  Y10T436/2575

摘要： A method is provided for joining a microchip device to a capillary tube. The microchip device has a capillary channel opening onto an edge surface of the device. A short hole is drilled into the edge surface, aligned with the capillary channel. The drilling is done with a flat bottom, preferably by a two-step drilling process. Then, the end of the capillary can be inserted into the hole so that its end is substantially flush with the flat bottom of the hole, thereby eliminating dead volume. Testing has shown that this connection provides very little band broadening of samples transported through the capillary channel into the capillary tube. The tip of the capillary tube can be tapered, so that it is suitable for use as an electrospray source for a mass spectrometer.

摘要翻译： 提供了一种将微芯片器件连接到毛细管上的方法。 微芯片装置具有在装置的边缘表面上开口的毛细通道。 在边缘表面钻出一个短孔，与毛细管通道对齐。 钻孔采用平坦的底部，优选通过两步钻孔工艺进行。 然后，毛细管的端部可以插入孔中，使得其端部与孔的平坦底部基本齐平，从而消除死体积。 测试表明，这种连接提供了通过毛细管通道进入毛细管的样品的极小带宽扩大。 毛细管的尖端可以是锥形的，使得其适合用作质谱仪的电喷雾源。

公开(公告)号：US20130253293A1

公开(公告)日：2013-09-26

申请号：US13608618

申请日：2012-09-10

申请人： Gregor Ocvirk ,  Karl-Heinz Kölker

发明人： Gregor Ocvirk ,  Karl-Heinz Kölker

IPC分类号： A61B5/1486

CPC分类号： G01N27/3271 ,  A61B5/14532 ,  A61B5/1486 ,  C12Q1/001 ,  H01M8/16 ,  Y02E60/527

摘要： The invention relates to a method for the electrochemical measurement of an analyte concentration in vivo, comprising a fuel cell with which the analyte to be measured is reacted catalytically with an enzyme contained in an enzyme layer and which supplies an electrical voltage, dependent on the analyte concentration to be measured, beween an anode and a cathode, which voltage is measured. In the catalytic reaction of the analyte to be measured in the enzyme layer, a product is generated which, as fuel of the fuel cell, oxidizes on the anode and is reduced on the cathode. The invention further relates to a fuel cell for such a method.

摘要翻译： 本发明涉及一种用于体内分析物浓度的电化学测量的方法，其包括燃料电池，待测分析物与酶层中包含的酶进行催化反应，并且根据分析物提供电压 在阳极和阴极之间要测量的浓度，测量哪个电压。 在酶层中要测量的分析物的催化反应中，产生作为燃料电池的燃料在阳极上氧化并在阴极上减少的产物。 本发明还涉及一种用于这种方法的燃料电池。

公开(公告)号：US20110218490A1

公开(公告)日：2011-09-08

申请号：US13110335

申请日：2011-05-18

申请人： Gregor Ocvirk ,  Hilmut Rinne ,  Arnulf Staib

发明人： Gregor Ocvirk ,  Hilmut Rinne ,  Arnulf Staib

IPC分类号： A61M5/168

CPC分类号： A61B5/14865 ,  A61B5/14532

摘要： The invention generally relates to a sensor system. In particular to a sensor for glucose monitoring. The invention also also relates to an arrangement and a method for monitoring a constituent and in particular glucose in body tissue using a sensor system.

摘要翻译： 本发明一般涉及传感器系统。 具体涉及用于葡萄糖监测的传感器。 本发明还涉及一种使用传感器系统监测身体组织中的成分，特别是葡萄糖的装置和方法。

公开(公告)号：US20090044604A1

公开(公告)日：2009-02-19

申请号：US11839240

申请日：2007-08-15

申请人： Gregor Ocvirk ,  Peter Kraemer

发明人： Gregor Ocvirk ,  Peter Kraemer

IPC分类号： G01N33/49 ,  G01N33/487

CPC分类号： A61B5/14528 ,  A61B5/14532 ,  A61B5/1473

摘要： A portable measuring facility for determining the concentration of an analyte in a living body may comprise a sensor configured to determine the concentration of an analyte in a liquid, and a liquid conveying facility. The liquid conveying facility may have a liquid line configured to be connected to a probe that is implantable into tissue of the living body, a pump configured to pump the liquid from the probe through the liquid line to the sensor, and a degassing facility configured to degas the liquid pumped from the probe through the liquid line to the sensor.

摘要翻译： 用于确定活体中的分析物浓度的便携式测量设备可以包括被配置为确定液体中的分析物的浓度的传感器和液体输送设备。 液体输送设备可以具有被配置为连接到可植入生物体的组织中的探针的液体线，被配置为将液体从探针通过液体线泵送到传感器的泵，以及被配置为 将从探针泵出的液体通过液体管道脱气到传感器。

公开(公告)号：US20050141592A1

公开(公告)日：2005-06-30

申请号：US11013048

申请日：2004-12-15

申请人： Gregor Ocvirk ,  Stefan Kalveram ,  Bernd Roesicke

发明人： Gregor Ocvirk ,  Stefan Kalveram ,  Bernd Roesicke

IPC分类号： B01L3/00 ,  C12Q1/54 ,  G01N33/48 ,  G01N33/66 ,  G01N33/86 ,  G01N35/08 ,  G01K7/00

CPC分类号： C12Q1/54 ,  B01L3/5027 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2300/1827 ,  B01L2400/0406 ,  G01N33/86

摘要： A test element for analysing sample material such as blood or urine comprising a test carrier which has an analytical area to which sample material can be applied, and a heating element in heat conducting contact with the analytical area. The heating element integrated into the test carrier is formed by a thermistor which self-heats and self-regulates to a preset target temperature when current flows through it.

摘要翻译： 用于分析诸如血液或尿液的样品材料的测试元件，包括具有可以施加样品材料的分析区域的测试载体和与分析区域进行导热接触的加热元件。 集成到测试载体中的加热元件由热敏电阻形成，该热敏电阻在电流流经时自热并自调节至预设目标温度。

公开(公告)号：US20050029190A1

公开(公告)日：2005-02-10

申请号：US10492256

申请日：2002-09-14

申请人： Carlo Effenhauser ,  Gregor Ocvirk ,  Wolfgang Fiedler

发明人： Carlo Effenhauser ,  Gregor Ocvirk ,  Wolfgang Fiedler

IPC分类号： G01N33/48 ,  A61M1/36 ,  B01D43/00 ,  B01J19/00 ,  B01L3/00 ,  B81B1/00 ,  G01N1/00 ,  G01N1/28 ,  G01N15/05 ,  G01N15/14 ,  G01N33/49 ,  B01D11/00

CPC分类号： G01N15/05 ,  A61M1/3693 ,  B01L3/502753 ,  B01L2200/0647 ,  B01L2300/0816 ,  G01N33/491 ,  G01N2015/055 ,  G01N2015/1486 ,  Y10T436/25 ,  Y10T436/25375

摘要： A method for separating particles from a fluid dispersion, particularly for separating corpuscular components from biological samples, above all from blood. A separating module suitable for performing the method has a substrate (5) with flow channels (3), comprising a feed channel (9) for supplying the dispersion to a junction (10), a first drain channel (11) for draining fluid having a reduced particle concentration away from the junction (10), and a second drain channel (12) for draining fluid having an increased particle concentration away from the junction (10). The fluid flows so much faster in the second drain channel than in the first drain channel (12) that due to the different flow speeds the dispersed particles preferentially flow at the junction (10) further in the second drain channel (12).

摘要翻译： 一种用于从流体分散体中分离颗粒的方法，特别是用于从生物样品中分离出红细胞成分，尤其是血液。 适于执行该方法的分离模块具有带有流动通道（3）的基底（5），包括用于将分散体供应到结（10）的进料通道（9），用于排出流体的第一排水通道（11） 离开结（10）的减少的颗粒浓度，以及用于排出离开结（10）的具有增加的颗粒浓度的流体的第二排水通道（12）。 流体在第二排水通道中比在第一排水通道（12）中流动得快得多，由于不同的流速，分散的颗粒优先在第二排水通道（12）中的结（10）处优先流动。