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    Modular implant system containing active substances and method for the production thereof
    1.
    发明授权
    Modular implant system containing active substances and method for the production thereof 有权
    含有活性物质的模块化植入体系及其生产方法

    公开(公告)号：US08003121B1

    公开(公告)日：2011-08-23

    申请号：US10343363

    申请日：2000-08-01

    申请人： Elvira Dingeldein ,  Helmut Wahlig ,  Jörg Bauer ,  Edgar Wüst ,  Christoph Sattig

    发明人： Elvira Dingeldein ,  Helmut Wahlig ,  Jörg Bauer ,  Edgar Wüst ,  Christoph Sattig

    IPC分类号： A61L24/00 ,  A61L24/06

    CPC分类号： A61L24/0015 ,  A61L24/06 ,  A61L2300/406 ,  A61L2300/416 ,  A61L2300/44 ,  C08L33/06

    摘要： System of implant components containing active agents, wherein each component is intended to function as an additive for an implant material produced with a powdery or finely granulated starting material and/or active agents and additives.Each component is powdery or finely granulated and includes at least one powdery or finely granulated active agent or additive having a higher dosage than the desired concentration for the application. The components themselves are made of a powdery or finely granulated starting material for the implant material, as well as of the active agent or additive. The active agents can be chemotherapeutical agents, such as antibiotics, whereas the additives can be x-ray contrast materials and/or or additives that alter the physical properties of the starting material, such as its elasticity or viscosity.

    摘要翻译： 包含活性剂的植入物组分的系统，其中每个组分旨在作为用粉末状或精细粒化的原料和/或活性剂和添加剂生产的植入材料的添加剂。 每种组分是粉状或细粒化的，并且包括至少一种粉末状或细粒状的活性剂或添加剂，其用量高于所需应用浓度。 组分本身由用于植入材料以及活性剂或添加剂的粉末状或精细制粒的起始材料制成。 活性剂可以是化学治疗剂，例如抗生素，而添加剂可以是改变起始物质的物理性质的X射线对比材料和/或添加剂，例如其弹性或粘度。

    Blister pack
    2.
    发明授权
    Blister pack 有权
    吸塑包装

    公开(公告)号：US06957909B1

    公开(公告)日：2005-10-25

    申请号：US09980547

    申请日：2000-07-20

    申请人： Elvira Dingeldein ,  Helmut Wahlig ,  Christoph Sattig ,  Edgar Wüst

    发明人： Elvira Dingeldein ,  Helmut Wahlig ,  Christoph Sattig ,  Edgar Wüst

    IPC分类号： A61B19/02 ,  A61F2/46 ,  B65D75/36 ,  B65D75/58 ,  B65D77/04 ,  B65D81/32 ,  B65D71/00 ,  B01F15/00 ,  B65D69/00

    CPC分类号： B65D77/0446 ,  A61B50/33 ,  B65D75/36 ,  B65D75/366 ,  B65D75/368 ,  B65D75/58 ,  B65D81/32 ,  B65D2575/365

    摘要： Blister packaging unit (10) for at least two components packed in separate individual packages, at least one of which has a pulverulent or granular consistency, which are to be prepared before use with the further packaged component(s) in a mixer or applicator to form a ready-to-use mixture. The individual packages of the components are inserted in correspondingly pre-shaped receptacles (32; 34) in the blister (30) of a suitable film or other material and this blister is closed on the side of the open mouth of the receptacles by a cover (36) of cardboard, plastic, metal or some other suitable material which may be torn off or opened in some other manner.The component(s) having the pulverulent or granular consistency is/are packaged in a respective individual blister pack (12; 14; 16) shaped at least approximately complementarily to the associated receptacle (32) in the blister packaging unit, the blister of which has the shape of an elongate trough element (12) of plastic material tapered at at least one end in the manner of a spout, which trough element(s) comprises a separate tear-off cover (16) of cardboard, plastic, metal or some other suitable material which may be torn off or opened in some other manner.

    摘要翻译： 吸塑包装单元（10）用于至少两个组件，其包装在单独的单个包装中，其中至少一个具有粉末或颗粒状稠度，其将在与混合器或涂布器中的另外包装的组分一起使用之前制备， 形成即用型混合物。 组件的各个包装被插入适当的胶片或其他材料的泡罩（30）中相应的预形状的容器（32; 34）中，并且该泡罩在容器的敞开的嘴的一侧通过盖子 （36）的纸板，塑料，金属或一些其他合适的材料，可以以某种其他方式被撕下或打开。 具有粉状或颗粒状稠度的组分被包装在与吸塑包装单元中的相关容器（32）至少大致互补成形的相应单独的泡罩包装（12; 14; 16）中，其泡罩 具有塑料材料的细长槽元件（12）的形状，其在至少一端以喷嘴的方式逐渐变细，所述槽元件包括纸板，塑料，金属或金属的分开的撕开盖（16） 可能以某种其他方式撕下或打开的一些其他合适的材料。

    Preparation and application device for implant materials with hand-operated pump
    3.
    发明授权
    Preparation and application device for implant materials with hand-operated pump 有权
    手动泵植入材料的制备和应用装置

    公开(公告)号：US06796701B2

    公开(公告)日：2004-09-28

    申请号：US10204390

    申请日：2002-08-20

    申请人： Helmut Wahlig ,  Elvira Dingeldein ,  Edgar Wüst ,  Christoph Sattig

    发明人： Helmut Wahlig ,  Elvira Dingeldein ,  Edgar Wüst ,  Christoph Sattig

    IPC分类号： B01F1306

    CPC分类号： A61B17/8827 ,  A61B2050/0066 ,  A61B2090/037 ,  A61F2002/30561 ,  A61F2002/4685 ,  A61F2250/0071 ,  A61M2005/31598 ,  B01F11/0082 ,  B01F13/002 ,  B01F13/0023 ,  B01F13/06 ,  B01F15/00506 ,  B01F2215/0029

    摘要： A preparation and application device for implant materials consisting of at least one powder or granulate component and one liquid component, which are to be prepared immediately before use, is disclosed. The device comprises a first container which holds the powder or granulate component in a sterile, closed-off manner; and a second container which holds the liquid component in a sterile, closed-off manner and which can be connected to the first container. A mixing shaft which is hollow and located on a mixing mechanism is guided out of the first container is hollow and joins a hand pump for producing negative pressure at its external end. A measuring device which indicates the negative pressure can be connected to the first container and the housing of the hand pump is configured in such a way that it is suitable for use as a handle for moving the mixing shaft.

    摘要翻译： 公开了一种用于由使用前立即制备的至少一种粉末或颗粒组分和一种液体组分组成的植入材料的制备和施用装置。 该装置包括将粉末或颗粒组分保持在无菌，封闭的方式的第一容器; 以及第二容器，其将液体组分保持在无菌，封闭的方式并且可连接到第一容器。 中空的位于混合机构上的混合轴被引导出第一容器中空，并且在其外端连接用于产生负压的手动泵。 指示负压的测量装置可以连接到第一容器，并且手动泵的壳体被构造成使其适于用作用于移动混合轴的手柄。

    Preparation and application device for materials to be prepared as a paste-like flowable mass, especially bone cement
    4.
    发明授权
    Preparation and application device for materials to be prepared as a paste-like flowable mass, especially bone cement 有权
    用于制备为糊状可流动物料，特别是骨水泥的材料的制备和施加装置

    公开(公告)号：US06755563B2

    公开(公告)日：2004-06-29

    申请号：US10275043

    申请日：2002-10-31

    申请人： Helmut Wahlig ,  Elvira Dingeldein ,  Christoph Sattig ,  Edgar Wüst

    发明人： Helmut Wahlig ,  Elvira Dingeldein ,  Christoph Sattig ,  Edgar Wüst

    IPC分类号： B01F1300

    CPC分类号： B01F11/0082 ,  A61B17/8827 ,  A61B2050/0066 ,  A61B2050/008 ,  A61B2050/0083 ,  A61B2050/0084 ,  A61F2002/30561 ,  A61F2002/4685 ,  A61F2250/0071 ,  B01F13/002 ,  B01F13/0023 ,  B01F13/06 ,  B01F15/00506 ,  B01F2215/0029 ,  B05C17/0052

    摘要： The invention relates to a preparation and application device for materials which are to be prepared as a paste-like, flowable mass from at least one powder or granulate component and one liquid component, especially bone cement, with an elongated mixing cylinder for receiving the components to be mixed, comprising in one end region a sealable through-opening that can optionally be provided with a discharge unit for the paste-like material to be prepared, and a piston which can be inserted into the other, opposite, open end. The piston is displaceable in the cylinder and seals against the inner wall of the cylinder. The piston is penetrated by an elongated mixing shaft sealed against the piston, and a mixing mechanism is disposed at the cylinder inside-end of the mixing shaft and a handle disposed at the cylinder outside-end of the mixing shaft. The open end of the cylinder located opposite the through-opening and receiving the piston is additionally provided with a removable sealing cap that can be secured on and removed from the cylinder or piston and has a through-opening for the mixing shaft. The piston on the side of the sealing cap has a vacuum fitting adapted for connection to a vacuum source, which can produce a vacuum in the interior of the cylinder through a passageway provided in the piston. The sealing cap includes a through-opening through which the vacuum line that is connected to the vacuum source can be connected to the vacuum fitting in the piston.

    摘要翻译： 本发明涉及一种用于材料的制备和施用装置，其由至少一种粉末或颗粒组分和一种液体组分，特别是骨粘固剂制成糊状的可流动物料，其具有用于接收组分的细长混合气缸 包括在一个端部区域中的可密封的通孔，其可以可选地设置有用于待制备的糊状材料的排出单元，以及能够插入另一个相对的开口端的活塞。 活塞可在气缸中移动并且密封在气缸的内壁上。 活塞被密封抵靠活塞的细长混合轴穿透，混合机构设置在混合轴的缸体内部，以及设置在混合轴的气缸外端的手柄。 位于与通孔相对并接收活塞的气缸的开口端还设置有可移除的密封盖，其可以固定在气缸或活塞上并从气缸或活塞上移除，并具有用于混合轴的通孔。 密封帽侧面的活塞具有适于连接到真空源的真空接头，该真空接头可以通过设置在活塞中的通道在气缸的内部产生真空。 密封盖包括通孔，连接到真空源的真空管线可通过该通孔连接到活塞中的真空接头。

    Device and method for mixing bone cement
    7.
    发明授权
    Device and method for mixing bone cement 有权
    骨水泥混合装置及方法

    公开(公告)号：US08191729B2

    公开(公告)日：2012-06-05

    申请号：US12200415

    申请日：2008-08-28

    申请人： Stefan Deusser ,  Christoph Sattig

    发明人： Stefan Deusser ,  Christoph Sattig

    IPC分类号： B01F15/02

    CPC分类号： A61B17/8833 ,  A61B17/8827 ,  A61B2017/8838 ,  B01F15/00512 ,  B01F15/0237

    摘要： Device and method for mixing bone cement, for injection into vertebra in particular, comprising a mixing beaker (1), manual stirring rod (6) and a cover (2), which fits in said mixing beaker (1) with a perfect fit, and the lowermost point of which features an extraction hollow cone (3) in which an extraction syringe for extraction by suction of bone cement mixed in said mixing beaker (1) is provided.

    摘要翻译： 用于混合骨水泥的装置和方法，用于特别注射到椎骨中，包括混合烧杯（1），手动搅拌棒（6）和盖（2），其以完美的配合装配在所述混合烧杯（1）中， 其最低点具有提取中空锥体（3），其中提供了通过吸入混合在所述混合烧杯（1）中的骨水泥提取的提取注射器。

    Bone cement system for bone augmentation
    9.
    发明授权
    Bone cement system for bone augmentation 有权
    用于骨增生的骨水泥系统

    公开(公告)号：US08546462B2

    公开(公告)日：2013-10-01

    申请号：US13173317

    申请日：2011-06-30

    申请人： Andreas Boger ,  Christoph Sattig ,  Stefan Deusser

    发明人： Andreas Boger ,  Christoph Sattig ,  Stefan Deusser

    IPC分类号： A61F2/28 ,  A61L24/06 ,  A61L24/02 ,  A61B17/56

    CPC分类号： A61L24/0084 ,  A61B17/8805 ,  A61L27/46 ,  A61L27/50 ,  A61L2400/06 ,  A61L2430/02 ,  C08L33/08 ,  C08L33/10

    摘要： A bone cement is provided that includes a solid component and a liquid component. The solid component and liquid component are mixed together to form the bone cement. After completion of the solid and liquid component mixing, the bone cement has an initial viscosity effective for manual application or manual injection onto or into a targeted anatomical location, e.g., bone, and the cement has stable viscosity range that over both time and temperature is effective for uniformly filling the targeted anatomical location, for example an osteoporotic bone or a fractured vertebral body, with minimal to no leakage of the cement from the targeted anatomical location. Additionally, both the initial viscosity and the stable viscosity of the bone cement are within a range that renders the bone cement effective for injection with a manually operated syringe or multiple syringes.

    摘要翻译： 提供了包括固体组分和液体组分的骨水泥。 将固体组分和液体组分混合在一起形成骨水泥。 在固体和液体组分混合完成后，骨水泥具有有效的手动施用或手动注射到目标解剖位置（例如骨）上的初始粘度，并且水泥具有稳定的粘度范围，在时间和温度上均为 有效地均匀地填充目标解剖学位置，例如骨质疏松的骨骼或骨折的椎体，其水泥从目标解剖位置的最小到不泄漏。 此外，骨水泥的初始粘度和稳定的粘度都在使得骨水泥有效地用手动操作的注射器或多个注射器注射的范围内。

    BONE CEMENT SYSTEM FOR BONE AUGMENTATION
    10.
    发明申请
    BONE CEMENT SYSTEM FOR BONE AUGMENTATION 有权
    骨水泥骨水泥系统

    公开(公告)号：US20120022542A1

    公开(公告)日：2012-01-26

    申请号：US13173317

    申请日：2011-06-30

    申请人： Andreas Boger ,  Christoph Sattig ,  Stefan Deusser

    发明人： Andreas Boger ,  Christoph Sattig ,  Stefan Deusser

    IPC分类号： A61B17/58 ,  A61L24/06

    CPC分类号： A61L24/0084 ,  A61B17/8805 ,  A61L27/46 ,  A61L27/50 ,  A61L2400/06 ,  A61L2430/02 ,  C08L33/08 ,  C08L33/10

    摘要： A bone cement is provided that includes a solid component and a liquid component. The solid component and liquid component are mixed together to form the bone cement. After completion of the solid and liquid component mixing, the bone cement has an initial viscosity effective for manual application or manual injection onto or into a targeted anatomical location, e.g., bone, and the cement has stable viscosity range that over both time and temperature is effective for uniformly filling the targeted anatomical location, for example an osteoporotic bone or a fractured vertebral body, with minimal to no leakage of the cement from the targeted anatomical location. Additionally, both the initial viscosity and the stable viscosity of the bone cement are within a range that renders the bone cement effective for injection with a manually operated syringe or multiple syringes.

    摘要翻译： 提供了包括固体组分和液体组分的骨水泥。 将固体组分和液体组分混合在一起形成骨水泥。 在固体和液体组分混合完成后，骨水泥具有有效的手动施用或手动注射到目标解剖位置（例如骨）上的初始粘度，并且水泥具有稳定的粘度范围，在时间和温度上均为 有效地均匀地填充目标解剖学位置，例如骨质疏松的骨骼或骨折的椎体，其水泥从目标解剖位置的最小到不泄漏。 此外，骨水泥的初始粘度和稳定的粘度均在使得骨水泥有效地用手动操作的注射器或多个注射器注射的范围内。