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    NOVEL MODULATORS OF TRAIL SIGNALLING
    2.
    发明申请
    NOVEL MODULATORS OF TRAIL SIGNALLING 审中-公开
    TRAIL信号的新型调制器

    公开(公告)号：US20130195884A1

    公开(公告)日：2013-08-01

    申请号：US13519955

    申请日：2010-12-30

    申请人： Michael Boutros ,  Henning Walczak ,  Sandra Steinbrink ,  Christina Falschlehner

    发明人： Michael Boutros ,  Henning Walczak ,  Sandra Steinbrink ,  Christina Falschlehner

    IPC分类号： A61K38/17 ,  A61K38/48 ,  A61K38/53 ,  G01N33/68 ,  A61K45/06 ,  A61K39/395 ,  C12Q1/68 ,  A61K38/46 ,  A61K38/50

    CPC分类号： A61K38/1709 ,  A61K38/177 ,  A61K38/465 ,  A61K38/4813 ,  A61K38/50 ,  A61K38/53 ,  A61K39/3955 ,  A61K45/06 ,  C07K14/4747 ,  C07K14/70575 ,  C12Q1/6876 ,  G01N33/6863

    摘要： The present invention relates to an agent for use as a modulator of apoptosis-factor-associated cell death, apoptosis, cell survival, migration and/or proliferation, a method of diagnosing or monitoring apoptosis-factor-associated conditions or disorders as well as a method of identifying a modulator of apoptosis-factor-associated cell death, apoptosis, cell survival, migration and/or proliferation. Preferably, the invention relates to TRAIL-induced cell death and/or TRAIL-induced apoptosis. Preferably the agents are used to stimulate and/or enable TRAIL-induced cell death or to inhibit TRAIL-induced cell death. The preferable use of the diagnostic tools is to diagnose sensitivity or resistance to TRAIL-induced cell death or induction of sensitivity or resistance to TRAIL-induced cell death by an agent.

    摘要翻译： 本发明涉及用作凋亡因子相关细胞死亡，凋亡，细胞存活，迁移和/或增殖的调节剂的试剂，诊断或监测凋亡因子相关病症或病症的方法以及 识别凋亡因子相关细胞死亡，凋亡，细胞存活，迁移和/或增殖的调节剂的方法。 优选地，本发明涉及TRAIL诱导的细胞死亡和/或TRAIL诱导的凋亡。 优选地，所述试剂用于刺激和/或使TRAIL诱导的细胞死亡或抑制TRAIL诱导的细胞死亡。 诊断工具的优选使用是诊断TRAIL诱导的细胞死亡的敏感性或抗性或诱导TRAIL诱导的细胞死亡的敏感性或抗性。

    Receptor that binds trail
    3.
    发明授权
    Receptor that binds trail 失效

    公开(公告)号：US06642358B1

    公开(公告)日：2003-11-04

    申请号：US09578392

    申请日：2000-05-25

    申请人： Charles Rauch ,  Henning Walczak

    发明人： Charles Rauch ,  Henning Walczak

    IPC分类号： C07K1400

    CPC分类号： C07K16/2878 ,  A61K38/00 ,  C07K14/70578 ,  C07K14/715 ,  C07K2317/34

    摘要： A protein designated TRAIL receptor binds the protein known as TNF-Related Apoptosis-Inducing Ligand (TRAIL). The TRAIL receptor finds use in purifying TRAIL or inhibiting activities thereof. Isolated DNA sequences encoding TRAIL-R polypeptides are provided, along with expression vectors containing the DNA sequences, and host cells transformed with such recombinant expression vectors. Antibodies that are immunoreactive with TRAIL-R are also provided.

    RECEPTOR THAT BINDS TRAIL
    8.
    发明申请
    RECEPTOR THAT BINDS TRAIL 审中-公开
    接收器绑定TRAIL

    公开(公告)号：US20100015137A1

    公开(公告)日：2010-01-21

    申请号：US12343429

    申请日：2008-12-23

    申请人： Charles Rauch ,  Henning Walczak

    发明人： Charles Rauch ,  Henning Walczak

    IPC分类号： A61K39/395

    CPC分类号： C07K14/70578 ,  A61K38/00 ,  C07K1/22 ,  C07K14/715

    摘要： A protein designated TRAIL receptor binds the protein known as TNF-Related Apoptosis-Inducing Ligand (TRAIL). The TRAIL receptor finds use in purifying TRAIL or inhibiting activities thereof. Isolated DNA sequences encoding TRAIL-R polypeptides are provided, along with expression vectors containing the DNA sequences, and host cells transformed with such recombinant expression vectors. Antibodies that are immunoreactive with TRAIL-R are also provided.

    摘要翻译： 称为TRAIL受体的蛋白质结合称为TNF相关凋亡诱导配体（TRAIL）的蛋白质。 TRAIL受体可用于纯化TRAIL或抑制其活性。 提供了编码TRAIL-R多肽的分离的DNA序列，以及含有DNA序列的表达载体和用这些重组表达载体转化的宿主细胞。 还提供了与TRAIL-R免疫反应的抗体。

    Receptor that binds trail
    9.
    发明授权
    Receptor that binds trail 失效
    绑定尾迹的受体

    公开(公告)号：US07528239B1

    公开(公告)日：2009-05-05

    申请号：US09378045

    申请日：1999-08-20

    申请人： Charles Rauch ,  Henning Walczak

    发明人： Charles Rauch ,  Henning Walczak

    IPC分类号： C07K16/00 ,  A61K39/395 ,  A61K39/00

    CPC分类号： C07K14/70578 ,  A61K38/00 ,  C07K1/22 ,  C07K14/715

    摘要： A protein designated TRAIL receptor binds the protein known as TNF-Related Apoptosis-Inducing Ligand (TRAIL). The TRAIL receptor finds use in purifying TRAIL or inhibiting activities thereof. Isolated DNA sequences encoding TRAIL-R polypeptides are provided, along with expression vectors containing the DNA sequences, and host cells transformed with such recombinant expression vectors. Antibodies that are immunoreactive with TRAIL-R are also provided.

    摘要翻译： 称为TRAIL受体的蛋白质结合称为TNF相关凋亡诱导配体（TRAIL）的蛋白质。 TRAIL受体可用于纯化TRAIL或抑制其活性。 提供了编码TRAIL-R多肽的分离的DNA序列，以及含有DNA序列的表达载体，以及用这些重组表达载体转化的宿主细胞。 还提供了与TRAIL-R免疫反应的抗体。