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公开(公告)号:US20100098730A1
公开(公告)日:2010-04-22
申请号:US12577967
申请日:2009-10-13
IPC分类号: A61K39/395 , C07K16/00 , A61P35/00
CPC分类号: C07K16/22 , A01K2217/07 , A01K2267/03 , A61K2039/505 , A61P35/00 , C07K16/32 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/71 , C07K2317/72 , C07K2317/73 , C07K2317/92
摘要: Variant immunoglobulins with one or more amino acid modifications in the Fc region that have increased in vivo half-lives, and methods of using the same are provided.
摘要翻译: 提供了具有增加的体内半衰期的Fc区中具有一个或多个氨基酸修饰的变体免疫球蛋白及其使用方法。
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公开(公告)号:US08771685B2
公开(公告)日:2014-07-08
申请号:US12975784
申请日:2010-12-22
申请人: Xiumin Wu , Yan Wu , Lanlan Yu , Napoleone Ferrara , Wei-Ching Liang , Yu-Ju G. Meng , Janet Tien
发明人: Xiumin Wu , Yan Wu , Lanlan Yu , Napoleone Ferrara , Wei-Ching Liang , Yu-Ju G. Meng , Janet Tien
IPC分类号: A61K39/395
CPC分类号: C07K16/22 , A61K2039/505 , A61K2039/507 , C07K16/24 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: The present invention concerns antibodies to Bv8 and the uses of same.
摘要翻译: 本发明涉及Bv8的抗体及其用途。
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公开(公告)号:US20120014941A1
公开(公告)日:2012-01-19
申请号:US12975784
申请日:2010-12-22
申请人: Xiumin Wu , Yan Wu , Lanlan Yu , Napoleone Ferrara , Wei-Ching Liang , Yu-Ju G. Meng , Janet Tien
发明人: Xiumin Wu , Yan Wu , Lanlan Yu , Napoleone Ferrara , Wei-Ching Liang , Yu-Ju G. Meng , Janet Tien
CPC分类号: C07K16/22 , A61K2039/505 , A61K2039/507 , C07K16/24 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: The present invention concerns antibodies to Bv8 and the uses of same.
摘要翻译: 本发明涉及Bv8的抗体及其用途。
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公开(公告)号:US08449885B2
公开(公告)日:2013-05-28
申请号:US12817827
申请日:2010-06-17
申请人: Yu-Ju G. Meng , Kyu H. Hong , Johnny Gutierrez
发明人: Yu-Ju G. Meng , Kyu H. Hong , Johnny Gutierrez
IPC分类号: A61K39/00 , A61K39/395 , C12N5/12 , C12P21/08 , C07K16/32
CPC分类号: G01N33/57496 , C07K16/22 , G01N33/74 , G01N2333/475
摘要: The vascular endothelial growth factor (VEGF) activity in a patient's bloodstream or other biological sample can serve as a diagnostic and prognostic index for cancer, diabetes, heart conditions, and other pathologies. Antibody-sandwich ELISA methods and kits for VEGF as an antigen are provided to detect types of VEGF levels in biological samples from animal models and human patients and can be used as a diagnostic/prognostic index.
摘要翻译: 患者血液或其他生物样品中的血管内皮生长因子(VEGF)活性可作为癌症,糖尿病,心脏病和其他病理学的诊断和预后指标。 提供抗体夹心ELISA方法和VEGF作为抗原的试剂盒,以检测来自动物模型和人类患者的生物样品中VEGF水平的类型,并可用作诊断/预后指标。
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公开(公告)号:US20090181014A1
公开(公告)日:2009-07-16
申请号:US11537292
申请日:2006-09-29
IPC分类号: A61K39/395 , C12N15/12 , C12N15/81 , C12N5/10 , C12N1/21 , C12N1/19 , C12P21/02 , C07K14/705 , C07K16/30 , C12N15/13 , C12N15/85 , C12N5/16 , C12P21/00 , A61K38/17 , A61P35/00 , C12N5/08 , G01N33/574 , C12Q1/68 , C12N15/70
CPC分类号: C07K16/30 , A61K38/00 , C07K14/705 , G01N33/574
摘要: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号:US20080227119A1
公开(公告)日:2008-09-18
申请号:US11866560
申请日:2007-10-03
申请人: Yu-Ju G. Meng , Kyu H. Hong , Johnny Gutierrez
发明人: Yu-Ju G. Meng , Kyu H. Hong , Johnny Gutierrez
CPC分类号: G01N33/57496 , C07K16/22 , G01N33/74 , G01N2333/475
摘要: The vascular endothelial growth factor (VEGF) activity in a patient's bloodstream or other biological sample can serve as a diagnostic and prognostic index for cancer, diabetes, heart conditions, and other pathologies. Antibody-sandwich ELISA methods and kits for VEGF as an antigen are provided to detect types of VEGF levels in biological samples from animal models and human patients and can be used as a diagnostic/prognostic index.
摘要翻译: 患者血液或其他生物样品中的血管内皮生长因子(VEGF)活性可作为癌症,糖尿病,心脏病和其他病理学的诊断和预后指标。 提供抗体夹心ELISA方法和VEGF作为抗原的试剂盒,以检测来自动物模型和人类患者的生物样品中VEGF水平的类型,并可用作诊断/预后指标。
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公开(公告)号:US09146245B2
公开(公告)日:2015-09-29
申请号:US13660563
申请日:2012-10-25
申请人: Yu-Ju G. Meng , Kyu H. Hong , Johnny Gutierrez
发明人: Yu-Ju G. Meng , Kyu H. Hong , Johnny Gutierrez
CPC分类号: G01N33/57496 , C07K16/22 , G01N33/74 , G01N2333/475
摘要: The vascular endothelial growth factor (VEGF) activity in a patient's bloodstream or other biological sample can serve as a diagnostic and prognostic index for cancer, diabetes, heart conditions, and other pathologies. Antibody-sandwich ELISA methods and kits for VEGF as an antigen are provided to detect types of VEGF levels in biological samples from animal models and human patients and can be used as a diagnostic/prognostic index.
摘要翻译: 患者血液或其他生物样品中的血管内皮生长因子(VEGF)活性可作为癌症,糖尿病,心脏病和其他病理学的诊断和预后指标。 提供抗体夹心ELISA方法和VEGF作为抗原的试剂盒,以检测来自动物模型和人类患者的生物样品中VEGF水平的类型,并可用作诊断/预后指标。
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公开(公告)号:US20100255515A1
公开(公告)日:2010-10-07
申请号:US12817827
申请日:2010-06-17
申请人: Yu-Ju G. Meng , Kyu H. Hong , Johnny Gutierrez
发明人: Yu-Ju G. Meng , Kyu H. Hong , Johnny Gutierrez
CPC分类号: G01N33/57496 , C07K16/22 , G01N33/74 , G01N2333/475
摘要: The vascular endothelial growth factor (VEGF) activity in a patient's bloodstream or other biological sample can serve as a diagnostic and prognostic index for cancer, diabetes, heart conditions, and other pathologies. Antibody-sandwich ELISA methods and kits for VEGF as an antigen are provided to detect types of VEGF levels in biological samples from animal models and human patients and can be used as a diagnostic/prognostic index.
摘要翻译: 患者血液或其他生物样品中的血管内皮生长因子(VEGF)活性可作为癌症,糖尿病,心脏病和其他病理学的诊断和预后指标。 提供抗体夹心ELISA方法和VEGF作为抗原的试剂盒,以检测来自动物模型和人类患者的生物样品中VEGF水平的类型,并可用作诊断/预后指标。
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公开(公告)号:US06927024B2
公开(公告)日:2005-08-09
申请号:US09449204
申请日:1999-11-24
申请人: Anthony H. Dodge , Yu-Ju G. Meng , Paul W. Sims , Dominick V. Sinicropi , P. Mickey Williams , Wai Lee Wong
发明人: Anthony H. Dodge , Yu-Ju G. Meng , Paul W. Sims , Dominick V. Sinicropi , P. Mickey Williams , Wai Lee Wong
CPC分类号: C12Q1/6804 , C40B40/00 , C12Q2563/179 , C12Q2545/114
摘要: An oligonucleotide assay is useful for the detection of target compounds in samples which may contain the target compound.
摘要翻译: 寡核苷酸测定可用于检测可能含有目标化合物的样品中的目标化合物。
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