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    Methods and compositions for prolonging elimination half-times of bioactive compounds
    8.
    发明授权
    Methods and compositions for prolonging elimination half-times of bioactive compounds 有权
    延长消除半衰期生物活性化合物的方法和组合物

    公开(公告)号：US07608681B2

    公开(公告)日：2009-10-27

    申请号：US10149835

    申请日：2000-12-22

    申请人： Mark S. Dennis ,  Henry B. Lowman ,  Warren L. DeLano

    发明人： Mark S. Dennis ,  Henry B. Lowman ,  Warren L. DeLano

    IPC分类号： A61K38/00 ,  A61K38/12 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K14/00 ,  C07K17/00

    CPC分类号： C07K1/047 ,  A61K38/00 ,  A61K47/62 ,  A61K47/643 ,  A61K47/65 ,  A61K47/68 ,  A61K2039/505 ,  C07K7/08 ,  C07K14/001 ,  C07K16/22 ,  C07K16/24 ,  C07K16/461 ,  C07K2317/55

    摘要： Peptide ligands having affinity for IgG or for serum albumin are disclosed. Also disclosed are hybrid molecules comprising a peptide ligand domain and an active domain. The active domain may comprise any molecule having utility as a therapeutic or diagnostic agent. The hybrid molecules of the invention may be prepared using any of a number techniques including production in and purification from recombinant organisms transformed or transfected with an isolated nucleic acid encoding the hybrid molecule, or by chemical synthesis of the hybrid. The hybrid molecules have utility as agents to alter the elimination half-times of active domain molecules. Elimination half-time is altered by generating a hybrid molecule of the present invention wherein the peptide ligand has binding affinity for a plasma protein. In a preferred embodiment, a bioactive molecule having a short elimination half-time is incorporated as or into an active domain of the hybrid molecules of the invention, and the binding affinity of the peptide ligand domain prolongs the elimination half-time of the hybrid as compared to that of the bioactive molecule.

    摘要翻译： 公开了对IgG或血清白蛋白具有亲和力的肽配体。 还公开了包含肽配体结构域和活性结构域的杂合分子。 活性结构域可以包含具有作为治疗剂或诊断剂的效用的任何分子。 本发明的杂交分子可以使用数种技术中的任何一种来制备，包括在编码杂交分子的分离的核酸转化或转染的重组生物中进行生产和纯化，或通过化学合成杂交体。 杂化分子具有用作改变活性结构域分子的消除半衰期的试剂。 通过产生本发明的杂合分子来改变消除半衰期，其中肽配体对血浆蛋白具有结合亲和力。 在优选的实施方案中，具有短消除半衰期的生物活性分子作为或掺入本发明的杂交分子的活性结构域，并且肽配体结构域的结合亲和力将杂交体的消除半衰期延长 与生物活性分子相比。