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    Compounds and methods for use in treating neoplasia and cancer based upon inhibitors of isoprenylcysteine methyltransferase
    5.
    发明申请
    Compounds and methods for use in treating neoplasia and cancer based upon inhibitors of isoprenylcysteine methyltransferase 审中-公开
    基于异戊二烯基半胱氨酸甲基转移酶抑制剂治疗肿瘤和癌症的化合物和方法

    公开(公告)号：US20070004803A1

    公开(公告)日：2007-01-04

    申请号：US10552754

    申请日：2004-03-26

    申请人： Richard Gibbs ,  Brian Henriksen ,  Christine Hrycyna ,  Jessica Anderson

    发明人： Richard Gibbs ,  Brian Henriksen ,  Christine Hrycyna ,  Jessica Anderson

    IPC分类号： A61K31/198 ,  C07C323/39

    CPC分类号： C07C323/59 ,  C07C2601/14 ,  C07C2603/74

    摘要： The present invention relates to a novel method for the treatment of neoplasia, including cancer and other diseases and conditions in humans and mammals. More particularly, in preferred aspects, the present invention provides a method for the use of prenylcysteine analogs for the treatment of neoplasia, hyperproliferative cell growth including psoriasis, restenosis following cardiovascular surgery, hyperplasia, including renal hyperplasia, chronic inflammatory diseases including rheumatoid and osteoarthritis, among others.

    摘要翻译： 本发明涉及一种用于治疗包括癌症和其他疾病和病症在人类和哺乳动物中的瘤形成的新方法。 更具体地说，在优选方面，本发明提供了一种使用异戊烯基半胱氨酸类似物用于治疗瘤形成，包括牛皮癣在内的过度增殖细胞生长，心血管手术后的再狭窄，包括肾增生，包括类风湿和骨关节炎在内的慢性炎性疾病， 等等

    Upright vacuum cleaner with cyclonic airflow
    6.
    发明申请
    Upright vacuum cleaner with cyclonic airflow 有权
    立式真空吸尘器带气旋气流

    公开(公告)号：US20050091787A1

    公开(公告)日：2005-05-05

    申请号：US10999382

    申请日：2004-11-30

    申请人： Kenneth Bair ,  Richard Gibbs ,  Mark Reindle ,  Michael Wright

    发明人： Kenneth Bair ,  Richard Gibbs ,  Mark Reindle ,  Michael Wright

    IPC分类号： A47L5/28 ,  A47L5/36 ,  A47L9/12 ,  A47L9/16 ,  B01D39/16 ,  B01D45/12 ,  B01D50/00 ,  B04C5/13 ,  B04C9/00

    CPC分类号： A47L5/28 ,  A47L5/365 ,  A47L9/127 ,  A47L9/1608 ,  A47L9/165 ,  A47L9/1666 ,  A47L9/1683 ,  A47L9/1691 ,  B01D39/1692 ,  B01D45/12 ,  B01D50/002 ,  B04C5/13 ,  B04C9/00 ,  B04C2009/004 ,  Y10S55/03

    摘要： An upright vacuum cleaner (A) includes an upright housing section (B) and a nozzle section (C). A cyclonic airflow dirt and dust separating chamber (54) is defined in said upright housing section. A suction source (E) pulls air and entrained dirt, dust, and other contaminants through a main suction opening (26) formed in the underside (24) of the nozzle and into the cyclonic airflow chamber (54). The cyclonic airflow chamber causes the suction airstream to travel in a cyclonic path such that the entrained contaminants are separated therefrom and deposited into a dirt container (52) that defines the chamber (54). A main filter element (K) filters residual contaminants from the suction airstream between the chamber and the suction source. The main filter element is preferably made from high-density polyethylene porous filter media. A final filter assembly (F) filters the suction airstream discharged by the suction source to ensure that the air discharged into the atmosphere is contaminant free, including those contaminants introduced into the airstream by the suction source itself.

    摘要翻译： 立式吸尘器（A）包括立式收纳部分（B）和喷嘴部分（C）。 在所述直立的壳体部分中限定有旋风气流污垢和灰尘分离室（54）。 吸入源（E）通过形成在喷嘴的下侧（24）中的主吸入口（26）将空气和夹带的污垢，灰尘和其它污染物吸入气旋气流室（54）。 气旋气流室使得吸入气流在气旋路径中行进，使得夹带的污染物从其分离并沉积到限定腔室（54）的污垢容器（52）中。 主过滤元件（K）从腔室和抽吸源之间的吸入空气中过滤残留污染物。 主过滤元件优选由高密度聚乙烯多孔过滤介质制成。 最后的过滤器组件（F）过滤由抽吸源排出的吸入空气，以确保排放到大气中的空气是无污染的，包括由吸入源本身引入到空气流中的那些污染物。

    Handle for a wheeled suitcase
    8.
    发明授权
    Handle for a wheeled suitcase 失效
    处理一个轮式手提箱

    公开(公告)号：US5351793A

    公开(公告)日：1994-10-04

    申请号：US58540

    申请日：1993-05-05

    申请人： Richard Gibbs

    发明人： Richard Gibbs

    IPC分类号： A45C13/26 ,  A45C5/14 ,  A45C13/28

    CPC分类号： A45C13/262

    摘要： The present invention relates to a handle for a suitcase, which has a bottom surface, a top surface, and at least four sides where a first and second sides oppose one another and a third and fourth sides oppose one another. The suitcase further includes a plurality of wheels disposed on the bottom surface to provide transitional movement of the suitcase when the suitcase is pivoted about the plurality of wheels and placed in an inclined position.The handle comprising a first and second straps each having a first and second ends, the first and second straps being coupled to opposite sides of the suitcase. The first and second straps are adapted to have a first and second length L1 and L2 defined by the distance from the top surface of the suitcase to a middle portion of the first and second straps, the middle portion of each the first and second straps being joined during transport of the suitcase to form a substantially right triangle having an angle A between the first and second straps where the first and second lengths have a relationship corresponding approximately to the equation L1 = L2 .times. cosine A.

    摘要翻译： 本发明涉及一种手提箱手柄，其具有底表面，顶表面和至少四个侧面，其中第一和第二边彼此相对，第三和第四边彼此相对。 手提箱还包括设置在底表面上的多个轮子，以便当行李箱围绕多个车轮枢转并且放置在倾斜位置时提供手提箱的过渡运动。 手柄包括第一和第二带，每个具有第一和第二端，第一和第二带耦合到手提箱的相对侧。 第一和第二带适于具有由从手提箱的顶面到第一和第二带的中间部分的距离限定的第一和第二长度L1和L2，每个第一和第二带的中间部分是 在手提箱的运输期间连接以形成在第一和第二带之间具有角度A的基本上直角的三角形，其中第一和第二长度具有近似等于L1 = L2×余弦A的关系。

    Ventilated fabric cover for stringed instruments
    9.
    发明授权
    Ventilated fabric cover for stringed instruments 失效
    用于弦乐器的通风织物罩

    公开(公告)号：US4601391A

    公开(公告)日：1986-07-22

    申请号：US699721

    申请日：1985-02-07

    申请人： Richard Gibbs ,  Robert J. Reynolds ,  Kevin Greenhaw

    发明人： Richard Gibbs ,  Robert J. Reynolds ,  Kevin Greenhaw

    IPC分类号： G10G7/00 ,  A45C11/00

    CPC分类号： G10G7/00

    摘要： The present invention provides a unique ventilated fabric cover reinforced at selected portions for protecting finishes of stringed instruments. In a presently preferred embodiment, the inventive fabric cover is composed of interlaced, natural fibers woven or knitted in a prescribed ventilated pattern, and reinforced at selective portions which are more subject to wear as the instrument is played over time. The ventilated fabric is configured to protect and surround the outer rear peripheral portion of the stringed instrument, and may be custom sized for a wide variety of guitars, violins, violas, lutes, stringed basses, cellos, or the like. The unique cover further comprises elastic banding disposed in a central portion of the fabric to effect a tensioned form fit with the outer rear peripheral portion of the instrument to be protected. Accordingly, the inventive ventilated fabric cover protects the delicate finish of stringed instruments which are easily scratched or marred, but will not adversely interfere with the acoustic quality of the sound produced by the stringed instrument.

    摘要翻译： 本发明提供了一种独特的通风织物罩，在选定的部分加强，以保护弦乐器的饰面。 在目前优选的实施例中，本发明的织物罩由以规定的通风图案编织或编织的交织的天然纤维组成，并且随着随着时间的推移随着乐器的演奏而更容易磨损的选择性部分被加强。 通风织物被配置为保护和围绕弦乐器的外部后周边部分，并且可以根据各种吉他，小提琴，中提琴，琵琶，弦乐，大提琴等定制尺寸。 独特的盖子还包括布置在织物的中心部分中的弹性条带，以实现与要保护的器械的外后周边部分的张紧形式的配合。 因此，本发明的通风织物罩保护易于划伤或损坏的弦乐器的微妙的光洁度，但不会不利地影响由弦乐器产生的声音的声学质量。

    Lawn and garden implement caddy
    10.
    发明申请
    Lawn and garden implement caddy 审中-公开
    草坪花园工具球童

    公开(公告)号：US20070120337A1

    公开(公告)日：2007-05-31

    申请号：US11699591

    申请日：2007-01-29

    申请人： Richard Gibbs

    发明人： Richard Gibbs

    IPC分类号： B62B1/00

    CPC分类号： A01B1/00 ,  B62B1/10 ,  B62B1/14 ,  B62B1/262 ,  B62B1/264 ,  B62B2202/50

    摘要： A lawn and garden implement caddy is disclosed for storing and transporting various implements, including long handled tools, hand tools and containers, useful in lawn and garden care. The caddy has a wheeled base with a front area defining a container platform and a rear area that supports the head portion of the long handled tools. A center support interconnects the base with the top support to support the top frame. A pair of shaped members define a container enclosure. A handle support member extends rearwardly from a top frame member to define a caddy handle. One or more handle support brackets are provided on the handle support member and/or top frame member to receive and support the handles of one or more of the long handled tools. Preferably a closing mechanism, comprising a support arm and hinge, selectively secures the handles in the handle support members.

    摘要翻译： 披露了一个草坪和花园工具罐，用于存放和运送各种工具，包括长期处理的工具，手工具和容器，可用于草坪和花园护理。 该球童具有一个带有前面区域的轮式基座，该前部区域限定了一个容器平台和一个支撑长柄工具的头部的后部区域。 中心支撑件将底座与顶部支撑件相互连接以支撑顶部框架。 一对成形构件限定容器外壳。 手柄支撑构件从顶部框架构件向后延伸以限定球童手柄。 一个或多个手柄支撑托架设置在手柄支撑构件和/或顶部框架构件上以接收和支撑一个或多个长处理工具的手柄。 优选地，包括支撑臂和铰链的闭合机构选择性地将手柄固定在手柄支撑构件中。