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1.
公开(公告)号:US20050026172A1
公开(公告)日:2005-02-03
申请号:US10776399
申请日:2004-02-10
申请人: Henry Li , Jon Chatterton , Wufang Fan , Ning Ke , Flossie Wong-Staal
发明人: Henry Li , Jon Chatterton , Wufang Fan , Ning Ke , Flossie Wong-Staal
IPC分类号: C12N15/11 , C12N15/113 , C12Q1/68 , C07H21/02
CPC分类号: C12N15/111 , C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/31 , C12Y207/10001 , C12Y207/10002
摘要: Libraries for generating small interfering RNA (siRNA) are provided where the members of the library are optimized to inhibit the expression of genes that encode a predetermined family of proteins. The members of the library target at least mRNA encoding all members of the family of proteins. Methods for generating siRNA libraries of the present invention are also provided.
摘要翻译: 提供用于产生小干扰RNA(siRNA)的文库,其中文库的成员被优化以抑制编码预定蛋白质家族的基因的表达。 图书馆的成员至少靶向编码蛋白质家族成员的mRNA。 还提供了用于产生本发明的siRNA文库的方法。
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2.
公开(公告)号:US20070087984A1
公开(公告)日:2007-04-19
申请号:US10570911
申请日:2004-08-24
申请人: Xiuyuan Hu , Henry Li , Ning Ke , Mirta Grifman , Cheryl Rogers , Kristen Difife , Cellia Habita , Wufang Fan , Kristina Rhoades , Philip Tan , Richard Tritz , Flossie Wong-Staal
发明人: Xiuyuan Hu , Henry Li , Ning Ke , Mirta Grifman , Cheryl Rogers , Kristen Difife , Cellia Habita , Wufang Fan , Kristina Rhoades , Philip Tan , Richard Tritz , Flossie Wong-Staal
IPC分类号: A61K48/00
CPC分类号: G01N33/5011 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2320/12 , C12Y114/19001 , C12Y207/01137 , C12Y207/11025 , C12Y301/04004 , C12Y402/01001 , G01N2510/00
摘要: The present invention is directed to methods of identifying agents useful for inhibiting cancer cells. The agents bind to one of the proteins described herein, or to a gene or mRNA encoding such protein. The invention is also directed to methods for inhibiting cancer cells by administering an agent that binds to one of the proteins described herein, or to a gene or mRNA encoding such protein.
摘要翻译: 本发明涉及鉴定可用于抑制癌细胞的药剂的方法。 这些试剂与本文所述的一种蛋白质结合,或与编码这种蛋白质的基因或mRNA结合。 本发明还涉及通过施用与本文所述的蛋白质结合的试剂或编码这种蛋白质的基因或mRNA来抑制癌细胞的方法。
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3.
公开(公告)号:US20070184459A1
公开(公告)日:2007-08-09
申请号:US11351522
申请日:2006-02-03
申请人: Henry Li , Ning Ke , Mirta Grifman , Gisela Claasen , Xiuyuan Hu , Kristen Defife , Cellia Habita , Wufang Fan , Kristina Rhoades , Philip Tan , Flossie Wong-Staal
发明人: Henry Li , Ning Ke , Mirta Grifman , Gisela Claasen , Xiuyuan Hu , Kristen Defife , Cellia Habita , Wufang Fan , Kristina Rhoades , Philip Tan , Flossie Wong-Staal
IPC分类号: C12Q1/68 , G01N33/574 , C12N15/09
CPC分类号: G01N33/5011 , G01N33/6872
摘要: The present invention provides methods for identifying agents useful for inhibiting cancer cells by binding to various nuclear receptor proteins, or to the genes or RNA encoding such proteins.
摘要翻译: 本发明提供了通过结合各种核受体蛋白质或编码这些蛋白质的基因或RNA鉴定可用于抑制癌细胞的药剂的方法。
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公开(公告)号:US07053193B2
公开(公告)日:2006-05-30
申请号:US10054935
申请日:2002-01-25
申请人: Zairen Sun , Wufang Fan , Karl F. Kovacs , Xuan Li , Gilbert Jay
发明人: Zairen Sun , Wufang Fan , Karl F. Kovacs , Xuan Li , Gilbert Jay
IPC分类号: C07H21/04
CPC分类号: G01N33/57415 , A01K2217/05 , A61K38/00 , C07K14/4702 , C12Q1/6886
摘要: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides, Urb-ctf, are expressed in breast cancer and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions especially related to breast cancer.
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公开(公告)号:US20050019818A1
公开(公告)日:2005-01-27
申请号:US10921807
申请日:2004-08-20
申请人: Youmin Shu , Wufang Fan , Karl Kovacs , Xuan Li , Gilbert Jay
发明人: Youmin Shu , Wufang Fan , Karl Kovacs , Xuan Li , Gilbert Jay
CPC分类号: C12Q1/6883 , A61K38/00 , C07K14/47 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G06Q30/0601
摘要: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in heart and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions of the heart and eye.
摘要翻译: 本发明涉及新型多核苷酸,它们编码的多肽,抗体及其特异性结合伴侣的所有方面及其在研究,诊断,药物发现,治疗,临床医学,法医学和医学等方面的应用。多核苷酸被表达 因此在各种方式中有用,包括但不限于作为分子标志物,作为药物靶标,以及用于检测,诊断,分期,监测,预后,预防或治疗,确定疾病的易感性等 和心脏和眼睛的条件。
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公开(公告)号:US06455292B1
公开(公告)日:2002-09-24
申请号:US09930181
申请日:2001-08-16
申请人: Youmin Shu , Wufang Fan , Karl F. Kovacs , Michael Zidanic , Gilbert Jay
发明人: Youmin Shu , Wufang Fan , Karl F. Kovacs , Michael Zidanic , Gilbert Jay
IPC分类号: C12N912
CPC分类号: C12N9/1205 , G01N33/573 , G01N2333/9121
摘要: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine. The polynucleotides are expressed in brain and pancreas and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to diseases and conditions, especially relating to brain and pancreas.
摘要翻译: 本发明涉及新型多核苷酸的所有方面,其编码的多肽,抗体及其特异性结合伴侣,以及它们在研究,诊断,药物发现,治疗,临床医学,法医学,病理学和医学中的应用。 多核苷酸在脑和胰腺中表达,因此可以多种方式使用,包括但不限于作为分子标志物,作为药物靶标,以及用于检测,诊断,分期,监测,预后,预防或治疗,确定易感性 对疾病和病症,特别是与脑和胰腺有关。
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公开(公告)号:US20050069886A1
公开(公告)日:2005-03-31
申请号:US10494940
申请日:2002-11-07
申请人: Zairen Sun , Xuan Li , Gilbert Jay , Karl Kovacs , Wufang Fan
发明人: Zairen Sun , Xuan Li , Gilbert Jay , Karl Kovacs , Wufang Fan
CPC分类号: C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are differentially-regulated in prostate cancer and are therefore useful in variety of ways. including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, to prostate cancer.
摘要翻译: 本发明涉及新型多核苷酸的所有方面,它们编码的多肽,抗体及其特异性结合伴侣,以及它们在研究,诊断,药物发现,治疗,临床医学,法医学和医学等中的应用。多核苷酸是差异化的 在前列腺癌中有调节作用,因此在各种方面都是有用的。 包括但不限于作为药物靶标的分子标记,以及用于检测,诊断,分期,监测,预后,预防或治疗,确定前列腺癌的疾病和病症等等。
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公开(公告)号:US06780595B2
公开(公告)日:2004-08-24
申请号:US10082272
申请日:2002-02-26
申请人: Youmin Shu , Wufang Fan , Karl F. Kovacs , Xuan Li , Gilbert Jay
发明人: Youmin Shu , Wufang Fan , Karl F. Kovacs , Xuan Li , Gilbert Jay
IPC分类号: C12Q168
CPC分类号: C12Q1/6883 , A61K38/00 , C07K14/47 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G06Q30/0601
摘要: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in heart and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions of the heart and eye.
摘要翻译: 本发明涉及新型多核苷酸,它们编码的多肽,抗体及其特异性结合伴侣的所有方面及其在研究,诊断,药物发现,治疗,临床医学,法医学和医学等方面的应用。多核苷酸被表达 因此在各种方式中有用,包括但不限于作为分子标志物,作为药物靶标,以及用于检测,诊断,分期,监测,预后,预防或治疗,确定疾病的易感性等 和心脏和眼睛的条件。
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公开(公告)号:US20060241015A1
公开(公告)日:2006-10-26
申请号:US10502394
申请日:2003-01-24
申请人: Zairen Sun , Xuan Li , Gilbert Jay , Karl Kovacs , Wufang Fan , Youmin Shu
发明人: Zairen Sun , Xuan Li , Gilbert Jay , Karl Kovacs , Wufang Fan , Youmin Shu
CPC分类号: G01N33/574 , A61K38/00 , C07K14/4748 , C12Q1/6886 , C12Q2600/136 , G06Q50/22 , Y02A90/22 , Y02A90/26
摘要: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are differentially expressed in prostate and breast cancers and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., cancers.
摘要翻译: 本发明涉及新型多核苷酸的所有方面,它们编码的多肽,抗体及其特异性结合伴侣,以及它们在研究,诊断,药物发现,治疗,临床医学,法医学和医学等中的应用。多核苷酸是差异化的 在前列腺癌和乳腺癌中表达,因此可用于多种方式,包括但不限于作为分子标志物,作为药物靶标,以及用于检测,诊断,分期,监测,预后,预防或治疗,确定易感性, 等等,癌症。
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10.
公开(公告)号:US20050120393A1
公开(公告)日:2005-06-02
申请号:US10485555
申请日:2002-08-02
申请人: Zairen Sun , Xuan Li , Gilbert Jay , Karl Kovacs , Youmin Shu , Wufang Fan
发明人: Zairen Sun , Xuan Li , Gilbert Jay , Karl Kovacs , Youmin Shu , Wufang Fan
IPC分类号: A01K67/00 , C07H21/04 , C07K14/47 , C07K14/705 , C12Q1/68 , G01N33/50 , G01N33/574 , G06F17/60
CPC分类号: C07K14/47 , A01K2267/0331 , C07K14/4702 , C07K14/705 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , G01N33/5091 , G01N33/57434 , G01N2500/10 , G01N2800/342
摘要: The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine, etc. The polynucleotides are expressed in prostate and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions relating to prostate, such as prostate cancers, as well as other disease and conditions.
摘要翻译: 本发明涉及新型多核苷酸,它们编码的多肽,抗体及其特异性结合伴侣的所有方面及其在研究,诊断,药物发现,治疗,临床医学,法医学,病理学和医学等方面的应用。 多核苷酸在前列腺中表达,因此可用于多种方式,包括但不限于作为分子标志物,作为药物靶标,以及用于检测,诊断,分期,监测,预后,预防或治疗,确定等等的倾向 ,与前列腺相关的疾病和病症,如前列腺癌,以及其他疾病和病症。
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