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公开(公告)号：US20150025066A1
公开(公告)日：2015-01-22
申请号：US14379625
申请日：2012-12-18
发明人： Henry Yu , Lizbeth Celeste Deselm
IPC分类号： C07D498/14 , C07D498/22 , A61K31/5383
CPC分类号： C07D498/14 , A61K31/5383 , C07D413/12 , C07D413/14 , C07D498/22 , Y02A50/409 , Y02A50/411
摘要： Compounds of the formula I in which A, L1, L2, X and Y have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of rheumatoid arthritis.
摘要翻译： 其中A，L1，L2，X和Y具有权利要求1所述含义的式I化合物是Syk的抑制剂，并且可以用于治疗类风湿性关节炎。
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公开(公告)号：US20130172351A1
公开(公告)日：2013-07-04
申请号：US13533759
申请日：2012-06-26
申请人： Henry Yu , Thomas E. Richardson , Robert James Foglesong , Lizbeth Celeste DeSelm , Andreas Goutopoulos
发明人： Henry Yu , Thomas E. Richardson , Robert James Foglesong , Lizbeth Celeste DeSelm , Andreas Goutopoulos
IPC分类号： A61K31/5377 , A61K31/415 , C07D405/10 , A61K31/4155 , C07D403/10 , C07D401/10 , A61K31/4709 , C07D417/10 , A61K31/427 , C07D413/10 , A61K31/423 , C07D471/04 , A61K31/437 , C07D403/04 , A61K31/506 , A61K45/06 , C07D231/06
CPC分类号： A61K31/415 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0048 , A61K9/0078 , A61K9/06 , A61K9/19 , A61K9/2018 , A61K9/2059 , A61K9/48 , A61K31/4155 , A61K31/423 , A61K31/427 , A61K31/437 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K45/06 , A61K47/06 , C07D231/06 , C07D231/12 , C07D401/04 , C07D401/06 , C07D401/10 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D409/04 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/10 , C07D471/04
摘要： Novel dihydropyrazole derivatives of formula (I) wherein L, R, R3, R4, R5, R6, R7, X1, X2, X3, X4, Y, m and n have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
摘要翻译： 式（I）的新型二氢吡唑衍生物其中L，R，R3，R4，R5，R6，R7，X1，X2，X3，X4，Y，m和n具有根据权利要求的含义，是正变构调节剂 FSH受体，并且可以特别用于治疗生育障碍。
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公开(公告)号：US08791114B2
公开(公告)日：2014-07-29
申请号：US13533759
申请日：2012-06-26
申请人： Henry Yu , Thomas E. Richardson , Robert James Foglesong , Lizbeth Celeste DeSelm , Andreas Goutopoulos
发明人： Henry Yu , Thomas E. Richardson , Robert James Foglesong , Lizbeth Celeste DeSelm , Andreas Goutopoulos
IPC分类号： C07D231/12 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D413/06 , C07D403/10 , A61K31/427 , C07D231/06 , C07D403/04 , A61K9/20 , C07D417/10 , A61K9/00 , A61K45/06 , C07D409/06 , A61K31/423 , A61K31/415 , C07D471/04 , A61K9/06 , A61K31/4155 , A61K31/4709 , A61K9/48 , A61K9/19 , A61K31/5377 , A61K31/437 , A61K31/506 , C07D413/10 , A61K47/06 , C07D401/10 , C07D405/10
CPC分类号： A61K31/415 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0048 , A61K9/0078 , A61K9/06 , A61K9/19 , A61K9/2018 , A61K9/2059 , A61K9/48 , A61K31/4155 , A61K31/423 , A61K31/427 , A61K31/437 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K45/06 , A61K47/06 , C07D231/06 , C07D231/12 , C07D401/04 , C07D401/06 , C07D401/10 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D409/04 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/10 , C07D471/04
摘要： Novel dihydropyrazole derivatives of formula (I) wherein L, R, R3, R4, R5, R6, R7, X1, X2, X3, X4, Y, m and n have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
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公开(公告)号：US10138233B2
公开(公告)日：2018-11-27
申请号：US14900215
申请日：2014-06-24
申请人： Merck Patent GmbH , Henry Yu , Thomas E. Richardson , Marianne Donnelly , Ngan Nguyen , Xuliang Jiang
IPC分类号： C07D471/04 , C07D498/04 , C07D493/14 , C07D471/02 , C07D498/14
摘要： The present invention relates to imidazole compounds, and pharmaceutically acceptable compositions thereof, useful as positive allosteric modulators of follicle stimulating hormone receptor (FSHR).
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公开(公告)号：US10081637B2
公开(公告)日：2018-09-25
申请号：US14900209
申请日：2014-06-24
申请人： MERCK PATENT GMBH , Henry Yu , Marianne Donnelly , Ngan Nguyen , Xuliang Jiang
发明人： Henry Yu , Marianne Donnelly , Ngan Nguyen , Xuliang Jiang
IPC分类号： C07D491/052
CPC分类号： C07D491/052
摘要： The present invention relates to pyrazole compounds, and pharmaceutically acceptable compositions thereof, useful as positive allosteric modulators of follicle stimulating hormone receptor (FSHR).
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公开(公告)号：US11365199B2
公开(公告)日：2022-06-21
申请号：US16108414
申请日：2018-08-22
申请人： Merck Patent GmbH
发明人： Henry Yu , Marianne Donnelly , Ngan Nguyen , Xuliang Jiang
IPC分类号： C07D491/052
摘要： The present invention relates to pyrazole compounds, and pharmaceutically acceptable compositions thereof, useful as positive allosteric modulators of follicle stimulating hormone receptor (FSHR).
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公开(公告)号：US10517872B2
公开(公告)日：2019-12-31
申请号：US15450463
申请日：2017-03-06
申请人： Merck Patent GmbH
IPC分类号： A61K31/5025 , C07D487/18 , C07D498/16 , C07D498/22
摘要： The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
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公开(公告)号：US10301299B2
公开(公告)日：2019-05-28
申请号：US15830675
申请日：2017-12-04
申请人： Merck Patent GmbH
IPC分类号： C07D417/06 , C07D413/06 , C07D417/14 , C07D277/46 , G01N33/68 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/498
摘要： Compounds of formula (I) wherein X1, X2, W, R1 to R5, L and m have the meaning according to the claims, are glucosidase inhibitors, and can be employed, inter alia, for the treatment of Alzheimer's disease.
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公开(公告)号：US09624246B2
公开(公告)日：2017-04-18
申请号：US15016584
申请日：2016-02-05
申请人： Merck Patent GmbH
IPC分类号： C07D413/10 , C07D498/22 , C07D487/18 , C07D498/16
CPC分类号： A61K31/5025 , C07D487/18 , C07D498/16 , C07D498/22
摘要： The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
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公开(公告)号：US09517227B2
公开(公告)日：2016-12-13
申请号：US14300945
申请日：2014-06-10
申请人： Merck Patent GmbH
发明人： Henry Yu , Thomas E. Richardson , Robert James Foglesong , Lizbeth Celeste Deselm , Andreas Goutopoulos
IPC分类号： C07D231/06 , C07D405/06 , C07D403/06 , C07D401/06 , C07D417/10 , C07D413/06 , A61K31/4155 , A61K31/5377 , A61K31/415 , C07D231/12 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/06 , A61K31/423 , A61K31/427 , A61K31/437 , A61K31/4709 , A61K31/506 , A61K45/06 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/10 , C07D413/10 , C07D471/04 , A61K9/00 , A61K47/06 , A61K9/06 , A61K9/19 , A61K9/20 , A61K9/48
CPC分类号： A61K31/415 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0048 , A61K9/0078 , A61K9/06 , A61K9/19 , A61K9/2018 , A61K9/2059 , A61K9/48 , A61K31/4155 , A61K31/423 , A61K31/427 , A61K31/437 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K45/06 , A61K47/06 , C07D231/06 , C07D231/12 , C07D401/04 , C07D401/06 , C07D401/10 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D409/04 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/10 , C07D471/04
摘要： Novel dihydropyrazole derivatives of formula (I) wherein L, R, R3, R4, R5, R6, R7, X1, X2, X3, X4, Y, m and n have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
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