Quaternary derivatives of noroxymorphone which relieve intestinal
immobility
    1.
    发明授权
    Quaternary derivatives of noroxymorphone which relieve intestinal immobility 失效
    noroxymorphone的第四纪衍生物可缓解肠道不动

    公开(公告)号:US4176186A

    公开(公告)日:1979-11-27

    申请号:US928821

    申请日:1978-07-28

    IPC分类号: C07D489/08 C07D489/00

    CPC分类号: C07D489/08

    摘要: Compounds of the formula ##STR1## wherein R is allyl or a related radical such as chloroallyl, cyclopropyl-methyl or propargyl, andX is the anion of an acid, especially a chloride, bromide, iodide or methylsulfate anion;the compounds prevent or relieve the intestinal mobility inhibiting side-effects of narcotic analgesics without interfering with the analgesic activity of the latter.

    摘要翻译: 其中R为烯丙基或相关基团如氯烯丙基,环丙基甲基或炔丙基,X为酸的阴离子,特别是氯离子,溴化物,碘化物或甲基硫酸根阴离子的式 该化合物可预防或缓解麻醉止痛药的肠道迁移性抑制副作用,而不会影响麻醉止痛药的止痛活性。