摘要:
Compounds of the formula ##STR1## wherein R is allyl or a related radical such as chloroallyl, cyclopropyl-methyl or propargyl, andX is the anion of an acid, especially a chloride, bromide, iodide or methylsulfate anion;the compounds prevent or relieve the intestinal mobility inhibiting side-effects of narcotic analgesics without interfering with the analgesic activity of the latter.
摘要:
Diastereoisomers of the compound of the formula ##STR1## and non-toxic, pharmacologically acceptable acid addition salts thereof; the isomers as well as their salts are useful as analgesics and morphine-antagonists.
摘要:
Compounds of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl,R.sub.2 is hydrogen, methyl or ethyl,R.sub.3 is hydrogen or methyl, andR.sub.4 is hydrogen, alkyl of 1 to 4 carbon atoms or alkanoyl of 2 to 5 carbon atoms,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as analgesics.
摘要:
Compounds of the formula ##SPC1##WhereinR is hydrogen, methyl or acetyl,R.sub.1 is methyl, phenyl, or hydrogen,Z is --CH=CH-- or --CH.sub.2 --CH.sub.2 --,Y is oxygen or sulfur, andR.sub.3 is hydrogen or methyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as analgesics and antitussives.
摘要:
The present invention relates to 14-hydroxy-N-(2-methoxyethyl)-7,8-dihydromorphine and -norisomorphine, processes for preparing them and their use as pharmaceutical compositions.
摘要:
Compounds of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl; and R.sub.2 is hydrogen, methyl or ethyl; and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as analgesics and morphine antagonists.
摘要:
Pharmaceutical compositions containing as an active ingredient a compound of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl, R.sub.2 is hydrogen, methyl or ethyl,R.sub.3 is hydrogen or methyl,R.sub.4 is ##STR2## R.sub.5 is hydrogen, methyl or acetyl, or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as analgesics.
摘要:
Pharmaceutical compositions containing as an active ingredient a compound of the formula ##STR1## wherein R is hydrogen, methyl or acetyl,R.sub.1 is methyl, phenyl or hydrogen,Z is --CH=CH-- or --CH.sub.2 --CH.sub.2 --, andR.sub.3 is hydrogen or methyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; and a method using the same as analgesics and antitussives.
摘要:
Pharmaceutical compositions containing as an active ingredient a compound of the formula ##STR1## wherein R is hydrogen, methyl or acetyl,R.sub.1 and R.sub.2, which may be identical to or different from each other, are each alkyl of 1 to 3 carbon atoms,R.sub.3 is hydrogen or methyl, andY is oxygen or sulfur,Or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as analgesics, antitussives and opiate-antagonists.
摘要:
The compound of the formula ##STR1## and non-toxic, pharmacologically acceptable acid addition salts thereof. The compound as well as its salts are useful as analgesics.