Nucleosides, nucleotides and oligonucleotides containing enzymatically
cleavable protecting groups
    1.
    发明授权
    Nucleosides, nucleotides and oligonucleotides containing enzymatically cleavable protecting groups 失效
    含有酶切割保护基团的核苷,核苷酸和寡核苷酸

    公开(公告)号:US5677441A

    公开(公告)日:1997-10-14

    申请号:US326490

    申请日:1994-10-20

    CPC分类号: C07H21/00 C07H19/04 Y02P20/55

    摘要: Process for the production of oligonucleotides of formula II, in which the exocyclic amino groups of the bases adenine, guanine, cytosine, 7-deazaadenine and 7-deazaguanine carry N-phenylacetyl groups, are used for oligonucleotide synthesis, wherein in a first step a starting nucleotide is bound to a solid carrier, subsequently the desired oligonucleotide is synthesized by stepwise coupling with appropriately activated further monomeric nucleotide building blocks of the general formula I with the above-mentioned meanings, if desired, trivalent phosphorus is oxidized to pentavalent phosphorus during and after the synthesis, the oligonucleotide is cleaved from the carrier and the 5' protecting groups are cleaved off. The phenylacetyl functional groups that protect exocyclic NH.sub.2 groups of the bases can be cleaved off in a mild way with penicillin amidohydrolase (EC 3.5.1.11).

    摘要翻译: 用于生产式II寡核苷酸的方法,其中碱基腺嘌呤,鸟嘌呤,胞嘧啶,7-脱氮鸟嘌呤和7-脱氮鸟嘌呤的环外氨基携带N-苯乙酰基用于寡核苷酸合成,其中在第一步中 起始核苷酸与固体载体结合,随后所需的寡核苷酸通过与适当活化的具有上述含义的通式I的其它单体核苷酸结构单元逐步偶联来合成,如果需要,三价磷被氧化成五价磷, 合成后,将寡核苷酸从载体上切下,5'保护基被切掉。 保护碱基的环外NH2基团的苯乙酰基官能团可以用青霉素酰胺水解酶(EC 3.5.1.11)以温和的方式裂解。

    Nucleosides and nucleoside derivatives containing enzymatically
cleavable protecting groups
    2.
    发明授权
    Nucleosides and nucleoside derivatives containing enzymatically cleavable protecting groups 失效
    含有酶切割保护基团的核苷和核苷衍生物

    公开(公告)号:US5756704A

    公开(公告)日:1998-05-26

    申请号:US844127

    申请日:1997-04-18

    CPC分类号: C07H21/00 C07H19/04 Y02P20/55

    摘要: Process for the production of oligonucleotides of formula II, in which the exocyclic amino groups of the bases adenine, guanine, cytosine, 7-deazaadenine and 7-deazaguanine carry N-phenylacetyl groups, are used for oligonucleotide synthesis, wherein in a first step a starting nucleotide is bound to a solid carrier, subsequently the desired oligonucleotide is synthesized by stepwise coupling with appropriately activated further monomeric nucleotide building blocks of the general formula I with the above-mentioned meanings, if desired, trivalent phosphorus is oxidized to pentavalent phosphorus during and after the synthesis, the oligonucleotide is cleaved from the carrier and the 5' protecting groups are cleaved off. The phenylacetyl functional groups that protect exocyclic NH.sub.2 groups of the bases can be cleaved off in a mild way with penicillin amidohydrolase (EC 3.5.1.11).

    摘要翻译: 用于生产式II寡核苷酸的方法,其中碱基腺嘌呤,鸟嘌呤,胞嘧啶,7-脱氮鸟嘌呤和7-脱氮鸟嘌呤的环外氨基携带N-苯乙酰基用于寡核苷酸合成,其中在第一步中 起始核苷酸与固体载体结合,随后所需的寡核苷酸通过与适当活化的具有上述含义的通式I的其它单体核苷酸结构单元逐步偶联来合成,如果需要,三价磷被氧化成五价磷, 合成后,将寡核苷酸从载体上切下,5'保护基被切掉。 保护碱基的环外NH2基团的苯乙酰基官能团可以用青霉素酰胺水解酶(EC 3.5.1.11)以温和的方式裂解。

    Hold circuits for telephone systems
    3.
    发明授权
    Hold circuits for telephone systems 失效
    保持电话系统的电路

    公开(公告)号:US5131031A

    公开(公告)日:1992-07-14

    申请号:US397971

    申请日:1989-08-24

    申请人: Herbert Waldman

    发明人: Herbert Waldman

    IPC分类号: H04M1/80 H04M3/428

    CPC分类号: H04M3/4283 H04M1/80 H04M3/428

    摘要: Modular hold circuits which may be independently connected to a telephone line and powered therefrom are provided in accordance with the teachings of the present invention. Hold circuits connectable to a telephone line in the same manner as a telephone instrument are employed to detect an actuating signal generated at any telephone instrument in an off-hook condition connected to that telephone line. Upon detection of such actuating signal, an impedance is placed across the telphone line to establish a hold condition. The hold condition established may be released by placing any telephone instrument connected to a telephone line in an off-hook condition, however, if the telephone line is provided with a "call waiting" feature, such off-hook condition must be maintained for an interval exceeding that associated with a "call waiting" signal for the hold condition to be released.

    摘要翻译: 根据本发明的教导,提供了可以独立地连接到电话线并由其供电的模块化保持电路。 以与电话仪器相同的方式连接到电话线路的保持电路用于在与该电话线路连接的摘机状态下检测在任何电话设备处产生的致动信号。 在检测到这种致动信号时,阻抗被放置在电话线之间以建立保持状态。 建立的保持条件可以通过将连接到电话线的任何电话设备放置在摘机状态来释放,然而,如果电话线路被提供“呼叫等待”功能,则必须保持这种摘机状态 间隔超过与“呼叫等待”信号相关联的保持状态的释放。

    Method and apparatus for detecting a prescribed audio frequency
actuating signal applied on to a telecommunication line
    5.
    发明授权
    Method and apparatus for detecting a prescribed audio frequency actuating signal applied on to a telecommunication line 失效
    用于检测施加到电信线路上的规定音频启动信号的方法和装置

    公开(公告)号:US5426691A

    公开(公告)日:1995-06-20

    申请号:US221829

    申请日:1994-04-01

    申请人: Herbert Waldman

    发明人: Herbert Waldman

    IPC分类号: H04M1/65 H04M1/654 H04M1/64

    CPC分类号: H04M1/654 H04M1/65

    摘要: An electrical apparatus, associated with a telecommunications line, includes a unique dual input/dual output prescribed audio actuating signal responsive circuit. The responsive circuit pursuant to a detection of the prescribed signal, in combination with a second signal pursuant to a detection by line pickup detection circuit of an off-hook condition of the telecommunications line, effecting production of an actuating output signal. The actuating signal upon suitable application, effecting an operational function of a suitably coupled associated electrical device. The associated device may be one of a number of electrical devices. In the preferred embodiment of the invention, this device is designated to be a time-day-date-stamp marker signal outputting device. The marker signal may then be recorded by a suitable recording device or, alternatively, not recorded but simply used as an audible time-day-date announcement clock.

    摘要翻译: 与电信线路相关联的电气设备包括唯一的双输入/双输出规定的音频启动信号响应电路。 响应电路根据检测到规定的信号,结合第二信号,根据线路检测电路检测到电信线路的摘机状态,实现致动输出信号的产生。 在适当应用时的致动信号,实现适当耦合的相关电气设备的操作功能。 相关联的设备可以是多个电气设备中的一个。 在本发明的优选实施例中,该装置被指定为时日日期标记信号输出装置。 然后,标记信号可以由合适的记录装置记录,或者替代地,不记录,而是简单地用作可听时间日期公告时钟。

    Abbreviated and enhanced dialing apparatus and methods particularly
adapted for cellular or other types of telephone systems
    6.
    发明授权
    Abbreviated and enhanced dialing apparatus and methods particularly adapted for cellular or other types of telephone systems 失效
    特别适用于蜂窝或其他类型的电话系统的缩写和增强的拨号设备和方法

    公开(公告)号:US5274693A

    公开(公告)日:1993-12-28

    申请号:US554133

    申请日:1990-07-17

    申请人: Herbert Waldman

    发明人: Herbert Waldman

    摘要: An abbreviated dialing apparatus especially suitable for cellular/mobile phone use, enabling a user to dial telephone numbers having repetitive digits without directly dialing all of the repetitive digits. The user, by executing a prescribed actuation of a prescribed key, such as the SEND key, can cause the system to complete an incomplete telephone number having repetitive finishing zeroes or other repetitive finishing digits, instead of directly dialing all of the repetitive digits. By determining whether a call is local or long distance, the apparatus determines the number of digits necessary to properly complete a telephone number and completes the number by filling in any missing finishing digits. Alternatively, the user by actuating a finish digit key or a finish zero key can cause the system to similarly fill in any missing finishing digits to complete an incomplete telephone number.

    摘要翻译: 一种特别适用于蜂窝/移动电话使用的缩位拨号装置,使得用户能够拨打具有重复数字的电话号码而不直接拨打所有的重复数字。 通过执行诸如SEND键的规定键的规定的动作,用户可以使系统完成具有重复完成零或其他重复完成数字的不完整的电话号码,而不是直接拨打所有的重复数字。 通过确定呼叫是本地还是长距离,设备确定正确完成电话号码所需的位数,并通过填写任何缺少的完成数字来完成该号码。 或者,通过激活完成数字键或完成零键,用户可以使系统类似地填充任何缺少的完成数字以完成不完整的电话号码。

    Automatic area code dialing apparatus and methods particularly adapted
for cellular or other types of telephone systems
    7.
    发明授权
    Automatic area code dialing apparatus and methods particularly adapted for cellular or other types of telephone systems 失效
    自动区域代码拨号设备和特别适用于蜂窝或其他类型的电话系统的方法

    公开(公告)号:US5157719A

    公开(公告)日:1992-10-20

    申请号:US491933

    申请日:1990-03-12

    申请人: Herbert Waldman

    发明人: Herbert Waldman

    摘要: Apparatus for eliminating the need to repeat dial the same area code on a given long distance call. The apparatus detects when a subscriber wishes to implement a long distance call. Upon detection of the start of a call, the apparatus automatically displays the last area code dialed. The subscriber if desiring the last area code merely dials seven digits. The apparatus recognizes that the subscriber has selected the last area code to cause the last area code dialed to be transmitted prior to the transmission of the seven digits thereby completing a telephone number. If the subscriber does not wish to utilize the last area code dialed he first dials a "1" and then dials in ten digits and the proper digits are transmitted with the area code digits being replaced in the area code storage memory. The apparatus is particularly adaptable for use by cellular subscribers due to the fact that it reduces the number of digits dialed, saves dialing time and is therefore inherently safer to utilize while operating a vehicle.

    摘要翻译: 用于消除在给定长途电话上重复拨打相同区号的需要的装置。 该装置检测用户何时希望实施长途电话。 当检测到呼叫开始时,设备自动显示拨打的最后一个区号。 如果希望最后一个区号的用户只拨7位数字。 该装置识别出用户已经选择了最后一个区域代码,以使得在发送七位数之前拨打的最后一个区号被发送,从而完成一个电话号码。 如果用户不希望利用拨打的最后一个区号,他首先拨打“1”,然后拨打十位数字,并在区域码存储存储器中区域代码数字被替换的情况下发送正确的数字。 该装置特别适用于蜂窝用户使用,因为它减少拨打的数量,节省拨号时间,因此在操作车辆时利用本来更安全。

    Abbreviated and enhanced dialing apparatus and methods particularly
adapted cellular or other types of telephone systems
    8.
    发明授权
    Abbreviated and enhanced dialing apparatus and methods particularly adapted cellular or other types of telephone systems 失效
    缩写和增强的拨号设备和方法特别适用于蜂窝或其他类型的电话系统

    公开(公告)号:US5402481A

    公开(公告)日:1995-03-28

    申请号:US173185

    申请日:1993-12-23

    申请人: Herbert Waldman

    发明人: Herbert Waldman

    摘要: An abbreviated dialing apparatus especially suitable for cellular/mobile phone use, enabling a user to dial telephone numbers having repetetive digits without directly dialing all of the repetetive digits. The user, by executing a prescribed actuation of a prescribed key, such as the SEND key, can cause the system to complete an incomplete telephone number having repetetive finishing zeroes or other repetetive finishing digits, instead of directly dialing all of the repetetive digits. By determining whether a call is local or long distance, the apparatus determines the number of digits necessary to properly complete a telephone number and completes the number by filling in any missing finishing digits. Alternatively, the user by actuating a finish digit key or a finish zero key can cause the system to similarly fill in any missing finishing digits to complete an incomplete telephone number.

    摘要翻译: 一种特别适用于蜂窝/移动电话使用的缩位拨号装置,使得用户能够拨打具有重复数字的电话号码而不直接拨打所有重复的数字。 用户通过执行诸如SEND键的规定键的规定的动作,可以使系统完成具有重复完成零或其他重复完成数字的不完整的电话号码,而不是直接拨打所有的重复数字。 通过确定呼叫是本地还是长距离,设备确定正确完成电话号码所需的位数,并通过填写任何缺少的完成数字来完成该号码。 或者,通过激活完成数字键或完成零键,用户可以使系统类似地填充任何缺少的完成数字以完成不完整的电话号码。

    Apparatus and methods for selectively forwarding telephone calls
    9.
    发明授权
    Apparatus and methods for selectively forwarding telephone calls 失效
    用于选择性转发电话呼叫的装置和方法

    公开(公告)号:US5168517A

    公开(公告)日:1992-12-01

    申请号:US322217

    申请日:1989-03-13

    申请人: Herbert Waldman

    发明人: Herbert Waldman

    IPC分类号: H04M1/00 H04M1/665 H04Q3/70

    摘要: A selective call-forwarding method and apparatus utilizes telephone company facilities whereby a calling party will only be forwarded if a preferred calling code number is entered by the calling party. Upon receipt of a preferred calling code, a detector operates to detect and validate the code. Once the code is detected and validated, the apparatus proceeds to implement a connection to a third phone based on the automatic implementation of telephone company operating procedures to make the connection and, thereby, to selectively connect a preferred calling party to a remote telephone whereby the preferred party can communicate with the subscriber who has the procured service.

    摘要翻译: 选择性呼叫转移方法和装置利用电话公司设施,由主叫方输入优先呼叫号码,主叫方将仅转发。 在接收到优选的呼叫代码时,检测器操作以检测和验证代码。 一旦代码被检测和验证,设备就会基于电话公司的操作程序的自动实现来实现到第三个电话的连接,以进行连接,从而选择性地将优选呼叫方连接到远程电话,由此 首选方可以与具有采购服务的用户通信。

    Method and apparatus for automatically limiting rewind in a telephone
answering machine
    10.
    发明授权
    Method and apparatus for automatically limiting rewind in a telephone answering machine 失效
    用于在电话应答机中自动限制倒带的方法和装置

    公开(公告)号:US3935389A

    公开(公告)日:1976-01-27

    申请号:US328900

    申请日:1973-02-02

    申请人: Herbert Waldman

    发明人: Herbert Waldman

    IPC分类号: H04M1/65 H04M1/64 G11B15/20

    CPC分类号: H04M1/6515

    摘要: A telephone answering apparatus has a forward drive time delay relay which causes a tape bearing a series of messages to advance for approximately 30 seconds subsequent to the reproduction of the last message in the series. The forward drive time delay relay cooperates with a recording amplifier so as to prevent recording of information on the advanced portion of the tape. The relay also cooperates with an erase circuit to cause recorded information on the advanced portion of tape to be erased to thereby create a no-signal or silent portions of tape. The advanced portions of the tape are detectable by a no-signal detector during rewind of the tape which automatically stops rewind when a no-signal portion is detected. A method is disclosed for generating silent portions on a tape and for automatically stopping rewind in a telephone answering apparatus at points, prior to complete rewind, where the no-signal portions are detected.

    摘要翻译: 电话应答装置具有正向驱动时间延迟继电器,该继电器使得带有一系列消息的磁带在该系列中的最后一个消息的再现之后提前约30秒。 正向驱动时间延迟继电器与记录放大器配合,以防止在磁带的高级部分上记录信息。 继电器还与擦除电路配合,使磁带的高级部分的记录信息被擦除,从而产生无信号或无声部分的磁带。 磁带的高级部分可以在磁带重绕期间被无信号检测器检测到,当检测到无信号部分时,磁带自动停止倒带。 公开了一种用于在磁带上产生无声部分并且在完成快退之前的点处自动停止电话应答设备的方法,其中检测到无信号部分。