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公开(公告)号：US20060234582A1
公开(公告)日：2006-10-19
申请号：US10540123
申请日：2003-12-17
申请人： Hermann Gohl , Reinhold Buck
发明人： Hermann Gohl , Reinhold Buck
CPC分类号： B29D99/005 , A61M1/16 , A61M1/34 , A61M1/3403 , A61M2205/3368 , B01D67/0009 , B01D67/0011 , B01D67/0013 , B01D69/02 , B01D69/08 , B01D71/68 , B01D2323/08 , B01D2323/12 , B01D2323/36 , B01D2323/38 , B01D2325/022 , D01D5/24 , Y10T428/2975 , Y10T442/3106 , Y10T442/3325 , Y10T442/612 , Y10T442/647
摘要： The present invention relates to a membrane being suitable for, for example, hemodialysis. Said membrane comprises at least one hydrophobic polymer and at least one hydrophilic polymer. According to the present invention the outer surface of the hollow fiber has pores in the range of 0.5-3 μm and the numbers of said pores in the outer surface are in the range of 10,000 to 150,000 pores per mm2, preferably in the range of 18,000 to 100,000 pores per mm2, and most preferably in the range of 20,000 to 100,000 pores per mm2. The present invention further relates to a process for the preparation of said membrane and use of said membrane in hemodialysis, hemodiafiltration and hemofiltration, and in dialysis and filtration in general, for example in water purification or dehydration.
摘要翻译： 本发明涉及一种适用于例如血液透析的膜。 所述膜包含至少一种疏水性聚合物和至少一种亲水性聚合物。 根据本发明，中空纤维的外表面具有在0.5-3μm范围内的孔，并且外表面中的所述孔的数量在每平方毫米2的10,000-15,000个孔的范围内 >，优选在每毫米2至18,000至100,000个孔的范围内，最优选在20,000至100,000个孔/ mm 2的范围内。 本发明还涉及一种制备所述膜的方法和所述膜在血液透析，血液透析滤过和血液滤过中的用途，以及在透析和过滤中，通常例如在水净化或脱水中。
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公开(公告)号：US5891338A
公开(公告)日：1999-04-06
申请号：US632850
申请日：1996-04-16
申请人： Carl-Martin Bell , Reinhold Buck , Barbara Thome , Markus Storr , Hermann Gohl
发明人： Carl-Martin Bell , Reinhold Buck , Barbara Thome , Markus Storr , Hermann Gohl
CPC分类号： B01D71/68 , B01D67/0011 , B01D69/087 , A61M1/1686 , B01D2323/08 , B01D2323/12 , B01D2325/32
摘要： Heat-sterilizable membranes are disclosed comprising at least two hydrophobic polymers which are normally immiscible with each other, and in which at least one of the hydrophobic polymers is normally unstable under sterilization conditions while at least one of the other hydrophobic polymers is normally stable at sterilization conditions, and in which the at least two hydrophobic polymers are compatibilized with each other so that the membrane formed therefrom is stable at such sterilization conditions.
摘要翻译： 公开了包含至少两种通常彼此不混溶的疏水性聚合物的热灭菌膜，其中至少一种疏水聚合物在灭菌条件下通常是不稳定的，而至少一种其它疏水性聚合物在灭菌时通常是稳定的 条件，并且其中所述至少两种疏水性聚合物彼此相容，使得由其形成的膜在这种灭菌条件下是稳定的。
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公开(公告)号：US20090047654A1
公开(公告)日：2009-02-19
申请号：US12219356
申请日：2008-07-21
申请人： Wolfgang Rapp , Reinhold Deppisch , Hermann Gohl , Bernd Wittner , Werner Beck
发明人： Wolfgang Rapp , Reinhold Deppisch , Hermann Gohl , Bernd Wittner , Werner Beck
IPC分类号： B01D15/38 , B01D67/00 , A01N1/00 , C07C229/26 , C07K5/09 , C07K7/06 , C07K7/08 , C07K5/11 , C07K14/00 , C07K7/54 , C08G63/91 , C08F8/32
CPC分类号： B01J20/28016 , A61K31/195 , B01J20/26 , B01J20/28033 , B01J20/3219 , B01J20/3242 , B01J20/3248 , G01N33/54353
摘要： A polymer affinity matrix for the binding of one or more substances in a fluid or removing said substance(s) from the fluid and/or decreasing the amount or concentration thereof in said fluid with a view to preventing, eliminating or reducing undesired activation of components in said fluid is described, as well as a method for removing said substance(s) from the fluid and/or decreasing the amount or concentration thereof in said fluid, a method for the production of said matrix, use of said matrix and a kit comprising said matrix. The polymer affinity matrix comprises a solid support, a spacer and a ligand, containing arginine as a binding unit.
摘要翻译： 用于结合流体中的一种或多种物质或从流体中除去所述物质和/或减少所述流体的量或浓度的聚合物亲和基质，以防止，消除或减少组分的不期望的活化 在所述流体中描述，以及用于从流体中除去所述物质和/或减少所述流体的量或浓度的方法，用于生产所述基质的方法，所述基质的使用和试剂盒 包括所述矩阵。 聚合物亲和基质包含固体支持物，间隔基和配体，其含有精氨酸作为结合单元。
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公开(公告)号：US20110031184A1
公开(公告)日：2011-02-10
申请号：US12446058
申请日：2007-10-11
申请人： Bernd Krause , Hermann Gohl , Markus Hornung , Carina Kraft
发明人： Bernd Krause , Hermann Gohl , Markus Hornung , Carina Kraft
CPC分类号： B01D71/68 , A61B5/14525 , A61M1/16 , B01D63/02 , B01D69/02 , B01D69/08 , B01D69/087 , B01D71/44 , B01D71/62 , B01D2323/06 , B01D2323/08 , B01D2323/12 , B01D2323/22 , B01D2325/022
摘要： The present invention concerns a semipermeable hollow fiber membrane having an outer wall surface, an inner wall surface and an interior lumen extending along the length thereof and having the selective layer on the outer wall surface with a surface roughness below 10 nm. According to the invention the membrane has the smallest pore size on the outer wall surface, and has an outer wall surface which is smooth, continuous and homogeneous in a nanoscopic scale and four to five distinct layers of different pore size and density. Further the present invention concerns a process for manufacturing thereof and the use thereof.
摘要翻译： 本发明涉及一种具有外壁表面，内壁表面和沿其长度延伸的内腔的半透性中空纤维膜，并且在外壁表面上具有表面粗糙度低于10nm的选择层。 根据本发明，膜在外壁表面具有最小的孔径，并且具有在纳米尺度上光滑，连续和均匀的外壁表面，以及不同孔径和密度的四至五个不同层。 此外，本发明涉及其制造方法及其用途。
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公开(公告)号：US20060138044A1
公开(公告)日：2006-06-29
申请号：US10532131
申请日：2003-10-17
申请人： Bernd Krause , Matthias Wessling , Hermann Gohl , Markus Storr
发明人： Bernd Krause , Matthias Wessling , Hermann Gohl , Markus Storr
IPC分类号： B01D71/68
CPC分类号： B01D67/002 , B01D67/0083 , B01D69/02 , B01D71/68 , B01D71/80 , B01D2325/36 , B29C44/3403
摘要： The membrane producible by shaping a polymer blend or a block copolymer comprising blocks of monomer units, loading the polymer blend or block copolymer with a blowing gas concentration within the polymer blend or block polymer above a critical concentration at a temperature below a critical temperature, but above the glass transition temperature of the polymer blend/gas or block copolymer/gas mixture and finally stabilizing the foam structure is characterized in that as polymer blend a homogeneous polymer blend comprising at least one hydrophilic and at least one hydrophobic polymer and/or a block copolymer of alternating blocks of hydrophilic and hydrophobic monomer units is used, both the polymer blend and the block copolymer having a solubility relating to the used foaming gas above the critical concentration. The said membrane is used for medical purposes, especially for the haemodialysis, haemofiltration, haemodiafiltration, plasmapherese, immunotherapy, micro- or ultrafiltration or gas separation.
摘要翻译： 该膜可以通过将包含单体单元的嵌段的聚合物共混物或嵌段共聚物成型，将聚合物共混物或嵌段共聚物以高于临界温度的临界浓度的聚合物共混物或嵌段聚合物内的吹入气体浓度加载， 高于聚合物共混物/气体或嵌段共聚物/气体混合物的玻璃化转变温度，并且最终稳定泡沫结构的特征在于，作为聚合物共混物，包含至少一种亲水和至少一种疏水性聚合物和/或嵌段的均匀聚合物共混物 使用亲水和疏水单体单元的交替嵌段的共聚物，聚合物共混物和嵌段共聚物具有高于临界浓度的所用发泡气体的溶解度。 所述膜用于医疗目的，特别用于血液透析，血液透析，血液透析，血浆置换，免疫治疗，微量或超滤或气体分离。
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公开(公告)号：US08596467B2
公开(公告)日：2013-12-03
申请号：US12446058
申请日：2007-10-11
申请人： Bernd Krause , Hermann Gohl , Markus Hornung , Carina Zweigart
发明人： Bernd Krause , Hermann Gohl , Markus Hornung , Carina Zweigart
CPC分类号： B01D71/68 , A61B5/14525 , A61M1/16 , B01D63/02 , B01D69/02 , B01D69/08 , B01D69/087 , B01D71/44 , B01D71/62 , B01D2323/06 , B01D2323/08 , B01D2323/12 , B01D2323/22 , B01D2325/022
摘要： The present invention concerns a semipermeable hollow fiber membrane having an outer wall surface, an inner wall surface and an interior lumen extending along the length thereof and having the selective layer on the outer wall surface with a surface roughness below 10 nm. According to the invention the membrane has the smallest pore size on the outer wall surface, and has an outer wall surface which is smooth, continuous and homogeneous in a nanoscopic scale and four to five distinct layers of different pore size and density. Further the present invention concerns a process for manufacturing thereof and the use thereof.
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7.发明申请Continuous Method For Production Of A Regioselective Porous Hollow Fibre Membrane 有权连续法制备区域选择性多孔中空纤维膜公开(公告)号：US20070296105A1
公开(公告)日：2007-12-27
申请号：US11631786
申请日：2005-07-04
申请人： Bernd Krause , Hermann Gohl , Christoph Beck , Jurgen Dannenmaier , Michael Muller , Edmund Kurz , Heinrich Malthaner , Christian Oehr , Markus Storr
发明人： Bernd Krause , Hermann Gohl , Christoph Beck , Jurgen Dannenmaier , Michael Muller , Edmund Kurz , Heinrich Malthaner , Christian Oehr , Markus Storr
CPC分类号： B01D61/00 , B01D67/0093 , B01D69/02 , B01D69/08 , B01D71/68 , B01D2323/38 , B01J20/261 , B01J20/262 , B01J20/265 , B01J20/28004 , B01J20/28021 , B01J20/28023 , B01J20/28033 , B01J20/28069 , B01J20/28085 , B01J20/3085 , B01J20/321 , B01J20/3212 , B01J20/3217 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3274 , B01J2220/445
摘要： A continuous method for production of a porous hollow fibre membrane having regioselective affinity for compounds in blood or other biologically active fluids to be removed during purification of blood or said fluids is disclosed, as well as a porous hollow fibre membrane produced by said method, an adsorption device containing such a porous hollow fibre membrane, and use of such a porous hollow fibre membrane.
摘要翻译： 公开了一种用于生产在血液或所述流体净化期间除去的血液或其它生物活性流体中的化合物的区域选择性亲和性的多孔中空纤维膜的连续方法，以及通过所述方法制备的多孔中空纤维膜， 含有这种多孔中空纤维膜的吸附装置，以及这种多孔中空纤维膜的使用。
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公开(公告)号：US20060134595A1
公开(公告)日：2006-06-22
申请号：US10520532
申请日：2003-07-04
申请人： Wolfgang Rapp , Reinhold Deppisch , Hermann Gohl , Bernd Wittner , Werner Beck
发明人： Wolfgang Rapp , Reinhold Deppisch , Hermann Gohl , Bernd Wittner , Werner Beck
CPC分类号： B01J20/28016 , A61K31/195 , B01J20/26 , B01J20/28033 , B01J20/3219 , B01J20/3242 , B01J20/3248 , G01N33/54353
摘要： A polymer affinity matrix for the binding of one or more substances in a fluid for removing said substance(s) from the fluid and/or decreasing the amount or concentration thereof in said fluid with a view to preventing, eliminating, or reducing undesired activation of components in said fluid is described, as well as a method for removing said substance(s) from the fluid and/or decreasing the amount or concentration thereof in said fluid, a method for the production of said matrix, use of said matrix and a kit comprising said matrix. The polymer affinity matrix comprises a solid support, a space and a ligand, containing arginine as a binding unit.
摘要翻译： 用于结合流体中的一种或多种物质以从流体中除去所述物质和/或降低其中所述物质的量或浓度的聚合物亲和基质，以防止，消除或减少不期望的活化 所述流体中的组分以及用于从流体中除去所述物质和/或减少所述流体中的量或浓度的方法，生产所述基质的方法，所述基质的使用和 试剂盒包括所述基质。 聚合物亲和基质包含含有精氨酸作为结合单元的固体支持物，空间和配体。
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