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公开(公告)号：US08124617B2
公开(公告)日：2012-02-28
申请号：US12065607
申请日：2006-09-01
申请人： Hidehisa Iwata , Yasuhisa Kohara , Sheldon X. Cao , Prasuna Guntupalli , Stephen L. Gwaltney , David J. Hosfield , Yan Liu , Jeffrey A Stafford , Beverly Wolgast
发明人： Hidehisa Iwata , Yasuhisa Kohara , Sheldon X. Cao , Prasuna Guntupalli , Stephen L. Gwaltney , David J. Hosfield , Yan Liu , Jeffrey A Stafford , Beverly Wolgast
IPC分类号： A61K31/44 , C07D513/02 , C07D515/02
CPC分类号： A61K31/437 , A61K9/2018 , A61K9/4858 , C07D471/02 , C07D471/04 , C12N9/1205 , C12Y207/01001
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein.
摘要翻译： 提供化合物，药物组合物，试剂盒和方法用于含有选自式（I）的化合物的葡糖激酶，其中变量如本文所定义。
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公开(公告)号：US20100069431A1
公开(公告)日：2010-03-18
申请号：US12065607
申请日：2006-09-01
申请人： Hidehisa Iwata , Yasuhisa Kohara , Sheldon X. Cao , Prasuna Guntupalli , Stephen L. Gwaltney , David J. Hosfield , Yan Liu , Jeffrey A. Stafford , Beverly Throop
发明人： Hidehisa Iwata , Yasuhisa Kohara , Sheldon X. Cao , Prasuna Guntupalli , Stephen L. Gwaltney , David J. Hosfield , Yan Liu , Jeffrey A. Stafford , Beverly Throop
IPC分类号： A61K31/437 , C07D471/02
CPC分类号： A61K31/437 , A61K9/2018 , A61K9/4858 , C07D471/02 , C07D471/04 , C12N9/1205 , C12Y207/01001
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein.
摘要翻译： 提供化合物，药物组合物，试剂盒和方法用于含有选自式（I）的化合物的葡糖激酶，其中变量如本文所定义。
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公开(公告)号：US08008332B2
公开(公告)日：2011-08-30
申请号：US11754205
申请日：2007-05-25
申请人： Sheldon X. Cao , Jun Feng , Stephen L. Gwaltney , David J. Hosfield , Robert J. Skene , Jeffrey A. Stafford , Mingnam Tang
发明人： Sheldon X. Cao , Jun Feng , Stephen L. Gwaltney , David J. Hosfield , Robert J. Skene , Jeffrey A. Stafford , Mingnam Tang
IPC分类号： A61K31/427 , A61K31/4402 , C07D231/56 , A61K31/4353 , A61K31/519 , A61K31/4995 , C07D487/04 , C07D471/04 , A61P3/10 , A61P9/00
CPC分类号： C07D417/12 , C07D401/12 , C07D471/04 , C07D487/04
摘要： Compounds are provided for use with hexokinases that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译： 提供了与己糖激酶一起使用的化合物，其包含：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号：US20110275665A1
公开(公告)日：2011-11-10
申请号：US13185166
申请日：2011-07-18
申请人： Sheldon X. Cao , Jun Feng , Stephen L. Gwaltney , David J. Hosfield , Robert J. Skene , Jeffrey A. Stafford , Mingnam Tang
发明人： Sheldon X. Cao , Jun Feng , Stephen L. Gwaltney , David J. Hosfield , Robert J. Skene , Jeffrey A. Stafford , Mingnam Tang
IPC分类号： A61K31/437 , A61P3/10 , A61K31/427 , A61P3/08 , C07D417/12 , C07D471/04
CPC分类号： C07D417/12 , C07D401/12 , C07D471/04 , C07D487/04
摘要： Compounds are provided for use with hexokinases that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译： 提供了与己糖激酶一起使用的化合物，其包含：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号：US20110070297A1
公开(公告)日：2011-03-24
申请号：US12958265
申请日：2010-12-01
申请人： Sheldon X. Cao , Jun Feng , Yasuhiro Imaeda , Stephen L. Gwaltney , David J. Hosfield , Nobuyuki Takakura , Mingnam Tang
发明人： Sheldon X. Cao , Jun Feng , Yasuhiro Imaeda , Stephen L. Gwaltney , David J. Hosfield , Nobuyuki Takakura , Mingnam Tang
IPC分类号： A61K31/5377 , C07D249/12 , A61K31/4196 , A61K9/127 , C07D401/12 , A61K31/4439 , C07D413/12 , C07D231/20 , A61K31/415 , C07D403/10 , C07D403/12 , A61K31/496 , A61K31/4178 , A61K31/506 , A61K31/427 , A61K31/4184 , C07D413/04 , A61K31/423 , C07D471/04 , A61K31/4353 , A61K31/517 , A61P3/10
CPC分类号： C07D249/12 , C07D231/12 , C07D231/20 , C07D249/08 , C07D249/14 , C07D401/04 , C07D401/12 , C07D407/04 , C07D409/12 , C07D417/12
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.
摘要翻译： 提供化合物，药物组合物，试剂盒和方法用于含有选自以下的化合物的葡糖激酶：其中变量如本文所定义。
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公开(公告)号：US07790734B2
公开(公告)日：2010-09-07
申请号：US10934326
申请日：2004-09-02
申请人： Sheldon X. Cao , Jun Feng , Stephen L. Gwaltney , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Xiao-Yi Xiao , Zhiyuan Zhang
发明人： Sheldon X. Cao , Jun Feng , Stephen L. Gwaltney , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Xiao-Yi Xiao , Zhiyuan Zhang
IPC分类号： C07D239/47 , C07D239/48 , C07D403/12 , A61K31/505
CPC分类号： C07D401/04
摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
摘要翻译： 提供化合物，药物，试剂盒和方法用于包含式I的DPP-IV抑制剂：其中取代基如本文所述。
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公开(公告)号：US08394843B2
公开(公告)日：2013-03-12
申请号：US13185166
申请日：2011-07-18
申请人： Jun Feng , Stephen L. Gwaltney , Robert J. Skene , Mingnam Tang , Sheldon X. Cao , David J. Hossfield , Jeffrey A. Stafford
发明人： Jun Feng , Stephen L. Gwaltney , Robert J. Skene , Mingnam Tang , Sheldon X. Cao , David J. Hossfield , Jeffrey A. Stafford
IPC分类号： C07D209/02 , C07D275/02 , A61K31/4035 , A61K31/4168 , C07D231/56 , C07D471/02 , C07D487/04 , A61K31/519 , A61K31/4152 , A61K31/416 , A61K31/437 , A61K31/4985 , A61P13/12
CPC分类号： C07D417/12 , C07D401/12 , C07D471/04 , C07D487/04
摘要： Compounds are provided which have the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture which contain such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to activate glucokinase.
摘要翻译： 提供了具有下式的化合物：其中变量如本文所定义。 还提供含有这些化合物的药物组合物，试剂盒和制品，用于制备化合物的方法和中间体，以及使用该化合物来激活葡糖激酶的方法。
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公开(公告)号：US20110082111A1
公开(公告)日：2011-04-07
申请号：US12962557
申请日：2010-12-07
申请人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. KALDOR , Andre A. KIRYANOV , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
发明人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. KALDOR , Andre A. KIRYANOV , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
IPC分类号： A61K31/675 , C07D487/04 , A61K31/551 , A61K31/397 , C07F9/165 , C07D487/14 , C07C229/34 , C07C229/22 , C07C69/74 , C07C69/75 , A61P35/00
CPC分类号： C07D487/04 , C07D487/14 , C07D519/00
摘要： Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
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公开(公告)号：US20090281092A1
公开(公告)日：2009-11-12
申请号：US12237306
申请日：2008-09-24
申请人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
发明人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
IPC分类号： A61K31/5513 , C07D487/04 , A61P35/00 , A61P29/00 , A61P37/00 , A61P9/00 , A61P25/00 , A61P19/00
CPC分类号： C07D487/04 , C07D487/14 , C07D519/00
摘要： Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
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公开(公告)号：US20090291938A1
公开(公告)日：2009-11-26
申请号：US12274213
申请日：2008-11-19
申请人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
发明人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
IPC分类号： A61K31/551 , C07D487/04
CPC分类号： C07D487/04
摘要： Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译： 提供下式的化合物用于激酶：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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