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18 条记录 (耗时 0.039 秒)

    Five-membered heterocyclic compounds
    3.
    发明申请
    Five-membered heterocyclic compounds 失效
    五元杂环化合物

    公开(公告)号：US20060135578A1

    公开(公告)日：2006-06-22

    申请号：US10527426

    申请日：2003-09-09

    申请人： Yu Momose ,  Nobuyuki Takakura ,  Tsuyoshi Maekawa ,  Hiroyuki Odaka ,  Hiroyuki Kimura

    发明人： Yu Momose ,  Nobuyuki Takakura ,  Tsuyoshi Maekawa ,  Hiroyuki Odaka ,  Hiroyuki Kimura

    IPC分类号： A61K31/422 ,  C07D413/14

    CPC分类号： C07D263/32 ,  C07F9/6558 ,  C07F9/65583

    摘要： The present invention provides a compound represented by the formula: wherein R1 is an optionally substituted 5-membered heterocyclic group; X, Y and V are the same or different and each is a bond, an oxygen atom, a sulfur atom and the like; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; ring A is an aromatic ring optionally further having 1 to 3 substituents; Z is —(CH2)n-Z1- or -Z1-(CH2)n— (n is an integer of 0 to 8, Z1 is a bond, an oxygen atom, a sulfur atom and the like); ring B is a nitrogen-containing heterocycle optionally further having 1 to 3 substituents; W is a bond or a divalent hydrocarbon group having 1 to 20 carbon atoms; R2 is a hydrogen atom, a cyano group, —PO(OR9)(OR10) (R9 and R10 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, and R9 and R10 are optionally bonded to form an optionally substituted ring) and the like, or a salt thereof, which has a superior adipose tissue weight decreasing action, a hypoglycemic action and a hypolipidemic action, and which is useful as an agent for the prophylaxis or treatment of obesity, diabetes mellitus, hyperlipidemia, impaired glucose tolerance, hypertension and the like.

    摘要翻译： 本发明提供由下式表示的化合物：其中R 1是任选取代的5元杂环基; X，Y和V相同或不同，各自为键，氧原子，硫原子等; Q为碳原子数为1〜20的二价烃基; 环A是任选进一步具有1至3个取代基的芳环; Z是 - （CH 2）n - - - - - - - - 1 - （CH 2） （n为0〜8的整数，Z 1为键，氧原子，硫原子等）; n为0〜8的整数。 环B是任选进一步具有1至3个取代基的含氮杂环; W是碳原子数为1〜20的键或二价烃基; R 2是氢原子，氰基，-PO（OR 9）（OR 10）（R 10） SUP＆gt;和R 10相同或不同，各自为氢原子或任选取代的烃基，R 9和R 10为 任选地键合以形成任选取代的环）等，或其盐，其具有优异的脂肪组织重量减少作用，降血糖作用和降血脂作用，并且其可用作预防或治疗 肥胖症，糖尿病，高脂血症，葡萄糖耐量降低，高血压等。

    Fused ring compounds and use thereof
    4.
    发明授权
    Fused ring compounds and use thereof 失效
    稠环化合物及其用途

    公开(公告)号：US08673942B2

    公开(公告)日：2014-03-18

    申请号：US12936785

    申请日：2009-04-09

    申请人： Tsuneo Yasuma ,  Nobuyuki Takakura

    发明人： Tsuneo Yasuma ,  Nobuyuki Takakura

    IPC分类号： A61K31/4436 ,  C07D417/14

    CPC分类号： C07D417/04 ,  C07D417/14

    摘要： The present invention aims to provide a glucokinase activator useful as a pharmaceutical agent such as an agent for the prophylaxis or treatment of diabetes, obesity and the like. The present invention provides a glucokinase activator containing a compound represented by the formula (I): wherein each symbol is defined in the specification, or a salt thereof or a prodrug thereof.

    摘要翻译： 本发明的目的在于提供一种用作预防或治疗糖尿病，肥胖症等药物的药剂的葡糖激酶活化剂。 本发明提供含有式（I）表示的化合物的葡糖激酶活化剂：其中每个符号在说明书中定义，或其盐或其前药。