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公开(公告)号：US20090291938A1
公开(公告)日：2009-11-26
申请号：US12274213
申请日：2008-11-19
申请人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
发明人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
IPC分类号： A61K31/551 , C07D487/04
CPC分类号： C07D487/04
摘要： Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译： 提供下式的化合物用于激酶：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号：US20110082111A1
公开(公告)日：2011-04-07
申请号：US12962557
申请日：2010-12-07
申请人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. KALDOR , Andre A. KIRYANOV , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
发明人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. KALDOR , Andre A. KIRYANOV , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
IPC分类号： A61K31/675 , C07D487/04 , A61K31/551 , A61K31/397 , C07F9/165 , C07D487/14 , C07C229/34 , C07C229/22 , C07C69/74 , C07C69/75 , A61P35/00
CPC分类号： C07D487/04 , C07D487/14 , C07D519/00
摘要： Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
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公开(公告)号：US20090281092A1
公开(公告)日：2009-11-12
申请号：US12237306
申请日：2008-09-24
申请人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
发明人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
IPC分类号： A61K31/5513 , C07D487/04 , A61P35/00 , A61P29/00 , A61P37/00 , A61P9/00 , A61P25/00 , A61P19/00
CPC分类号： C07D487/04 , C07D487/14 , C07D519/00
摘要： Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
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公开(公告)号：US20110201818A1
公开(公告)日：2011-08-18
申请号：US12680183
申请日：2008-09-24
申请人： Takashi Ichikawa , Benjamin Jones , Andre A. Kiryanov , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Sheldon X. Cao , Betty Lam , Victoria Feher , Stephen W. Kaldor , Yan Liu , Jeffrey A Stafford
发明人： Takashi Ichikawa , Benjamin Jones , Andre A. Kiryanov , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Sheldon X. Cao , Betty Lam , Victoria Feher , Stephen W. Kaldor , Yan Liu , Jeffrey A Stafford
IPC分类号： C07D211/72
CPC分类号： C07D487/04 , C07D487/14 , C07D519/00
摘要： Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译： 提供下式的化合物用于激酶：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号：US20100075973A1
公开(公告)日：2010-03-25
申请号：US12544419
申请日：2009-08-20
申请人： Sheldon X. Cao , Takashi Ichikawa , Andre A. Kiryanov , Christopher McBride , Srinivasa Reddy Natala , Stephen W. Kaldor , Jeffrey A. Stafford
发明人： Sheldon X. Cao , Takashi Ichikawa , Andre A. Kiryanov , Christopher McBride , Srinivasa Reddy Natala , Stephen W. Kaldor , Jeffrey A. Stafford
IPC分类号： A61K31/5025 , C07D471/14 , A61P35/00
CPC分类号： C07D487/14
摘要： The present invention provides PLK inhibitors of the formula wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using the compounds.
摘要翻译： 本发明提供下式的PLK抑制剂，其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 和使用该化合物的方法。
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公开(公告)号：US20140206680A1
公开(公告)日：2014-07-24
申请号：US14128576
申请日：2012-06-20
申请人： Mark E. Adams , Rongliang Chen , Mitsunori Kono , Betty Lam , Matthew Lardy , Srinivasa Reddy Natala , Steven James Wilkens , Zhe Nie
发明人： Mark E. Adams , Rongliang Chen , Mitsunori Kono , Betty Lam , Matthew Lardy , Srinivasa Reddy Natala , Steven James Wilkens , Zhe Nie
IPC分类号： C07D498/04 , A61K31/437 , C07D495/04 , A61K31/519 , A61K31/5383 , C07D487/04 , A61K31/4985 , C07D471/04 , A61K31/4365
CPC分类号： C07D471/04 , A61K31/4365 , A61K31/437 , A61K31/4985 , A61K31/519 , A61K31/5365 , A61K31/5383 , C07D487/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要： Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein G, p, R1, R2, R3a, R4, and R5 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating disorders, diseases, and conditions involving the immune system and inflammation, including rheumatoid arthritis, cancer, and other disorders, diseases, and conditions for which inhibition of SYK is indicated.
摘要翻译： 公开了式1的化合物及其药学上可接受的盐，其中G，p，R1，R2，R3a，R4和R5在说明书中定义。 本公开还涉及用于制备式1化合物的材料和方法，含有它们的药物组合物及其用于治疗涉及免疫系统和炎症的疾病，疾病和病症的用途，包括类风湿性关节炎，癌症和其它疾病 ，疾病和表示SYK抑制的病症。
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公开(公告)号：US09688689B2
公开(公告)日：2017-06-27
申请号：US14709852
申请日：2015-05-12
申请人： Ha-Soon Choi , James Paul Lajiness , Srinivasa Reddy Natala , Bao Nguyen , Hank Michael James Petrassi , Zhicheng Wang
发明人： Ha-Soon Choi , James Paul Lajiness , Srinivasa Reddy Natala , Bao Nguyen , Hank Michael James Petrassi , Zhicheng Wang
IPC分类号： C07D493/08 , A61K31/443 , A61K31/4245 , A61K31/4155 , A61K31/506 , A61K31/34 , A61K31/4439 , A61K31/5377 , A61K31/351 , A61K31/4545 , A61K31/4525 , A61K31/497 , A61K31/444 , A61K45/06 , C07D491/18
CPC分类号： A61K31/443 , A61K31/34 , A61K31/351 , A61K31/4155 , A61K31/416 , A61K31/4245 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4525 , A61K31/4545 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06 , A61L27/54 , A61L2300/412 , A61L2430/06 , C07D491/18 , C07D493/08 , C12N5/0655 , C12N2501/999 , C12N2506/1346
摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds, and methods of using such compounds for treatment of joint damage or joint injury in a mammal, and for inducing differentiation of mesenchymal stem cells into chondrocytes.
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公开(公告)号：US06852754B1
公开(公告)日：2005-02-08
申请号：US10763993
申请日：2004-01-22
IPC分类号： C07D307/00 , A61K31/35 , C07D307/92
CPC分类号： C07D307/00
摘要： The subject invention provides novel compositions of biologically active linderazulene terpene compounds which can advantageously be used for treating cancer and stopping cell proliferation.
摘要翻译： 本发明提供了可以有利地用于治疗癌症和阻止细胞增殖的生物活性粘多菌萜烯化合物的新组合物。
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