公开(公告)号：US07090970B2

公开(公告)日：2006-08-15

申请号：US10475807

申请日：2002-12-03

Applicant: Hideo Anraku ,  Ryusuke Okamoto

Inventor： Hideo Anraku ,  Ryusuke Okamoto

IPC: A01N1/02 ,  C09K3/00 ,  G01N33/48 ,  B01D21/26

CPC classification number: G01N33/5002 ,  B01L3/50215 ,  B01L2300/12

Abstract: A composition for blood serum or plasma separation which has improved compatibility between a cyclopentadiene oligomer and a phthalic ester and generates no oily ingredient suspending in the blood serum or plasma after centrifugal separation regardless of the conditions for the centrifugal separation; and a vessel for blood examination which contains the composition. The composition for blood serum or plasma separation comprises: a polycyclic hydrocarbon compound having an unsaturated and/or saturated cyclic structure in the molecule and having a solidifying point or pour point of 0° C. or lower; a cyclopentadiene oligomer; and a phthalic ester.

Abstract translation: 一种用于血清或血浆分离的组合物，其具有改善环戊二烯低聚物和邻苯二甲酸酯之间的相容性，并且在离心分离后不产生悬浮在血清或血浆中的油性成分，而与离心分离条件无关; 和含有该组合物的血液检查用血管。 用于血清或血浆分离的组合物包括：分子中具有不饱和和/或饱和环状结构并具有0℃或更低的凝固点或倾点的多环烃化合物; 环戊二烯低聚物; 和邻苯二甲酸酯。

公开(公告)号：US06821785B1

公开(公告)日：2004-11-23

申请号：US10009683

申请日：2002-02-22

Applicant: Hideo Anraku ,  Ryusuke Okamoto

Inventor： Hideo Anraku ,  Ryusuke Okamoto

IPC: A61M532

CPC classification number: A61B5/154 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150351 ,  A61B5/150389 ,  A61B5/150496 ,  A61B5/150732 ,  B01L3/502 ,  B01L3/5082 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/0672 ,  B01L2300/0854 ,  B01L2400/0683

Abstract: The present invention has for its object to provide a vacuum sampling tube which is capable of preventing a pretreating reagent accommodated in the vacuum sampling tube from entering the blood vessel and the like even in the event of a backflow of a specimen, such as blood, during vacuum sampling, such as vacuum blood collecting, and a vacuum sampling method.

Abstract translation: 本发明的目的是提供一种真空采样管，其能够防止容纳在真空取样管中的预处理试剂即使在诸如血液的样品的回流的情况下也进入血管等， 在真空采样中，例如真空采血，以及真空采样方法。

公开(公告)号：US06565814B1

公开(公告)日：2003-05-20

申请号：US09622891

申请日：2000-08-30

Applicant: Hideo Anraku ,  Ryusuke Okamoto

Inventor： Hideo Anraku ,  Ryusuke Okamoto

IPC: B01L300

CPC classification number: B01L3/50825

Abstract: A closure structure is provided for a vacuum specimen collection container which can maintain a vacuum pressure within the specimen collection tube and which includes a needle cannula penetrating portion having needle hole sealability. The closure structure can be detachably fitted in an open end of a specimen collection container in an airtight manner to maintain a vacuum condition within the specimen collection container. The closure structure includes a grip section, a rubber elastic needle cannula penetrating portion disposed to fill up a through-hole in a grip section and a rubber elastic fitting portion configured to follow an interior surface profile of an open end of a specimen collection container, thereby to fit therein in a airtight fashion. The grip section has a higher rigidity relative to the needle cannula penetrating portion and the fitting portion. A tubular side wall of a grip section has on its inner side at least one raised portion or recessed portion to prevent kickback.

Abstract translation: 为真空样本采集容器提供封闭结构，其能够保持样品收集管内的真空压力，并且其包括具有针孔密封性的针插管穿透部分。 封闭结构可以以气密的方式可拆卸地装配在样本收集容器的开口端，以保持样本收集容器内的真空状态。 封闭结构包括握持部分，设置成填充握持部分中的通孔的橡胶弹性针插管穿透部分和构造成跟随样本收集容器的开口端的内表面轮廓的橡胶弹性配合部分， 从而以气密方式装配在其中。 握持部具有相对于针插管穿透部和配合部的更高的刚性。 把手部分的管状侧壁的内侧具有至少一个凸起部分或凹进部分，以防止反冲。

公开(公告)号：US5776357A

公开(公告)日：1998-07-07

申请号：US809421

申请日：1997-04-28

Applicant: Ryusuke Okamoto ,  Hideo Anraku

Inventor： Ryusuke Okamoto ,  Hideo Anraku

IPC: B01D17/02 ,  B01D21/00 ,  G01N33/48 ,  G01N33/49

CPC classification number: G01N33/491 ,  B01D17/0208 ,  B01D21/01 ,  G01N33/48 ,  B01D2221/10

Abstract: The present invention relates to a serum or plasma separating composition comprising an oligomer of cyclopentadiene, an organic gelling agent and a dispersant for the organic gelling agent. The organic gelling agent is a condensation product of sorbitol and an aromatic aldehyde. The dispersant for the organic gelling agent is a polyoxyethylene-polyoxypropylene block copolymer having HLB of 1.0 to 9.0. The invention provides a serum or plasma separating composition which does not give out a bad smell by sterilization with radiation, has no influence derived from hemolysis, etc. on biochemical examination values of serum or plasma, does not cause phase separation of components, and is equal to the prior art in serum or plasma separating property, preservation stability, etc. Furthermore, the invention provides a serum or plasma separating composition which hardly brings about flow during preservation by standing in a horizontal lying position and hardly exhibits impaired invertibility with the lapse of time.

Abstract translation: PCT No.PCT / JP96 / 02390 Sec。 371日期1997年04月28日 102（e）1997年4月28日PCT PCT 1996年8月26日PCT公布。 出版物WO97 / 08548 日本3月6日公开本发明涉及包含环戊二烯低聚物，有机胶凝剂和有机胶凝剂分散剂的血清或血浆分离组合物。 有机胶凝剂是山梨糖醇与芳族醛的缩合产物。 有机胶凝剂的分散剂是HLB为1.0〜9.0的聚氧乙烯 - 聚氧丙烯嵌段共聚物。 本发明提供一种血清或血浆分离组合物，其通过放射线灭菌不会产生不良气味，对血清或血浆的生物化学检查值没有影响来自溶血等，不会引起组分的相分离，并且是 等同于现有技术的血清或血浆分离性能，保存稳定性等。此外，本发明提供一种血清或血浆分离组合物，其通过在水平躺卧位置站立而几乎不会在保存期间产生流动，并且几乎不显示与经过的可逆性受损 的时间。

公开(公告)号：US20060175280A1

公开(公告)日：2006-08-10

申请号：US10564718

申请日：2004-07-16

Applicant: Hideo Anraku ,  Masahiro Nakaizumi ,  Mitsuru Naruta

Inventor： Hideo Anraku ,  Masahiro Nakaizumi ,  Mitsuru Naruta

IPC: B65D51/00 ,  B65D39/00 ,  B65D41/00 ,  A61B19/00

CPC classification number: B01L3/50825 ,  A61B5/15003 ,  A61B5/150274 ,  A61B5/150351 ,  A61B5/150389 ,  A61B5/150473 ,  A61B5/150572 ,  A61B5/150732 ,  B01L2200/0689 ,  B01L2300/042

Abstract: It is the object of the present invention to provide a sealed container which comprises a container comprising a thermoplastic resin and a stopper which is hardly slackening even when used in combination with the container, and a vacuum specimen-sampling container comprising the sealed container. The present invention is a sealed container, which comprises a container with an end being closed and the other end being open, comprising a thermoplastic resin, and a stopper being detachable and capable of sealing the open end of the container, the stopper having a head portion capable of being grasped, a leg portion A being extended downward from the head portion, being along an internal wall surface of the open end of the container, and being capable of exerting a fitting force to the internal wall surface, and a leg portion B being extended downward from the head portion, being along an external wall surface of the open end of the container, and being capable of exerting a fitting force to the external wall surface, and at least a portion of the leg portion B of the stopper contacting with the container and at least a portion of the container contacting with the leg portion A of the stopper having a deflection temperature under load of 60° C. or more under a load of 0.45 MPa or 0.46 MPa.

Abstract translation: 本发明的目的是提供一种密封容器，该密封容器包括一个包含热塑性树脂的容器和即使与该容器结合使用也几乎不松弛的塞子，以及包括该密封容器的真空样品取样容器。 本发明是一种密封容器，其包括端部封闭的容器，另一端是开口的，包括热塑性树脂，以及可拆卸并能够密封容器的开口端的止动件，止动件具有头部 能够被抓握的部分，从头部向下延伸的腿部A沿着容器的开口端的内壁表面，并且能够对内壁表面施加配合力，并且腿部 B从头部向下延伸，沿着容器的开口端的外壁表面延伸，并且能够对外壁表面施加配合力，并且止动件的腿部B的至少一部分 与容器接触，容器的至少一部分与止动件的腿部A接触，在0.45MPa或0的负荷下，负载挠曲温度为60℃以上 .46 MPa。

公开(公告)号：US06495367B1

公开(公告)日：2002-12-17

申请号：US09204052

申请日：1998-12-03

Applicant: Hironobu Isogawa ,  Hideo Anraku

Inventor： Hironobu Isogawa ,  Hideo Anraku

IPC: G01N3386

CPC classification number: C12Q1/56 ,  G01N33/5002 ,  G01N33/86 ,  Y10T436/108331

Abstract: A blood component deposition-preventing agent and a blood coagulation accelerator are provided, which are substantially indifferent to blood coagulation activity and serum chemistry parameters. Also provided is plastic blood test ware and a blood test matrix which do not confound measured values. A blood component deposition-preventing agent comprising a random copolymer of a monomer component (a) giving a water-soluble homopolymer and a monomer component (b) giving a water-insoluble homopolymer, a blood coagulation accelerator comprising a substantially blood-insoluble antimicrobial composition comprising a carrier and, as supported thereon, an antimicrobial metal, and a blood test ware or matrix carrying them on its inside wall or surface are provided.

Abstract translation: 提供了血液成分沉积防止剂和凝血促进剂，其基本上对凝血活性和血清化学参数无影响。 还提供塑料血液检测仪器和不会混淆测量值的血液测试基质。 一种含有赋予水溶性均聚物的单体成分（a）和赋予水不溶性均聚物的单体成分（b）的无规共聚物的血液成分防止剂，含有实质上不溶血的抗微生物组合物的凝血促进剂 包括载体，并且在其上支撑抗微生物金属，并且提供在其内壁或表面上承载它们的血液检验制品或基质。

公开(公告)号：US08623655B2

公开(公告)日：2014-01-07

申请号：US13320782

申请日：2011-01-25

Applicant: Hideo Anraku ,  Masatoshi Niunoya

Inventor： Hideo Anraku ,  Masatoshi Niunoya

IPC: B01D43/00

CPC classification number: G01N33/491 ,  C08G2650/58 ,  C08L71/02 ,  Y10T137/794 ,  Y10T436/106664 ,  Y10T436/25

Abstract: The invention provides a serum or plasma separating composition which can compensate for the lack of initial thixotropy even at a reduced inorganic powder concentration and in which crevices or the like are less likely to be created in a partition wall formed of the separating composition after being centrifuged. The serum or plasma separating composition contains a liquid resin component having a partition wall-forming capability, a hydrophilic inorganic powder, a hydrophobic inorganic powder, and an organic compound serving as a thixotropy enhancer, wherein the organic compound is a polyalkylene glycol and/or a derivative thereof and is made of at least one type of polymer.

Abstract translation: 本发明提供血清或血浆分离组合物，其即使在降低的无机粉末浓度下也可补偿初始触变性的缺乏，并且在离心后在分离组合物形成的分隔壁中不太可能产生裂缝等 。 血清或血浆分离组合物含有具有分隔壁形成能力的液体树脂组分，亲水性无机粉末，疏水性无机粉末和用作触变增强剂的有机化合物，其中有机化合物是聚亚烷基二醇和/或 其衍生物由至少一种类型的聚合物制成。

公开(公告)号：US4856533A

公开(公告)日：1989-08-15

申请号：US823437

申请日：1986-01-28

Applicant: Hideo Anraku ,  Yoshikata Shoji

Inventor： Hideo Anraku ,  Yoshikata Shoji

IPC: A61L31/10 ,  B01L3/14

CPC classification number: B01L3/5082 ,  A61L31/10

Abstract: A vacuum blood-collection tube comprising a tube-shaped vessel having an opening through which air can be removed, and a plug that makes the opening air-tight to maintain low-pressure conditions inside the said vessel, the raw materials of the said vessel being polyethyleneterephthalate, a copolymer of polyethyleneterephthalate, or an acrylonitrile resin, and the inner walls of said vessel incorporating a hydrophilic substance that is either difficult or impossible to dissolve in water and that prevent blood clots from adhering to the inner walls of said tube, a water-soluble substance, and a adsorptive inorganic substance.

Abstract translation: 一种真空采血管，其特征在于，具有管状容器，该管状容器具有能够除去空气的开口，以及使所述开口不透气以保持所述容器内的低压状态的塞子，所述容器的原料 作为聚对苯二甲酸乙二醇酯，聚对苯二甲酸乙二醇酯或丙烯腈树脂的共聚物和所述容器的内壁，其包含困难或不可能溶解在水中并且防止血块粘附到所述管的内壁的亲水性物质， 水溶性物质和吸附性无机物质。

公开(公告)号：US08642254B2

公开(公告)日：2014-02-04

申请号：US12302146

申请日：2007-05-25

Applicant: Hideo Anraku ,  Hiroaki Taira

Inventor： Hideo Anraku ,  Hiroaki Taira

IPC: A01N1/02 ,  B01D21/26 ,  G01N31/00

CPC classification number: G01N33/5002 ,  Y10T436/10

Abstract: Disclosed is a composition for the separation of a serum or plasma, which comprises a cyclopentadiene oligomer, can be used for separating a serum or plasma by utilizing the difference in specific gravity among blood components, and enables to provide a serum or plasma having no oily component floating therein after centrifugal separation. The composition comprises a trimellitic acid ester and/or a pyromellitate ester and a cyclopentadiene oligomer. Alternatively, the composition comprises an aromatic esterified compound and a cyclopentadiene oligomer as the main ingredients and additionally comprises an inorganic micropowder and an organic gelling agent as thixotropy-imparting agents, wherein the organic gelling agent is contained in an amount of less than 0.06 parts by weight relative to 100 parts by weight of the cyclopentadiene oligomer.

Abstract translation: 公开了一种用于分离包含环戊二烯低聚物的血清或血浆的组合物，其可用于通过利用血液成分之间的比重差异来分离血清或血浆，并且能够提供没有油性的血清或血浆 离心分离后其组分浮动。 组合物包含偏苯三酸酯和/或均苯四酸酯和环戊二烯低聚物。 或者，组合物包含芳族酯化化合物和环戊二烯低聚物作为主要成分，另外包含作为触变性赋予剂的无机微粉和有机胶凝剂，其中有机胶凝剂的含量小于0.06份 相对于100重量份的环戊二烯低聚物。

公开(公告)号：US07726498B2

公开(公告)日：2010-06-01

申请号：US10564718

申请日：2004-07-16

Applicant: Hideo Anraku ,  Masahiro Nakaizumi ,  Mitsuru Naruta

Inventor： Hideo Anraku ,  Masahiro Nakaizumi ,  Mitsuru Naruta

IPC: B65D39/00

CPC classification number: B01L3/50825 ,  A61B5/15003 ,  A61B5/150274 ,  A61B5/150351 ,  A61B5/150389 ,  A61B5/150473 ,  A61B5/150572 ,  A61B5/150732 ,  B01L2200/0689 ,  B01L2300/042

Abstract: It is the object of the present invention to provide a sealed container which comprises a container comprising a thermoplastic resin and a stopper which is hardly slackening even when used in combination with the container, and a vacuum specimen-sampling container comprising the sealed container.The present invention is a sealed container, which comprises a container with an end being closed and the other end being open, comprising a thermoplastic resin, and a stopper being detachable and capable of sealing the open end of the container, the stopper having a head portion capable of being grasped, a leg portion A being extended downward from the head portion, being along an internal wall surface of the open end of the container, and being capable of exerting a fitting force to the internal wall surface, and a leg portion B being extended downward from the head portion, being along an external wall surface of the open end of the container, and being capable of exerting a fitting force to the external wall surface, and at least a portion of the leg portion B of the stopper contacting with the container and at least a portion of the container contacting with the leg portion A of the stopper having a deflection temperature under load of 60° C. or more under a load of 0.45 MPa or 0.46 MPa.

Abstract translation: 本发明的目的是提供一种密封容器，该密封容器包括一个包含热塑性树脂的容器和即使与该容器结合使用也几乎不松弛的塞子，以及包括该密封容器的真空样品取样容器。 本发明是一种密封容器，其包括端部封闭的容器，另一端是开口的，包括热塑性树脂，以及可拆卸并能够密封容器的开口端的止动件，止动件具有头部 能够被抓握的部分，从头部向下延伸的腿部A沿着容器的开口端的内壁表面，并且能够对内壁表面施加配合力，并且腿部 B从头部向下延伸，沿着容器的开口端的外壁表面延伸，并且能够对外壁表面施加配合力，并且止动件的腿部B的至少一部分 与容器接触，容器的至少一部分与止动件的腿部A接触，在0.45MPa或0的负荷下，负载挠曲温度为60℃以上 .46 MPa。