公开(公告)号：US20060175280A1

公开(公告)日：2006-08-10

申请号：US10564718

申请日：2004-07-16

申请人： Hideo Anraku ,  Masahiro Nakaizumi ,  Mitsuru Naruta

发明人： Hideo Anraku ,  Masahiro Nakaizumi ,  Mitsuru Naruta

IPC分类号： B65D51/00 ,  B65D39/00 ,  B65D41/00 ,  A61B19/00

CPC分类号： B01L3/50825 ,  A61B5/15003 ,  A61B5/150274 ,  A61B5/150351 ,  A61B5/150389 ,  A61B5/150473 ,  A61B5/150572 ,  A61B5/150732 ,  B01L2200/0689 ,  B01L2300/042

摘要： It is the object of the present invention to provide a sealed container which comprises a container comprising a thermoplastic resin and a stopper which is hardly slackening even when used in combination with the container, and a vacuum specimen-sampling container comprising the sealed container. The present invention is a sealed container, which comprises a container with an end being closed and the other end being open, comprising a thermoplastic resin, and a stopper being detachable and capable of sealing the open end of the container, the stopper having a head portion capable of being grasped, a leg portion A being extended downward from the head portion, being along an internal wall surface of the open end of the container, and being capable of exerting a fitting force to the internal wall surface, and a leg portion B being extended downward from the head portion, being along an external wall surface of the open end of the container, and being capable of exerting a fitting force to the external wall surface, and at least a portion of the leg portion B of the stopper contacting with the container and at least a portion of the container contacting with the leg portion A of the stopper having a deflection temperature under load of 60° C. or more under a load of 0.45 MPa or 0.46 MPa.

摘要翻译： 本发明的目的是提供一种密封容器，该密封容器包括一个包含热塑性树脂的容器和即使与该容器结合使用也几乎不松弛的塞子，以及包括该密封容器的真空样品取样容器。 本发明是一种密封容器，其包括端部封闭的容器，另一端是开口的，包括热塑性树脂，以及可拆卸并能够密封容器的开口端的止动件，止动件具有头部 能够被抓握的部分，从头部向下延伸的腿部A沿着容器的开口端的内壁表面，并且能够对内壁表面施加配合力，并且腿部 B从头部向下延伸，沿着容器的开口端的外壁表面延伸，并且能够对外壁表面施加配合力，并且止动件的腿部B的至少一部分 与容器接触，容器的至少一部分与止动件的腿部A接触，在0.45MPa或0的负荷下，负载挠曲温度为60℃以上 .46 MPa。

公开(公告)号：US06495367B1

公开(公告)日：2002-12-17

申请号：US09204052

申请日：1998-12-03

申请人： Hironobu Isogawa ,  Hideo Anraku

发明人： Hironobu Isogawa ,  Hideo Anraku

IPC分类号： G01N3386

CPC分类号： C12Q1/56 ,  G01N33/5002 ,  G01N33/86 ,  Y10T436/108331

摘要： A blood component deposition-preventing agent and a blood coagulation accelerator are provided, which are substantially indifferent to blood coagulation activity and serum chemistry parameters. Also provided is plastic blood test ware and a blood test matrix which do not confound measured values. A blood component deposition-preventing agent comprising a random copolymer of a monomer component (a) giving a water-soluble homopolymer and a monomer component (b) giving a water-insoluble homopolymer, a blood coagulation accelerator comprising a substantially blood-insoluble antimicrobial composition comprising a carrier and, as supported thereon, an antimicrobial metal, and a blood test ware or matrix carrying them on its inside wall or surface are provided.

摘要翻译： 提供了血液成分沉积防止剂和凝血促进剂，其基本上对凝血活性和血清化学参数无影响。 还提供塑料血液检测仪器和不会混淆测量值的血液测试基质。 一种含有赋予水溶性均聚物的单体成分（a）和赋予水不溶性均聚物的单体成分（b）的无规共聚物的血液成分防止剂，含有实质上不溶血的抗微生物组合物的凝血促进剂 包括载体，并且在其上支撑抗微生物金属，并且提供在其内壁或表面上承载它们的血液检验制品或基质。

公开(公告)号：US08642254B2

公开(公告)日：2014-02-04

申请号：US12302146

申请日：2007-05-25

申请人： Hideo Anraku ,  Hiroaki Taira

发明人： Hideo Anraku ,  Hiroaki Taira

IPC分类号： A01N1/02 ,  B01D21/26 ,  G01N31/00

CPC分类号： G01N33/5002 ,  Y10T436/10

摘要： Disclosed is a composition for the separation of a serum or plasma, which comprises a cyclopentadiene oligomer, can be used for separating a serum or plasma by utilizing the difference in specific gravity among blood components, and enables to provide a serum or plasma having no oily component floating therein after centrifugal separation. The composition comprises a trimellitic acid ester and/or a pyromellitate ester and a cyclopentadiene oligomer. Alternatively, the composition comprises an aromatic esterified compound and a cyclopentadiene oligomer as the main ingredients and additionally comprises an inorganic micropowder and an organic gelling agent as thixotropy-imparting agents, wherein the organic gelling agent is contained in an amount of less than 0.06 parts by weight relative to 100 parts by weight of the cyclopentadiene oligomer.

摘要翻译： 公开了一种用于分离包含环戊二烯低聚物的血清或血浆的组合物，其可用于通过利用血液成分之间的比重差异来分离血清或血浆，并且能够提供没有油性的血清或血浆 离心分离后其组分浮动。 组合物包含偏苯三酸酯和/或均苯四酸酯和环戊二烯低聚物。 或者，组合物包含芳族酯化化合物和环戊二烯低聚物作为主要成分，另外包含作为触变性赋予剂的无机微粉和有机胶凝剂，其中有机胶凝剂的含量小于0.06份 相对于100重量份的环戊二烯低聚物。

公开(公告)号：US07726498B2

公开(公告)日：2010-06-01

申请号：US10564718

申请日：2004-07-16

申请人： Hideo Anraku ,  Masahiro Nakaizumi ,  Mitsuru Naruta

发明人： Hideo Anraku ,  Masahiro Nakaizumi ,  Mitsuru Naruta

IPC分类号： B65D39/00

CPC分类号： B01L3/50825 ,  A61B5/15003 ,  A61B5/150274 ,  A61B5/150351 ,  A61B5/150389 ,  A61B5/150473 ,  A61B5/150572 ,  A61B5/150732 ,  B01L2200/0689 ,  B01L2300/042

摘要： It is the object of the present invention to provide a sealed container which comprises a container comprising a thermoplastic resin and a stopper which is hardly slackening even when used in combination with the container, and a vacuum specimen-sampling container comprising the sealed container.The present invention is a sealed container, which comprises a container with an end being closed and the other end being open, comprising a thermoplastic resin, and a stopper being detachable and capable of sealing the open end of the container, the stopper having a head portion capable of being grasped, a leg portion A being extended downward from the head portion, being along an internal wall surface of the open end of the container, and being capable of exerting a fitting force to the internal wall surface, and a leg portion B being extended downward from the head portion, being along an external wall surface of the open end of the container, and being capable of exerting a fitting force to the external wall surface, and at least a portion of the leg portion B of the stopper contacting with the container and at least a portion of the container contacting with the leg portion A of the stopper having a deflection temperature under load of 60° C. or more under a load of 0.45 MPa or 0.46 MPa.

摘要翻译： 本发明的目的是提供一种密封容器，该密封容器包括一个包含热塑性树脂的容器和即使与该容器结合使用也几乎不松弛的塞子，以及包括该密封容器的真空样品取样容器。 本发明是一种密封容器，其包括端部封闭的容器，另一端是开口的，包括热塑性树脂，以及可拆卸并能够密封容器的开口端的止动件，止动件具有头部 能够被抓握的部分，从头部向下延伸的腿部A沿着容器的开口端的内壁表面，并且能够对内壁表面施加配合力，并且腿部 B从头部向下延伸，沿着容器的开口端的外壁表面延伸，并且能够对外壁表面施加配合力，并且止动件的腿部B的至少一部分 与容器接触，容器的至少一部分与止动件的腿部A接触，在0.45MPa或0的负荷下，负载挠曲温度为60℃以上 .46 MPa。

公开(公告)号：US07090970B2

公开(公告)日：2006-08-15

申请号：US10475807

申请日：2002-12-03

申请人： Hideo Anraku ,  Ryusuke Okamoto

发明人： Hideo Anraku ,  Ryusuke Okamoto

IPC分类号： A01N1/02 ,  C09K3/00 ,  G01N33/48 ,  B01D21/26

CPC分类号： G01N33/5002 ,  B01L3/50215 ,  B01L2300/12

摘要： A composition for blood serum or plasma separation which has improved compatibility between a cyclopentadiene oligomer and a phthalic ester and generates no oily ingredient suspending in the blood serum or plasma after centrifugal separation regardless of the conditions for the centrifugal separation; and a vessel for blood examination which contains the composition. The composition for blood serum or plasma separation comprises: a polycyclic hydrocarbon compound having an unsaturated and/or saturated cyclic structure in the molecule and having a solidifying point or pour point of 0° C. or lower; a cyclopentadiene oligomer; and a phthalic ester.

摘要翻译： 一种用于血清或血浆分离的组合物，其具有改善环戊二烯低聚物和邻苯二甲酸酯之间的相容性，并且在离心分离后不产生悬浮在血清或血浆中的油性成分，而与离心分离条件无关; 和含有该组合物的血液检查用血管。 用于血清或血浆分离的组合物包括：分子中具有不饱和和/或饱和环状结构并具有0℃或更低的凝固点或倾点的多环烃化合物; 环戊二烯低聚物; 和邻苯二甲酸酯。

公开(公告)号：US5041558A

公开(公告)日：1991-08-20

申请号：US36886

申请日：1987-04-10

申请人： Hideo Anraku

发明人： Hideo Anraku

IPC分类号： C07F5/06 ,  C07F15/02 ,  C07F15/04 ,  C07F15/06 ,  C12Q1/56

CPC分类号： C12Q1/56 ,  C07F15/025 ,  C07F15/045 ,  C07F15/065 ,  C07F5/069 ,  G01N2333/96458 ,  Y10S514/802

摘要： An accelerator of the activity of hydrolase consisting of a coordination compound or a metal complex containing, as a ligand, an organic cyclic compound with carbonyl groups adjacent to each other in the structure shown in the following general formula I that are substantially in the same plane as each other; ##STR1## (wherein A is the cyclic compound moiety.)

摘要翻译： 在由以下通式I所示的结构基本上位于同一平面中的由配位化合物或含有作为配体的具有羰基相邻的有机环状化合物的配位化合物或金属络合物组成的水解酶活性的促进剂 作为对方; （I）（其中A是环状化合物部分。

公开(公告)号：US20090146099A1

公开(公告)日：2009-06-11

申请号：US12302146

申请日：2007-05-25

申请人： Hideo Anraku ,  Hiroaki Taira

发明人： Hideo Anraku ,  Hiroaki Taira

IPC分类号： B03D3/00

CPC分类号： G01N33/5002 ,  Y10T436/10

摘要： Disclosed is a composition for the separation of a serum or plasma, which comprises a cyclopentadiene oligomer, can be used for separating a serum or plasma by utilizing the difference in specific gravity among blood components, and enables to provide a serum or plasma having no oily component floating therein after centrifugal separation. The composition comprises a trimellitic acid ester and/or a pyromellitate ester and a cyclopentadiene oligomer. Alternatively, the composition comprises an aromatic esterified compound and a cyclopentadiene oligomer as the main ingredients and additionally comprises an inorganic micropowder and an organic gelling agent as thixotropy-imparting agents, wherein the organic gelling agent is contained in an amount of less than 0.06 parts by weight relative to 100 parts by weight of the cyclopentadiene oligomer.

摘要翻译： 公开了用于分离包含环戊二烯低聚物的血清或血浆的组合物，其可以通过利用血液成分之间的比重差异来分离血清或血浆，并且能够提供没有油性的血清或血浆 离心分离后其组分浮动。 组合物包含偏苯三酸酯和/或均苯四酸酯和环戊二烯低聚物。 或者，组合物包含芳族酯化化合物和环戊二烯低聚物作为主要成分，另外包含作为触变性赋予剂的无机微粉和有机胶凝剂，其中有机胶凝剂的含量小于0.06份 相对于100重量份的环戊二烯低聚物。

公开(公告)号：US5888824A

公开(公告)日：1999-03-30

申请号：US648132

申请日：1996-07-05

申请人： Hironobu Isogawa ,  Hideo Anraku

发明人： Hironobu Isogawa ,  Hideo Anraku

IPC分类号： C12Q1/56 ,  G01N33/50 ,  G01N33/86 ,  G01N33/48

CPC分类号： C12Q1/56 ,  G01N33/5002 ,  G01N33/86 ,  Y10T436/108331

摘要： This invention has for its object to provide a blood component deposition-preventing agent and a blood coagulation accelerator, which are substantially indifferent to blood coagulation activity and serum chemistry parameters and a plastic blood test ware and a blood test matrix which do not confound measured values. The invention relates to a blood component deposition-preventing agent comprising a random copolymer of a monomer component (a) giving a water-soluble homopolymer and a monomer component (b) giving a water-insoluble homopolymer, a blood coagulation accelerator comprising a substantially blood-insoluble antimicrobial composition comprising a carrier and, as supported thereon, an antimicrobial metal, and a blood test ware or matrix carrying them on its inside wall or surface.

摘要翻译： PCT No.PCT / JP95 / 00461 Sec。 371日期：1996年7月5日第 102（e）日期1996年7月5日PCT 1995年3月17日PCT公布。 第WO96 / 09541号公报 日本特开1996年3月28日本发明的目的在于提供一种对血液凝固活性和血液化学参数基本无影响的血液成分沉积防止剂和凝血促进剂，以及塑料血液试验用品和血液试验用基质， 不要混淆测量值。 本发明涉及含有赋予水溶性均聚物的单体成分（a）和赋予水不溶性均聚物的单体成分（b）的无规共聚物的血液成分防止剂，含有大致血液的凝血促进剂 - 不溶性抗微生物组合物，其包含载体和支撑在其上的抗微生物金属，以及在其内壁或表面上携带它们的血液检验制品或基质。

公开(公告)号：US5510237A

公开(公告)日：1996-04-23

申请号：US391262

申请日：1995-02-21

申请人： Hironobu Isogawa ,  Hideo Anraku

发明人： Hironobu Isogawa ,  Hideo Anraku

IPC分类号： G01N33/49 ,  G01N33/50 ,  A01N1/02 ,  C09K3/00

CPC分类号： G01N33/5002 ,  G01N33/491

摘要： The invention provides a serum or plasma separating composition which comprises a cyclopentadiene resin, a viscosity adjusting agent and an organic gelling agent. The composition is characterized in that the cyclopentadiene resin is a liquid resin at a temperature of 25.degree. C., the viscosity adjusting agent being a liquid ester obtained from propionic acid, butyric acid, benzoic acid or phthalic acid, the organic gelling agent being a condensation product of sorbitol and an aromatic aldehyde, the composition containing 0.8 to 25 parts by weight of the viscosity adjusting agent and 0.03 to 0.9 part by weight of the organic gelling agent per 100 parts by weight of the cyclopentadiene resin. The composition forms a satisfactory separating layer even when subjected to a centrifugal separation operation at a set temperature of 4.degree. C.

摘要翻译： 本发明提供血清或血浆分离组合物，其包含环戊二烯树脂，粘度调节剂和有机胶凝剂。 该组合物的特征在于环戊二烯树脂是25℃温度下的液体树脂，粘度调节剂是由丙酸，丁酸，苯甲酸或邻苯二甲酸得到的液体酯，有机胶凝剂为 山梨糖醇与芳香醛缩合产物，该组合物含有0.8-25重量份的粘度调节剂和每100重量份环戊二烯树脂为0.03至0.9重量份的有机胶凝剂。 即使在4℃的设定温度下进行离心分离操作，该组合物形成令人满意的分离层。

公开(公告)号：US5413786A

公开(公告)日：1995-05-09

申请号：US135755

申请日：1993-10-13

申请人： Hideo Anraku

发明人： Hideo Anraku

IPC分类号： C07F5/06 ,  C07F15/02 ,  C07F15/04 ,  C07F15/06 ,  C12Q1/56 ,  A61K38/43 ,  A01N43/16 ,  A61K31/295

CPC分类号： C12Q1/56 ,  C07F15/025 ,  C07F15/045 ,  C07F15/065 ,  C07F5/069 ,  G01N2333/96458 ,  Y10S514/802

摘要： Blood coagulation is accelerated by contacting blood with an accelerator of hydrolase activity. The activation of the precursors of serine protease including Factor XII and the enzyme activity of serine protease is accelerated. The accelerator is a metal complex containing a ligand which is a cyclic compound having a five- or six-membered ring containing carbonyl groups adjacent to each other. Examples of such ligands are oxidized alkylgallate, partially or totally oxidized ellagic acid, partially or completely oxidized 1,4- di(3,4-dihydroxyphenyl) 2,3-dimethylbutane, 1,2,3-triketohydroindene and isatin. The metal of the complex is preferably Fe, Co, Ni, or Al. The complex may be combined with a hydrolase as a co-accelerator of coagulation, an organic acid having an amino salt and/or a quaternary nitrogen or an antifibrinolysis agent and/or an anti-plasmin agent.

摘要翻译： 通过使血液与水解酶活性的促进剂接触来加速血液凝固。 促进丝氨酸蛋白酶前体的活化，包括因子XII和丝氨酸蛋白酶的酶活性。 加速剂是含有配体的金属络合物，该配体是具有彼此相邻的含有羰基的五元或六元环的环状化合物。 这种配体的实例是氧化的烷基镓酸盐，部分或全部氧化的鞣花酸，部分或完全氧化的1,4-二（3,4-二羟基苯基）2,3-二甲基丁烷，1,2,3-三氯代氢茚和靛红。 络合物的金属优选为Fe，Co，Ni或Al。 络合物可以与作为凝结剂的共促进剂的水解酶，具有氨基盐和/或季氮的有机酸或抗纤维蛋白溶解剂和/或抗纤维蛋白溶酶剂组合。