公开(公告)号：US5077010A

公开(公告)日：1991-12-31

申请号：US219011

申请日：1988-07-14

申请人： Hideo Ishizaka ,  Yoshio Saito ,  Yukihide Miyata ,  Takashi Koizumi ,  Yasuhiro Asai ,  Shinichi Nakama ,  Tadashi Uekusa ,  Shinichi Matsuda ,  Koichi Yamada

发明人： Hideo Ishizaka ,  Yoshio Saito ,  Yukihide Miyata ,  Takashi Koizumi ,  Yasuhiro Asai ,  Shinichi Nakama ,  Tadashi Uekusa ,  Shinichi Matsuda ,  Koichi Yamada

IPC分类号： B01L3/00 ,  G01N35/00 ,  G01N35/10

CPC分类号： B01L3/505 ,  G01N35/00009 ,  G01N2035/00455 ,  G01N2035/00673 ,  G01N2035/00752 ,  G01N2035/1025

摘要： A long-test-film cassette for biochemical analysis comprises an unused film cassette part accommodating an unused long test film for biochemical analysis, and a used film cassette part for accommodating the long test film which has been pulled out of the unused film cassette part and used for biochemical analysis. A leading edge of the film is secured to a reel in the used film cassette part. In a cassette loading system, the unused film cassette part is provided with a protruded test film outlet portion and is loaded to a refrigerating compartment of an analysis apparatus with the test film outlet portion fitted in a hole of the refrigerating compartment.

公开(公告)号：US5094816A

公开(公告)日：1992-03-10

申请号：US715697

申请日：1991-06-17

申请人： Hideo Ishizaka ,  Shinichi Nakama ,  Tadashi Uekusa ,  Yoshio Saito ,  Yukihide Miyata ,  Takashi Koizumi

发明人： Hideo Ishizaka ,  Shinichi Nakama ,  Tadashi Uekusa ,  Yoshio Saito ,  Yukihide Miyata ,  Takashi Koizumi

IPC分类号： G01N35/00 ,  G01N35/10

CPC分类号： G01N35/00009 ,  G01N33/48764 ,  G01N2035/00455 ,  G01N2035/00752 ,  G01N2035/1025 ,  Y10S435/808 ,  Y10T436/110833 ,  Y10T436/113332

摘要： A biochemical analysis apparatus for applying a liquid sample onto a long test film, incubating the sample-applied film portion by an incubator, and measuring the degree of color formation at the sample-applied portion comprises a test film conveyor for continuously conveying at least the part of the long test film inside of the incubator so that a speed v [cm/min.] at which the part of the long test film inside of the incubator is conveyed is expressed as v=n.l. The incubator is constituted so that a length L [cm] of the incubator in the direction of conveyance of the long test film satisfies the condition of L.gtoreq.(nt+1).l, where l [cm] denotes the length of a portion of the long test film necessary for a single step of sample application, t [min.] denotes the incubation time, and n [number/min.] denotes the number of repetitions of sample application per unit time.

公开(公告)号：US5004582A

公开(公告)日：1991-04-02

申请号：US219027

申请日：1988-07-14

申请人： Yukihide Miyata ,  Hideo Ishizaka ,  Yoshio Saito ,  Takashi Koizumi

发明人： Yukihide Miyata ,  Hideo Ishizaka ,  Yoshio Saito ,  Takashi Koizumi

IPC分类号： B01L7/00 ,  G01N35/00 ,  G01N35/10

CPC分类号： G01N35/00009 ,  B01L7/00 ,  G01N2035/00455 ,  G01N2035/00752 ,  G01N2035/1025

摘要： A biochemical analysis apparatus comprises a sample accommodating region, a refrigerator for keeping cool a long test film containing a reagent which reacts with a liquid sample to give rise to a change in optical density, and a test film conveyor for sequentially pulling out the long test film from the refrigerator. A sample applicator takes up the liquid sample from the sample accommodating region and applies it to the long test film at the position to which the long test film has been pulled out of the refrigerator. An incubator maintains the sample-applied portion of the long test film at a predetermined temperature for a predetermined time. A detector irradiates light to the sample-applied portion of the long test film, and measures the optical density given rise to by the reaction during or after the passage of the predetermined time.

摘要翻译： 生物化学分析装置包括样品容纳区域，用于保持冷却包含与液体样品反应以产生光密度变化的试剂的长试验膜的冰箱，以及用于顺次拔出长试验的试片输送机 电影从冰箱。 样品涂布器从样品容纳区域吸取液体样品，并将其在长测试膜从冰箱中拉出的位置处施加到长测试膜。 培养箱将预定时间的长测试膜的样品施加部分保持在预定温度。 检测器将光照射到长测试膜的样品施加部分，并测量通过预定时间期间或之后由反应引起的光密度。

公开(公告)号：US5169600A

公开(公告)日：1992-12-08

申请号：US587492

申请日：1990-09-21

申请人： Hideo Ishizaka ,  Yukihide Miyata ,  Yoshio Saito ,  Koichi Yamada

发明人： Hideo Ishizaka ,  Yukihide Miyata ,  Yoshio Saito ,  Koichi Yamada

IPC分类号： G01N35/00 ,  G01N35/10

CPC分类号： G01N35/00009 ,  G01N33/48764 ,  G01N2035/00455 ,  G01N2035/00752 ,  G01N2035/1025 ,  Y10S435/809 ,  Y10T436/110833

摘要： A biochemical analysis apparatus comprises a sample accommodating region, an accommodating region for test films containing a reagent which reacts with a liquid sample to give rise to a change in optical density, and a conveyor for sequentially pulling out each test film from the test film accommodating region. An applicator takes up the liquid sample from the sample accommodating region and applies it to the test film at the position to which the test film has been pulled out. An incubator incubates the sample-applied film portion for a predetermined time, and a detector measures the optical density of the sample-applied film portion during or after the passage of the predetermined time. The conveyor, the incubator and the detector are provided to correspond to each of the test films, and a movement device moves the applicator to apply the liquid sample to the test films.

摘要翻译： 生物化学分析装置包括样品容纳区域，包含与液体样品反应以产生光密度变化的试剂的测试膜的容纳区域和用于从测试膜容纳的顺序地拉出每个测试膜的传送器 地区。 涂抹器从样品容纳区域取出液体样品，并在测试膜被拉出的位置将其施加到测试膜上。 孵育器将样品施加膜部分保温预定时间，并且检测器测量在预定时间过程中或之后的样品施加膜部分的光密度。 提供输送机，培养箱和检测器以对应于每个测试膜，并且移动装置移动施加器以将液体样品施加到测试膜。

公开(公告)号：US5122343A

公开(公告)日：1992-06-16

申请号：US617293

申请日：1990-11-19

申请人： Hideo Ishizaka ,  Yukihide Miyata ,  Yoshio Saito ,  Kiyoshi Yamada

发明人： Hideo Ishizaka ,  Yukihide Miyata ,  Yoshio Saito ,  Kiyoshi Yamada

IPC分类号： G01N35/00 ,  G01N35/10

CPC分类号： G01N35/00009 ,  G01N33/48764 ,  G01N2035/00455 ,  G01N2035/00752 ,  G01N2035/1025 ,  Y10T436/110833

摘要： A biochemical analysis apparatus includes a sample accommodating region, an accommodating region for test films containing a reagent which reacts with a liquid sample to give rise to a change in optical density, and a conveyor for sequentially pulling out each test film from the test film accommodating region. An applicator takes up the liquid sample fromt he sample accommodating region and applies it to the test film at the position to which the test film has been pulled out. An incubator incubates the sample-applied film portion for a predetermined time, and a detector measures the optical density of the sample applied applied film portion during or after the passage of the predetermined time. The conveyor, the incubator and the detector are provided to correspond to each of the test films, and a movement device moves the applicator to apply the liquid sample to the test films.

公开(公告)号：US4959976A

公开(公告)日：1990-10-02

申请号：US444906

申请日：1989-12-04

申请人： Shinichi Matsuda ,  Yoshio Saito ,  Hideo Ishizaka

发明人： Shinichi Matsuda ,  Yoshio Saito ,  Hideo Ishizaka

IPC分类号： F25B21/02 ,  G01N35/00 ,  F25D23/12 ,  G01N31/00

CPC分类号： F25B21/02 ,  G01N35/00009 ,  G01N2035/00277 ,  G01N2035/00445 ,  G01N2035/00455

摘要： A refrigerator comprises a cassette accommodating section which is enclosed by a wall, kept at a low temperature, and capable of accommodating a film feed cassette in such a way that it can be released therefrom. The film feed cassette houses therein a long test film containing a reagent which will react with a liquid sample and give rise to a change in optical density. The film feed cassette has a film outlet through which the long test film is fed out. The refrigerator has a film outlet which is formed in the wall at a position corresponding to the position of the film outlet of the film feed cassette and through which the long test film is pulled out. An air stream jetting system jets dry air to the surface of the portion of the long test film positioned between the film outlet of the film feed cassette and the film outlet of the refrigerator. The air stream jetting system comprises a device wherein two air drying chambers are alternately operated, which allows dry air to be generated approximately continuously, and wet air does not enter a dry air feed-out path even for an instant.

摘要翻译： 一种冰箱包括一个由墙壁封闭的盒子，该盒子保持在低温，并且能够以这样一种方式容纳一个胶片供给盒，使得它可以被释放。 胶片馈送盒中装有长试纸，该试片含有将与液体样品反应并引起光密度变化的试剂。 胶片进纸盒具有胶片出口，长的测试胶片通过胶片出口送出。 冰箱具有薄膜出口，该薄膜出口形成在与薄膜供给盒的薄膜出口的位置相对应的位置的壁中，长的测试薄膜被拉出。 空气流喷射系统将干燥空气喷射到位于胶片供给盒的胶片出口和冰箱的胶片出口之间的长测试胶片部分的表面。 空气流喷射系统包括一种装置，其中两个空气干燥室交替地操作，这允许大致连续地产生干燥空气，并且湿空气即使在瞬间也不会进入干燥空气排出通道。

公开(公告)号：US5096828A

公开(公告)日：1992-03-17

申请号：US680792

申请日：1991-04-03

申请人： Hideo Ishizaka ,  Yukihide Miyata

发明人： Hideo Ishizaka ,  Yukihide Miyata

IPC分类号： G01N35/00 ,  G01N35/10

CPC分类号： G01N35/00009 ,  G01N2035/00435 ,  G01N2035/00445 ,  G01N2035/00455 ,  G01N35/00712 ,  G01N35/1083 ,  Y10T436/110833

摘要： A biochemical analysis method comprises the steps of accommodating a long test film in a refrigerator, repeatedly pulling the long test film out of the refrigerator until a sample-applying portion, i.e., the next unused portion of the test film, is aligned with a sample applying position, applying a liquid samples onto the sample-applying portions of the long test film at which time the sample-applying portions become sample-applied portions, incubating the sample-applied portions, and irradiating light to the sample-applied portions in order to determine optical densities, which depend on the how much of a certain constituent in a liquid sample existed and therefore reacted with a reagent in a reagent layer of the test film. The length of a sample-applying portion to which a present sample will be applied, is changed in accordance with conditions which exist after the analysis of the sample applied to the test film immediately prior to the present sample has been finished. Alternatively, nearly the whole sample-applying portion that was positioned upstream from the sample-applied portion is pulled back into the refrigerator after the above mentioned measurement of the optical density is completed, and is pulled out prior to the next application of a sample so that the sample-applying portion positioned in the refrigerator is brought to the sample applying position.

摘要翻译： 生物化学分析方法包括以下步骤：在冰箱中容纳长的测试薄膜，将长的测试薄膜反复拉出冰箱，直到样品施加部分，即测试薄膜的下一未使用部分与样品 施加位置，将液体样品施加到长测试膜的样品施加部分上，此时样品施加部分成为样品施加部分，孵育样品施加部分，并按顺序向样品施加部分照射光 以确定光密度，其取决于存在液体样品中的某些成分的多少，并因此与测试膜的试剂层中的试剂反应。 根据在本样品完成前立即对施加到测试膜上的样品进行分析之后存在的条件来改变要施加本样品的样品施加部分的长度。 或者，在上述光密度的测量完成之后，位于样品施加部分上游的几乎整个样品施加部分被拉回到冰箱中，并且在下一次施加样品之前被拉出 将位于冰箱中的样品施加部分带到样品施加位置。

公开(公告)号：US4954319A

公开(公告)日：1990-09-04

申请号：US284638

申请日：1988-12-15

申请人： Takashi Koizumi ,  Hideo Ishizaka

发明人： Takashi Koizumi ,  Hideo Ishizaka

IPC分类号： G01N35/00

CPC分类号： G01N35/00009 ,  G01N2035/00445 ,  G01N2035/00455 ,  Y10T436/110833

摘要： A new mechanism for supplying in sequence unused regions of an analytical tape by predetermined length to an analytical section arranged in an apparatus for biochemical analysis of a liquid sample is disclosed. The mechanism comprises a driving means for moving the analytical tape to supply its unused regions to the analytical section; a means for detecting length of the unused regions of the tape supplied to the analytical section comprising a roller which is arranged in contact with a surface of the tape so that it rotates with movement of the tape for the supply of the unused regions to the analytical section and a means for detecting number or angle of the rotation of the roller, and a means for controlling operation of the driving means according to the detected number or angle of the rotation of the roller.

摘要翻译： 公开了一种用于将分析带的未使用区域预定长度提供给布置在用于液体样品的生物化学分析的装置中的分析部分的新机制。 该机构包括用于移动分析带以将其未使用的区域供应到分析部分的驱动装置; 用于检测供应到分析部分的带的未使用区域的长度的装置，包括布置成与带的表面接触的辊，使得其随着带的移动而旋转以便将未使用区域供应到分析 以及用于检测辊的旋转数量或角度的装置，以及用于根据检测到的辊的旋转数量或角度来控制驱动装置的操作的装置。

公开(公告)号：US5139743A

公开(公告)日：1992-08-18

申请号：US526960

申请日：1990-05-22

申请人： Hideo Ishizaka ,  Yoshio Saito

发明人： Hideo Ishizaka ,  Yoshio Saito

IPC分类号： G01N35/00 ,  G01N35/04 ,  G01N35/10

CPC分类号： G01N35/00663 ,  G01N33/48764 ,  G01N35/00009 ,  G01N2035/00019 ,  G01N2035/00039 ,  G01N2035/00435 ,  G01N2035/00445 ,  G01N2035/00455 ,  G01N2035/00673 ,  G01N2035/00752 ,  G01N2035/0441 ,  G01N2035/1025 ,  G01N35/1083 ,  Y10T436/110833

摘要： A biochemical analysis apparatus comprises a sample accommodating region, an accommodating region for a test film reacting with a liquid sample to give rise to a change, and a conveyor for sequentially pulling out the test film from the test film accommodating region. An applicator takes up the liquid sample from the sample accommodating region and applies it to the test film at the position to which the test film has been pulled out. An incubator incubates the sample-applied film portion for a predetermined time, and a measuring device measures the change at the sample-applied film portion during or after the passage of the predetermined time. Both the incubator and the measuring device are provided at the position where the sample application onto the test film is carried out by the sample application means.

摘要翻译： 生物化学分析装置包括样品容纳区域，用于与液体样品反应以产生变化的测试膜的容纳区域和用于从测试膜容纳区域顺序地拉出测试膜的输送器。 涂抹器从样品容纳区域取出液体样品，并在测试膜被拉出的位置将其施加到测试膜上。 孵育器将样品施加膜部分孵育预定时间，并且测量装置测量在预定时间过程中或之后的样品施加膜部分处的变化。 孵育器和测量装置均设置在由样品施加装置进行到试片上的样品施加的位置。

公开(公告)号：US4751377A

公开(公告)日：1988-06-14

申请号：US947221

申请日：1986-12-29

申请人： Hideo Ishizaka ,  Yuji Ohara

发明人： Hideo Ishizaka ,  Yuji Ohara

IPC分类号： G01N21/59 ,  H04N1/401 ,  H04N1/407 ,  H04N1/23

CPC分类号： H04N1/4015 ,  G01N21/5911 ,  H04N1/4078

摘要： In a light beam scanning recording apparatus, a light beam is modulated by a modulator according to image signals and is caused to scan a photosensitive recording material, and the recording material is developed. The apparatus is provided with a signal converting section which converts image signals to be input into the modulator according to a predetermined conversion table so that desired image densities can be obtained on the recording material, a test pattern signal generating section which generates test pattern signals bearing thereon different image densities and inputs them into the modulator, an image density measuring system which measures the image densities of the test pattern on the recording material developed after scanning by a light beam modulated according to the test pattern signals, and a conversion table making section which determines, on the basis of the relation between the test pattern signals and the image densities of the test pattern measured by the image density measuring system and desired image signal-image density characteristics, the image signals corresponding to the image densities obtained by the respective test pattern signals referring to the desired image signal-image density characteristics, thereby obtaining the relation between the image signals and the test pattern signals, and makes the conversion table on the basis of the relation between the image signals and the test pattern signal.

摘要翻译： 在光束扫描记录装置中，根据图像信号由调制器调制光束，并且对光敏记录材料进行扫描，并且显影记录材料。 该装置设置有信号转换部分，该信号转换部分根据预定的转换表转换要输入到调制器的图像信号，从而可以在记录材料上获得期望的图像密度;测试图案信号产生部分， 在其上具有不同的图像密度并将其输入到调制器中，图像浓度测量系统，其测量通过根据测试图案信号调制的光束在扫描之后显影的记录材料上的测试图案的图像密度，以及转换表制作部分 其基于测试图案信号与由图像浓度测量系统测量的测试图案的图像浓度和期望的图像信号 - 图像密度特性之间的关系，确定与由各个图像信号获得的图像密度相对应的图像信号 参考所需图像的测试图案信号 信号图像浓度特性，从而获得图像信号和测试图案信号之间的关系，并且基于图像信号和测试图案信号之间的关系进行转换表。