公开(公告)号：US20100048666A1

公开(公告)日：2010-02-25

申请号：US12440540

申请日：2007-09-10

申请人： Hideo Kato ,  Osamu Nagata ,  Yoshiyuki Iwabuchi ,  Takahiro Sato ,  Junichiro Uda ,  Tutomu Inoue ,  Hiroshi Nakamura ,  Nobuhide Kawasaki ,  Ippei Tanaka ,  Naoki Kurita ,  Tomohiko Ishikawa

发明人： Hideo Kato ,  Osamu Nagata ,  Yoshiyuki Iwabuchi ,  Takahiro Sato ,  Junichiro Uda ,  Tutomu Inoue ,  Hiroshi Nakamura ,  Nobuhide Kawasaki ,  Ippei Tanaka ,  Naoki Kurita ,  Tomohiko Ishikawa

IPC分类号： A61K31/382 ,  C07D335/02 ,  A61K31/381 ,  C07D333/38 ,  C07D333/32 ,  A61P13/02 ,  A61P13/08 ,  A61P13/10 ,  A61P3/10 ,  A61P35/00

CPC分类号： C07D335/02 ,  C07D333/24 ,  C07D333/28 ,  C07D333/32 ,  C07D333/38 ,  C07D333/48

摘要： A compound represented by the formula (1) or a salt thereof ( represents a single bond, or a double bond; R1 represents hydrogen atom, or an alkyl group; R2 and R3 represent hydrogen atom, or an alkyl group; R4 and R5 represent hydrogen atom, hydroxy group, an alkoxyl group, a halogen atom, or a mono- or di-alkyl-substituted amino group; R6 represents hydrogen atom, cyano group, an alkoxycarbonyl group, or carboxy group; R7 represents one or two of substituents on the benzene ring (the substituents are selected from hydrogen atom, a halogen atom, nitro group, cyano group, hydroxy group, amino group, an alkyl group, and an alkoxyl group); A represents a 5-membered or 6-membered non-aromatic heterocyclic ring containing one or two contiguous sulfur atoms (the sulfur atoms may independently form oxide); W represents oxo group, hydrogen atom, an alkyl group, hydroxy group, an alkoxyl group, or a halogen atom; and X represents oxygen atom, or sulfur atom), or a salt thereof, which has a superior suppressing action against prostaglandin E2 production and is useful as an active ingredient of medicaments with reduced adverse reactions such as gastrointestinal disorders.

摘要翻译： 由式（1）表示的化合物或其盐（表示单键或双键; R1表示氢原子或烷基; R2和R3表示氢原子或烷基; R4和R5表示 氢原子，羟基，烷氧基，卤素原子或一或二烷基取代的氨基; R 6表示氢原子，氰基，烷氧基羰基或羧基; R 7表示一个或两个取代基 在苯环上（取代基选自氢原子，卤素原子，硝基，氰基，羟基，氨基，烷基和烷氧基）; A表示5元或6元非 含有一个或两个相邻硫原子的杂环（硫原子可以独立地形成氧化物）; W表示氧代基，氢原子，烷基，羟基，烷氧基或卤素原子; X表示氧原子 ，或硫原子）或其盐 对前列腺素E2产生的抑制作用较差，并且可用作具有减少的不良反应如胃肠道疾病的药物的活性成分。

公开(公告)号：US08148421B2

公开(公告)日：2012-04-03

申请号：US12440540

申请日：2007-09-10

申请人： Hideo Kato ,  Osamu Nagata ,  Yoshiyuki Iwabuchi ,  Takahiro Sato ,  Junichiro Uda ,  Tutomu Inoue ,  Hiroshi Nakamura ,  Nobuhide Kawasaki ,  Ippei Tanaka ,  Naoki Kurita ,  Tomohiko Ishikawa

发明人： Hideo Kato ,  Osamu Nagata ,  Yoshiyuki Iwabuchi ,  Takahiro Sato ,  Junichiro Uda ,  Tutomu Inoue ,  Hiroshi Nakamura ,  Nobuhide Kawasaki ,  Ippei Tanaka ,  Naoki Kurita ,  Tomohiko Ishikawa

IPC分类号： A61K31/382 ,  C07D335/02

CPC分类号： C07D335/02 ,  C07D333/24 ,  C07D333/28 ,  C07D333/32 ,  C07D333/38 ,  C07D333/48

摘要： A compound represented by the formula (1) or a salt thereof ( represents a single bond, or a double bond; R1 represents hydrogen atom, or an alkyl group; R2 and R3 represent hydrogen atom, or an alkyl group; R4 and R5 represent hydrogen atom, hydroxy group, an alkoxyl group, a halogen atom, or a mono- or di-alkyl-substituted amino group; R6 represents hydrogen atom, cyano group, an alkoxycarbonyl group, or carboxy group; R7 represents one or two of substituents on the benzene ring (the substituents are selected from hydrogen atom, a halogen atom, nitro group, cyano group, hydroxy group, amino group, an alkyl group, and an alkoxyl group); A represents a 5-membered or 6-membered non-aromatic heterocyclic ring containing one or two contiguous sulfur atoms (the sulfur atoms may independently form oxide); W represents oxo group, hydrogen atom, an alkyl group, hydroxy group, an alkoxyl group, or a halogen atom; and X represents oxygen atom, or sulfur atom), or a salt thereof, which has a superior suppressing action against prostaglandin E2 production and is useful as an active ingredient of medicaments with reduced adverse reactions such as gastrointestinal disorders.

摘要翻译： 由式（1）表示的化合物或其盐（表示单键或双键; R1表示氢原子或烷基; R2和R3表示氢原子或烷基; R4和R5表示 氢原子，羟基，烷氧基，卤素原子或一或二烷基取代的氨基; R 6表示氢原子，氰基，烷氧基羰基或羧基; R 7表示一个或两个取代基 在苯环上（取代基选自氢原子，卤素原子，硝基，氰基，羟基，氨基，烷基和烷氧基）; A表示5元或6元非 含有一个或两个相邻硫原子的杂环（硫原子可以独立地形成氧化物）; W表示氧代基，氢原子，烷基，羟基，烷氧基或卤素原子; X表示氧原子 ，或硫原子）或其盐 对前列腺素E2产生的抑制作用较差，并且可用作具有减少的不良反应如胃肠道疾病的药物的活性成分。

公开(公告)号：US20060051314A1

公开(公告)日：2006-03-09

申请号：US10514722

申请日：2003-06-26

申请人： Hideo Kato ,  Osamu Nagata ,  Hiroyuki Nakano ,  Yasushi Okamoto ,  Naoki Kurita ,  Ippei Tanaka

发明人： Hideo Kato ,  Osamu Nagata ,  Hiroyuki Nakano ,  Yasushi Okamoto ,  Naoki Kurita ,  Ippei Tanaka

IPC分类号： A61K31/785 ,  A61K31/47

CPC分类号： A61K31/78 ,  A23L33/16

摘要： A medicament for preventive and/or therapeutic treatment of constipation and/or a symptom resulting from constipation which comprises magnesium polycarbophil as an active ingredient. The medicament of the present invention can exhibit high efficacy by promoting a normal defecation without causing a side effect such as a watery stool, an overloose stool, or hypercalcemia.

摘要翻译： 用于预防和/或治疗便秘和/或由便秘引起的症状的药物，其包含聚卡卡非因为活性成分。 本发明的药物通过促进正常排便而不会引起副作用如水便，过多的粪便或高钙血症，可以表现出高效力。

公开(公告)号：US5213806A

公开(公告)日：1993-05-25

申请号：US796669

申请日：1991-11-25

申请人： Yasuo Ito ,  Hideo Kato ,  Osamu Nagata ,  Masaharu Yamazaki ,  Takeo Ishibashi ,  Masakazu Kitayama

发明人： Yasuo Ito ,  Hideo Kato ,  Osamu Nagata ,  Masaharu Yamazaki ,  Takeo Ishibashi ,  Masakazu Kitayama

IPC分类号： A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K9/58 ,  A61K31/78 ,  A61K47/38 ,  A61P1/10 ,  A61P1/12

CPC分类号： A61K31/78 ,  A61K9/1652 ,  A61K9/2054 ,  Y10S514/867

摘要： A pharmaceutical composition capable of being disintegrated in an acidic environment, which comprises calcium polycarbophil and 1 to 80% by weight of a cellulose derivative such as carboxymethylcellulose or low substituted hydroxypropylcellulose based on the calcium polycarbophil. The pharmaceutical composition in a form of a tablet, a capsule, or granules is useful as a bulk-forming laxative or an antidiarrheic agent since it can be disintegrated readily in the stomach and form a complete dispersion of polycarbophil in the digestive tract.

公开(公告)号：US5793696A

公开(公告)日：1998-08-11

申请号：US826820

申请日：1997-04-08

申请人： Tomoharu Tanaka ,  Masaki Momodomi ,  Hideo Kato ,  Hiroto Nakai ,  Yoshiyuki Tanaka ,  Riichiro Shirota ,  Seiichi Aritome ,  Yasuo Itoh ,  Yoshihisa Iwata ,  Hiroshi Nakamura ,  Hideko Odaira ,  Yutaka Okamoto ,  Masamichi Asano ,  Kaoru Tokushige

发明人： Tomoharu Tanaka ,  Masaki Momodomi ,  Hideo Kato ,  Hiroto Nakai ,  Yoshiyuki Tanaka ,  Riichiro Shirota ,  Seiichi Aritome ,  Yasuo Itoh ,  Yoshihisa Iwata ,  Hiroshi Nakamura ,  Hideko Odaira ,  Yutaka Okamoto ,  Masamichi Asano ,  Kaoru Tokushige

IPC分类号： G06F11/10 ,  G11C16/10 ,  G11C16/12 ,  G11C16/24 ,  G11C16/34 ,  G11C29/00 ,  G11C29/34 ,  G11C29/52 ,  G11C13/00

CPC分类号： G11C29/785 ,  G06F11/1008 ,  G11C16/10 ,  G11C16/12 ,  G11C16/24 ,  G11C16/3436 ,  G11C16/344 ,  G11C16/3454 ,  G11C29/34 ,  G11C29/52 ,  G06F11/1068 ,  G06F2201/81 ,  G06F2212/2022

摘要： The time required for the program verify and erase verify operations can be shortened. The change of threshold values of memory cells can be suppressed even if the write and erase operations are executed repetitively. After the program and erase operations, whether the operations were properly executed can be judged simultaneously for all bit lines basing upon a change, after the pre-charge, of the potential at each bit line, without changing the column address. In the data rewrite oepration, the rewrite operation is not effected for a memory cell with the data once properly written, by changing the data in the data register.

公开(公告)号：US5615165A

公开(公告)日：1997-03-25

申请号：US576564

申请日：1995-12-21

申请人： Tomoharu Tanaka ,  Masaki Momodomi ,  Hideo Kato ,  Hiroto Nakai ,  Yoshiyuki Tanaka ,  Riichiro Shirota ,  Seiichi Aritome ,  Yasuo Itoh ,  Yoshihisa Iwata ,  Hiroshi Nakamura ,  Hideko Odaira ,  Yutaka Okamoto ,  Masamichi Asano ,  Kaoru Tokushige

发明人： Tomoharu Tanaka ,  Masaki Momodomi ,  Hideo Kato ,  Hiroto Nakai ,  Yoshiyuki Tanaka ,  Riichiro Shirota ,  Seiichi Aritome ,  Yasuo Itoh ,  Yoshihisa Iwata ,  Hiroshi Nakamura ,  Hideko Odaira ,  Yutaka Okamoto ,  Masamichi Asano ,  Kaoru Tokushige

IPC分类号： G06F11/10 ,  G11C16/10 ,  G11C16/12 ,  G11C16/24 ,  G11C16/34 ,  G11C29/00 ,  G11C29/34 ,  G11C29/52 ,  G11C13/00

CPC分类号： G11C29/785 ,  G06F11/1008 ,  G11C16/10 ,  G11C16/12 ,  G11C16/24 ,  G11C16/3436 ,  G11C16/344 ,  G11C16/3454 ,  G11C29/34 ,  G11C29/52 ,  G06F11/1068 ,  G06F2201/81 ,  G06F2212/2022

摘要： The time required for the program verify and erase verify operations can be shortened. The change of threshold values of memory cells can be suppressed even if the write and erase operations are executed repetitively. After the program and erase operations, whether the operations were properly executed can be judged simultaneously for all bit lines basing upon a change, after the pre-charge, of the potential at each bit line, without changing the column address. In the data rewrite operation, the rewrite operation is not effected for a memory cell with the data once properly written, by changing the data in the data register.

摘要翻译： 可以缩短程序验证和擦除验证操作所需的时间。 即使重复执行写入和擦除操作，也可以抑制存储单元的阈值变化。 在编程和擦除操作之后，可以根据每个位线上的电位的预充电之后的所有位线同时判断操作，而不改变列地址。 在数据重写操作中，通过改变数据寄存器中的数据，对具有一次适当写入的数据的存储单元不进行重写操作。

公开(公告)号：US5546351A

公开(公告)日：1996-08-13

申请号：US326281

申请日：1994-10-20

申请人： Tomoharu Tanaka ,  Masaki Momodomi ,  Hideo Kato ,  Hiroto Nakai ,  Yoshiyuki Tanaka ,  Riichiro Shirota ,  Seiichi Aritome ,  Yasuo Itoh ,  Yoshihisa Iwata ,  Hiroshi Nakamura ,  Hideko Odaira ,  Yutaka Okamoto ,  Masamichi Asano ,  Kaoru Tokushige

发明人： Tomoharu Tanaka ,  Masaki Momodomi ,  Hideo Kato ,  Hiroto Nakai ,  Yoshiyuki Tanaka ,  Riichiro Shirota ,  Seiichi Aritome ,  Yasuo Itoh ,  Yoshihisa Iwata ,  Hiroshi Nakamura ,  Hideko Odaira ,  Yutaka Okamoto ,  Masamichi Asano ,  Kaoru Tokushige

IPC分类号： G06F11/10 ,  G11C16/10 ,  G11C16/12 ,  G11C16/24 ,  G11C16/34 ,  G11C29/00 ,  G11C29/34 ,  G11C29/52 ,  G11C13/00

CPC分类号： G11C29/785 ,  G06F11/1008 ,  G11C16/10 ,  G11C16/12 ,  G11C16/24 ,  G11C16/3436 ,  G11C16/344 ,  G11C16/3454 ,  G11C29/34 ,  G11C29/52 ,  G06F11/1068 ,  G06F2201/81 ,  G06F2212/2022

摘要： The time required for the program verify and erase verify operations can be shortened. The change of threshold values of memory cells can be suppressed even if the write and erase operations are executed repetitively. After the program and erase operations, whether the operations were properly executed can be judged simultaneously for all bit lines basing upon a change, after the pre-charge, of the potential at each bit line, without changing the column address. In the data rewrite operation, the rewrite operation is not effected for a memory cell with the data once properly written, by changing the data in the data register.

公开(公告)号：US5361227A

公开(公告)日：1994-11-01

申请号：US992653

申请日：1992-12-18

申请人： Tomoharu Tanaka ,  Masaki Momodomi ,  Hideo Kato ,  Hiroto Nakai ,  Yoshiyuki Tanaka ,  Riichiro Shirota ,  Seiichi Aritome ,  Yasuo Itoh ,  Yoshihisa Iwata ,  Hiroshi Nakamura ,  Hideko Odaira ,  Yutaka Okamoto ,  Masamichi Asano ,  Kaoru Tokushige

发明人： Tomoharu Tanaka ,  Masaki Momodomi ,  Hideo Kato ,  Hiroto Nakai ,  Yoshiyuki Tanaka ,  Riichiro Shirota ,  Seiichi Aritome ,  Yasuo Itoh ,  Yoshihisa Iwata ,  Hiroshi Nakamura ,  Hideko Odaira ,  Yutaka Okamoto ,  Masamichi Asano ,  Kaoru Tokushige

IPC分类号： G06F11/10 ,  G11C16/10 ,  G11C16/12 ,  G11C16/24 ,  G11C16/34 ,  G11C29/00 ,  G11C29/34 ,  G11C29/52 ,  G11C13/00

CPC分类号： G11C29/785 ,  G06F11/1008 ,  G11C16/10 ,  G11C16/12 ,  G11C16/24 ,  G11C16/3436 ,  G11C16/344 ,  G11C16/3454 ,  G11C29/34 ,  G11C29/52 ,  G06F11/1068 ,  G06F2201/81 ,  G06F2212/2022

摘要： The time required for the program verify and erase verify operations can be shortened. The change of threshold values of memory cells can be suppressed even if the write and erase operations are executed repetitively. After the program and erase operations, whether the operations were properly executed can be judged simultaneously for all bit lines basing upon a change, after the pre-charge, of the potential at each bit line, without changing the column address. In the data rewrite operation, the rewrite operation is not effected for a memory cell with the data once properly written, by changing the data in the data register.

摘要翻译： 可以缩短程序验证和擦除验证操作所需的时间。 即使重复执行写入和擦除操作，也可以抑制存储单元的阈值变化。 在编程和擦除操作之后，可以根据每个位线上的电位的预充电之后的所有位线同时判断操作，而不改变列地址。 在数据重写操作中，通过改变数据寄存器中的数据，对具有一次适当写入的数据的存储单元不进行重写操作。

公开(公告)号：US5818791A

公开(公告)日：1998-10-06

申请号：US826152

申请日：1997-03-27

申请人： Tomoharu Tanaka ,  Masaki Momodomi ,  Hideo Kato ,  Hiroto Nakai ,  Yoshiyuki Tanaka ,  Riichiro Shirota ,  Seiichi Aritome ,  Yasuo Itoh ,  Yoshihisa Iwata ,  Hiroshi Nakamura ,  Hideko Odaira ,  Yutaka Okamoto ,  Masamichi Asano ,  Kaoru Tokushige

发明人： Tomoharu Tanaka ,  Masaki Momodomi ,  Hideo Kato ,  Hiroto Nakai ,  Yoshiyuki Tanaka ,  Riichiro Shirota ,  Seiichi Aritome ,  Yasuo Itoh ,  Yoshihisa Iwata ,  Hiroshi Nakamura ,  Hideko Odaira ,  Yutaka Okamoto ,  Masamichi Asano ,  Kaoru Tokushige

IPC分类号： G06F11/10 ,  G11C16/10 ,  G11C16/12 ,  G11C16/24 ,  G11C16/34 ,  G11C29/00 ,  G11C29/34 ,  G11C29/52 ,  G11C13/00

CPC分类号： G11C29/785 ,  G06F11/1008 ,  G11C16/10 ,  G11C16/12 ,  G11C16/24 ,  G11C16/3436 ,  G11C16/344 ,  G11C16/3454 ,  G11C29/34 ,  G11C29/52 ,  G06F11/1068 ,  G06F2201/81 ,  G06F2212/2022

摘要： The time required for the program verify and erase verify operations can be shortened. The change of threshold values of memory cells can be suppressed even if the write and erase operations are executed repetitively. After the program and erase operations, whether the operations were properly executed can be judged simultaneously for all bit lines basing upon a change, after the pre-charge, of the potential at each bit line, without changing the column address. In the data rewrite operation, the rewrite operation is not effected for a memory cell with the data once properly written, by changing the data in the data register.

公开(公告)号：US5724300A

公开(公告)日：1998-03-03

申请号：US784927

申请日：1997-01-16

申请人： Tomoharu Tanaka ,  Masaki Momodomi ,  Hideo Kato ,  Hiroto Nakai ,  Yoshiyuki Tanaka ,  Riichiro Shirota ,  Seiichi Aritome ,  Yasuo Itoh ,  Yoshihisa Iwata ,  Hiroshi Nakamura ,  Hideko Odaira ,  Yutaka Okamoto ,  Masamichi Asano ,  Kaoru Tokushige

发明人： Tomoharu Tanaka ,  Masaki Momodomi ,  Hideo Kato ,  Hiroto Nakai ,  Yoshiyuki Tanaka ,  Riichiro Shirota ,  Seiichi Aritome ,  Yasuo Itoh ,  Yoshihisa Iwata ,  Hiroshi Nakamura ,  Hideko Odaira ,  Yutaka Okamoto ,  Masamichi Asano ,  Kaoru Tokushige

IPC分类号： G06F11/10 ,  G11C16/10 ,  G11C16/12 ,  G11C16/24 ,  G11C16/34 ,  G11C29/00 ,  G11C29/34 ,  G11C29/52 ,  G11C13/00

CPC分类号： G11C29/785 ,  G06F11/1008 ,  G11C16/10 ,  G11C16/12 ,  G11C16/24 ,  G11C16/3436 ,  G11C16/344 ,  G11C16/3454 ,  G11C29/34 ,  G11C29/52 ,  G06F11/1068 ,  G06F2201/81 ,  G06F2212/2022

摘要： The time required for the program verify and erase verify operations can be shortened. The change of threshold values of memory cells can be suppressed even if the write and erase operations are executed repetitively. After the program and erase operations, whether the operations were properly executed can be judged simultaneously for all bit lines basing upon a change, after the pre-charge, of the potential at each bit line, without changing the column address. In the data rewrite operation, the rewrite operation is not effected for a memory cell with the data once properly written, by changing the data in the data register.