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47 条记录 (耗时 0.046 秒)

    Method of dressing an abrasive cloth and apparatus therefor
    1.
    发明授权
    Method of dressing an abrasive cloth and apparatus therefor 失效
    磨砂布的修整方法及其设备

    公开(公告)号：US5984764A

    公开(公告)日：1999-11-16

    申请号：US861200

    申请日：1997-05-21

    申请人： Hideo Saito ,  Hiromi Nishihara ,  Fumitaka Ito ,  Hironobu Hirata

    发明人： Hideo Saito ,  Hiromi Nishihara ,  Fumitaka Ito ,  Hironobu Hirata

    IPC分类号： B24B37/04 ,  B24B53/007 ,  B24D7/06 ,  B24B1/00

    CPC分类号： B24B53/017 ,  B24B37/042 ,  B24D7/06

    摘要： The present invention relates to a method of discovering optimal conditions such as the rotational speed ratio of an abrasive cloth and a dresser, to improve the flatness of the abrasive cloth after it has been dressed. A narrow annular dresser having an inner diameter of at least the width of a wide annular utilization region of the abrasive cloth is pressed while rotating against the abrasive cloth which is fixed onto a turn table. A rotational motion is imparted to the abrasive cloth in the same direction as the rotation of the dresser and at a predetermined rotational speed. The abrasive cloth is dressed thereby in such a manner that there is a uniform distribution of distances through which the grindstone slides over various points within the utilization region of the abrasive cloth.

    摘要翻译： 本发明涉及一种发现最佳条件的方法，例如研磨布和修整器的转速比，以提高研磨布整修后的平整度。 具有至少宽度大的研磨布的环形利用区域的内径的窄环形修整器在被固定到转台上的研磨布上旋转时被按压。 旋转运动以与修整器的旋转相同的方向并以预定的转速传递给研磨布。 研磨布以这样一种方式穿着，使磨石在研磨布的利用区域内的各个点上滑动穿过该距离的均匀分布。

    Headstock of a polishing machine
    2.
    发明授权
    Headstock of a polishing machine 失效
    抛光机头架

    公开(公告)号：US6027401A

    公开(公告)日：2000-02-22

    申请号：US955701

    申请日：1997-10-23

    申请人： Hideo Saito ,  Fumitaka Ito

    发明人： Hideo Saito ,  Fumitaka Ito

    IPC分类号： B24B37/30 ,  B24B41/04 ,  B24B7/22

    CPC分类号： B24B37/30 ,  B24B41/042

    摘要： The present invention provides a headstock of a polishing machine, having a simple structure and capable of tracing a pad surface. The headstock of the present invention is formed of a spindle, a holder plate, a spherical bearing, and a plate spring. The holder plate is connected to a lower end portion of the spindle via the spherical bearing and the plate spring. A workpiece is attached to the lower surface of the holder plate. The spherical bearing has a center of tilting movement on a rotation axis of the spindle. The holder plate has a balance plate. The center of gravity of the holder plate including the balance plate coincides with the center of tilting movement of the spherical bearing. The plate spring has an axisymmetric shape. More specifically, the plate spring has an opening portion at the center and a plurality of arm portions extending to the outer periphery in the diameter direction. The plate spring is connected to the lower end of the spindle by use of first fitting holes which are formed along the inner periphery, and the plate spring is also attached to the holder plate by use of second fitting holes which are formed in the distal end of the plate spring. The first and second fitting holes are respectively located on small- and large-diameter circles which are concentrically arranged around the rotation axis of the spindle.

    摘要翻译： 本发明提供一种抛光机的头架，其具有简单的结构并且能够跟踪垫表面。 本发明的主轴箱由主轴，保持板，球面轴承和板簧构成。 保持板通过球面轴承和板簧连接到主轴的下端部分。 工件附接到保持板的下表面。 球面轴承在主轴的旋转轴线上具有倾斜运动的中心。 支架板具有平衡板。 包括平衡板的保持板的重心与球面轴承的倾斜运动的中心重合。 板簧具有轴对称形状。 更具体地，板簧在中心具有开口部分，并且在直径方向上延伸到外周的多个臂部分。 板簧通过使用沿着内周形成的第一嵌合孔连接到主轴的下端，并且板簧也通过使用形成在远端的第二装配孔附接到保持板 的板簧。 第一和第二装配孔分别位于围绕主轴的旋转轴线同心布置的小直径和大直径的圆周上。

    Pyrrolidinyl and pyrrolinyl ethylamine compounds as kappa agonists
    5.
    发明授权
    Pyrrolidinyl and pyrrolinyl ethylamine compounds as kappa agonists 失效
    吡咯烷基和吡咯啉基乙胺化合物作为κ激动剂

    公开(公告)号：US06310061B2

    公开(公告)日：2001-10-30

    申请号：US09770515

    申请日：2001-01-26

    申请人： Fumitaka Ito ,  Hiroshi Kondo

    发明人： Fumitaka Ito ,  Hiroshi Kondo

    IPC分类号： A61K31445

    CPC分类号： C07D213/82 ,  C07D207/10 ,  C07D207/12 ,  C07D207/20 ,  C07D207/24 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  Y02P20/55

    摘要： A compound of the following formula: and the salts thereof, wherein A is hydrogen, halo, or hydroxy; the broken line represents an optional double bond with proviso that if the broken line is a double bond, then A is absent; Ar1 is optionally substituted phenyl; Ar2 is aryl or heteroaryl selected from phenyl, napththyl, or pyridyl, the aryl or heteroaryl being optionally substituted; R1 is hydrogen, hydroxy, or C1-C4 alkyl; and R2 and R3 are independently selected from optionally substituted C1-C7 alkyl, C3-C6 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, or R2 and R3, together with the nitrogen atom to which they are attached, form an optionally substituted pyrrolidine, piperidine or morpholine ring. These compounds are useful as kappa agonists.

    摘要翻译： 下式的化合物及其盐，其中A是氢，卤素或羟基; 虚线表示任选的双键，条件是如果虚线是双键，则A不存在; Ar1是任选取代的苯基; Ar2是选自苯基，萘乙基或吡啶基的芳基或杂芳基，芳基或杂芳基任选被取代; R1是氢，羟基或C1-C4烷基; 并且R 2和R 3独立地选自任选取代的C 1 -C 7烷基，C 3 -C 6环烷基，C 2 -C 6烯基，C 2 -C 6炔基或R 2和R 3与它们所连接的氮原子一起形成任选取代的 吡咯烷，哌啶或吗啉环。 这些化合物可用作κ激动剂。

    Pyrrolidinyl and pyrrolinyl ethylamine compounds as kappa agonists
    6.
    发明授权
    Pyrrolidinyl and pyrrolinyl ethylamine compounds as kappa agonists 失效

    公开(公告)号：US06307061B2

    公开(公告)日：2001-10-23

    申请号：US09771029

    申请日：2001-01-26

    申请人： Fumitaka Ito ,  Hiroshi Kondo

    发明人： Fumitaka Ito ,  Hiroshi Kondo

    IPC分类号： C07D20704

    CPC分类号： C07D213/82 ,  C07D207/10 ,  C07D207/12 ,  C07D207/20 ,  C07D207/24 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  Y02P20/55

    摘要： A compound of the following formula: and the salts thereof, wherein A is hydrogen, halo, hydroxy, or the like; the broken line represents an optional double bond with proviso that if the broken line is a double bond, then A is absent; Ar1 is optionally substituted phenyl or the like; Ar2 is aryl or heteroaryl selected from phenyl, napththyl, pyridyl, and the like, the aryl or heteroaryl being optionally substituted; R1 is hydrogen, hydroxy, C1-C4 alkyl, or the like; and R2 and R3 are independently selected from optionally substituted C1-C7 alkyl, C3-C6 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, and the like or R2 and R3, together with the nitrogen atom to which they are attached, form an optionally substituted pyrrolidine, piperidine or morpholine ring. These compounds are useful as kappa agonists.

    Pyrrolidinyl and pyrrolinyl ethylamine compounds as kappa agonists
    7.
    发明授权
    Pyrrolidinyl and pyrrolinyl ethylamine compounds as kappa agonists 失效
    吡咯烷基和吡咯啉基乙胺化合物作为κ激动剂

    公开(公告)号：US06201007B1

    公开(公告)日：2001-03-13

    申请号：US09254805

    申请日：1999-03-12

    申请人： Fumitaka Ito ,  Hiroshi Kondo

    发明人： Fumitaka Ito ,  Hiroshi Kondo

    IPC分类号： A61K31402

    CPC分类号： C07D213/82 ,  C07D207/10 ,  C07D207/12 ,  C07D207/20 ,  C07D207/24 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  Y02P20/55

    摘要： A compound of the following formula: and the salts thereof wherein A is hydrogen, halo, or hydroxy, broken line represents an optional double bond with proviso that if the broken line is a double bond, then A is absent; Ar1 is optionally substituted phenyl; Ar2 is aryl or heteroaryl selected from phenyl, napththyl, or pyridyl, the aryl or heteroaryl being optionally substituted; R1 is hydrogen, hydroxy, or C1-C4 alkyl; and R2 and R3 are independently selected from optionally substituted C1-C7 alkyl, C3-C6 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, or R2 and R3, together with the nitrogen atom to which they are attached, form an optionally substituted pyrrolidine. These compounds are useful as kappa agonists.

    摘要翻译： 下式的化合物及其盐，其中A是氢，卤素或羟基，虚线代表任选的双键，条件是如果虚线是双键，则A不存在; Ar1是任选取代的苯基; Ar2是选自苯基，萘乙基或吡啶基的芳基或杂芳基，芳基或杂芳基任选被取代; R1是氢，羟基或C1-C4烷基; 并且R 2和R 3独立地选自任选取代的C 1 -C 7烷基，C 3 -C 6环烷基，C 2 -C 6烯基，C 2 -C 6炔基或R 2和R 3与它们所连接的氮原子一起形成任选取代的 吡咯烷。 这些化合物可用作κ激动剂。

    Pyrrolidinyl hydroxamic acid compounds and their production process
    8.
    发明授权
    Pyrrolidinyl hydroxamic acid compounds and their production process 失效
    吡咯烷基异羟肟酸化合物及其制备方法

    公开(公告)号：US5952369A

    公开(公告)日：1999-09-14

    申请号：US913823

    申请日：1997-09-26

    申请人： Fumitaka Ito

    发明人： Fumitaka Ito

    IPC分类号： C07D295/12 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61P1/00 ,  A61P7/00 ,  A61P7/10 ,  A61P23/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/28 ,  A61P29/00 ,  A61P43/00 ,  C07D20060101 ,  C07D207/12 ,  C07D213/54 ,  C07D295/13 ,  C07D307/79 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  A61K31/41

    CPC分类号： C07D213/54 ,  C07D207/12 ,  C07D295/13 ,  C07D307/79 ,  C07D405/12 ,  C07D409/12 ,  Y02P20/55

    摘要： A compound of formula (I) ##STR1## and its pharmaceutically acceptable salt, wherein A is hydrogen or OY, wherein Y is a hydroxy protecting group; Ar is phenyl optionally substituted with one or more substituents selected from halo, hydroxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, CF.sub.3, C.sub.1 -C.sub.4 alkoxy-C.sub.1 -C.sub.4 alkyloxy and carboxy-C.sub.1 -C.sub.4 alkyloxy;X is phenyl, naphthyl, biphenyl, indanyl, benzofuranyl, benzothiophenyl, 1-tetralone-6-yl,C.sub.1 -C.sub.4 alkylenedioxy, pyridyl, furyl and thienyl these groups optionally being substituted with up to three substituents selected from halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, hydroxy, NO.sub.2, CF.sub.3 and SO.sub.2 CH.sub.3 ; andR is hydrogen, C.sub.1 -C.sub.4 alkyl or a hydroxy protecting group. These compounds and pharmaceutical compositions containing them are useful as analgesic, anti-inflammatory, diuretic, anesthetic or neuroprotective agents, or an agent for stroke or treatment of functional bowel diseases such as abdominal pain, for the treatment of a mammalian subject, especially a human subject. Further, the present invention provides processes for producing the hydroxamic compounds of formula (I) and their intermediate compounds of the formula. ##STR2##

    摘要翻译： PCT No.PCT / JP96 / 00820 Sec。 371日期：1997年9月26日 102（e）1997年9月26日PCT PCT 1996年3月28日PCT公布。 WO96 / 30339 PCT公开号 日期：1996年10月3日一种式（I）化合物及其药学上可接受的盐，其中A为氢或OY，其中Y为羟基保护基; Ar是任选被一个或多个选自卤素，羟基，C 1 -C 4烷基，C 1 -C 4烷氧基，CF 3，C 1 -C 4烷氧基-C 1 -C 4烷氧基和羧基-C 1 -C 4烷氧基的取代基取代的苯基; X是苯基，萘基，联苯基，茚满基，苯并呋喃基，苯并噻吩基，1-四氢萘酮-6-基，C 1 -C 4亚烷基二氧基，吡啶基，呋喃基和噻吩基，这些基团任选被至多三个选自卤素，C 1 -C 4烷基， C 1 -C 4烷氧基，羟基，NO 2，CF 3和SO 2 CH 3; 和R是氢，C 1 -C 4烷基或羟基保护基。 这些化合物和含有它们的药物组合物可用作止痛剂，抗炎剂，利尿剂，麻醉剂或神经保护剂，或用于中风或治疗功能性肠病如腹痛的药剂，用于治疗哺乳动物受试者，特别是人 学科。 此外，本发明提供了制备式（I）的异羟肟酸化合物及其下式的中间体化合物的方法。