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公开(公告)号：US20050042745A1
公开(公告)日：2005-02-24
申请号：US10891477
申请日：2004-07-15
摘要： An object of the present invention is to construct a culture device optimized for culturing animal cells. The present invention provides a device for culturing cells which comprises at least one water-containing polymer gel film for adhering animal cells onto at least one surface of the film, and has a structure capable of supplying different liquids to both sides of the film.
摘要翻译： 本发明的目的是构建用于培养动物细胞的培养装置。 本发明提供了一种用于培养细胞的装置，该装置包括至少一个用于将动物细胞粘附在膜的至少一个表面上的含水聚合物凝胶膜，并且具有能够向膜两侧供应不同液体的结构。
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公开(公告)号：US07358082B2
公开(公告)日：2008-04-15
申请号：US10891477
申请日：2004-07-15
摘要： An object of the present invention is to construct a culture device optimized for culturing animal cells. The present invention provides a device for culturing cells which comprises at least one water-containing polymer gel film for adhering animal cells onto at least one surface of the film, and has a structure capable of supplying different liquids to both sides of the film.
摘要翻译： 本发明的目的是构建用于培养动物细胞的培养装置。 本发明提供了一种用于培养细胞的装置，该装置包括至少一个用于将动物细胞粘附在膜的至少一个表面上的含水聚合物凝胶膜，并且具有能够向膜两侧供应不同液体的结构。
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公开(公告)号：US07022523B2
公开(公告)日：2006-04-04
申请号：US10691506
申请日：2003-10-24
申请人： Hirohiko Tsuzuki , Satoru Toda , Makoto Kato
发明人： Hirohiko Tsuzuki , Satoru Toda , Makoto Kato
IPC分类号： C12N5/00
CPC分类号： C12N5/00 , C12N5/0068 , C12N2533/54 , C12N2533/72 , C12N2533/74
摘要： A carrier for cell culture comprising a water-containing polymer gel containing chitosan, wherein the water-containing polymer gel is coated with collagen and/or alginic acid, and a carrier for cell culture, which comprises a gel layer containing chitosan and an inorganic layer adjacently provided to the gel layer.
摘要翻译： 1.一种细胞培养用载体，其特征在于，含有含有壳聚糖的含水聚合物凝胶，其中，所述含水聚合物凝胶用胶原和/或藻酸包被，以及用于细胞培养的载体，其含有含有壳聚糖和无机层的凝胶层 相邻地提供到凝胶层。
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公开(公告)号：US07449343B2
公开(公告)日：2008-11-11
申请号：US11218656
申请日：2005-09-06
申请人： Hirohiko Tsuzuki
发明人： Hirohiko Tsuzuki
IPC分类号： G01N33/558 , G01N33/553
CPC分类号： G01N33/54373 , Y10S436/805
摘要： It is an object of the present invention to provide a measurement method which can suppress noise when a specific binding reaction between a physiologically active substance and a test substance is measured using a surface plasmon resonance measurement device. The present invention provides a method for measuring a change in surface plasmon resonance which comprises: using a surface plasmon resonance measurement device comprising a metal film, a light source for generating a light beam, an optical system for allowing the above-described light beam to enter the interface of the metal film so that total reflection conditions can be obtained at the interface thereof and so that various incidence angles can be included, a flow channel system comprising a cell formed on the above-described metal film, and a light-detecting means for detecting the state of surface plasmon resonance by measuring the intensity of the light beam totally reflected at the above interface, and exchanging the liquid contained in the above flow channel system with another liquid, wherein the liquid in the above-described flow channel system is exchanged with another liquid obtained by eliminating insoluble matters from a measurement solvent, and the change in surface plasmon resonance is then measured in a state where the flow of the liquid has been stopped.
摘要翻译： 本发明的目的是提供一种测量方法，当使用表面等离子体共振测量装置测量生理活性物质和测试物质之间的特异性结合反应时，可以抑制噪声。 本发明提供了一种用于测量表面等离子体共振的变化的方法，包括：使用表面等离子体共振测量装置，其包括金属膜，用于产生光束的光源，用于允许上述光束 进入金属膜的界面，使得能够在其界面获得全反射条件，并且可以包括各种入射角，包括形成在上述金属膜上的单元的流路系统和光检测 用于通过测量在上述界面全反射的光束强度来检测表面等离子体共振的状态的装置，以及将上述流道系统中所含的液体与另一种液体进行交换，其中上述流道系统 与通过从测量溶剂中除去不溶物质而获得的另一种液体以及表面质膜的变化进行交换 然后在液体的流动停止的状态下测量单次共振。
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公开(公告)号：US20060187460A1
公开(公告)日：2006-08-24
申请号：US11354839
申请日：2006-02-16
申请人： Hirohiko Tsuzuki
发明人： Hirohiko Tsuzuki
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： It is an object of the present invention to provide a method for obtaining a chromatogram using the SPR analysis method. The present invention provides a method for measuring the change in the surface plasmon resonance by using a surface plasmon resonance measurement device which comprises a metal film, a light source for generating a light beam, an optical system for allowing such a light beam to enter the interface of the metal film so that total reflection conditions can be obtained at the interface thereof and so that various incidence angles can be included, a flow channel system comprising a cell formed on said metal film, and a light-detecting means for detecting the state of surface plasmon resonance by measuring the intensity of the light beam totally reflected at said interface, and exchanging a liquid contained in the flow channel system; wherein the measurement is carried out by supplying a liquid at a liquid amount such that the absolute amount of molecules adsorbed on the metal film surface is lower than the saturated adsorption amount of said molecules on said metal film surface.
摘要翻译： 本发明的目的是提供使用SPR分析方法获得色谱图的方法。 本发明提供了一种用于通过使用表面等离子体共振测量装置来测量表面等离子体共振的变化的方法，所述表面等离子体共振测量装置包括金属膜，用于产生光束的光源，用于允许这种光束进入 使得能够在其界面处获得全反射条件，并且可以包括各种入射角，包括形成在所述金属膜上的单元的流路系统和用于检测状态的光检测装置 通过测量在所述界面处全反射的光束的强度，并且更换包含在所述流道系统中的液体的表面等离子体共振; 其中所述测量是通过以液体量供给液体来进行的，以使吸附在所述金属膜表面上的分子的绝对量低于所述金属膜表面上的所述分子的饱和吸附量。
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公开(公告)号：US06274301B1
公开(公告)日：2001-08-14
申请号：US09174011
申请日：1998-10-16
IPC分类号： G03C1498
CPC分类号： G03C1/49863 , G03C1/002 , G03C1/04 , G03C1/34 , G03C1/49845 , G03C2200/22 , G03C2200/36
摘要： A photothermographic recording element having improved image tone and improved tone stability during storage is provided wherein at least one of constituent layers comprises (a) polymeric microparticulates containing a dyestuff, (b) microcapsules containing a dyestuff, and/or (c) an organic or inorganic pigment.
摘要翻译： 提供了具有改善的图像色调并且在存储期间具有改善的色调稳定性的光热记录元件，其中至少一个构成层包含（a）含有染料的聚合物微粒，（b）含有染料的微胶囊和/或（c）有机或 无机颜料。
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公开(公告)号：US6093529A
公开(公告)日：2000-07-25
申请号：US60881
申请日：1998-04-16
CPC分类号： G03C1/49845 , G03C1/49872 , G03C1/49863
摘要： An imaging material is provided in the form of a photothermographic or thermographic image forming layer containing an organic silver salt on one surface of a support and further comprising a polyvalent metal ion and a phthalic acid compound on the image forming layer-bearing surface of the support. The imaging material has improved shelf stability before and after image formation and the ease of handling and produces high-quality blue black tone images.
摘要翻译： 成像材料以支持体的一个表面上含有有机银盐的光热照相或热成像图像形式的形式提供，并且在载体的图像形成层承载表面上还包含多价金属离子和邻苯二甲酸化合物 。 成像材料在图像形成之前和之后具有改善的储存稳定性和易于处理并产生高质量的蓝黑色调图像。
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公开(公告)号：US5922529A
公开(公告)日：1999-07-13
申请号：US996914
申请日：1997-12-23
申请人： Hirohiko Tsuzuki , Hisashi Okada , Yoshio Inagaki
发明人： Hirohiko Tsuzuki , Hisashi Okada , Yoshio Inagaki
CPC分类号： G03C1/49854 , G03C1/49845
摘要： A photothermographic material has a photosensitive layer containing a binder, organic silver salt, reducing agent, and silver halide on one surface of a support. The photosensitive layer further contains a specific sulfur-containing compound and a merocyanine dye of specific structure and has an absorbance of 0.15-1.0 at an exposure wavelength. Sharpness, sensitivity, and aging stability are improved.
摘要翻译： 光热敏成像材料在载体的一个表面上具有含有粘合剂，有机银盐，还原剂和卤化银的感光层。 感光层还含有特定的含硫化合物和特定结构的部花青染料，并且在曝光波长下的吸光度为0.15-1.0。 清晰度，灵敏度和老化稳定性得到提高。
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9.发明授权公开(公告)号：US08236575B2
公开(公告)日：2012-08-07
申请号：US12744311
申请日：2008-11-21
申请人： Koichi Minami , Hirohiko Tsuzuki
发明人： Koichi Minami , Hirohiko Tsuzuki
IPC分类号： G01N33/543
CPC分类号： G01N33/542 , G01N21/6428
摘要： A first reactant, which is provided with a reaction site for specific binding with an analyte, and a fluorescent label site, and a second reactant, which is provided with a reaction site for specific binding with the analyte, and a fluorescence recognition site for recognizing fluorescence produced by the fluorescent label site of the first reactant, are respectively fixed onto a support such that the first reactant and the second reactant have a positional relationship adapted for the binding with the analyte.
摘要翻译： 提供有用于与分析物特异性结合的反应位点的第一反应物和荧光标记位点，以及第二反应物，其具有用于与分析物特异性结合的反应位点和用于识别的荧光识别位点 由第一反应物的荧光标记位点产生的荧光分别固定在载体上，使得第一反应物和第二反应物具有适于与分析物结合的位置关系。
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10.发明授权公开(公告)号：US07723122B2
公开(公告)日：2010-05-25
申请号：US11213716
申请日：2005-08-30
申请人： Hirohiko Tsuzuki
发明人： Hirohiko Tsuzuki
CPC分类号： G01N21/553 , G01N21/276 , Y10S436/805 , Y10T436/24
摘要： It is an object of the present invention to provide a method for analyzing the interaction of a test substance with a ligand by analyzing a phenomenon whereby multiple test substances are simultaneously adsorbed to a ligand. The present invention provides a method for analyzing the interaction of test substances with a ligand by measuring the change in the surface plasmon resonance using a surface plasmon resonance measurement device wherein the above-described method comprises: supplying a solution containing two or more types of test substances after supplying a solution containing no test substances; measuring the change in the surface plasmon resonance; and analyzing the difference between the change in the surface plasmon resonance that is predicted from the adsorption rate constant (ka) and dissociation rate constant (kd) of each of the test substances that had previously been measured and the change in the surface plasmon resonance that has actually been measured.
摘要翻译： 本发明的目的是提供一种通过分析同时将多种测试物质吸附到配体上的现象来分析测试物质与配体的相互作用的方法。 本发明提供了一种通过使用表面等离子体共振测量装置测量表面等离子体共振的变化来分析测试物质与配体的相互作用的方法，其中上述方法包括：提供含有两种或多种类型的测试的溶液 提供不含检测物质的溶液后的物质; 测量表面等离子体共振的变化; 并分析从先前测量的每种测试物质的吸附速率常数（ka）和解离速率常数（kd）预测的表面等离子体共振的变化与表面等离子体共振的变化之间的差异， 实际上已被测量。
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