公开(公告)号：US5679859A

公开(公告)日：1997-10-21

申请号：US616082

申请日：1996-03-14

申请人： Hirokazu Murata ,  Hideki Ushio ,  Atsushi Furutani ,  Hiroaki Hibino ,  Etsuko Fukuda

发明人： Hirokazu Murata ,  Hideki Ushio ,  Atsushi Furutani ,  Hiroaki Hibino ,  Etsuko Fukuda

IPC分类号： C07C225/22 ,  C07C209/82

CPC分类号： C07C225/22

摘要： The present invention concerns a process for producing crystals of 3-amino-2-hydroxyacetophenone salt having a high bulk density and improved flow properties, by treating 3-amino-2-hydroxyacetophenone of formula (1) ##STR1## or hydrogen halide salt thereof with sulfuric acid, in a solvent.

摘要翻译： 本发明涉及一种通过处理式（1）的3-氨基-2-羟基苯乙酮或其卤化氢盐来制备具有高堆积密度和改善流动性的3-氨基-2-羟基苯乙酮盐晶体的方法 用硫酸，在溶剂中。

公开(公告)号：US20060217565A1

公开(公告)日：2006-09-28

申请号：US11443300

申请日：2006-05-31

申请人： Hiroaki Hibino ,  Susumu Ohtsuka ,  Yasunobu Miyamoto ,  Tomoyasu Yoshida ,  Itsuo Okumoto

发明人： Hiroaki Hibino ,  Susumu Ohtsuka ,  Yasunobu Miyamoto ,  Tomoyasu Yoshida ,  Itsuo Okumoto

IPC分类号： C07D311/02

CPC分类号： C07C205/37 ,  C07C201/12 ,  C07D311/24

摘要： A process for producing a dicarboxylic acid compound represented by the formula (4): wherein R1 and R2 are the same or different and each represents lower alkyl and the wavy line indicates that this compound is the E- or Z-isomer or a mixture of them, characterized by reacting a compound represented by the formula (2): wherein R1, R2 and the wavy line have the same meanings as the above, and one of X2 and X3 represents hydrogen and the other represents halogen, with nitrophenol represented by the formula (3): in the presence of a base; a process for producing a nitrochromone compound represented by the formula (5): wherein R1 has the same meaning as the above, characterized by reacting the dicarboxylic acid compound or carboxylic acid thereof with an acid; a process for producing an aminochromone compound which comprises reducing the nitrochromone compound; and a process for producing an amidochromone compound which comprises acylating the aminochromone compound are provided.

公开(公告)号：US20090054669A1

公开(公告)日：2009-02-26

申请号：US12225071

申请日：2007-03-09

申请人： Shinya Tanaka ,  Hiroaki Hibino

发明人： Shinya Tanaka ,  Hiroaki Hibino

IPC分类号： C07D301/27

CPC分类号： C07D303/30 ,  H05K1/0326

摘要： A process for producing an epoxy compound represented by the formula (3): wherein Ar1, Ar2, Ar3, R1, R2, R3, Q1 and Q2 are as defined below, which comprises reacting a dihydroxy compound represented by the formula (1): HO-Q1-Ar1—Ar2—Ar3-Q1-OH  (1) wherein Q1 denotes a single bond, Ar1, Ar2 and Ar3 each denotes any one of divalent groups represented by the following formulas: and a compound represented by the formula (2): wherein R1, R2 and R3 denote hydrogen atom, Q2 denotes a straight-chain alkylene group having 1 to 8 carbon atoms, and X denotes halogen atom, in the presence of at least one selected from the group consisting of an amine compound and an ammonium salt, and further reacting the obtained reaction mixture and an inorganic base by mixing.

摘要翻译： 一种制备由式（3）表示的环氧化合物的方法：其中Ar1，Ar2，Ar3，R1，R2，R3，Q1和Q2如下所定义，其包括使由式（1）表示的二羟基化合物： HO-Q1-Ar1-Ar2-Ar3-Q1-OH（1）<？in-line-formula description =“In-line-formula”=“lead” 其中Q1表示单键，Ar1，Ar2和Ar3各自表示由下式表示的二价基团中的任一个：和由式（2）表示的化合物：其中R1，R2 R3表示氢原子，Q2表示碳原子数1〜8的直链亚烷基，X表示卤素原子，在选自胺化合物和铵盐中的至少一种的存在下，进一步 通过混合使获得的反应混合物和无机碱反应。

公开(公告)号：US07511171B2

公开(公告)日：2009-03-31

申请号：US10594501

申请日：2005-03-29

申请人： Hiroaki Hibino ,  Tomoyasu Yoshida

发明人： Hiroaki Hibino ,  Tomoyasu Yoshida

IPC分类号： C07C65/01

CPC分类号： C07C51/09 ,  C07C65/24

摘要： The present invention provides a method for producing a compound represented by the formula (3): wherein n is an integer of 1 to 6, characterized by the steps of hydrolyzing a solution containing an ester compound represented by the formula (1): wherein R is a lower alkyl group and n is an integer of 1 to 6, and a compound represented by the formula (2): wherein R is as defined above, adjusting the pH of the resulting solution to pH 4 to 8, and then subjecting to phase separation to obtain an organic layer containing the carboxylic acid of formula (3).

摘要翻译： 本发明提供一种制备由式（3）表示的化合物的方法：其中n为1至6的整数，其特征在于水解含有由式（1）表示的酯化合物的溶液的步骤：其中R 为低级烷基，n为1〜6的整数，式（2）表示的化合物：其中R如上定义，将所得溶液的pH调节至pH4〜8，然后使 得到含有式（3）的羧酸的有机层。

公开(公告)号：US20120164558A1

公开(公告)日：2012-06-28

申请号：US13394232

申请日：2010-09-09

申请人： Noriyuki Hida ,  Hiroaki Hibino ,  Toru Onodera

发明人： Noriyuki Hida ,  Hiroaki Hibino ,  Toru Onodera

IPC分类号： H01M8/10 ,  B01J31/10 ,  C08G75/24 ,  C07C309/39 ,  C07C303/22

CPC分类号： C07C309/73 ,  C08G61/10 ,  C08G2261/1452 ,  C08G2261/312 ,  C08G2261/516 ,  C08L65/00 ,  H01M8/1025 ,  H01M8/1027 ,  H01M2300/0082

摘要： Provided are a biphenyltetrasulfonic acid compound represented by the formula (1): wherein R1 represents a hydrogen atom, a cation, a hydrocarbon group, or the like; R2 represents a hydrogen atom, an alkyl group, an aryl group, an aryloxy group, an aralkyl group, an aralkyoxy group, or the like; and X1 represents a chlorine atom, a bromine atom, an iodine atom, a hydroxyl group, an amino group, or the like, and a polymer containing a structural unit originating from the biphenyltetrasulfonic acid compound.

摘要翻译： 提供由式（1）表示的联苯基四磺酸化合物：其中R 1表示氢原子，阳离子，烃基等; R2表示氢原子，烷基，芳基，芳氧基，芳烷基，芳烷氧基等; X 1表示氯原子，溴原子，碘原子，羟基，氨基等，以及含有源自联苯基四磺酸化合物的结构单元的聚合物。

公开(公告)号：US20120123154A1

公开(公告)日：2012-05-17

申请号：US13386935

申请日：2010-07-26

申请人： Noriyuki Hida ,  Hiroaki Hibino

发明人： Noriyuki Hida ,  Hiroaki Hibino

IPC分类号： C07C309/73 ,  C07C205/06

CPC分类号： C07C303/32 ,  C07B37/04 ,  C07C201/12 ,  C07C309/39 ,  C07C205/06

摘要： A method for producing a biaryl compound represented by the formula (2) Ar—Ar   (2) wherein Ar represents an aromatic group which can have a substituent, comprising conducting a coupling reaction of a compound represented by the formula (1) Ar—Cl   (1) wherein Ar represents the same meaning as defined above, in the presence of copper metal and a copper salt.

摘要翻译： 制备由式（2）表示的联芳基化合物的方法Ar-Ar（2）其中Ar表示可以具有取代基的芳香族基团，包括进行由式（1）表示的化合物的Ar-Cl （1）其中Ar表示与上述相同的含义，在铜金属和铜盐存在下。

公开(公告)号：US20050085664A1

公开(公告)日：2005-04-21

申请号：US10506119

申请日：2003-02-27

申请人： Hiroaki Hibino ,  Susumu Ohtsuka ,  Yasunobu Miyamoto ,  Tomoyasu Yoshida ,  Itsuo Okumoto

发明人： Hiroaki Hibino ,  Susumu Ohtsuka ,  Yasunobu Miyamoto ,  Tomoyasu Yoshida ,  Itsuo Okumoto

IPC分类号： C07C205/37 ,  C07D311/24 ,  C07C25/53

CPC分类号： C07C205/37 ,  C07C201/12 ,  C07D311/24

摘要： A process for producing a dicarboxylic acid compound represented by the formula (4): wherein R1 and R2 are the same or different and each represents lower alkyl and the wavy line indicates that this compound is the E- or Z-isomer or a mixture of them, characterized by reacting a compound represented by the formula (2): wherein R1, R2 and the wavy line have the same meanings as the above, and one of X2 and X3 represents hydrogen and the other represents halogen, with nitrophenol represented by the formula (3): in the presence of a base; a process for producing a nitrochromone compound represented by the formula (5): wherein R1 has the same meaning as the above, characterized by reacting the dicarboxylic acid compound or carboxylic acid thereof with an acid; a process for producing an aminochromone compound which comprises reducing the nitrochromone compound; and a process for producing an amidochromone compound which comprises acylating the aminochromone compound are provided.

摘要翻译： 一种由式（4）表示的二羧酸化合物的制备方法：其中R 1和R 2相同或不同，各自代表低级烷基和波浪线 表示该化合物是E-或Z-异构体或它们的混合物，其特征在于使由式（2）表示的化合物：其中R 1，R 2， >和波浪线具有与上述相同的含义，X 2和X 3之一表示氢，而另一个表示卤素，由式（ 3）：在一个基地的存在下; 一种制备由式（5）表示的硝基色酮化合物的方法：其中R 1具有与上述相同的含义，其特征在于使二羧酸化合物或其羧酸与酸反应; 一种制备氨基色酮化合物的方法，其包括还原硝基色酮化合物; 并提供了包括酰化氨基色酮化合物的酰胺色酮化合物的制备方法。

公开(公告)号：US06861566B2

公开(公告)日：2005-03-01

申请号：US10468226

申请日：2002-03-11

申请人： Hiroaki Hibino ,  Susumu Ohtsuka ,  Yasunobu Miyamoto ,  Itsuo Okumoto

发明人： Hiroaki Hibino ,  Susumu Ohtsuka ,  Yasunobu Miyamoto ,  Itsuo Okumoto

IPC分类号： C07C17/32 ,  C07C17/26 ,  C07C22/04 ,  C07C41/30 ,  C07C17/00 ,  C07C22/00 ,  C07C25/00

CPC分类号： C07C41/30 ,  C07C17/2632 ,  C07C22/04 ,  C07C43/225

摘要： There is provided an industrially advantageous process for producing a 1-chloro-4-arylbutane represented by the general formula (2): wherein R represents hydrogen, lower alkyl, or lower alkoxy, characterized by reacting 1-bromo-3-chloropropane with a compound represented by the general formula (1): wherein R is as defined above; and X represents chlorine, bromine, or iodine, in a solvent.

摘要翻译： 提供了用于制备由通式（2）表示的1-氯-4-芳基丁烷的工业上有利的方法：其中R表示氢，低级烷基或低级烷氧基，其特征在于使1-溴-3-氯丙烷与 由通式（1）表示的化合物：其中R如上定义; X表示氯，溴或碘。

公开(公告)号：US09079830B2

公开(公告)日：2015-07-14

申请号：US13386935

申请日：2010-07-26

申请人： Noriyuki Hida ,  Hiroaki Hibino

发明人： Noriyuki Hida ,  Hiroaki Hibino

IPC分类号： C07C309/00 ,  C07C303/32 ,  C07B37/04 ,  C07C201/12

CPC分类号： C07C303/32 ,  C07B37/04 ,  C07C201/12 ,  C07C309/39 ,  C07C205/06

摘要： A method for producing a biaryl compound represented by the formula (2) Ar—Ar  (2) wherein Ar represents an aromatic group which can have a substituent, comprising conducting a coupling reaction of a compound represented by the formula (1) Ar—Cl  (1) wherein Ar represents the same meaning as defined above, in the presence of copper metal and a copper salt.

摘要翻译： 制备由式（2）表示的联芳基化合物的方法Ar-Ar（2）其中Ar表示可以具有取代基的芳香族基团，包括进行由式（1）表示的化合物的Ar-Cl （1）其中Ar表示与上述相同的含义，在铜金属和铜盐存在下。

公开(公告)号：US20070197824A1

公开(公告)日：2007-08-23

申请号：US10594501

申请日：2005-03-29

申请人： Hiroaki Hibino ,  Tomoyasu Yoshida

发明人： Hiroaki Hibino ,  Tomoyasu Yoshida

IPC分类号： C07C51/367

CPC分类号： C07C51/09 ,  C07C65/24

摘要： The present invention provides a method for producing a compound represented by the formula (3): wherein n is an integer of 1 to 6, characterized by the steps of hydrolyzing a solution containing an ester compound represented by the formula (1): wherein R is a lower alkyl group and n is an integer of 1 to 6, and a compound represented by the formula (2): wherein R is as defined above, adjusting the pH of the resulting solution to pH 4 to 8, and then subjecting to phase separation to obtain an organic layer containing the carboxylic acid of formula (3).

摘要翻译： 本发明提供一种制备由式（3）表示的化合物的方法：其中n为1至6的整数，其特征在于水解含有由式（1）表示的酯化合物的溶液的步骤：其中R 为低级烷基，n为1〜6的整数，式（2）表示的化合物：其中R如上定义，将所得溶液的pH调节至pH4〜8，然后使 得到含有式（3）的羧酸的有机层。