公开(公告)号：US07974671B2

公开(公告)日：2011-07-05

申请号：US10572357

申请日：2004-09-03

申请人： Michiyuki Fujiwara ,  Tsuneaki Kawaguchi ,  Fumio Kawaguchi ,  Shingo Kawasaki ,  Atsushi Maki ,  Yukiko Hirabayashi ,  Yukari Yamamoto ,  Masashi Kiguchi ,  Hiroki Sato ,  Tsuyoshi Yamamoto ,  Takushige Katsura ,  Hideo Kawaguchi

发明人： Michiyuki Fujiwara ,  Tsuneaki Kawaguchi ,  Fumio Kawaguchi ,  Shingo Kawasaki ,  Atsushi Maki ,  Yukiko Hirabayashi ,  Yukari Yamamoto ,  Masashi Kiguchi ,  Hiroki Sato ,  Tsuyoshi Yamamoto ,  Takushige Katsura ,  Hideo Kawaguchi

IPC分类号： A61B5/00

CPC分类号： A61B5/14553 ,  A61B5/0042 ,  A61B5/0059 ,  A61B5/0261 ,  A61B5/0476 ,  A61B5/0478 ,  A61B5/0482 ,  A61B5/0484 ,  A61B5/0488 ,  A61B5/11 ,  A61B5/6822 ,  A61B5/742 ,  A61B2562/0209 ,  A61B2562/0233 ,  A61B2562/046

摘要： A living body information signal processing system (100) combining organically a living body optical measurement apparatus and a brain wave measurement apparatus, the living body optical measurement apparatus (300) in which inspection light of from visible to near infrared is irradiated on a head portion of a subject (140) and the penetration light is received and which measures an optical characteristic variation induced by a brain activity inside the head portion as a living body optical signal and the brain wave measurement apparatus (400) which measures an electrical characteristic variation induced by a brain activity inside the head portion of the subject as a brain wave signal, is provided with a probe device (50) used for both apparatus; and a living body information signal processing and displaying device (200) which displays the living body optical signal corresponding to respective measurement positions from the living body optical measurement apparatus and the brain wave signal corresponding to respective measurement positions from the brain wave measurement apparatus on a common display device while correlating the respective measurement positions each other, thereby, with the system comprehensive observation of both data can be achieved.

摘要翻译： 一种生物体信息信号处理系统（100），其组织有机地生物体光学测量装置和脑电波测定装置，所述生物体光学测量装置（300）将从所述可见光到近红外线的检查光照射在头部 并且测量由头部内部的脑活动引起的作为生物体光信号的光学特性变化和测量电特性变化的脑波测量装置（400）的穿透光， 通过作为脑波信号的被检体头部内的脑活动，设置有用于两个装置的探针装置（50）; 以及生物体信息信号处理和显示装置（200），其从来自所述生物体光学测量装置的对应于各测量位置的生物体光信号和对应于来自所述脑波测量装置的各测量位置的脑波信号 共同显示装置，同时将各个测量位置相互关联，从而可以实现对两个数据的系统综合观察。

公开(公告)号：US07516021B2

公开(公告)日：2009-04-07

申请号：US11570558

申请日：2005-06-08

申请人： Hiroki Sato ,  Atsushi Maki ,  Tsuyoshi Yamamoto ,  Masashi Kiguchi

发明人： Hiroki Sato ,  Atsushi Maki ,  Tsuyoshi Yamamoto ,  Masashi Kiguchi

IPC分类号： G01N31/00

CPC分类号： A61B5/7264 ,  A61B5/0059 ,  A61B5/7425 ,  A61B5/743 ,  G06F19/00 ,  G16H40/63

摘要： Apparatus and method for hemoglobin measurement including irradiating light to a living body, detecting light that has propagated through the living body, and acquiring measured data that represents a change in the concentration of oxidized hemoglobin in the living body and a change in the concentration of deoxidized hemoglobin; irradiating light to the living body, detecting light that has propagated through the living body, and acquiring measured data that represents a change in the concentration of oxidized hemoglobin in the living body and a change in the concentration of deoxidized hemoglobin; classifying the data measured at the first step and the data measured at the second step according to each of an increase or a decrease in the concentration of oxidized hemoglobin and an increase or a decrease in the concentration of deoxidized hemoglobin; and displaying the classifications determined at the third step.

摘要翻译： 用于血红蛋白测量的装置和方法，包括向生物体照射光，检测通过活体传播的光，并获取表示生物体中氧化血红蛋白浓度变化的测量数据和脱氧浓度变化 血红蛋白 对生物体照射光，检测通过生物体传播的光，获取表示生物体中氧化血红蛋白浓度变化的测定数据和脱氧血红蛋白浓度的变化; 根据氧化血红蛋白浓度的增加或减少以及脱氧血红蛋白浓度的增加或减少，分别在第一步骤测量的数据和在第二步骤测量的数据; 并显示在第三步确定的分类。

公开(公告)号：US07890270B2

公开(公告)日：2011-02-15

申请号：US12392207

申请日：2009-02-25

申请人： Hiroki Sato ,  Atsushi Maki ,  Tsuyoshi Yamamoto ,  Masashi Kiguchi

发明人： Hiroki Sato ,  Atsushi Maki ,  Tsuyoshi Yamamoto ,  Masashi Kiguchi

IPC分类号： G01N31/00

CPC分类号： A61B5/7264 ,  A61B5/0059 ,  A61B5/7425 ,  A61B5/743 ,  G06F19/00 ,  G16H40/63

摘要： A living body light measuring device including plural light-radiating devices for radiating light to a head of a subject, plural light-receiving devices for detecting light which is transmitted through the head of the subject after radiation from the light-radiating devices, a calculator for calculating a change of concentration of oxidized and deoxidized hemoglobin in the head of the subject at a measurement point using a pair of each of the plural light-radiating devices and corresponding ones of the light-receiving devices. The calculator decides whether the oxidized hemoglobin concentration change and the deoxidized hemoglobin concentration change are statistically significant at each of the measurement points, and the display displays the decisions regarding the individual measurement points.

摘要翻译： 一种生物体光测量装置，包括：多个用于将光照射到被检体的头部的光辐射装置;多个光检测装置，用于检测从所述光辐射装置辐射后透过所述被检体的头部的光;计算器 用于使用多个光辐射装置和对应的光接收装置中的每一个来计算测量点处的受试者头部中的氧化和脱氧血红蛋白的浓度的变化。 计算器确定每个测量点氧化血红蛋白浓度变化和脱氧血红蛋白浓度变化是否具有统计学意义，显示显示各个测量点的决定。

公开(公告)号：US20080040049A1

公开(公告)日：2008-02-14

申请号：US11570558

申请日：2005-06-08

申请人： Hiroki Sato ,  Atsushi Maki ,  Tsuyoshi Yamamoto ,  Masashi Kiguchi

发明人： Hiroki Sato ,  Atsushi Maki ,  Tsuyoshi Yamamoto ,  Masashi Kiguchi

IPC分类号： G06F19/00

CPC分类号： A61B5/7264 ,  A61B5/0059 ,  A61B5/7425 ,  A61B5/743 ,  G06F19/00 ,  G16H40/63

摘要： In the past, comparison of mean values or variances measured from multiple subjects with one another has been a mainstream of diagnostic support to be achieved using cerebral activity signals. However, in this case, it is hard to absorb individual differences, and the precision in a diagnostic support technology is low. In order to improve the precision in the diagnostic support technology, the property of data acquired by an optical organism measurement system is utilized in order to create and display information representing a change in the condition of each person. Thus, diagnosis of each person is effectively supported. Measured light signals are used to calculate and record changes in the concentrations of oxidized hemoglobin (Hb), deoxidized Hb, and total Hb respectively. Based on each data (representing the Hb concentration changes), two or more Hb concentration changes (for example, the oxidized Hb concentration change and deoxidized Hb concentration change) are classified according to whether the changes are increases or decreases, and indicated in the form of symbols, an image, or a graph. Thus, an examining person is provided with compressed and simplified information and supported in diagnosis.

摘要翻译： 在过去，从多个受试者相互测量的平均值或差异的比较已经成为使用脑活动信号来实现的诊断支持的主流。 然而，在这种情况下，难以吸收个体差异，诊断支持技术的精度低。 为了提高诊断支持技术的精度，利用光学生物测量系统获取的数据的属性来创建和显示表示每个人的状况变化的信息。 因此，有效地支持每个人的诊断。 测量光信号用于计算和记录氧化血红蛋白（Hb），脱氧Hb和总Hb的浓度变化。 基于每个数据（表示Hb浓度变化），根据变化是增加还是减少来分类两种或更多种Hb浓度变化（例如，氧化的Hb浓度变化和脱氧的Hb浓度变化），并以表格 的符号，图像或图形。 因此，检查人员被提供压缩和简化的信息并且在诊断中被支持。

公开(公告)号：US07991447B2

公开(公告)日：2011-08-02

申请号：US10577944

申请日：2004-07-01

申请人： Hiroki Sato ,  Masashi Kiguchi ,  Atsushi Maki ,  Tsuyoshi Yamamoto

发明人： Hiroki Sato ,  Masashi Kiguchi ,  Atsushi Maki ,  Tsuyoshi Yamamoto

IPC分类号： A61B5/1455

CPC分类号： A61B5/14553

摘要： To control information obtained from inside of a living body with higher precision as compared to that in the conventional technology by controlling a ratio of intensities of light, directed to a trial body, in a plurality of wavelength ranges different in peak wavelength from each other, a measurement error included in information obtained from the living body can be controlled by changing a ratio of intensity of the light in the first wavelength range against that of the light in the second wavelength range. When intensity of irradiated light is limited from the viewpoint of safety to the trial subject, keeping a ratio of the light irradiated to the trial body in the first wavelength range against that of the light in the second wavelength range under a prespecified value and also changing the ratio of irradiated light intensities under the prespecified value.

摘要翻译： 通过在峰值波长不同的多个波长范围内控制指向试验体的光的强度比，通过控制比现有技术更高的精度从内部获得的生物体的信息， 可以通过改变第一波长范围内的光的强度与第二波长范围内的光的强度的比例来控制从生物体获得的信息中包括的测量误差。 当照射光的强度从安全性的角度受限于试验对象时，将照射在试验体上的光的第1波长范围内的光与第2波长范围内的光的比例保持在规定值以下， 照射光强度的比例在预先指定的值之下。

公开(公告)号：US07285790B2

公开(公告)日：2007-10-23

申请号：US11044040

申请日：2005-01-28

申请人： Naoki Tanaka ,  Takusige Katura ,  Masashi Kiguchi ,  Hiroki Sato ,  Atsushi Maki

发明人： Naoki Tanaka ,  Takusige Katura ,  Masashi Kiguchi ,  Hiroki Sato ,  Atsushi Maki

IPC分类号： A61B5/00

CPC分类号： A61B5/16 ,  A61B5/14553 ,  A61B5/6814

摘要： A response period is determined arbitrarily. A satisfactory detecting ability may not be provided because of an artifact or the like contained in a signal. Therefore, an effective detection method and an effective display method of presenting results of detection must be developed. A series of tasks (stimuli) or a selected measurement signal is used as a reference signal, and a phase difference of any other measurement signal from the reference signal is calculated. The synchronousness of the phase of the measurement signal with the phase of the reference signal is numerically expressed. The thus obtained numerical value is statistically processed in order to numerically express a degree of reliability. Thus, a brain activity or a functional connectivity is visualized.

摘要翻译： 响应时间是任意确定的。 由于信号中包含的伪影等，不能提供令人满意的检测能力。 因此，必须开发一种提供检测结果的有效检测方法和有效的显示方法。 使用一系列任务（刺激）或所选择的测量信号作为参考信号，并且计算来自参考信号的任何其它测量信号的相位差。 测量信号的相位与参考信号的相位的同步性被数字表示。 对这样得到的数值进行统计处理，以便数值地表达可靠度。 因此，大脑活动或功能连接可视化。

公开(公告)号：US06907279B2

公开(公告)日：2005-06-14

申请号：US10452052

申请日：2003-06-03

申请人： Hiroki Sato ,  Atsushi Maki ,  Masashi Kiguchi

发明人： Hiroki Sato ,  Atsushi Maki ,  Masashi Kiguchi

IPC分类号： G01N21/17 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B10/00

CPC分类号： A61B5/14553 ,  A61B5/0042 ,  A61B5/7264 ,  A61B2562/0233 ,  A61B2562/046

摘要： The invention provides optical technique for measuring metabolism in a living body that can further reduce an error in measurement even if distance between irradiation and detection is fixed. The living body is classified into measurement regions and different measuring wavelengths are set according to the classification. For example, the head is classified into four regions of a parietal region, a frontal region, a temporal region and an occipital region and a wavelength according to each tissue is set in a wavelength selecting system. In measurement, wavelengths according to each measurement region are selected by multiple wavelengths-light radiating means. Besides, for a region having large personal difference, premeasurement is made using plural combinations of wavelengths and wavelengths are selected using a calculated error in measurement as a criterion.

摘要翻译： 本发明提供了用于测量生物体内新陈代谢的光学技术，即使照射和检测之间的距离固定也能进一步降低测量误差。 将生物体分为测量区域，根据分类设置不同的测量波长。 例如，在波长选择系统中设置头部分为顶叶区域，正面区域，时间区域和枕骨区域的四个区域，并且根据每个组织设置波长。 在测量中，根据每个测量区域的波长由多个波长 - 光辐射装置选择。 此外，对于具有大的个人差异的区域，使用多个波长组合进行预测量，并且使用计算的测量误差作为标准来选择波长。

公开(公告)号：US20060006343A1

公开(公告)日：2006-01-12

申请号：US11044040

申请日：2005-01-28

申请人： Naoki Tanaka ,  Takusige Katura ,  Masashi Kiguchi ,  Hiroki Sato ,  Atsushi Maki

发明人： Naoki Tanaka ,  Takusige Katura ,  Masashi Kiguchi ,  Hiroki Sato ,  Atsushi Maki

IPC分类号： A61B8/06

CPC分类号： A61B5/16 ,  A61B5/14553 ,  A61B5/6814

摘要： A response period is determined arbitrarily. A satisfactory detecting ability may not be provided because of an artifact or the like contained in a signal. Therefore, an effective detection method and an effective display method of presenting results of detection must be developed. A series of tasks (stimuli) or a selected measurement signal is used as a reference signal, and a phase difference of any other measurement signal from the reference signal is calculated. The synchronousness of the phase of the measurement signal with the phase of the reference signal is numerically expressed. The thus obtained numerical value is statistically processed in order to numerically express a degree of reliability. Thus, a brain activity or a functional connectivity is visualized.

摘要翻译： 响应时间是任意确定的。 由于信号中包含的伪影等，不能提供令人满意的检测能力。 因此，必须开发一种提供检测结果的有效检测方法和有效的显示方法。 使用一系列任务（刺激）或所选择的测量信号作为参考信号，并且计算来自参考信号的任何其它测量信号的相位差。 测量信号的相位与参考信号的相位的同步性被数字表示。 对这样得到的数值进行统计处理，以便数值地表达可靠度。 因此，大脑活动或功能连接可视化。

公开(公告)号：US20070135694A1

公开(公告)日：2007-06-14

申请号：US10577944

申请日：2004-07-01

申请人： Hiroki Sato ,  Massashi Kiguchi ,  Atsushi Maki ,  Tsuyoshi Yamamoto

发明人： Hiroki Sato ,  Massashi Kiguchi ,  Atsushi Maki ,  Tsuyoshi Yamamoto

IPC分类号： A61B5/00

CPC分类号： A61B5/14553

摘要： To control information obtained from inside of a living body with higher precision as compared to that in the conventional technology by controlling a ratio of intensities of light, directed to a trial body, in a plurality of wavelength ranges different in peak wavelength from each other, a measurement error included in information obtained from the living body can be controlled by changing a ratio of intensity of the light in the first wavelength range against that of the light in the second wavelength range. When intensity of irradiated light is limited from the viewpoint of safety to the trial subject, by keeping a ratio of the light irradiated to the trial body in the first wavelength range against that of the light in the second wavelength range under a prespecified value and also by changing the ratio of irradiated light intensities under the prespecified value, a measurement error included in information obtained from the living body can be controlled.

摘要翻译： 通过在峰值波长不同的多个波长范围内控制指向试验体的光的强度比，通过控制比现有技术更高的精度从内部获得的生物体的信息， 可以通过改变第一波长范围内的光的强度与第二波长范围内的光的强度的比例来控制从生物体获得的信息中包括的测量误差。 当照射光的强度从安全性的角度受限于试验对象时，通过将照射到试验体的光在第一波长范围内的光与第二波长范围内的光的比例保持在规定值，并且还 通过改变预定值下的照射光强度的比率，可以控制从活体获得的信息中包括的测量误差。

公开(公告)号：US20140107439A1

公开(公告)日：2014-04-17

申请号：US14117154

申请日：2012-06-15

申请人： Hirokazu Atsumori ,  Hiroki Sato ,  Masashi Kiguchi

发明人： Hirokazu Atsumori ,  Hiroki Sato ,  Masashi Kiguchi

IPC分类号： A61B5/16 ,  A61B5/1455

CPC分类号： A61B5/165 ,  A61B5/14551

摘要： Disclosed is a device using a biological optical measurement technology to evaluate mood states in daily life of an examinee by presenting a first task once or a plurality of times and then presents a second task a plurality of times, calculating a hemoglobin signal of a predetermined measurement point for the first task and a hemoglobin signal of a predetermined measurement point for the second task, and calculating quantitative values using the obtained hemoglobin signals.

摘要翻译： 公开了一种使用生物光学测量技术的装置，通过呈现第一任务一次或多次来评估受试者的日常生活中的情绪状态，然后多次呈现第二任务，计算预定测量的血红蛋白信号 指定第一任务和第二任务的预定测量点的血红蛋白信号，以及使用获得的血红蛋白信号计算定量值。