Abstract:
In one embodiment, the invention provides a method of treating a subject who suffers from a neoplasm (including a cancer such as a radiotherapeutic-resistant cancer) by administering to the subject a therapeutically effective amount of (a) 5-formyl-2′-deoxyuridine (fdU or foUdR) or a 5-formyl-2′-deoxyuridine derivative, optionally in combination with 5-hydroxy-2′-deoxyuridine (hUdR); and (b) at least one composition selected from the group consisting of either 5-fluorouracil (5-FU), a 5-FU prodrug (e.g. 5-fluoro-2′-deoxyuridine (FdU)) or 5-FU metabolite. In a preferred embodiment, a subject who suffers from colorectal cancer (CRC) or metastatic colorectal cancer (mCRC) is treated with a therapeutically-effective amount of fdU and either 5-FU or the 5-FU prodrug 5-fluoro-2′-deoxyuridine (FdU). Related pharmaceutical compositions are also provided.
Abstract:
In one embodiment, the invention provides a method of treating a subject who suffers from a neoplasm (including a cancer such as a radiotherapeutic-resistant cancer) by administering to the subject a therapeutically effective amount of (a) 5-formyl-2′-deoxyuridine (fdU or foUdR) or a 5-formyl-2′-deoxyuridine derivative, optionally in combination with 5-hydroxy-2′-deoxyuridine (hUdR); and (b) at least one composition selected from the group consisting of either 5-fluorouracil (5-FU), a 5-FU prodrug (e.g. 5-fluoro-2′-deoxyuridine (FdU)) or 5-FU metabolite. In a preferred embodiment, a subject who suffers from colorectal cancer (CRC) or metastatic colorectal cancer (mCRC) is treated with a therapeutically-effective amount of fdU and either 5-FU or the 5-FU prodrug 5-fluoro-2′-deoxyuridine (FdU). Related pharmaceutical compositions are also provided.
Abstract:
There is provided a semiconductor device capable of supplying an analog input signal higher than or equal to an operating power supply voltage. An electrostatic discharge protection circuit corresponding to the analog input signal is provided for an external terminal that is supplied with an analog input signal generated with a first power supply voltage. A voltage divider resistor divides the analog input signal passing through the electrostatic discharge protection circuit into a voltage corresponding to a second power supply voltage lower that the first power supply voltage. An input circuit operating on the second power supply voltage receives the analog input signal divided by the voltage divider resistor to form an internal analog signal. There are provided first and second unidirectional elements. The first unidirectional element passes current from the input circuit's input terminal to the second power supply voltage. The second unidirectional element passes current from a circuit ground potential to a first circuit's input terminal.
Abstract:
A super high density optical disk apparatus is obtained by using an exchangeable recording medium having a recording capacity of at least 1.5 Gb/in.sup.2 in an optical recording and reading apparatus for recording or reading at least using a laser beam or by using one of means which can record on a recording medium only once and means which can record at least two times repeatedly as recording means to be used.
Abstract:
A magneto-optical disk system includes a magneto-optical disk and a disk drive. The magneto-optical disk drives provides a function of controlling the shape of a recorded domain by using a short wavelength laser beam and a test recording and a function of recording a using a pulse train. The magneto-optical disk has a laminated layer structure capable of obtaining a high S/N ratio and stabilizing a heat conduction. The magneto-optical disk drive with the recorded domain shape control function using a short wavelength laser beam and a test recording and with the pulse train recording record function is organically coupled with the magneto-optical disk having the laminated layer structure with a stabilized heat conduction to make the disk and the disk drive have an integrity therebetween, providing a magneto-optical disk having a recording capacity four times as large as the first generation magneto-optical disk system.
Abstract:
A pit edge interval correcting method in an optical recording/read-out apparatus wherein as data items to be used to correct pit edge intervals for cancellation of a thermal interference from a previously recorded pattern, there is formed a table representing relationships between kinds of record patterns and edge shift quantities of the patterns in a read-out signal. Edge shift quantities of particular patterns with respect to a unitary variation quantity of a recording medium surface temperature (an ambient temperature of an optical disk) and edge shift quantities of particular patterns with respect to a unitary variation quantity of laser power are beforehand acquired as correction control data. Before actual data are recorded, the particular patterns are again recorded on a medium and read out therefrom. If an edge shift occurs in a read-out signal, a variation quantity of the recording medium surface temperature and a variation quantity of the laser power are separately obtained based on a quantity of the edge shift occurring and the correction control data collected in advance. Using each variation quantity, the value set to the laser power is altered and/or the data in the table are updated to correct the actual data.
Abstract:
A developer composition for a lithographic printing plate provided with a coated layer composed of a photosensitive polymer having in the main chain thereof groups of formula (I) ##STR1## wherein X and Y independently represent hydrogen, halogen, cyano or nitro and n is an integer of 1 or 2, comprising:(A) benzyl alcohol,(B) tetrahydrofurfuryl alcohol and(C) at least one acid selected from the group consisting of a mineral acid, an organic carboxylic acid and an organic sulfonic acid.
Abstract:
In the present invention, by making the width of the write element larger than the track pitch and securing a write magnetic field strong enough to reverse the magnetization of the magnetic layer, and further by writing while shifting a write head comprising the write element, a magnetic disk drive, of which the track width is narrower than the write element width, and the storage capacity is large, is realized.
Abstract:
Embodiments of the present invention provide a process that monitors a magnetic playback signal while gradually increasing an electricity supply amount for a heater to thereby determine contact between a magnetic head slider and a magnetic disk medium. According to one embodiment, after components for configuring a magnetic recording/playback portion are assembled into a housing, magnetic information is played back on a specific track of a magnetic disk medium by using a playback element while gradually increasing an electricity supply amount for a heater of a magnetic head slider. An amplitude of a playback signal is measured at a plurality of portions along a circumferential direction of the track. Contact between the magnetic head slider and the magnetic disk medium is detected in accordance with an increase in variation in the measured amplitude. Then, a value obtained by subtracting an predetermined value of an electricity amount from an electricity amount in the event of detection of the contact is stored (set) as an appropriate electricity amount for the magnetic head slider into a storage portion.
Abstract:
A write head's material having a great thermal expansion coefficient expands due to Joule heat resulting from a write current and a temperature rise dependent on high-frequency core loss, thereby causing the head's flying surface to protrude toward a magnetic disk. This phenomenon is called TPR (thermal protrusion). It is essential that the flying height be accurately determined and managed in consideration of TPR. A magnetic disk drive for actual use or a magnetic disk drive that is in a testing process but similar to the one for actual use is used to measure TPR amount changes resulting from a write operation, store the resulting measured data in a memory or on the magnetic disk, and perform flying height management with the stored measured data. Further, flying height management is performed as needed in conjunction with a SMART function. The present invention makes it possible to perform high-reliability flying height management.