摘要:
The present invention provides a compound of general formula (I): ##STR1## wherein X represents group (II) or (III): ##STR2## wherein Y represents a leaving group and Z represents an oligonucleotide. The compound can specifically transfer oligonucleotides to cells which specifically recognize a specified saccharide construction. Accordingly, the compound can be used as an antiviral agent or an antitumor agent.
摘要:
The present invention relates to a compound represented by the following formula, a pharmacologically acceptable salt thereof, or a use thereof as a pharmaceutical: wherein R1 and R2 are substituents adjacent to each other, and together with two carbon atoms to each of which they attach, form a 5- to 7-membered non-aromatic carbocyclic group or the like, which may be substituted by 1 to 4 substituents selected from (1) an oxo group, (2) a hydroxyl group, and the like; R3 represents a hydrogen atom or the like; and R6 represents a hydrogen atom or the like. This compound has a superior strength of binding to a 5-HT1A receptor and an antagonism to the receptor, and is useful as an agent for treating or preventing lower urinary tract symptoms, and particularly symptoms regarding urinary storage.
摘要翻译:本发明涉及由下式表示的化合物,其药理学上可接受的盐或其作为药物的用途:其中R 1和R 2是相邻的取代基 并且与它们各自连接的两个碳原子一起形成5-至7-元非芳族碳环基等,其可以被1至4个选自以下的取代基取代:(1)氧代 基团,(2)羟基等; R 3表示氢原子等; R 6表示氢原子等。 该化合物与5-HT 1A受体的结合强度优异,对受体具有拮抗作用,可用作治疗或预防下尿路症状的药剂,特别是有关尿液储存的症状。
摘要:
Certain embodiments provide method for manufacturing a solid-state imaging device, including forming an electrode and forming a second impurity layer. The electrode is formed on a semiconductor substrate including a first impurity layer of a first conductivity type on a surface. The second impurity layer is a second conductivity type and is formed by implanting an impurity of a second conductivity type into the first impurity layer in an oblique direction with respect to the surface of the semiconductor substrate on the condition that the impurity penetrates an end portion of the electrode, based on a position of the electrode. The second impurity layer is bonded to the first impurity layer to constitute a photodiode, and a portion of the second impurity layer is disposed under the electrode.
摘要:
A flight control method and device for correcting a reference trajectory based on a distance from a current position to a target position in a spacecraft in flight. A CPU included in the spacecraft generates a reference trajectory which is a trajectory for allowing the spacecraft in flight to arrive at the target position on a celestial body with the atmosphere, and which is identified based on velocity or energy of the spacecraft and on drag acceleration of the spacecraft. The CPU calculates a ratio between the range that is a distance from the current position based on the reference trajectory to the target position, and the real range that is a real distance from a current position to the target position, and corrects the reference trajectory by calculating the drag acceleration in the reference trajectory using the calculated ratio.
摘要:
An image reading device, which has an image sensor having a plurality of sensor chips therein and being capable of outputting data in parallel through a plurality of output channels, includes an image reading section configured to perform reading of images in either of two outputting modes, one being a parallel outputting mode in which start signals are simultaneously inputted to the plurality of sensor chips so that pieces of data in the plurality of the sensor chips are outputted in parallel through the plurality of output channels, respectively, the other one being an interval outputting mode in which start signals are sequentially inputted to the plurality of sensor chips at intervals of time between any two successive inputs of the start signals, respectively, so that respective pieces of data in the plurality of sensor chips are sequentially outputted through any one of the plurality of output channels, and a mode selection section configured to select either of the two outputting modes in accordance with a set resolution.
摘要:
An operation determination processing section of a center extracts words included in the utterance of a driver and an operator, reads an attribute associated with each word from a synonym and related word in which an attribute is stored so as to be associated with each word, reads a domain of a candidate or the like for the task associated with the attribute from the synonym and related word in which domains of a candidate for a task associated with the read attribute or domains of a task to be actually performed are stored, totals the domains read for each word for words included in the utterance of the driver or the like, and estimates those related to a domain with a highest total score as the candidate for the task and the task to be actually performed. In this manner, it is possible to estimate the task with high accuracy.
摘要:
In a plasma processing apparatus, electromagnetic waves are radiated from slots of waveguides into a processing chamber via dielectric windows that are supported on beams, thereby generating a plasma. A substrate, which is an object of processing, is processed by the generated plasma. Dielectric plates are attached to those surfaces of the beams, which are opposed to the processing chamber. The thickness of each dielectric plate is set at ½ or more of the intra-dielectric wavelength of the electromagnetic waves. Using the plasma processing apparatus, a large-area processing can uniformly be performed.
摘要:
A CCD color image sensor which prevents unnecessary charge from overflowing in a photoelectric conversion element. An image input apparatus having the CCD color image sensor comprises transferring unit which transfers effective charge accumulated in the photoelectric conversion element provided for each of the colors (R, G and B), extracted as an output signal, to a shift register by opening a shift gate; and discarding unit which discards unnecessary charge accumulated in the photoelectric conversion element by opening the shift gate at different timing from one color to another immediately before the photoelectric conversion element starts accumulating effective charge again. The discarding unit discards unnecessary charge immediately before effective charge accumulates, and discards unnecessary charge by opening the shift gate before unnecessary charge overflows in the photoelectric conversion element.
摘要:
The present invention provides a compound represented by the following formula [wherein T represents a single bond, a C1-C4 alkylene group which may have a substituent and the like; formula (I-1) represents a single bond or a double bond; A represents a single bond, a bivalent 5- to 14-membered heterocyclic group which may have a substituent and the like; Y represents a single bond and the like; Z represents a methylene group and the like; ring G represents a phenylene group and the like which may condense with a 5- to 6-membered ring and may have a heteroatom; Ra and Rb are the same as or different from each other and represent a hydrogen atom and the like; W represents a single bond and the like; R′ represents 1 to 4 independent hydrogen atoms and the like; and R″ represents 1 to 4 independent hydrogen atoms and the like] or a salt thereof, or a hydrate thereof
摘要:
A loudspeaker unit which requires no particular procedure for correction of the acoustic characteristic even if the installation environment of the loudspeaker unit changes, and which can correct, in addition to the frequency characteristic, a sound lag and a phase shift ascribable to the reverberation and an echo of a sound. The loudspeaker unit picks up a sound regenerating from the loud speaker with a microphone, and compares in real time a sound from a sound source with a regenerative sound, referring to a difference therebetween, with reference to the characteristic at an optional frequency and the characteristic of the reverberation or the echo each including the delay time, respectively, and corrects the signal to be sent to the loudspeaker by the result of arithmetic.