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    Process for production of 8,11-eicosadienoic acid using Mortierella alpina
    1.
    发明授权
    Process for production of 8,11-eicosadienoic acid using Mortierella alpina 失效
    使用高山被孢霉生产8,11-二十碳烯酸的方法

    公开(公告)号：US5376541A

    公开(公告)日：1994-12-27

    申请号：US953044

    申请日：1992-09-29

    申请人： Hiroshi Kawashima ,  Kengo Akimoto ,  Hideaki Yamada ,  Sakayu Shimizu

    发明人： Hiroshi Kawashima ,  Kengo Akimoto ,  Hideaki Yamada ,  Sakayu Shimizu

    IPC分类号： C12P7/64 ,  C12R1/645 ,  C12R1/66 ,  C12R1/785 ,  C12R1/80 ,  C12P7/40 ,  C12P7/62

    CPC分类号： C12P7/6427 ,  C12P7/6472

    摘要： A process for the production of 8,11-eicosadienoic acid or a lipid containing 8,11-eicosadienoic acid comprising the steps of, culturing a microorganism having an ability to produce an omega 9 type polyunsaturated fatty acid in a medium supplemented with a .DELTA.5 desaturase inhibitor, or adding a .DELTA.5 desaturase inhibitor to a medium in which said microorganism has been cultured and further culturing the microorganism to produce 8,11-eicosadienoic acid, or a lipid containing 8,11-eicosadienoic acid, and recovering the 8,11-eicosadienoic acid, or the lipid containing 8,11-eicosadienoic acid.

    摘要翻译： 制备8,11-二十碳二烯酸或含有8,11-二十碳二烯酸的脂质的方法，包括以下步骤：在补充有DELTA 5的培养基中培养具有产生ω9型多不饱和脂肪酸的能力的微生物 去饱和酶抑制剂，或向已经培养了所述微生物的培养基中加入DELTA5去饱和酶抑制剂，并进一步培养该微生物以产生8,11-二十碳二烯酸或含有8,11-二十碳二烯酸的脂质， 11-二十碳二烯酸或含有8,11-二十碳二烯酸的脂质。

    Microorganism secreting out lipid and process for producing the lipid and lipid balls having the lipid encapsulating therein by using the mircroorganism
    6.
    发明授权
    Microorganism secreting out lipid and process for producing the lipid and lipid balls having the lipid encapsulating therein by using the mircroorganism 有权
    分泌脂质的微生物和通过使用微生物制备脂质和脂质球的方法，其中脂质和脂质包封在其中

    公开(公告)号：US07157254B1

    公开(公告)日：2007-01-02

    申请号：US09807541

    申请日：2000-08-11

    申请人： Kengo Akimoto ,  Hiroshi Kawashima ,  Sakayu Shimizu

    发明人： Kengo Akimoto ,  Hiroshi Kawashima ,  Sakayu Shimizu

    IPC分类号： C12P7/64

    CPC分类号： A61K31/202 ,  A23C9/1528 ,  A23C11/04 ,  A23D9/00 ,  A23K20/158 ,  A23L2/52 ,  A23L5/00 ,  A23L31/00 ,  A23L33/12 ,  A23L33/14 ,  A23V2002/00 ,  A61K8/14 ,  A61K8/92 ,  A61K8/925 ,  A61K8/99 ,  A61K31/201 ,  A61Q19/00 ,  C12P7/6472 ,  C12R1/645 ,  A23V2200/224 ,  A23V2250/18 ,  A23V2250/1862 ,  A23V2250/187 ,  A23V2250/1868

    摘要： There are provided microorganisms having a property of producing a lipid containing unsaturated fatty acids as constituent fatty acids and extracellularly secreting the produced lipid encapsulated in lipid vesicles, methods of screening said microorganisms, as well as methods of efficiently producing a fatty acid-containing lipid using said microorganisms. Furthermore, there are provided lipid vesicles encapsulating a lipid containing unsaturated fatty acids, and foods, cosmetics, and animal feeds comprising said lipid vesicles added thereto. Artificially treated microorganisms or microorganisms collected from nature are grown on a solid medium, and microbial strains that form lipid vesicles at the periphery of the colonies and/or microbial strains that, when cultured in a transparent liquid medium, make the culture liquid cloudy are selected. The microorganisms obtained are cultured, lipid-containing lipid vesicles secreted in the culture liquid, are separated from the culture liquid, and the lipid is separated and purified.

    摘要翻译： 提供了具有产生含有不饱和脂肪酸的脂质作为构成脂肪酸并细胞外分泌包封在脂质囊泡中的所产生的脂质的性质的微生物，筛选所述微生物的方法以及使用以下方法有效生产含脂肪酸的脂质： 说微生物。 此外，提供了包含含有不饱和脂肪酸的脂质的脂质囊泡，以及包含所述脂质囊泡的食品，化妆品和动物饲料。 人造处理的微生物或自然界收集的微生物在固体培养基上生长，并且在菌落和/或微生物菌株的周围形成脂质囊泡的微生物菌株，当在透明液体培养基中培养时，选择培养液混浊 。 培养得到的微生物，分泌到培养液中的含有脂质的脂质囊泡与培养液分离，分离纯化脂质。

    Process for producing omega-9 highly unsaturated fatty acid and lipid containing the same
    7.
    发明授权
    Process for producing omega-9 highly unsaturated fatty acid and lipid containing the same 失效
    生产ω-9高度不饱和脂肪酸和含有它的脂质的方法

    公开(公告)号：US6150144A

    公开(公告)日：2000-11-21

    申请号：US917230

    申请日：1997-08-25

    申请人： Kengo Akimoto ,  Hiroshi Kawashima ,  Sakayu Shimizu

    发明人： Kengo Akimoto ,  Hiroshi Kawashima ,  Sakayu Shimizu

    IPC分类号： C12P7/64 ,  C12R1/645

    CPC分类号： C12P7/6427 ,  C12P7/6472

    摘要： The present invention discloses a process for producing lipid containing omega-9 highly unsaturated fatty acid by culturing in a medium a mutant strain obtained by mutation on a microorganism having the ability to produce arachidonic acid belonging to the genus Mortierella and so forth, in which .DELTA.12 desaturation activity is decreased or lost, but at least one of .DELTA.5 desaturation activity, .DELTA.6 desaturation activity and chain length elongation activity is elevated. Moreover, the present invention also discloses a process for producing omega-9 highly unsaturated fatty acid by collecting omega-9 highly unsaturated fatty acid from the culture or lipid described above.

    摘要翻译： 本发明公开了一种生产含有ω-9高度不饱和脂肪酸的脂质的方法，该方法是在培养基中培养由具有产生属于高山被孢霉属属的花生四烯酸的能力的微生物上突变获得的突变株，其中DELTA 12去饱和活性降低或丧失，但DELTA5去饱和活性，DELTA 6去饱和活性和链长伸长活性中的至少一种升高。 此外，本发明还公开了通过从上述培养物或脂质中收集ω-9高度不饱和脂肪酸来生产ω-9高度不饱和脂肪酸的方法。

    Microorganisms that extracellularly secrete lipids and methods of producing lipid and lipid vesicles encapsulating lipids using said microorganisms
    10.
    发明申请
    Microorganisms that extracellularly secrete lipids and methods of producing lipid and lipid vesicles encapsulating lipids using said microorganisms 审中-公开
    细胞外分泌脂质的微生物和使用所述微生物包裹脂质的脂质和脂质囊泡的产生方法

    公开(公告)号：US20070077637A1

    公开(公告)日：2007-04-05

    申请号：US11606920

    申请日：2006-12-01

    申请人： Kengo Akimoto ,  Hiroshi Kawashima ,  Sakayu Shimizu

    发明人： Kengo Akimoto ,  Hiroshi Kawashima ,  Sakayu Shimizu

    IPC分类号： C12P7/64 ,  C12N1/16

    CPC分类号： A61K31/202 ,  A23C9/1528 ,  A23C11/04 ,  A23D9/00 ,  A23K20/158 ,  A23L2/52 ,  A23L5/00 ,  A23L31/00 ,  A23L33/12 ,  A23L33/14 ,  A23V2002/00 ,  A61K8/14 ,  A61K8/92 ,  A61K8/925 ,  A61K8/99 ,  A61K31/201 ,  A61Q19/00 ,  C12P7/6472 ,  C12R1/645 ,  A23V2200/224 ,  A23V2250/18 ,  A23V2250/1862 ,  A23V2250/187 ,  A23V2250/1868

    摘要： There are provided microorganisms having a property of producing a lipid containing unsaturated fatty acids as constituent fatty acids and extracellularly secreting the produced lipid encapsulated in lipid vesicles, methods of screening said microorganisms, as well as methods of efficiently producing a fatty acid-containing lipid using said microorganisms. Furthermore, there are provided lipid vesicles encapsulating a lipid containing unsaturated fatty acids, and foods, cosmetics, and animal feeds comprising said lipid vesicles added thereto. Artificially treated microorganisms or microorganisms collected from nature are grown on a solid medium, and microbial strains that form lipid vesicles at the periphery of the colonies and/or microbial strains that, when cultured in a transparent liquid medium, make the culture liquid cloudy are selected. The microorganisms obtained are cultured, lipid-containing lipid vesicles secreted in the culture liquid, are separated from the culture liquid, and the lipid is separated and purified.

    摘要翻译： 提供了具有产生含有不饱和脂肪酸的脂质作为构成脂肪酸并细胞外分泌包封在脂质囊泡中的所产生的脂质的性质的微生物，筛选所述微生物的方法以及使用以下方法有效生产含脂肪酸的脂质： 说微生物。 此外，提供了包含含有不饱和脂肪酸的脂质的脂质囊泡，以及包含所述脂质囊泡的食品，化妆品和动物饲料。 人造处理的微生物或自然界收集的微生物在固体培养基上生长，并且在集落和/或微生物菌株的周围形成脂质囊泡的微生物菌株，当在透明液体培养基中培养时，选择培养液混浊 。 培养得到的微生物，分泌到培养液中的含有脂质的脂质囊泡与培养液分离，分离纯化脂质。