公开(公告)号：US06461827B1

公开(公告)日：2002-10-08

申请号：US09423104

申请日：1999-10-29

申请人： Hiroshi Oda ,  Nobuyuki Sato ,  Masazumi Nishikawa ,  Kosuke Seiki ,  Yoshihiro Urade ,  Yutaka Eguchi ,  Naomi Eguchi

发明人： Hiroshi Oda ,  Nobuyuki Sato ,  Masazumi Nishikawa ,  Kosuke Seiki ,  Yoshihiro Urade ,  Yutaka Eguchi ,  Naomi Eguchi

IPC分类号： G01N3353

CPC分类号： G01N33/88 ,  G01N33/573 ,  Y10S435/81 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/811

摘要： The present invention provides a method for detecting or predicting ischemic disorders in a subject by using as an indication the concentration of human lipocalin-type prostaglandin D synthase (hPGDS) in body fluid samples from the subject. More specifically, the method comprises comparing the hPGDS concentrations in the body fluid samples from a subject with the reference values established for a normal subject, thereby detecting or predicting the ischemic disorders.

摘要翻译： 本发明提供了通过使用来自受试者的体液样品中的人脂质运载蛋白型前列腺素D合成酶（hPGDS）的浓度的指示来检测或预测受试者的缺血性障碍的方法。 更具体地，该方法包括将来自受试者的体液样品中的hPGDS浓度与为正常受试者建立的参考值进行比较，从而检测或预测缺血性疾病。

公开(公告)号：US20080233597A1

公开(公告)日：2008-09-25

申请号：US10573324

申请日：2004-09-24

申请人： Yasuhiko Shiina ,  Hiroshi Oda ,  Kosuke Seiki ,  Toshio Ushiyama ,  Yoshihiro Urade ,  Naomi Eguchi ,  Yutaka Eguchi

发明人： Yasuhiko Shiina ,  Hiroshi Oda ,  Kosuke Seiki ,  Toshio Ushiyama ,  Yoshihiro Urade ,  Naomi Eguchi ,  Yutaka Eguchi

IPC分类号： G01N33/53 ,  G01N33/00 ,  C07K16/18 ,  G01N33/536

CPC分类号： G01N33/573 ,  C07K16/40 ,  G01N33/564 ,  G01N2333/99 ,  G01N2800/102

摘要： A method of readily detecting or differentiating rheumatoid arthritis, which has so far been diagnosed in a comprehensive manner based on various tests and clinical symptoms, and a method of readily and objectively estimating the stage of disease and the degree of dysfunction with regard to rheumatoid arthritis are provided.The detection and differentiation of rheumatoid arthritis are performed by measuring the levels of L-PGDS in a sample such as a body fluid such that the measurement value is used as an index. Further, the stage of disease or the degree of dysfunction of a rheumatoid arthritis patient is determined using the measurement value as an index.

摘要翻译： 一种容易地检测或分化类风湿性关节炎的方法，其迄今为止已经基于各种试验和临床症状以综合方式进行诊断，以及容易且客观地估计疾病阶段和关于类风湿性关节炎的功能障碍程度的方法 被提供。 类风湿性关节炎的检测和分化通过测定体液等样品中的L-PGDS的水平来进行，以使测定值作为指标。 此外，使用测量值作为指标来确定类风湿性关节炎患者的疾病阶段或功能障碍程度。

公开(公告)号：US07399596B2

公开(公告)日：2008-07-15

申请号：US10573072

申请日：2004-09-24

申请人： Hiroshi Oda ,  Kosuke Seiki ,  Yasuhiko Shiina ,  Nobuyuki Sato ,  Satoru Takeda ,  Naomi Eguchi ,  Yoshihiro Urade

发明人： Hiroshi Oda ,  Kosuke Seiki ,  Yasuhiko Shiina ,  Nobuyuki Sato ,  Satoru Takeda ,  Naomi Eguchi ,  Yoshihiro Urade

IPC分类号： G01N33/53

CPC分类号： C12Q1/533 ,  G01N33/689 ,  G01N2800/368

摘要： Provided are: a method for predicting the onset of pregnancy-induced hypertension (PIH) by precisely detecting abnormalities that occur before the onset of PIH (where such abnormalities have been impossible to detect by various conventional testing methods for PIH) while imposing less of a burden on a subject; a method for evaluating a fetus and placental functions in PIH; and a method for detecting PIH, which comprises measuring the level of human lipocalin-type prostaglandin D synthase (L-PGDS) in a body fluid sample collected from a subject.

摘要翻译： 提供：通过精确检测在PIH发病之前发生的异常（其中这种异常不可能通过各种常规的PIH检测方法检测）而预测妊娠诱发的高血压（PIH）的发作的方法，同时施加较少的 一个主题的负担; 用于评估PIH中胎儿和胎盘功能的方法; 以及检测PIH的方法，其包括测量从受试者收集的体液样品中的人脂笼蛋白型前列腺素D合成酶（L-PGDS）的水平。

公开(公告)号：US20070020609A1

公开(公告)日：2007-01-25

申请号：US10573072

申请日：2004-09-24

申请人： Hiroshi Oda ,  Kosuke Seiki ,  Yasuhiko Shiina ,  Nobuyuki Sato ,  Satoru Takeda ,  Naomi Eguchi ,  Yoshihiro Urade

发明人： Hiroshi Oda ,  Kosuke Seiki ,  Yasuhiko Shiina ,  Nobuyuki Sato ,  Satoru Takeda ,  Naomi Eguchi ,  Yoshihiro Urade

IPC分类号： C12Q1/00

CPC分类号： C12Q1/533 ,  G01N33/689 ,  G01N2800/368

摘要： Provided are: a method for predicting the onset of pregnancy-induced hypertension (PIH) by precisely detecting abnormalities that occur before the onset of PIH (where such abnormalities have been impossible to detect by various conventional testing methods for PIH) while imposing less of a burden on a subject; a method for evaluating a fetus and placental functions in PIH; and a method for detecting PIH, which comprises measuring the level of human lipocalin-type prostaglandin D synthase (L-PGDS) in a body fluid sample collected from a subject.

摘要翻译： 提供：通过精确检测在PIH发病之前发生的异常（其中这种异常不可能通过各种常规的PIH检测方法检测）而预测妊娠诱发的高血压（PIH）的发作的方法，同时施加较少的 一个主题的负担; 用于评估PIH中胎儿和胎盘功能的方法; 以及检测PIH的方法，其包括测量从受试者收集的体液样品中的人脂笼蛋白型前列腺素D合成酶（L-PGDS）的水平。

公开(公告)号：US07314727B2

公开(公告)日：2008-01-01

申请号：US10333336

申请日：2001-06-07

申请人： Mitsuhito Mase ,  Hiroya Nakau ,  Takashi Inui ,  Naomi Eguchi ,  Yoshihiro Urade ,  Kosuke Seiki ,  Hiroshi Oda ,  Hiroshi Nakajima ,  Nobuyuki Sato

发明人： Mitsuhito Mase ,  Hiroya Nakau ,  Takashi Inui ,  Naomi Eguchi ,  Yoshihiro Urade ,  Kosuke Seiki ,  Hiroshi Oda ,  Hiroshi Nakajima ,  Nobuyuki Sato

IPC分类号： G01N33/53 ,  G01N33/537 ,  G01N33/543 ,  G01N33/573 ,  G01N33/542

CPC分类号： G01N33/573 ,  G01N33/6896 ,  G01N2333/9015 ,  G01N2333/90245 ,  G01N2800/2814

摘要： The present invention relates to methods for differentiating demential diseases comprising measuring the concentration of human lipocalin-type prostaglandin D synthase in a sample of a body fluid collected from a subject and kits for differentiating demential diseases comprising an antibody specific to human lipocalin-type prostaglandin D synthase.

摘要翻译： 本发明涉及用于分化痴呆疾病的方法，包括测量从受试者收集的体液样品中的人脂笼蛋白型前列腺素D合成酶的浓度和用于分化痴呆疾病的试剂盒，所述试剂盒包含对人脂质运载蛋白型前列腺素D特异的抗体 合酶。

公开(公告)号：US20050272767A1

公开(公告)日：2005-12-08

申请号：US10919473

申请日：2004-08-17

申请人： Yoshihiro Urade ,  Naomi Eguchi ,  Kosuke Aritake ,  Yo Sato ,  Masako Taniike ,  Ikuko Mori ,  Masashi Miyano

发明人： Yoshihiro Urade ,  Naomi Eguchi ,  Kosuke Aritake ,  Yo Sato ,  Masako Taniike ,  Ikuko Mori ,  Masashi Miyano

IPC分类号： G01N33/50 ,  A01K67/027 ,  A01N25/00 ,  A01N43/42 ,  A61K31/185 ,  A61K31/403 ,  A61K31/4166 ,  A61K31/454 ,  A61K31/47 ,  A61K31/501 ,  A61K31/53 ,  A61K45/00 ,  A61P3/10 ,  A61P9/10 ,  A61P21/00 ,  A61P21/04 ,  A61P43/00 ,  C12N15/85 ,  C12N15/90 ,  G01N33/15

CPC分类号： G01N33/5088 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  A61K31/47 ,  C12N15/8509 ,  C12N15/90 ,  G01N2800/2892 ,  G01N2800/324 ,  G01N2800/325

摘要： An object of the present invention is to provide a method which is able to prevent or improve the progress of myolytic diseases such as muscular dystrophy. Such an object is able to be solved by a method where an effective dose of an inhibitor for hematopoietic prostaglandin D synthase (H-PGDS) or an antagonist to prostaglandin D receptor is administered to a patient who needs it. The present invention also provides a method for screening compounds which are able to prevent the progress of myolytic diseases and to improve it using human H-PGDS overexpressed transgenic mice.

摘要翻译： 本发明的目的是提供能够防止或改善诸如肌营养不良症的肌溶解性疾病进展的方法。 能够通过以下方法解决这样的问题：将有效剂量的造血前列腺素D合成酶（H-PGDS）抑制剂或前列腺素D受体拮抗剂的有效剂量施用于需要其的患者。 本发明还提供了一种筛选化合物的方法，所述化合物能够防止肌溶解性疾病的进展，并使用人H-PGDS过量表达的转基因小鼠进行改良。

公开(公告)号：US20050227984A1

公开(公告)日：2005-10-13

申请号：US11139530

申请日：2005-05-31

申请人： Yoshihiro Urade ,  Naomi Eguchi ,  Kosuke Aritake ,  Yo Sato ,  Keiichi Kadoyama ,  Masako Taniike

发明人： Yoshihiro Urade ,  Naomi Eguchi ,  Kosuke Aritake ,  Yo Sato ,  Keiichi Kadoyama ,  Masako Taniike

IPC分类号： A61K31/381 ,  A61K31/454 ,  A61K31/53 ,  A61K45/06 ,  A61P25/00 ,  A61P43/00 ,  C07D333/68 ,  G01N33/50 ,  G01N33/68 ,  G01N33/88 ,  A61K31/558

CPC分类号： A61K45/06 ,  A61K31/381 ,  A61K31/454 ,  A61K31/53 ,  G01N33/5088 ,  G01N33/6896 ,  G01N33/88

摘要： There are provided a compound for treatment or prevention of brain injury caused by diseases such as cerebrovascular disorder, brain degenerative disease and demyelinating disease and a method for screening the same. Brain injury in which prostaglandin D2 is participated is treated or prevented by inhibition of hematopoietic prostaglandin D synthase induced in microglia cell or macrophage of brain injury area by diseases such as cerebrovascular disorder, brain degenerative disease or demyelinating disease or by inhibition of activation of prostaglandin D receptor expressed in astroglia cell around the injured area. There is also provided a method of testing those pharmaceutical substances using a transgenic mouse in which human hematopoietic prostaglandin D synthase is expressed in large amounts.

摘要翻译： 提供了治疗或预防由脑血管障碍，脑退行性疾病和脱髓鞘疾病等疾病引起的脑损伤的化合物及其筛选方法。 通过抑制由脑血管障碍，脑退行性疾病或脱髓鞘疾病等脑损伤区域的小胶质细胞或巨噬细胞诱导的造血前列腺素D合成酶来治疗或预防前列腺素D 2 2参与的脑损伤 或通过抑制在损伤区域周围的星形胶质细胞中表达的前列腺素D受体的活化来抑制。 还提供了使用其中大量表达人造血前列腺素D合成酶的转基因小鼠来测试这些药物的方法。

公开(公告)号：US07238718B2

公开(公告)日：2007-07-03

申请号：US10919473

申请日：2004-08-17

申请人： Yoshihiro Urade ,  Naomi Eguchi ,  Kosuke Aritake ,  Yo Sato ,  Masako Taniike ,  Ikuko Mori ,  Masashi Miyano

发明人： Yoshihiro Urade ,  Naomi Eguchi ,  Kosuke Aritake ,  Yo Sato ,  Masako Taniike ,  Ikuko Mori ,  Masashi Miyano

IPC分类号： A61K31/41 ,  A61K31/40 ,  A61K31/185

CPC分类号： G01N33/5088 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  A61K31/47 ,  C12N15/8509 ,  C12N15/90 ,  G01N2800/2892 ,  G01N2800/324 ,  G01N2800/325

摘要： An object of the present invention is to provide a method which is able to prevent or improve the progress of myolytic diseases such as muscular dystrophy. Such an object is able to be solved by a method where an effective dose of an inhibitor for hematopoietic prostaglandin D synthase (H-PGDS) or an antagonist to prostaglandin D receptor is administered to a patient who needs it. The present invention also provides a method for screening compounds which are able to prevent the progress of myolytic diseases and to improve it using human H-PGDS overexpressed transgenic mice.

摘要翻译： 本发明的目的是提供能够防止或改善诸如肌营养不良症的肌溶解性疾病进展的方法。 能够通过以下方法解决这样的问题：将有效剂量的造血前列腺素D合成酶（H-PGDS）抑制剂或前列腺素D受体拮抗剂的有效剂量施用于需要其的患者。 本发明还提供了一种筛选化合物的方法，所述化合物能够防止肌溶解性疾病的进展，并使用人H-PGDS过量表达的转基因小鼠进行改良。

公开(公告)号：US20050222235A1

公开(公告)日：2005-10-06

申请号：US10520781

申请日：2003-07-14

申请人： Yoshihiro Urade ,  Naomi Eguchi ,  Kosuke Aritake ,  Yo Sato ,  Keiichi Kadoyama ,  Masako Taniike

发明人： Yoshihiro Urade ,  Naomi Eguchi ,  Kosuke Aritake ,  Yo Sato ,  Keiichi Kadoyama ,  Masako Taniike

IPC分类号： A61K31/381 ,  A61K31/454 ,  A61K31/53 ,  A61K45/06 ,  A61P25/00 ,  A61P43/00 ,  C07D333/68 ,  G01N33/50 ,  G01N33/68 ,  G01N33/88 ,  A61K31/4164 ,  A61K31/403

CPC分类号： A61K45/06 ,  A61K31/381 ,  A61K31/454 ,  A61K31/53 ,  G01N33/5088 ,  G01N33/6896 ,  G01N33/88

摘要： There are provided a compound for treatment or prevention of brain injury caused by diseases such as cerebrovascular disorder, brain degenerative disease and demyelinating disease and a method for screening the same. Brain injury in which prostaglandin D2 is participated is treated or prevented by inhibition of hematopoietic prostaglandin D synthase induced in microglia cell or macrophage of brain injury area by diseases such as cerebrovascular disorder, brain degenerative disease or demyelinating disease or by inhibition of activation of prostaglandin D receptor expressed in astroglia cell around the injured area. There is also provided a method of testing those pharmaceutical substances using a transgenic mouse in which human hematopoietic prostaglandin D synthase is expressed in large amounts.

公开(公告)号：US08568967B2

公开(公告)日：2013-10-29

申请号：US11920543

申请日：2006-05-17

申请人： Yoshihiro Urade ,  Naomi Eguchi ,  Kosuke Aritake ,  Sawako Hyo ,  Hiroshi Takenaka ,  Ryo Kawata

发明人： Yoshihiro Urade ,  Naomi Eguchi ,  Kosuke Aritake ,  Sawako Hyo ,  Hiroshi Takenaka ,  Ryo Kawata

IPC分类号： A61K38/43 ,  A61K38/00 ,  C12Q1/00 ,  C12N9/00 ,  C12N9/90 ,  C07K1/00

CPC分类号： G01N33/88 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0368 ,  C12N9/90 ,  C12N15/8509 ,  C12Q1/26 ,  G01N2800/24

摘要： A method is provided for diagnosis of the severity of a condition in an eosinophilic inflammatory disease such as nasal polyp and for prediction of the recurrence of the disease.

摘要翻译： 提供了一种用于诊断嗜酸性炎性疾病如鼻息肉中的病症严重程度并预测疾病复发的方法。