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18 条记录 (耗时 0.027 秒)

    Process for preparing FR900482 and compounds analogous thereto
    5.
    发明授权
    Process for preparing FR900482 and compounds analogous thereto 失效
    制备FR900482及其类似物的方法

    公开(公告)号：US06423530B1

    公开(公告)日：2002-07-23

    申请号：US09705898

    申请日：2000-11-06

    申请人： Masaru Tsuboi ,  Shiho Shimizu ,  Michio Yamashita ,  Yasuhisa Tsurumi ,  Seiji Hashimoto

    发明人： Masaru Tsuboi ,  Shiho Shimizu ,  Michio Yamashita ,  Yasuhisa Tsurumi ,  Seiji Hashimoto

    IPC分类号： C12N114

    CPC分类号： C12P17/188 ,  Y10S435/929

    摘要： A process for producing a compound of the general formula (I): (wherein R1 represents hydrogen, a lower alkanoyl group or a lower alkyl group; R2 and R3 each represents hydrogen or a lower alkanoyl group) characterized in that a compound of the general formula (II): (wherein R1, R2 and R3 are respectively as defined above) is reacted with a culture of a strain of microorganism belonging to the genus Fusarium or its cells harvested by filtering the broth.

    摘要翻译： 一种制备通式（I）的化合物的方法（其中R 1表示氢，低级烷酰基或低级烷基; R 2和R 3各自表示氢或低级烷酰基），其特征在于通式 式（II）:(其中R1，R2和R3分别如上定义）与属于镰刀菌属的微生物菌株或通过过滤肉汤收获的细胞的培养物反应。

    WF14573 or its salt, production thereof and use thereof
    6.
    发明授权
    WF14573 or its salt, production thereof and use thereof 失效
    WF14573或其盐，其制备及其用途

    公开(公告)号：US06730776B1

    公开(公告)日：2004-05-04

    申请号：US09646342

    申请日：2000-09-18

    申请人： Yasuhiro Hori ,  Shigehiro Takase ,  Yasuhisa Tsurumi ,  Michizane Hashimoto ,  Motohiro Hino

    发明人： Yasuhiro Hori ,  Shigehiro Takase ,  Yasuhisa Tsurumi ,  Michizane Hashimoto ,  Motohiro Hino

    IPC分类号： C07K750

    CPC分类号： C07K7/56 ,  A61K38/00

    摘要： The present invention provides a new antimicrobial compound WF14573, and a process for producing WF14573 by (a) culturing a WF14573A and/or B-producing microorganism in a nutrient medium and recovering WF14573A and/or B from the resultant cultured broth or (b) deacylating WF14573A and/or B in the presence of a microbial substance which is capable of deacylating WF14573A and/or B. Also provided are an antimicrobial agent comprising WF14573 and carrier(s), a pharmaceutical composition comprising an effective amount of WF14573 and pharmaceutically acceptable carrier(s), a method for killing microorganisms by applying WF14573 to the microorganisms, and use of WF14573 for the treatment of infectious diseases caused by pathogenic microorganisms.

    摘要翻译： 本发明提供了一种新的抗微生物化合物WF14573，以及（a）在营养培养基中培养WF14573A和/或产生B生物的微生物并从所得培养液中回收WF14573A和/或B或（b）生产WF14573的方法， 在能够脱酰基WF14573A和/或B的微生物物质存在下脱酰基WF14573A和/或B。还提供了包含WF14573和载体的抗微生物剂，包含有效量的WF14573和药学上可接受的药物组合物 载体，通过向微生物施用WF14573杀死微生物的方法，以及使用WF14573来治疗由病原微生物引起的感染性疾病。

    Process for preparing FR900482 and compounds analogous thereto
    10.
    发明授权
    Process for preparing FR900482 and compounds analogous thereto 失效
    制备FR900482及其类似物的方法

    公开(公告)号：US06204031B1

    公开(公告)日：2001-03-20

    申请号：US09284481

    申请日：1999-04-22

    申请人： Masaru Tsuboi ,  Shiho Shimizu ,  Michio Yamashita ,  Yasuhisa Tsurumi ,  Seiji Hashimoto

    发明人： Masaru Tsuboi ,  Shiho Shimizu ,  Michio Yamashita ,  Yasuhisa Tsurumi ,  Seiji Hashimoto

    IPC分类号： C12P1718

    CPC分类号： C12P17/188 ,  Y10S435/929

    摘要： A process for producing a compound of the general formula (I): (wherein R1 represents hydrogen, a lower alkanoyl group or a lower alkyl group; R2 and R3each represents hydrogen or a lower alkanoyl group) characterized in that a compound of the general formula (II): (wherein R1, R2 and R3 are respectively as defined above) is reacted with a culture of a strain of microorganism belonging to the genus Fusarium or its cells harvested by filtering the broth.

    摘要翻译： 一种制备通式（I）的化合物的方法（其中R 1表示氢，低级烷酰基或低级烷基; R 2和R 3表示氢或低级烷酰基），其特征在于通式 （II）（其中R1，R2和R3分别如上定义）与属于镰刀菌属的微生物菌株或通过过滤肉汤收获的细胞的培养物反应。