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1.发明授权WS7622A mono- or di- sulfate, process for preparation thereof and use thereof 失效WS7622A单硫酸盐或二硫酸盐，其制备方法和用途
公开(公告)号：US5292510A
公开(公告)日：1994-03-08
申请号：US713295
申请日：1991-06-11
申请人： Shigehiro Takase , Hiroshi Hatanaka , Masami Ezaki , Eisaku Tsujii , Masanori Okamoto , Nobuharu Shigematsu , Masakuni Okuhara
发明人： Shigehiro Takase , Hiroshi Hatanaka , Masami Ezaki , Eisaku Tsujii , Masanori Okamoto , Nobuharu Shigematsu , Masakuni Okuhara
IPC分类号： A61K38/00 , A61K38/55 , A61K39/12 , A61P9/10 , A61P11/00 , A61P29/00 , C07K1/113 , C07K4/04 , C07K14/00 , C07K14/195 , C07K14/36 , C07K14/81 , C12P1/06 , C12P21/00 , C12R1/465 , A61K35/74
摘要： WS7622A mono- or di-sulfate and pharmaceutically acceptable salts thereof. WS7622A exhibits human leukocyte elastase-inhibiting activity.
摘要翻译： WS7622A单硫酸盐或二硫酸盐及其药学上可接受的盐。 WS7622A具有人白细胞弹性蛋白酶抑制活性。
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2.发明授权Prophylactic/therapeutic composition for disseminated intravascular coagulation, chronic respiratory tract infectious disease or chronic bronchitis 失效弥散性血管内凝血，慢性呼吸道感染性疾病或慢性支气管炎的预防/治疗组合物
公开(公告)号：US5279826A
公开(公告)日：1994-01-18
申请号：US899915
申请日：1992-06-17
申请人： Noriaki Inamura , Yasuhiko Shinguh , Kunio Nakahara , Yoshitada Notsu , Masanori Okamoto , Shigehiro Takase , Hiroshi Hatanaka , Masami Ezaki , Eisaku Tsujii , Nobuharu Shigematsu , Masakuni Okuhara
发明人： Noriaki Inamura , Yasuhiko Shinguh , Kunio Nakahara , Yoshitada Notsu , Masanori Okamoto , Shigehiro Takase , Hiroshi Hatanaka , Masami Ezaki , Eisaku Tsujii , Nobuharu Shigematsu , Masakuni Okuhara
CPC分类号： C07K4/04 , C07K14/811 , A61K38/00 , A61K39/00
摘要： A method for therapy of disseminated intravascular coagulation, or chronic respiratory tract infectious disease characterized by administering to a patient in need thereof an effective dose suitable for therapeutic treatment of said condition of WS7622A mono- or di-sulfate ester or their pharmaceutically acceptable salt.
摘要翻译： 一种用于治疗弥漫性血管内凝血或慢性呼吸道感染性疾病的方法，其特征在于向有需要的患者施用适于治疗所述WS7622A单硫酸酯或二硫酸酯或其药学上可接受的盐的病症的有效剂量。
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公开(公告)号：US06537789B1
公开(公告)日：2003-03-25
申请号：US09656420
申请日：2000-09-06
申请人： Satoshi Ueda , Miho Tanaka , Masami Ezaki , Kazutoshi Sakamoto , Seiji Hashimoto , Nobutaka Oohata , Masaru Tsuboi , Michio Yamashita
发明人： Satoshi Ueda , Miho Tanaka , Masami Ezaki , Kazutoshi Sakamoto , Seiji Hashimoto , Nobutaka Oohata , Masaru Tsuboi , Michio Yamashita
IPC分类号： C12N914
摘要： There is provided a cyclic lipopeptide acylase which is capable of deacylating the acyl side chain of a cyclic lipopeptide compound, e.g. Substance FR901379 or its analog, of the following general formula [I] with effectiveness as well a method of producing a cyclic peptide compound which comprises using the acylase. [wherein R1 is acyl; R2 is hydroxy or acyloxy; R3 is hydrogen or hydroxy; R4 is hydrogen or hydroxy; R5 is hydrogen or hydroxysulfonyloxy; and R6 is hydrogen or carbamoyl.]
摘要翻译： 提供了能够使环状脂肽化合物的酰基侧链脱酰化的环状脂肽酰基酶。 物质FR901379或其类似物，具有以下通式[I]，其有效性以及包括使用酰基转移酶的环肽化合物的制备方法[其中R1为酰基; R2为羟基或酰氧基; R3为氢或羟基; R4 是氢或羟基; R 5是氢或羟基磺酰氧基; 和R6是氢或氨基甲酰基。]
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公开(公告)号：US5436140A
公开(公告)日：1995-07-25
申请号：US225915
申请日：1994-04-11
申请人： Tohru Kino , Motoaki Nishikawa , Masami Ezaki , Sumio Kiyoto , Masakuni Okuhara , Shigehiro Takase , Satoshi Okada , Nobuharu Shigematsu
发明人： Tohru Kino , Motoaki Nishikawa , Masami Ezaki , Sumio Kiyoto , Masakuni Okuhara , Shigehiro Takase , Satoshi Okada , Nobuharu Shigematsu
摘要： The novel peptides WS-9326A, WS-9326B, their derivatives and pharmaceutically acceptable salts thereof have useful pharmacological activities, particularly in the treatment and/or prevention of asthma and/or pain. A method for the production of the peptides WS-9326A and WS-9326B and derivatives thereof using Streptomyces violaceoniger No. 9326 in a biologically pure form is described herein.
摘要翻译： 新型肽WS-9326A，WS-9326B及其衍生物和药学上可接受的盐具有有用的药理活性，特别是用于治疗和/或预防哮喘和/或疼痛。 本文描述了以生物纯的形式生产肽WS-9326A和WS-9326B及其衍生物的方法。
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5.发明授权WS7622A, B, C and D substances, derivatives thereof, processes for preparation thereof and use for treatment of pulmonary emphysema and adult respiratory distress syndrome 失效WS7622A，B，C和D物质，其衍生物，其制备方法和用于治疗肺气肿和成人呼吸窘迫综合征
公开(公告)号：US5167958A
公开(公告)日：1992-12-01
申请号：US645820
申请日：1991-01-25
申请人： Hiroshi Hatanaka , Masami Ezaki , Eisaku Tsujii , Masanori Okamoto , Nobuharu Shigematsu , Masakuni Okuhara , Shigehiro Takase
发明人： Hiroshi Hatanaka , Masami Ezaki , Eisaku Tsujii , Masanori Okamoto , Nobuharu Shigematsu , Masakuni Okuhara , Shigehiro Takase
IPC分类号： C12P1/04 , A61K35/74 , A61P1/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P43/00 , C07G99/00 , C12P1/06 , C12R1/465
CPC分类号： C12P1/06 , Y10S435/886
摘要： A method of treating pulmonary emphysema or adult respiratory distress syndrome in a subject in need thereof which comprises administering to the subject an effective amount of WS7622A, B, C and/or D, derivatives thereof, or their pharmaceutically acceptable salt.
摘要翻译： 一种在有需要的受试者中治疗肺气肿或成人呼吸窘迫综合征的方法，其包括向受试者施用有效量的WS7622A，B，C和/或D，其衍生物或其药学上可接受的盐。
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公开(公告)号：US4654211A
公开(公告)日：1987-03-31
申请号：US677013
申请日：1984-11-30
CPC分类号： C12P1/06 , Y10S435/886
摘要： Antibiotic FR-900451 is produced by Streptomyces griseorubiginosus No. 43708 (FERM BP-699).
摘要翻译： 抗生素FR-900451由灰霉链霉菌No.43708（FERM BP-699）生产。
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公开(公告)号：US06146872A
公开(公告)日：2000-11-14
申请号：US147352
申请日：1998-12-31
申请人： Satoshi Ueda , Miho Tanaka , Masami Ezaki , Kazutoshi Sakamoto , Seiji Hashimoto , Nobutaka Oohata , Masaru Tsuboi , Michio Yamashita
发明人： Satoshi Ueda , Miho Tanaka , Masami Ezaki , Kazutoshi Sakamoto , Seiji Hashimoto , Nobutaka Oohata , Masaru Tsuboi , Michio Yamashita
摘要： The present invention provides a cyclic lipopeptide acylase which may effectively deacylate the acyl side chain of a cyclic lipopeptide compound, specifically FR901379 Substance or its analog thereof shown by the following general formula [I], and a process for production of a cyclic peptide compound which comprises the use of said acylase. ##STR1##
摘要翻译： PCT No.PCT / JP97 / 02003 Sec。 371 1998年12月31日第 102（e）日期1998年12月31日PCT提交1997年6月11日PCT公布。 第WO97 / 47738号公报 日期：1997年12月18日本发明提供一种环状脂肽酰基转移酶，其可以有效地脱酰化环状脂肽化合物的酰基侧链，特别是FR901379由以下通式[I]表示的物质或其类似物， 包括使用所述酰基转移酶的环肽化合物。
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公开(公告)号：US4939241A
公开(公告)日：1990-07-03
申请号：US173294
申请日：1988-03-25
申请人： Masakuni Okuhara , Toshio Goto , Masami Ezaki , Miho Tanaka , Shigehiro Takase , Hidenori Nakajima , Hideo Hirai , Akira Katayama
发明人： Masakuni Okuhara , Toshio Goto , Masami Ezaki , Miho Tanaka , Shigehiro Takase , Hidenori Nakajima , Hideo Hirai , Akira Katayama
IPC分类号： A61K31/22 , A61P35/00 , C07C67/00 , C07C241/00 , C07C245/18 , C12P13/00 , C12R1/465
CPC分类号： C12P13/04 , C07C245/18 , C12P13/00 , Y10S435/886
摘要： The invention relates to compounds of antitumor activity of the formula: ##STR1## ps in which R.sup.1 is hydrogen, lower allkyl, halo(lower)alkyl or aryl,R.sup.2 is hydrogen, hydroxy or protected hydroxy,R.sup.3 is hydrogen,R.sup.4 is aminocarboxy(lower)alkyl, protected amino(lower)alkyl or protected aminocarboxy(lower)alkyl, andR.sup.5 is hydrogen or lower alkyl, or its pharmaceutical acceptable salt.
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公开(公告)号：US06573084B1
公开(公告)日：2003-06-03
申请号：US09656417
申请日：2000-09-06
申请人： Satoshi Ueda , Miho Tanaka , Masami Ezaki , Kazutoshi Sakamoto , Seiji Hashimoto , Nobutaka Oohata , Masaru Tsuboi , Michio Yamashita
发明人： Satoshi Ueda , Miho Tanaka , Masami Ezaki , Kazutoshi Sakamoto , Seiji Hashimoto , Nobutaka Oohata , Masaru Tsuboi , Michio Yamashita
IPC分类号： C12N120
摘要： There is provided a cyclic lipopeptide acylase which is capable of deacylating the acyl side chain of a cyclic lipopeptide compound, e.g. Substance FR901379 or its analog, of the following general formula [I] with effectiveness as well a method of producing a cyclic peptide compound which comprises using the acylase. [wherein R1 is acyl; R2 is hydroxy or acyloxy; R3 is hydrogen or hydroxy; R4 is hydrogen or hydroxy; R5 is hydrogen or hydroxysulfonyloxy; and R6 is hydrogen or carbamoyl.]
摘要翻译： 提供了能够使环状脂肽化合物的酰基侧链脱酰化的环状脂肽酰基酶。 物质FR901379或其类似物，具有以下通式[I]，其有效性以及包含使用酰基转移酶的环肽化合物的制备方法。[其中R 1为酰基; R 2为羟基或酰氧基; R 3为氢或羟基; R4是氢或羟基; R5是氢或羟基磺酰氧基; 和R6是氢或氨基甲酰基。]
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公开(公告)号：US06521600B1
公开(公告)日：2003-02-18
申请号：US09720331
申请日：2001-01-18
IPC分类号： A61K317028
CPC分类号： C12R1/645 , C07J63/008 , C12P19/60 , Y10S435/911
摘要： The present invention provides a new bioactive compound of formula (I), which has an antimicrobial activity against pathogenic microorganisms, and a process for production thereof. Also provided are a pharmaceutical composition comprising the compound and pharmaceutically acceptable carrier, a use of the WF002 as a medicament and use of the compound for manufacture of the medicament for treatment of infectious disease.
摘要翻译： 本发明提供了具有抗病原微生物的抗微生物活性的新的式（I）生物活性化合物及其生产方法。 还提供了包含该化合物和药学上可接受的载体的药物组合物，该WF002作为药物的用途以及该化合物用于制备用于治疗感染性疾病的药物的用途。
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