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公开(公告)号：US4910017A
公开(公告)日：1990-03-20
申请号：US261929
申请日：1988-10-25
CPC分类号： C12P1/02 , Y10S435/911
摘要： This invention relates to new compounds WF 2015 A and B which have immunosuppressing activity and antitumor activity, to a process for producing WF 2015 A and B by culturing a WF 2015 A and/or B-producing strain belonging to the genus Scolecobasidium in a nutrient medium, and to a pharmaceutical composition comprising the same.
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公开(公告)号：US5545542A
公开(公告)日：1996-08-13
申请号：US415160
申请日：1995-03-31
申请人： Hidenori Nakajima , Yasuhiro Hori , Toshio Goto , Shigehiro Takase , Koen Verhaeghe , Hiroshi Terano , Masakuni Okuhara
发明人： Hidenori Nakajima , Yasuhiro Hori , Toshio Goto , Shigehiro Takase , Koen Verhaeghe , Hiroshi Terano , Masakuni Okuhara
CPC分类号： C12P1/04 , Y10S435/822 , Y10S435/874
摘要： WB2663 substance-producing bacteria belonging to the genus Pseudomonas are cultured to produce a physiologically active substance, from which are isolated neutral substances WB2663A, WB2663B and WB2663C having respective specific rotations[.alpha.].sub.D.sup.23 : -36.degree. (C=0.5, CH.sub.2 Cl.sub.2),[.alpha.].sub.D.sup.23 : -12.degree. (C=0.5, CH.sub.2 Cl.sub.2),[.alpha.].sub.D.sup.23 : -9.degree. (C=0.5, CH.sub.2 Cl.sub.2),These substances have an excellent antitumor effect.
摘要翻译： 培养属于假单胞菌属的WB2663物质产生细菌以产生生理活性物质，从其中分离具有各自的特定旋度αD23：-36°（C = 0.5，CH 2 Cl 2）的分离的中性物质WB2663A，WB2663B和WB2663C， αD23：-12°（C = 0.5，CH 2 Cl 2），αD 23：-9（C = 0.5，CH 2 Cl 2）。这些物质具有优异的抗肿瘤效果。
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公开(公告)号：US4743614A
公开(公告)日：1988-05-10
申请号：US859587
申请日：1986-03-04
IPC分类号： A61K38/00 , C07D207/20 , C07D233/54 , C07K5/072 , C12P13/00 , A61K31/165 , A61K31/195 , A61K31/405 , A61K31/415
CPC分类号： C07D233/64 , C07D207/20 , C07K5/06113 , C12P13/005 , C12P13/02 , C12P13/04 , C12R1/645 , A61K38/00
摘要： Novel compounds of the following formula have restorative pharmacological activities in immuno-deficient hosts, ##STR1## wherein R.sup.1 is amino or a protected amino group,R.sup.2 is hydrogen, carboxy or a protected carboxy group,R.sup.3 is hydrogen, carboxy or a protected carboxy group,R.sup.4 is lower alkyl, amino(lower)alkyl, protected amino(lower)alkyl, carbamoyl(lower)alkyl or protected carbamoyl(lower)alkyl,R.sup.5 is hydrogen or lower alkyl, andR.sup.6 is hydrogen, hydroxyphenyl(lower)alkyl, imidazolyl(lower)alkyl or indolyl(lower)alkyl.
摘要翻译： 下式的新化合物在免疫缺陷型宿主中具有恢复性药理学活性，其中R1是氨基或被保护的氨基，R2是氢，羧基或被保护的羧基，R3是氢，羧基或被保护的羧基 ，R4是低级烷基，氨基（低级）烷基，被保护的氨基（低级）烷基，氨基甲酰基（低级）烷基或被保护的氨基甲酰基（低级）烷基，R5是氢或低级烷基，R6是氢，羟基苯基（低级）烷基， 咪唑基（低级）烷基或吲哚基（低级）烷基。
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公开(公告)号：US4670259A
公开(公告)日：1987-06-02
申请号：US813065
申请日：1985-12-24
IPC分类号： C12N1/16 , A61K36/06 , A61K36/07 , A61P35/00 , C07G11/00 , C12N1/14 , C12P1/02 , C12R1/645 , A61K35/70 , A61K35/72
CPC分类号： C12P1/02
摘要： The invention relates to a new compound, designated FR-68504. The compound has antitimor activities and is effective in the treatment of various tumors in both human beings and animals.There is also provided a process for preparing FR-68504 compound which comprises culturing a FR-68504 producing strain belonging to the genus Amauroascus in a nutrient medium.Pharmaceutical composition comprising FR-68504 as an active ingredient is also described.
摘要翻译： 本发明涉及一种名为FR-68504的新化合物。 该化合物具有抗肿瘤活性，在人和动物的各种肿瘤治疗中均有效。 还提供了制备FR-68504化合物的方法，该方法包括在营养培养基中培养属于阿莫罗氏菌属的FR-68504生产菌株。 还描述了包含FR-68504作为活性成分的药物组合物。
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公开(公告)号：US4605559A
公开(公告)日：1986-08-12
申请号：US646090
申请日：1984-08-31
CPC分类号： C12P1/06 , H05K1/0298
摘要： The invention relates to a new compound, FR-900447, and pharmaceutically acceptable salts thereof having antimicrobial and antitumor activity, to a pharmaceutically composition thereof, and to a process for production thereof by culturing Streptomyces rubropurpureus FERM BP-584 in nutrient medium under aerobic condition.
摘要翻译： 本发明涉及一种具有抗微生物和抗肿瘤活性的新化合物FR-900447及其药学上可接受的盐及其药物组合物，以及通过在需氧条件下在营养培养基中培养罗氏假单胞菌FERM BP-584的方法 。
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6.发明授权Biologically pure culture of Streptomyces sandaensis No. 6897 失效Streptomyces sandaensis No.6897的生物纯培养
公开(公告)号：US4743555A
公开(公告)日：1988-05-10
申请号：US913478
申请日：1986-09-30
申请人： Masanobu Kohsaka , Hiroshi Terano , Tadaaki Komori , Morita Iwami , Michio Yamashita , Masashi Hashimoto , Itsuo Uchida , Shigehiro Takase
发明人： Masanobu Kohsaka , Hiroshi Terano , Tadaaki Komori , Morita Iwami , Michio Yamashita , Masashi Hashimoto , Itsuo Uchida , Shigehiro Takase
IPC分类号： A61K31/535 , A61P31/04 , A61P35/00 , C07D498/04 , C07D498/18 , C12N1/20 , C12P17/18 , C12R1/465
CPC分类号： C07D498/18 , C12P17/188 , C12R1/465 , Y02P20/55 , Y10S435/886
摘要： A biologically pure culture of Streptomyces sandaensis which is capable of producing an antitumor and antimicrobial compound, designated FR-900482 substance, is disclosed.
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7.发明授权Biologically active WS 6049 substances, a process for the production thereof and their pharmaceutical compositions 失效生物活性WS 6049物质，其制备方法及其药物组合物
公开(公告)号：US4578271A
公开(公告)日：1986-03-25
申请号：US491170
申请日：1983-05-03
IPC分类号： C07G11/00 , A61K35/74 , A61P31/04 , A61P35/00 , C12N1/20 , C12P1/04 , C12P1/06 , C12P13/00 , C12R1/03 , A61K35/00
CPC分类号： C12R1/03 , C12P1/06 , Y10S435/825
摘要： Novel compounds designated as WS 6049-A and WS 6049-B are disclosed, as well as compositions containing the compounds thereof, a method of treating microbial infections, a method of prolonging the survival time of the patient with lymphocytic leukemia by administering the compounds thereof, and a process for making the WS 6049 substances, are disclosed. As indicated above, the novel compounds have antimicrobial and antileukemic activities which make them useful against a variety of pathogenic microorganisms and leukemic tumors.
摘要翻译： 公开了称为WS 6049-A和WS 6049-B的新化合物，以及含有其化合物的组合物，治疗微生物感染的方法，通过施用其化合物延长患有淋巴细胞白血病的患者的存活时间的方法 ，以及制备WS 6049物质的方法。 如上所述，新化合物具有抗微生物和抗白血病活性，使其可用于各种致病微生物和白血病肿瘤。
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公开(公告)号：US4861774A
公开(公告)日：1989-08-29
申请号：US947759
申请日：1986-12-30
申请人： Masanobu Kohsaka , Hiroshi Terano , Tadaaki Komori , Morita Iwami , Michio Yamashita , Masashi Hashimoto , Itsuo Uchida , Shigehiro Takase
发明人： Masanobu Kohsaka , Hiroshi Terano , Tadaaki Komori , Morita Iwami , Michio Yamashita , Masashi Hashimoto , Itsuo Uchida , Shigehiro Takase
IPC分类号： A61K31/535 , A61P31/04 , A61P35/00 , C07D498/18 , C12P17/18 , C12R1/465
CPC分类号： C07D498/18 , C12P17/188 , C12R1/465 , Y02P20/55
摘要： The invention relates to a method for treatment of carcinoma or sarcoma tumor in mammals which comprises administering to said mammal an effective amount of a tetracyclo compound of the formula: ##STR1## in which R.sup.1 is formyl, protected formyl, hydroxymethyl, protected hydroxymethyl, arylaminomethyl, carboxy, protected carboxy, aryliminomethyl, hydroxyiminomethyl, alkoxyiminomethyl, acyloxyiminomethyl, semicarbazonomethyl or arylsemicarbazonomethyl,R.sup.2 is hydroxy, alkoxy, or protected hydroxy,R.sup.3 is hydrogen and R.sup.4 is methyl, hydroxymethyl or protected hydroxymethyl, orR.sup.3 and R.sup.4 are combined together to form methylene or oxo,R.sup.5 is hydroxy, alkoxy or protected hydroxy, andR.sup.6 is hydrogen, imino-protective group or alkyl,and pharmaceutically acceptable salts thereof.
摘要翻译： 本发明涉及一种治疗哺乳动物癌或肉瘤肿瘤的方法，包括向所述哺乳动物施用有效量的下式的四环化合物：其中R 1为甲酰基，被保护的甲酰基，羟甲基，保护的羟甲基，芳基氨基甲基 羧基，保护的羧基，芳基亚氨基甲基，羟基亚氨基甲基，烷氧基亚氨基甲基，酰氧基亚氨基甲基，氨基甲酰基甲基或芳基氨基丙基甲基，R2是羟基，烷氧基或被保护的羟基，R3是氢，R4是甲基，羟甲基或保护的羟甲基，或R3和R4组合在一起形成 亚甲基或氧代，R 5为羟基，烷氧基或保护的羟基，R 6为氢，亚氨基保护基或烷基，及其药学上可接受的盐。
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9.发明授权
公开(公告)号：US4645765A
公开(公告)日：1987-02-24
申请号：US743616
申请日：1985-06-11
申请人： Masanobu Kohsaka , Hiroshi Terano , Tadaaki Komori , Morita Iwami , Michio Yamashita , Masashi Hashimoto , Itsuo Uchida , Shigehiro Takase
发明人： Masanobu Kohsaka , Hiroshi Terano , Tadaaki Komori , Morita Iwami , Michio Yamashita , Masashi Hashimoto , Itsuo Uchida , Shigehiro Takase
IPC分类号： A61K31/535 , A61P31/04 , A61P35/00 , C07D498/04 , C07D498/18 , C12N1/20 , C12P17/18 , C12R1/465
CPC分类号： C07D498/18 , C12P17/188 , C12R1/465 , Y02P20/55 , Y10S435/886
摘要： New tetracyclo compounds of the formula: ##STR1## in which R.sup.1 is formyl, protected formyl, hydroxymethyl, protected hydroxymethyl, arylaminomethyl, carboxy, protected carboxy or substituted iminomethyl,R.sup.2 is hydroxy, alkoxy or protected hydroxy,R.sup.3 is hydrogen and R.sup.4 is methyl, hydroxymethyl or protected hydroxymethyl, orR.sup.3 and R.sup.4 are combined together to form methylene or oxo,R.sup.5 is hydroxy, alkoxy or protected hydroxy, andR.sup.6 is hydrogen, imino-protective group or alkyl,and pharmaceutically acceptable salts thereof, which have pharmacological activities such as antitumor activity, antimicrobial activity, and the like, and a process for their production and a pharmaceutical composition containing the same.
摘要翻译： 新的下式的四环化合物：其中R 1是甲酰基，保护的甲酰基，羟甲基，保护的羟甲基，芳基氨基甲基，羧基，被保护的羧基或取代的亚氨基甲基，R2是羟基，烷氧基或保护的羟基，R3是氢， R 4是甲基，羟甲基或被保护的羟甲基，或者R 3和R 4结合在一起形成亚甲基或氧代，R 5是羟基，烷氧基或保护的羟基，R 6是氢，亚氨基保护基或烷基，及其药学上可接受的盐， 具有抗肿瘤活性，抗菌活性等药理活性，及其制造方法和含有该药物组合物的药物组合物。
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