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37 条记录 (耗时 0.026 秒)

    WF14573 or its salt, production thereof and use thereof
    2.
    发明授权
    WF14573 or its salt, production thereof and use thereof 失效
    WF14573或其盐，其制备及其用途

    公开(公告)号：US06730776B1

    公开(公告)日：2004-05-04

    申请号：US09646342

    申请日：2000-09-18

    申请人： Yasuhiro Hori ,  Shigehiro Takase ,  Yasuhisa Tsurumi ,  Michizane Hashimoto ,  Motohiro Hino

    发明人： Yasuhiro Hori ,  Shigehiro Takase ,  Yasuhisa Tsurumi ,  Michizane Hashimoto ,  Motohiro Hino

    IPC分类号： C07K750

    CPC分类号： C07K7/56 ,  A61K38/00

    摘要： The present invention provides a new antimicrobial compound WF14573, and a process for producing WF14573 by (a) culturing a WF14573A and/or B-producing microorganism in a nutrient medium and recovering WF14573A and/or B from the resultant cultured broth or (b) deacylating WF14573A and/or B in the presence of a microbial substance which is capable of deacylating WF14573A and/or B. Also provided are an antimicrobial agent comprising WF14573 and carrier(s), a pharmaceutical composition comprising an effective amount of WF14573 and pharmaceutically acceptable carrier(s), a method for killing microorganisms by applying WF14573 to the microorganisms, and use of WF14573 for the treatment of infectious diseases caused by pathogenic microorganisms.

    摘要翻译： 本发明提供了一种新的抗微生物化合物WF14573，以及（a）在营养培养基中培养WF14573A和/或产生B生物的微生物并从所得培养液中回收WF14573A和/或B或（b）生产WF14573的方法， 在能够脱酰基WF14573A和/或B的微生物物质存在下脱酰基WF14573A和/或B。还提供了包含WF14573和载体的抗微生物剂，包含有效量的WF14573和药学上可接受的药物组合物 载体，通过向微生物施用WF14573杀死微生物的方法，以及使用WF14573来治疗由病原微生物引起的感染性疾病。

    Cyclic tetrapeptide compound and use thereof
    3.
    发明授权
    Cyclic tetrapeptide compound and use thereof 失效
    环状四肽化合物及其用途

    公开(公告)号：US06656905B1

    公开(公告)日：2003-12-02

    申请号：US09806500

    申请日：2001-05-04

    申请人： Hiroaki Mori ,  Kazutoshi Sakamoto ,  Yasuhisa Tsurumi ,  Shigehiro Takase ,  Motohiro Hino

    发明人： Hiroaki Mori ,  Kazutoshi Sakamoto ,  Yasuhisa Tsurumi ,  Shigehiro Takase ,  Motohiro Hino

    IPC分类号： A61K3807

    CPC分类号： A61K38/12 ,  C07K5/126

    摘要： A cyclic tetrapeptide compound and use thereof. Especially, a compound WF27082, a process for production of the compound by culturing, in a nutrient medium, a WF27082-producing strain belonging to Acremonium and recovering the compound from a culture broth, a pharmaceutical composition containing the compound as an active ingredient, in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient, the compound for use as a medicament, a use of the compound for manufacture of a medicament for inhibiting histone deacetylase, a use of the compound for manufacture of a medicament for treating or preventing inflammatory disorders, diabetes, diabetic complications, homozygous thalassemia, fibrosis, cirrhosis, acute promyelocytic leukaemia (APL), protozoal infections, organ transplant rejections, autoimmune diseases, or tumors, a use of histone deacetylase inhibitors as an immunosuppressant or an antitumor agent, and a use of histone deacetylase inhibitors for manufacture of a medicament for treating or preventing organ transplant rejections, autoimmune diseases or tumors are described.

    摘要翻译： 一种环状四肽化合物及其用途。 特别地，化合物WF27082是通过在营养培养基中培养属于顶孢菌属的WF27082产生菌株并从培养液中回收化合物，将含有该化合物作为活性成分的药物组合物生产化合物的方法， 与药学上可接受的，基本上无毒的载体或赋形剂的相关联，用作药物的化合物，该化合物用于制备用于抑制组蛋白脱乙酰酶的药物的用途，该化合物用于制备用于治疗或 预防炎性疾病，糖尿病，糖尿病并发症，纯合地中海贫血，纤维化，肝硬化，急性早幼粒细胞白血病（APL），原生动物感染，器官移植排斥，自身免疫疾病或肿瘤，组蛋白脱乙酰酶抑制剂作为免疫抑制剂或抗肿瘤剂的用途， 以及使用组蛋白脱乙酰酶抑制剂来制造用于治疗或预防的药物 描述器官移植排斥，自身免疫性疾病或肿瘤。