公开(公告)号：US4280996A

公开(公告)日：1981-07-28

申请号：US75684

申请日：1979-09-13

申请人： Hiroyuki Okamoto ,  Yoshio Tsuda ,  Kazumasa Yokoyama

发明人： Hiroyuki Okamoto ,  Yoshio Tsuda ,  Kazumasa Yokoyama

IPC分类号： A61K47/44 ,  A23L1/30 ,  A61K9/00 ,  A61K9/10 ,  A61K9/107 ,  A61K31/16 ,  A61K31/20 ,  A61K31/23 ,  A61K31/685 ,  A61K35/54 ,  A61K36/00 ,  A61K36/48 ,  A61K38/00 ,  A61K47/28 ,  A61P3/06 ,  B01F17/14 ,  A61K31/56 ,  B01J13/00

CPC分类号： A61K9/0029 ,  A61K31/685 ,  A61K36/48

摘要： A stable fat emulsion having low side effects, which is suitable as nutritive infusion fluid for intravenous injection, is provided. The emulsion contains 5-50 (W/V) % of soybean oil, yolk phospholipids in a weight ratio to the soybean oil of 1/4-1/25, 0.01-0.30 (W/V) % of a fatty acid or salt thereof having 12-20 carbon atoms and the balance of water.

摘要翻译： 提供了一种适用作静脉注射用营养输液的稳定的副作用低的脂肪乳剂。 该乳液含有5-50（W / V）％的大豆油，与大豆油的重量比为1 / 4-1 / 25,2.01-0.30（W / V）％的脂肪酸​​或盐的蛋黄磷脂 其具有12-20个碳原子，余量为水。

公开(公告)号：US4049683A

公开(公告)日：1977-09-20

申请号：US583293

申请日：1975-06-03

申请人： Hiroyuki Okamoto ,  Yoshio Tsuda ,  Kazumasa Yokoyama

发明人： Hiroyuki Okamoto ,  Yoshio Tsuda ,  Kazumasa Yokoyama

IPC分类号： C07B59/00 ,  C07B31/00 ,  C07C67/00 ,  C11C3/08 ,  C11C3/10 ,  G21H5/02

CPC分类号： C11C3/10 ,  G21H5/02

摘要： A method for preparing a vegetable oil labelled with .sup.14 C or .sup.3 H, characterized by transesterifying a vegetable oil with at least one of the chemically same fatty acids labelled with .sup.14 C or .sup.3 H as those constituting said vegetable oil. The resulting labelled vegetable oil can be used in measuring biological metabolic activity of man or an animal or as a biological tracer reagent.

摘要翻译： 一种制备用14C或3H标记的植物油的方法，其特征在于将植物油与至少一种用14C或3H标记的化学相同的脂肪酸与构成所述植物油的那些脂肪酸进行酯交换。 所得到的标记植物油可用于测量人或动物的生物代谢活性或作为生物示踪试剂。

公开(公告)号：US4605650A

公开(公告)日：1986-08-12

申请号：US751850

申请日：1983-07-05

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

IPC分类号： A61K9/00 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  A61K31/40

CPC分类号： A61K9/0026 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  Y10S514/832 ,  Y10S514/833

摘要： A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 to 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

公开(公告)号：US4713459A

公开(公告)日：1987-12-15

申请号：US830094

申请日：1986-02-18

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Tadakazu Suyama

IPC分类号： A01N1/02 ,  A61K9/00 ,  C07D209/30 ,  C07D209/44 ,  C07D209/52 ,  C07D215/18 ,  C07D217/22 ,  C07D221/04 ,  C25B3/08 ,  A61K31/47 ,  A61K31/40 ,  C07D209/10

CPC分类号： A61K9/0026 ,  A01N1/02 ,  A01N1/0226 ,  C07D209/30 ,  C07D209/44 ,  C07D209/52 ,  C07D215/18 ,  C07D217/22 ,  C07D221/04 ,  C25B3/08

摘要： A novel compound of the formula, ##STR1## wherein R denotes a lower perfluoroalkyl group, l is an integer of 3 or 4, n+m is an integer of 2 or 3, provided that n may be zero, and at least one of ring A and ring B may be substituted by a lower perfluoroalkyl group, prepared by reacting the corresponding perhydro compound with fluorine is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

公开(公告)号：US4654337A

公开(公告)日：1987-03-31

申请号：US751880

申请日：1985-07-05

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

IPC分类号： A61K9/00 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  C07D223/00 ,  A61K31/435

CPC分类号： A61K9/0026 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  Y10S514/832 ,  Y10S514/833

摘要： A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 or 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

公开(公告)号：US4591599A

公开(公告)日：1986-05-27

申请号：US670971

申请日：1984-11-13

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Tadakazu Suyama

IPC分类号： A61K9/00 ,  C07D455/02 ,  C07D471/04 ,  C07D487/04 ,  C25B3/08 ,  C07D487/06 ,  A61K31/40

CPC分类号： A61K9/0026 ,  C07D455/02 ,  C07D471/04 ,  C07D487/04 ,  C25B3/08

摘要： A perfluorobicyclo compound of the general formula: ##STR1## wherein either or both of Ring A and Ring B may optionally be substituted with lower perfluoroalkyl group (s) and m and n each represent 3 or 4.

摘要翻译： 一种具有下列通式的全氟二环化合物：其中环A和环B中的任一个或两者可以任选地被低级全氟烷基取代，m和n各自表示3或4。

公开(公告)号：US4425347A

公开(公告)日：1984-01-10

申请号：US454105

申请日：1982-12-28

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

IPC分类号： A01N1/02 ,  A61K9/10 ,  A61K31/435 ,  A61P7/08 ,  B01F17/14 ,  C07D455/02

CPC分类号： C07D455/02 ,  A01N1/021 ,  A61K31/435 ,  Y10S514/832

摘要： A perfluorobicyclo compound emulsion preparation having oxygen carrying ability containing a perfluorobicyclo compound of the general formula: ##STR1## wherein R represents a perfluoromethyl group or perfluoroethyl group, as an oxygen carrying component.

摘要翻译： 一种全氟双环化合物乳液制剂，其具有含有下列通式的全氟二环化合物的氧承载能力：其中R表示全氟甲基或全氟乙基，作为携氧组分。

公开(公告)号：US4613605A

公开(公告)日：1986-09-23

申请号：US751948

申请日：1985-07-05

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

IPC分类号： A61K9/00 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  A61K31/445 ,  C07D453/00

CPC分类号： A61K9/0026 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  Y10S514/832 ,  Y10S514/833

摘要： A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 or 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

公开(公告)号：US4530926A

公开(公告)日：1985-07-23

申请号：US505324

申请日：1983-06-17

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

IPC分类号： A01N1/02 ,  C07D455/03 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08 ,  A61K31/55 ,  A61K31/40 ,  A61K31/445 ,  C07D455/06

CPC分类号： C07D455/00 ,  A01N1/021 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08

摘要： A novel compound of the formula, ##STR1## wherein k, j, l and m are zero or an integer of from 1 to 3, and n is an integer of from 1 to 3, the rings A, B and C being optionally substituted with at least one trifluoromethyl group, prepared by reacting the corresponding perhydro compound with fluorine is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

摘要翻译： 式（I）的新颖化合物，其中k，j，l和m为0或1〜3的整数，n为1〜3的整数，环A，B，C 任选地被至少一个三氟甲基取代，其通过使相应的全氢化合物与氟反应制备，可用作能够在水乳液中携带氧气的材料，用于挽救患有大量出血的患者和用于在移植中保存内脏。

公开(公告)号：US4542147A

公开(公告)日：1985-09-17

申请号：US505322

申请日：1983-06-17

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

IPC分类号： A61K9/00 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  C07D209/94 ,  A61K31/40

CPC分类号： A61K9/0026 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  Y10S514/832 ,  Y10S514/833

摘要： A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 to 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

摘要翻译： 一种下式的新化合物，其中k为0或1〜2的整数，j为1〜3的整数，l和m分别为0或1〜3的整数，n为 通过使与其对应的全氟化合物与氟反应来制备环A，B和C任选被至少一个三氟甲基或四氟乙基取代的整数。 该化合物可用作能够在水性乳液中携带氧气的材料，用于挽救患有大量出血的患者和用于在移植中保存内部器官。