公开(公告)号：US20150087799A1

公开(公告)日：2015-03-26

申请号：US14343912

申请日：2012-09-11

申请人： Hisanori Kishida ,  Takashi Hasegawa ,  Nobuyoshi Nomura ,  Makoto Takahashi ,  Joseph Schroeder ,  Manuel Natal

发明人： Hisanori Kishida ,  Takashi Hasegawa ,  Nobuyoshi Nomura ,  Makoto Takahashi ,  Joseph Schroeder ,  Manuel Natal

IPC分类号： C08G63/08

CPC分类号： C08G63/08 ,  C08G63/823

摘要： This invention provides a method for synthesizing semi-crystalline polylactides (PLA) even from a lactide mixture including meso-LA and rac-LA. According to the invention, when a mixture of racemic lactide and meso-lactide ispolymerized using a catalyst capable of iso-selectively polymerizing L-lactide and D-lactide, an amorphous poly (meso-lactide) block is formed from meso-lactide and a semi-crystalline poly (racemic lactide) block is formed from racemic lactide by separately polymerizing racemic lactide and meso-lactide by taking advantage of a difference in physicochemical properties between racemic lactide and meso-lactide, whereby polylactide which is semi-crystalline as a whole is produced.

摘要翻译： 本发明提供了即使由包括meso-LA和rac-LA的丙交酯混合物合成半结晶聚交酯（PLA）的方法。 根据本发明，当外消旋丙交酯和内消旋丙交酯的混合物使用能够同时选择性聚合L-丙交酯和D-丙交酯的催化剂进行聚合时，由内消旋丙交酯形成无定形的聚（内消旋丙交酯）嵌段， 通过利用外消旋丙交酯和内消旋丙交酯之间的物理化学性质的差异，通过分别外消旋丙交酯和内消旋丙交酯聚合形成半结晶聚（外消旋丙交酯）嵌段，由此作为整体是半结晶的聚丙交酯 生产。

公开(公告)号：US09284403B2

公开(公告)日：2016-03-15

申请号：US14343912

申请日：2012-09-11

申请人： Hisanori Kishida ,  Takashi Hasegawa ,  Nobuyoshi Nomura ,  Makoto Takahashi ,  Joseph Schroeder ,  Manuel Natal

发明人： Hisanori Kishida ,  Takashi Hasegawa ,  Nobuyoshi Nomura ,  Makoto Takahashi ,  Joseph Schroeder ,  Manuel Natal

IPC分类号： C08G63/00 ,  C08G63/08 ,  C08G63/82

CPC分类号： C08G63/08 ,  C08G63/823

摘要： This invention provides a method for synthesizing semi-crystalline polylactides (PLA) even from a lactide mixture including meso-LA and rac-LA. According to the invention, when a mixture of racemic lactide and meso-lactide ispolymerized using a catalyst capable of iso-selectively polymerizing L-lactide and D-lactide, an amorphous poly (meso-lactide) block is formed from meso-lactide and a semi-crystalline poly (racemic lactide) block is formed from racemic lactide by separately polymerizing racemic lactide and meso-lactide by taking advantage of a difference in physicochemical properties between racemic lactide and meso-lactide, whereby polylactide which is semi-crystalline as a whole is produced.

摘要翻译： 本发明提供了即使由包括meso-LA和rac-LA的丙交酯混合物合成半结晶聚交酯（PLA）的方法。 根据本发明，当外消旋丙交酯和内消旋丙交酯的混合物使用能够同时选择性聚合L-丙交酯和D-丙交酯的催化剂进行聚合时，由内消旋丙交酯形成无定形的聚（内消旋丙交酯）嵌段， 通过利用外消旋丙交酯和内消旋丙交酯之间的物理化学性质的差异，通过分别外消旋丙交酯和内消旋丙交酯聚合形成半结晶聚（外消旋丙交酯）嵌段，由此作为整体是半结晶的聚丙交酯 生产。

公开(公告)号：US20130178598A1

公开(公告)日：2013-07-11

申请号：US13704793

申请日：2011-06-16

申请人： Hisanori Kishida ,  Takashi Hasegawa ,  Kenji Miyaguchi ,  Takehiko Moriya ,  Nobuyoshi Nomura ,  Ryohei Ogawa

发明人： Hisanori Kishida ,  Takashi Hasegawa ,  Kenji Miyaguchi ,  Takehiko Moriya ,  Nobuyoshi Nomura ,  Ryohei Ogawa

IPC分类号： C08G63/84

CPC分类号： C08G63/84 ,  C08G63/08 ,  C08G63/82 ,  C08G63/823 ,  C08L101/16

摘要： To provide a method capable of producing stereocomplex polylactic acid, the method being capable of using carbon neutral materials that are not competitive from foods, such as saccharides, without the use of a method for designing optical resolution, which requires complicated operations and high cost and is difficult to perform mass production. The production method of the present invention comprises: a step of reacting glycerin with sodium hydroxide in high-temperature and high-pressure water to produce a racemic sodium lactate aqueous solution; a step of separating sodium from the racemic sodium lactate aqueous solution to recover racemic lactic acid; a step of dimerizing the racemic lactic acid to produce a lactide mixture containing meso lactide and racemic lactide; a step of separating meso lactide from the mixture to recover racemic lactide; and a step of polymerizing the racemic lactide with a salen-metal complex as a catalyst to produce stereocomplex polylactic acid.

摘要翻译： 为了提供能够制备立体络合物聚乳酸的方法，该方法能够使用与诸如糖类之类的食品不具有竞争力的碳中和材料，而不需要使用设计光学拆分的方法，这需要复杂的操作和高成本， 难以进行批量生产。 本发明的制造方法包括：使甘油与氢氧化钠在高温高压水中反应生成外消旋乳酸钠水溶液的工序; 从外消旋乳酸钠水溶液中分离钠以回收外消旋乳酸的步骤; 使外消旋乳酸二聚以产生含有内消旋丙交酯和外消旋丙交酯的丙交酯混合物的步骤; 从混合物中分离内消旋丙交酯以回收外消旋丙交酯的步骤; 以及将外消旋丙交酯与作为催化剂的盐金属络合物聚合以制备立体络合物聚乳酸的步骤。

公开(公告)号：US09056946B2

公开(公告)日：2015-06-16

申请号：US13704793

申请日：2011-06-16

申请人： Hisanori Kishida ,  Takashi Hasegawa ,  Kenji Miyaguchi ,  Takehiko Moriya ,  Nobuyoshi Nomura ,  Ryohei Ogawa

发明人： Hisanori Kishida ,  Takashi Hasegawa ,  Kenji Miyaguchi ,  Takehiko Moriya ,  Nobuyoshi Nomura ,  Ryohei Ogawa

IPC分类号： C08G63/00 ,  C08G63/84 ,  C08G63/82 ,  C08G63/08 ,  C08L101/16

CPC分类号： C08G63/84 ,  C08G63/08 ,  C08G63/82 ,  C08G63/823 ,  C08L101/16

摘要： To provide a method capable of producing stereocomplex polylactic acid, the method being capable of using carbon neutral materials that are not competitive from foods, such as saccharides, without the use of a method for designing optical resolution, which requires complicated operations and high cost and is difficult to perform mass production. The production method of the present invention comprises: a step of reacting glycerin with sodium hydroxide in high-temperature and high-pressure water to produce a racemic sodium lactate aqueous solution; a step of separating sodium from the racemic sodium lactate aqueous solution to recover racemic lactic acid; a step of dimerizing the racemic lactic acid to produce a lactide mixture containing meso lactide and racemic lactide; a step of separating meso lactide from the mixture to recover racemic lactide; and a step of polymerizing the racemic lactide with a salen-metal complex as a catalyst to produce stereocomplex polylactic acid.

摘要翻译： 为了提供能够制备立体络合物聚乳酸的方法，该方法能够使用与诸如糖类之类的食品不具有竞争力的碳中和材料，而不需要使用设计光学拆分的方法，这需要复杂的操作和高成本， 难以进行批量生产。 本发明的制造方法包括：使甘油与氢氧化钠在高温高压水中反应生成外消旋乳酸钠水溶液的工序; 从外消旋乳酸钠水溶液中分离钠以回收外消旋乳酸的步骤; 使外消旋乳酸二聚以产生含有内消旋丙交酯和外消旋丙交酯的丙交酯混合物的步骤; 从混合物中分离内消旋丙交酯以回收外消旋丙交酯的步骤; 以及将外消旋丙交酯与作为催化剂的盐金属络合物聚合以制备立体络合物聚乳酸的步骤。

公开(公告)号：US20090088589A1

公开(公告)日：2009-04-02

申请号：US11994263

申请日：2006-06-29

申请人： Heiji Enomoto ,  Fangming Jin ,  Takehiko Moriya ,  Kenji Kakeda ,  Yoshitoshi Sekiguchi ,  Hisanori Kishida

发明人： Heiji Enomoto ,  Fangming Jin ,  Takehiko Moriya ,  Kenji Kakeda ,  Yoshitoshi Sekiguchi ,  Hisanori Kishida

IPC分类号： C07C59/08 ,  B01J19/24 ,  B01J10/00

CPC分类号： C11C3/003 ,  B01J19/0013 ,  B01J19/285 ,  B01J2219/00006 ,  B01J2219/00094 ,  B01J2219/00099 ,  C01B3/32 ,  C01B3/50 ,  C01B2203/02 ,  C01B2203/04 ,  C01B2203/0465 ,  C01B2203/066 ,  C01B2203/1217 ,  C07C51/02 ,  C07C51/41 ,  Y02E50/13 ,  C07C59/08

摘要： A process for producing lactic acid according to the invention is characterized in that glycerin is subjected to a hydrothermal reaction under an alkaline condition at a temperature in the range of 150 to 400° C. and under pressure equal to or more than the saturated vapor pressure at the temperature. The glycerin produced from plant fats, animal fats or the like or pure product synthesized chemically or a discharge containing glycerin generated at the production of diesel fuel oil from fats, in which the fats are subjected to a transesterification with alcohol in the presence of an alkali catalyst in order to obtain fatty acid ester is preferably used as a starting material.

摘要翻译： 根据本发明的制备乳酸的方法的特征在于，甘油在碱性条件下在150-400℃的温度和在等于或大于饱和蒸气压的压力下进行水热反应 在温度。 从植物脂肪，动物脂肪等制造的甘油或化学合成的纯产品或者在生产来自脂肪的柴油燃料油时产生的甘油的排出物，其中脂肪在碱的存在下与醇进行酯交换 为了得到脂肪酸酯，优选使用催化剂作为原料。

公开(公告)号：US07829740B2

公开(公告)日：2010-11-09

申请号：US11994263

申请日：2006-06-29

申请人： Heiji Enomoto ,  Fangming Jin ,  Takehiko Moriya ,  Kenji Kakeda ,  Yoshitoshi Sekiguchi ,  Hisanori Kishida

发明人： Heiji Enomoto ,  Fangming Jin ,  Takehiko Moriya ,  Kenji Kakeda ,  Yoshitoshi Sekiguchi ,  Hisanori Kishida

IPC分类号： C07C59/08

CPC分类号： C11C3/003 ,  B01J19/0013 ,  B01J19/285 ,  B01J2219/00006 ,  B01J2219/00094 ,  B01J2219/00099 ,  C01B3/32 ,  C01B3/50 ,  C01B2203/02 ,  C01B2203/04 ,  C01B2203/0465 ,  C01B2203/066 ,  C01B2203/1217 ,  C07C51/02 ,  C07C51/41 ,  Y02E50/13 ,  C07C59/08

摘要： A process for producing lactic acid according to the invention is characterized in that glycerin is subjected to a hydrothermal reaction under an alkaline condition at a temperature in the range of 150 to 400° C. and under pressure equal to or more than the saturated vapor pressure at the temperature. The glycerin produced from plant fats, animal fats or the like or pure product synthesized chemically or a discharge containing glycerin generated at the production of diesel fuel oil from fats, in which the fats are subjected to a transesterification with alcohol in the presence of an alkali catalyst in order to obtain fatty acid ester is preferably used as a starting material.

摘要翻译： 根据本发明的制备乳酸的方法的特征在于，甘油在碱性条件下在150-400℃的温度和在等于或大于饱和蒸气压的压力下进行水热反应 在温度。 从植物脂肪，动物脂肪等制造的甘油或化学合成的纯产品或者在生产来自脂肪的柴油燃料油时产生的甘油的排出物，其中脂肪在碱的存在下与醇进行酯交换 为了得到脂肪酸酯，优选使用催化剂作为原料。

公开(公告)号：US20100047140A1

公开(公告)日：2010-02-25

申请号：US12606473

申请日：2009-10-27

申请人： Heiji ENOMOTO ,  Fangming Jin ,  Takehiko Moriya ,  Kenji Kakeda ,  Yoshitoshi Sekiguchi ,  Hisanori Kishida

发明人： Heiji ENOMOTO ,  Fangming Jin ,  Takehiko Moriya ,  Kenji Kakeda ,  Yoshitoshi Sekiguchi ,  Hisanori Kishida

IPC分类号： B01J19/00

CPC分类号： C11C3/003 ,  B01J19/0013 ,  B01J19/285 ,  B01J2219/00006 ,  B01J2219/00094 ,  B01J2219/00099 ,  C01B3/32 ,  C01B3/50 ,  C01B2203/02 ,  C01B2203/04 ,  C01B2203/0465 ,  C01B2203/066 ,  C01B2203/1217 ,  C07C51/02 ,  C07C51/41 ,  Y02E50/13 ,  C07C59/08

摘要： An apparatus for producing lactic acid according to the invention comprises a reactor carrying out: subjecting glycerin to a hydrothermal reaction under an alkaline condition, supplying an alkaline solution comprising glycerin; and continuously producing lactic acid, wherein glycerin is subjected to a hydrothermal reaction under an alkaline condition at a temperature in the range of 150 to 400° C. and under pressure equal to or more than the saturated vapor pressure at the temperature. The glycerin produced from plant fats, animal fats or the like or pure product synthesized chemically or a discharge containing glycerin generated at the production of diesel fuel oil from fats, in which the fats are subjected to a transesterification with alcohol in the presence of an alkali catalyst in order to obtain fatty acid ester is preferably used as a starting material.

摘要翻译： 根据本发明的乳酸的制造装置包括反应器，其在碱性条件下进行甘油进行水热反应，供给包含甘油的碱性溶液; 并连续生产乳酸，其中甘油在碱性条件下在150-400℃的温度和在该温度下等于或大于饱和蒸汽压的压力下进行水热反应。 从植物脂肪，动物脂肪等制造的甘油或化学合成的纯产品或者在生产来自脂肪的柴油燃料油时产生的甘油的排出物，其中脂肪在碱的存在下与醇进行酯交换 为了得到脂肪酸酯，优选使用催化剂作为原料。